Promoter aberrant methylation status of ADRA1A is associated with hepatocellular carcinoma

References

• Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. PMID: 30207593.
   PubMed Web of Science ®Google Scholar
• Marengo A, Rosso C, Bugianesi E. Liver cancer: connections with obesity, fatty liver, and cirrhosis. Annu Rev Med. 2016;67:103–117. PMID: 26473416.
   PubMed Web of Science ®Google Scholar
• Bevilacqua M, Norbiato G, Chebat E, et al. Changes in alpha-1 and beta-2 adrenoceptor density in human hepatocellular carcinoma. Cancer. 1991;67(10):2543–2551. PMID: 1849789.
   PubMed Web of Science ®Google Scholar
• Oben JA, Roskams T, Yang S, et al. Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury. Hepatology. 2003;38(3):664–673. PMID: 12939593.
   PubMed Web of Science ®Google Scholar
• Huan HB, Wen XD, Chen XJ, et al. Sympathetic nervous system promotes hepatocarcinogenesis by modulating inflammation through activation of alpha1-adrenergic receptors of Kupffer cells. Brain Behav Immun. 2017;59:118–134. PMID: 27585737.
   PubMed Web of Science ®Google Scholar
• Martinez-Salas SG, Campos-Peralta JM, Pares-Hipolito J, et al. Alpha1A-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed. Auton Autacoid Pharmacol. 2007;27(3):137–142. PMID: 17584443.
   PubMedGoogle Scholar
• Jensen KJ, Alpini G, Glaser S. Hepatic nervous system and neurobiology of the liver. Compr Physiol. 2013;3(2):655–666. PMID: 23720325.
   PubMed Web of Science ®Google Scholar
• Wong CC, Li W, Chan B, et al. Epigenomic biomarkers for prognostication and diagnosis of gastrointestinal cancers. Semin Cancer Biol. 2019;55:90–105. PMID: 29665409.
   PubMed Web of Science ®Google Scholar
• Li L, Li C, Mao H, et al. Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers. Sci Rep. 2016;6:26591. PMID: 27225590.
   PubMed Web of Science ®Google Scholar
• Robertson KD. DNA methylation and human disease. Nat Rev Genet. 2005;6(8):597–610. PMID: 16136652.
   PubMed Web of Science ®Google Scholar
• Zhang H, Ye J, Weng X, et al. Comparative transcriptome analysis reveals that the extracellular matrix receptor interaction contributes to the venous metastases of hepatocellular carcinoma. Cancer Genet. 2015;208(10):482–491. PMID: 26271415.
   PubMed Web of Science ®Google Scholar
• Tang L, Tan YX, Jiang BG, et al. The prognostic significance and therapeutic potential of hedgehog signaling in intrahepatic cholangiocellular carcinoma. Clin Cancer Res. 2013;19(8):2014–2024. PMID: 23493353.
   PubMed Web of Science ®Google Scholar
• Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003;349(21):2042–2054. PMID: 14627790.
   PubMed Web of Science ®Google Scholar
• Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003;33(Suppl):245–254. PMID: 12610534.
   PubMed Web of Science ®Google Scholar
• Hao X, Luo H, Krawczyk M, et al. DNA methylation markers for diagnosis and prognosis of common cancers. Proc Natl Acad Sci U S A. 2017;114(28):7414–7419. PMID: 28652331.
   PubMed Web of Science ®Google Scholar
• Cole SW, Sood AK. Molecular pathways: beta-adrenergic signaling in cancer. Clin Cancer Res. 2012;18(5):1201–1206. PMID: 22186256.
   PubMed Web of Science ®Google Scholar
• Luo DL, Gao J, Fan LL, et al. Receptor subtype involved in alpha 1-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytes. Acta Pharmacol Sin. 2007;28(7):968–974. PMID: 17588332.
   PubMed Web of Science ®Google Scholar
• Eng JW, Kokolus KM, Reed CB, et al. A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response. Cancer Immunol Immunother. 2014;63(11):1115–1128. PMID: 25307152.
   PubMed Web of Science ®Google Scholar
• Froelunde AS, Ohlenbusch M, Hansen KB, et al. Murine breast cancer feed arteries are thin-walled with reduced alpha1A-adrenoceptor expression and attenuated sympathetic vasocontraction. Breast Cancer Res. 2018;20(1):20. PMID: 29566737.
   PubMedGoogle Scholar
• Kavelaars A. Regulated expression of alpha-1 adrenergic receptors in the immune system. Brain Behav Immun. 2002;16(6):799–807. PMID: 12480508.
   PubMed Web of Science ®Google Scholar
• Kassahun WT, Gunl B, Jonas S, et al. Altered liver alpha1-adrenoceptor density and phospholipase C activity in the human hepatocellular carcinoma. Eur J Pharmacol. 2011;670(1):92–95. PMID: 21910987.
   PubMed Web of Science ®Google Scholar
• Soeda J, Mouralidarane A, Ray S, et al. The beta-adrenoceptor agonist isoproterenol rescues acetaminophen-injured livers through increasing progenitor numbers by Wnt in mice. Hepatology. 2014;60(3):1023–1034. PMID: 24923719.
   PubMed Web of Science ®Google Scholar
• Hassan S, Karpova Y, Baiz D, et al. Behavioral stress accelerates prostate cancer development in mice. J Clin Invest. 2013;123(2):874–886. PMID: 23348742.
   PubMed Web of Science ®Google Scholar
• Thaker PH, Han LY, Kamat AA, et al. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med. 2006;12(8):939–944. PMID: 16862152.
   PubMed Web of Science ®Google Scholar
• Wu FQ, Fang T, Yu LX, et al. ADRB2 signaling promotes HCC progression and sorafenib resistance by inhibiting autophagic degradation of HIF1alpha. J Hepatol. 2016;65(2):314–324. PMID: 27154061.
   PubMed Web of Science ®Google Scholar
• Li J, Yang XM, Wang YH, et al. Monoamine oxidase A suppresses hepatocellular carcinoma metastasis by inhibiting the adrenergic system and its transactivation of EGFR signaling. J Hepatol. 2014;60(6):1225–1234. PMID: 24607627.
   PubMed Web of Science ®Google Scholar
• Lamkin DM, Sung HY, Yang GS, et al. alpha2-Adrenergic blockade mimics the enhancing effect of chronic stress on breast cancer progression. Psychoneuroendocrinology. 2015;51:262–270. PMID: 25462899.
   PubMed Web of Science ®Google Scholar
• Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 2012;21(3):309–322. PMID: 22439926.
   PubMed Web of Science ®Google Scholar
• Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013;19(11):1423–1437. PMID: 24202395.
   PubMed Web of Science ®Google Scholar
• Campbell PJ, Getz G, Stuart JM, et al. Pan-cancer analysis of whole genomes. bioRxiv. 2017:162784. DOI:10.1101/162784 PMID.
   Google Scholar
• Priestley P, Baber J, Lolkema MP, et al. Pan-cancer whole-genome analyses of metastatic solid tumours. Nature. 2019;575:210–216. PMID: 31645765.
   PubMed Web of Science ®Google Scholar
• White TA, Kwon EM, Fu R, et al. The Monoamine Oxidase A gene promoter repeat and prostate cancer risk. Prostate. 2012;72(15):1622–1627. PMID.
   PubMed Web of Science ®Google Scholar
• Lambert MP, Paliwal A, Vaissiere T, et al. Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake. J Hepatol. 2011;54(4):705–715. PMID: 21146512.
   PubMed Web of Science ®Google Scholar
• Yamashita T, Ji J, Budhu A, et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology. 2009;136(3):1012–1024. PMID: 19150350.
   PubMed Web of Science ®Google Scholar
• Wang HW, Hsieh TH, Huang SY, et al. Forfeited hepatogenesis program and increased embryonic stem cell traits in young hepatocellular carcinoma (HCC) comparing to elderly HCC. BMC Genomics. 2013;14:736. PMID: 24160375.
   PubMed Web of Science ®Google Scholar
• Pan Y, Liu G, Zhou F, et al. DNA methylation profiles in cancer diagnosis and therapeutics. Clin Exp Med. 2018;18(1):1–14. PMID: 28752221.
   PubMed Web of Science ®Google Scholar
• Villanueva A, Portela A, Sayols S, et al. DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma. Hepatology. 2015;61(6):1945–1956. PMID: 25645722.
   PubMed Web of Science ®Google Scholar
• Qiu J, Peng B, Tang Y, et al. CpG methylation signature predicts recurrence in early-stage hepatocellular carcinoma: results from a multicenter study. J Clin Oncol. 2017;35(7):734–742. PMID: 28068175.
   PubMed Web of Science ®Google Scholar
• Xu RH, Wei W, Krawczyk M, et al. Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma. Nat Mater. 2017;16(11):1155–1161. PMID: 29035356.
   PubMed Web of Science ®Google Scholar
• Bronkhorst AJ, Ungerer V, Holdenrieder S. The emerging role of cell-free DNA as a molecular marker for cancer management. Biomol Detect Quantif. 2019;17:100087. PMID: 30923679.
   PubMedGoogle Scholar