Effects of Maternal Vitamin D3 Supplementation on Offspring Epigenetic Clock of Gestational Age at Birth: A Post-hoc Analysis of a Randomized Controlled Trial

References

• Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14:R115.
   PubMed Web of Science ®Google Scholar
• Hannum G, Guinney J, Zhao L, et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell. 2013;49:359–367.
   PubMed Web of Science ®Google Scholar
• Horvath S, Erhart W, Brosch M, et al. Obesity accelerates epigenetic aging of human liver. Proc Natl Acad Sci U S A. 2014;111:15538–15543.
   PubMed Web of Science ®Google Scholar
• Nevalainen T, Kananen L, Marttila S, et al. Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals. Clin Epigenetics. 2017;9:20.
   PubMed Web of Science ®Google Scholar
• Horvath S, Garagnani P, Bacalini MG, et al. Accelerated epigenetic aging in Down syndrome. Aging Cell. 2015;14:491–495.
   PubMed Web of Science ®Google Scholar
• Horvath S, Langfelder P, Kwak S, et al. Huntington’s disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels. Aging (Albany NY). 2016;8:1485–1512.
   PubMedGoogle Scholar
• Maierhofer A, Flunkert J, Oshima J, et al. Accelerated epigenetic aging in Werner syndrome. Aging (Albany NY). 2017;9:1143–1152.
   PubMedGoogle Scholar
• Voisey J, Lawford BR, Morris CP, et al. Epigenetic analysis confirms no accelerated brain aging in schizophrenia. NPJ Schizophr. 2017;3:26.
   PubMed Web of Science ®Google Scholar
• Horvath S, Gurven M, Levine ME, et al. An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease. Genome Biol. 2016;17:171.
   PubMed Web of Science ®Google Scholar
• Chen BH, Marioni RE, Colicino E, et al. DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging (Albany NY). 2016;8:1844–1865.
   PubMedGoogle Scholar
• Marioni RE, Harris SE, Shah S, et al. The epigenetic clock and telomere length are independently associated with chronological age and mortality. Int J Epidemiol. 2016;45:424–432.
   PubMed Web of Science ®Google Scholar
• Perna L, Zhang Y, Mons U, et al. Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort. Clin Epigenetics. 2016;8:64.
   PubMed Web of Science ®Google Scholar
• Knight AK, Craig JM, Theda C, et al. An epigenetic clock for gestational age at birth based on blood methylation data. Genome Biol. 2016;17:206.
   PubMed Web of Science ®Google Scholar
• Bohlin J, Haberg SE, Magnus P, et al. Prediction of gestational age based on genome-wide differentially methylated regions. Genome Biol. 2016;17:207.
   PubMed Web of Science ®Google Scholar
• Girchenko P, Lahti J, Czamara D, et al. Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth. Clin Epigenetics. 2017;9:49.
   PubMed Web of Science ®Google Scholar
• Girchenko P, Lahti M, Tuovinen S, et al. Cohort profile: prediction and prevention of preeclampsia and intrauterine growth restriction (PREDO) study. Int J Epidemiol. 2017;46:1380–1g.
   PubMed Web of Science ®Google Scholar
• Suarez A, Lahti J, Czamara D, et al. The epigenetic clock at birth: associations with maternal antenatal depression and child psychiatric problems. J Am Acad Child Adolesc Psychiatry. 2018;57:321–8.e2.
   PubMed Web of Science ®Google Scholar
• Khouja JN, Simpkin AJ, O’Keeffe LM, et al. Epigenetic gestational age acceleration: a prospective cohort study investigating associations with familial, sociodemographic and birth characteristics. Clin Epigenetics. 2018;10:86.
   PubMed Web of Science ®Google Scholar
• Zhu HD, Bhagatwala J, Huang Y, et al. Race/ethnicity-specific association of vitamin D and global DNA methylation: cross-sectional and interventional findings. PloS One. 2016;11:e0152849.
   Web of Science ®Google Scholar
• Zhu HD, Wang XL, Shi HD, et al. A genome-wide methylation study of severe vitamin D deficiency in African American adolescents. J Pediatr-US. 2013;162:1004–U165.
   PubMed Web of Science ®Google Scholar
• Chen L, Dong Y, Bhagatwala J, et al. Effects of vitamin D3 supplementation on epigenetic aging in overweight and obese African Americans with suboptimal vitamin D status: a randomized clinical trial. J Gerontol A Biol Sci Med Sci. 2019;74:91–98.
   PubMed Web of Science ®Google Scholar
• Raikkonen K, Pesonen AK, Roseboom TJ, et al. Early determinants of mental health. Best Pract Res Clin Endocrinol Metab. 2012;26:599–611.
   PubMed Web of Science ®Google Scholar
• Hollis BW, Wagner CL. Vitamin D supplementation during pregnancy: improvements in birth outcomes and complications through direct genomic alteration. Mol Cell Endocrinol. 2017;453:113–130.
   PubMed Web of Science ®Google Scholar
• Javed R, Chen W, Lin F, et al. Infant’s DNA methylation age at birth and epigenetic aging accelerators. Biomed Res Int. 2016;2016:4515928.
   PubMed Web of Science ®Google Scholar
• Heindel JJ, Vandenberg LN. Developmental origins of health and disease: a paradigm for understanding disease etiology and prevention. Curr Opin Pediatr. 2015;27:248–253.
   PubMed Web of Science ®Google Scholar
• Xue J, Schoenrock SA, Valdar W, et al. Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations. Clin Epigenetics. 2016;8:107.
   PubMed Web of Science ®Google Scholar
• Junge KM, Bauer T, Geissler S, et al. Increased vitamin D levels at birth and in early infancy increase offspring allergy risk—evidence for involvement of epigenetic mechanisms. J Allergy Clin Immunol. 2016;137:610–613.
   PubMed Web of Science ®Google Scholar
• Dong Y, Pollock N, Stallmann-Jorgensen IS, et al. Low 25-hydroxyvitamin D levels in adolescents: race, season, adiposity, physical activity, and fitness. Pediatrics. 2010;125:1104–1111.
   PubMed Web of Science ®Google Scholar
• Hollis BW, Johnson D, Hulsey TC, et al. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res. 2011;26:2341–2357.
   PubMed Web of Science ®Google Scholar
• Johnson DD, Wagner CL, Hulsey TC, et al. Vitamin D deficiency and insufficiency is common during pregnancy. Am J Perinatol. 2010;28:7–12.
   Web of Science ®Google Scholar
• Hamilton SA, McNeil R, Hollis BW, et al. Profound vitamin D deficiency in a diverse group of women during pregnancy living in a sun-rich environment at latitude 32 degrees N. Int J Endocrinol. 2010;2010:917428.
   PubMed Web of Science ®Google Scholar
• Wagner CL, McNeil R, Hamilton SA, et al. A randomized trial of vitamin D supplementation in 2 community health center networks in South Carolina. Am J Obstet Gynecol. 2013;208:137 e1–e13.
   Web of Science ®Google Scholar
• Dhingra R, Kwee LC, Diaz-Sanchez D, et al. Evaluating DNA methylation age on the illumina MethylationEPIC bead chip. PloS One. 2019;14:e0207834.
   PubMed Web of Science ®Google Scholar
• Aryee MJ, Jaffe AE, Corrada-Bravo H, et al. Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics. 2014;30:1363–1369.
   PubMed Web of Science ®Google Scholar