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Epigenetics Volume 15, 2020 - Issue 12
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Brief Report

The curious case of Merkel cell carcinoma: epigenetic youth and lack of pluripotency

Emil Chteinberga Department of Pathology, GROW-School for Oncology & Developmental Biology, Maastricht University, Medical Centre+, Maastricht, The Netherlands;b Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen, University Hospital, Aachen, Germany;c Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, GermanyORCID Iconhttps://orcid.org/0000-0002-9231-9291
ORCID Icon,
Julia Vogtd Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, GermanyORCID Iconhttps://orcid.org/0000-0001-9190-3931
ORCID Icon,
Julia Kolarovad Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany
,
Felix Bormanne Bioinformatics.Expert UG, Berlin, Germany
,
Joost van den Oordf Department of Pathology and Laboratory Translational Cell and Tissue Research, University of Leuven, KU, Leuven, Belgium
,
Ernst Jan Speela Department of Pathology, GROW-School for Oncology & Developmental Biology, Maastricht University, Medical Centre+, Maastricht, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-3016-2989
ORCID Icon,
Véronique Winnepenninckxa Department of Pathology, GROW-School for Oncology & Developmental Biology, Maastricht University, Medical Centre+, Maastricht, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-9625-2442
ORCID Icon,
Anna Kordelia Kurzg Department of Internal Medicine IV, University Hospital Aachen, Aachen, Germany
,
Martin Zenkeb Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen, University Hospital, Aachen, Germany;c Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, GermanyORCID Iconhttps://orcid.org/0000-0002-1107-3251
ORCID Icon,
Reiner Siebertd Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany
&
Axel zur Hausena Department of Pathology, GROW-School for Oncology & Developmental Biology, Maastricht University, Medical Centre+, Maastricht, The NetherlandsCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4781-0372
ORCID Icon show all
Pages 1319-1324 | Received 10 Jan 2020, Accepted 21 Apr 2020, Published online: 30 May 2020

References

  • Schadendorf D, Lebbé C, zur Hausen A, et al. Merkel cell carcinoma: epidemiology, prognosis, therapy and unmet medical needs. Eur J Cancer. 2017;71:53–69.
  • Harms PW, Harms KL, Moore PS, et al. The biology and treatment of Merkel cell carcinoma: current understanding and research priorities. Nat Rev Clin Oncol. 2018;15:763–776.
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  • Lu X, Zhou Y, Meng J, et al. Epigenetic age acceleration of cervical squamous cell carcinoma converged to human papillomavirus 16/18 expression, immunoactivation, and favourable prognosis. Clin Epigenetics. 2020;12:23.
  • Sauer CM, Haugg AM, Chteinberg E, et al. Reviewing the current evidence supporting early B-cells as the cellular origin of Merkel cell carcinoma. Crit Rev Oncol Hematol. 2017;116:99–105.
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  • Müller F-J, Schuldt BM, Williams R, et al. A bioinformatic assay for pluripotency in human cells. Nat Methods. 2011;8:315–317.
  • Horvath S. Erratum to: DNA methylation age of human tissues and cell types. Genome Biol. 2015;16:96.
  • Stölzel F, Brosch M, Horvath S, et al. Dynamics of epigenetic age following hematopoietic stem cell transplantation. Haematologica. 2017;102:e321–e3.
  • Rosen ST, Gould VE, Salwen HR, et al. Establishment and characterization of a neuroendocrine skin carcinoma cell line. Lab Invest. 1987;56:302–312.
  • Van Gele M, Leonard JH, Van Roy N, et al. Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma. Int J Cancer. 2002;101:137–145.
  • Houben R, Shuda M, Weinkam R, et al. Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens. J Virol. 2010;84:7064–7072.
  • Leonard JH, Dash P, Holland P, et al. Characterisation of four Merkel cell carcinoma adherent cell lines. Int J Cancer. 1995;60:100–107.

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