Advanced search
Publication Cover
Epigenetics Volume 15, 2020 - Issue 12
Submit an article Journal homepage
1,450
Views
4
CrossRef citations to date
0
Altmetric
Research Paper

Relationship between redox potential of glutathione and DNA methylation level in liver of newborn guinea pigs

Angela Mungala Lengoa Department of Nutrition, Université De Montréal, CHU Sainte-Justine, Montréal, QC, CanadaView further author information
,
Clémence Guirautb Department of Paediatrics, CHU Sainte-Justine, Université De Montréal, Montréal, QC, CanadaORCID Iconhttps://orcid.org/0000-0002-7828-6067View further author information
ORCID Icon,
Ibrahim Mohameda Department of Nutrition, Université De Montréal, CHU Sainte-Justine, Montréal, QC, Canada;b Department of Paediatrics, CHU Sainte-Justine, Université De Montréal, Montréal, QC, CanadaORCID Iconhttps://orcid.org/0000-0002-9860-0279View further author information
ORCID Icon &
Jean-Claude Lavoiea Department of Nutrition, Université De Montréal, CHU Sainte-Justine, Montréal, QC, Canada;b Department of Paediatrics, CHU Sainte-Justine, Université De Montréal, Montréal, QC, CanadaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5910-0300View further author information
ORCID Icon
Pages 1348-1360 | Received 07 Feb 2020, Accepted 22 May 2020, Published online: 28 Jun 2020

  • Barker DJ. The fetal and infant origins of adult disease. BMJ. 1990;301:1111.
  • Barker DJ. Fetal origins of coronary heart disease. BMJ. 1995;311:171-174.
  • Godfrey KM, Sheppard A, Gluckman PD, et al. Epigenetic gene promoter methylation at birth is associated with child’s later adiposity. Diabetes. 2011;60:1528–1534.
  • Heijmans BT, Tobi EW, Stein AD, et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A. 2008;105:17046–17049.
  • Jurkowska RZ, Jurkowski TP, Jeltsch A. Structure and function of mammalian DNA methyltransferases. Chembiochem. 2011;12:206–222.
  • Okano M, Bell DW, Haber DA, et al. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999;99:247–257.
  • Miozzo F, Arnould H, de Thonel A, et al. Alcohol exposure promotes DNA methyltransferase DNMT3A upregulation through reactive oxygen species-dependent mechanisms. Cell Stress Chaperones. 2018;23:115–126.
  • Remely M, Ferk F, Sterneder S, et al. Vitamin E Modifies High-Fat Diet-Induced Increase of DNA Strand Breaks, and Changes in Expression and DNA Methylation of Dnmt1 and MLH1 in C57BL/6J Male Mice. Nutrients. 2017;9:607.
  • Yara S, Levy E, Elremaly W, et al. Total parenteral nutrition induces sustained hypomethylation of DNA in newborn guinea pigs. Pediatr Res. 2013;73:592–595.
  • Elremaly W, Mohamed I, Rouleau T, et al. Adding glutathione to parenteral nutrition prevents alveolar loss in newborn Guinea pig. Free Radic Biol Med. 2015;87:274–281.
  • Yin R, Mao SQ, Zhao B, et al. Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals. J Am Chem Soc. 2013;135:10396–10403.
  • Koivunen P, Laukka T. The TET enzymes. Cell Mol Life Sci. 2018;75:1339–1348.
  • Lavoie JC, Belanger S, Spalinger M, et al. Admixture of a multivitamin preparation to parenteral nutrition: the major contributor to in vitro generation of peroxides. Pediatrics. 1997;99:E6.
  • Miloudi K, Comte B, Rouleau T, et al. The mode of administration of total parenteral nutrition and nature of lipid content influence the generation of peroxides and aldehydes. Clin Nutr. 2012;31:526–534.
  • Lavoie JC, Mohamed I, Nuyt AM, et al. Impact of SMOFLipid on pulmonary alveolar development in newborn guinea pigs. JPEN J Parenter Enteral Nutr. 2018;42:1314–1321.
  • Elremaly W, Rouleau T, Lavoie JC. Inhibition of hepatic methionine adenosyltransferase by peroxides contaminating parenteral nutrition leads to a lower level of glutathione in newborn Guinea pigs. Free Radic Biol Med. 2012;53:2250–2255.
  • Mohamed I, Elremaly W, Rouleau T, et al. Oxygen and parenteral nutrition two main oxidants for extremely preterm infants: ‘It all adds up’. J Neonatal Perinatal Med. 2015;8:189–197.
  • Mohamed I, Elremaly W, Rouleau T, et al. Ascorbylperoxide contaminating parenteral nutrition is associated with bronchopulmonary dysplasia or death in extremely preterm infants. JPEN J Parenter Enteral Nutr. 2017;41:1023–1029.
  • Knafo L, Chessex P, Rouleau T, et al. Association between hydrogen peroxide-dependent byproducts of ascorbic acid and increased hepatic acetyl-CoA carboxylase activity. Clin Chem. 2005;51:1462–1471.
  • Khashu M, Harrison A, Lalari V, et al. Impact of shielding parenteral nutrition from light on routine monitoring of blood glucose and triglyceride levels in preterm neonates. Arch Dis Child Fetal Neonatal Ed. 2009;94:F111–5.
  • Lavoie JC, Chessex P, Rouleau T, et al. Shielding parenteral multivitamins from light increases vitamin A and E concentration in lung of newborn guinea pigs. Clin Nutr. 2007;26:341–347.
  • Lavoie JC, Rouleau T, Tsopmo A, et al. Influence of lung oxidant and antioxidant status on alveolarization: role of light-exposed total parenteral nutrition. Free Radic Biol Med. 2008;45:572–577.
  • Michalski MC, Calzada C, Makino A, et al. Oxidation products of polyunsaturated fatty acids in infant formulas compared to human milk–a preliminary study. Mol Nutr Food Res. 2008;52:1478–1485.
  • Lavoie JC, Chessex P, Rouleau T, et al. Light-induced byproducts of vitamin C in multivitamin solutions. Clin Chem. 2004;50:135–140.
  • Laborie S, Lavoie JC, Chessex P. Paradoxical role of ascorbic acid and riboflavin in solutions of total parenteral nutrition: implication in photoinduced peroxide generation. Pediatr Res. 1998;43:601–606.
  • Laborie S, Lavoie JC, Pineault M, et al. Contribution of multivitamins, air, and light in the generation of peroxides in adult and neonatal parenteral nutrition solutions. Ann Pharmacother. 2000;34:440–445.
  • Lavoie JC, Rouleau T, Chessex P. Interaction between ascorbate and light-exposed riboflavin induces lung remodeling. J Pharmacol Exp Ther. 2004;311:634–639.
  • Hoffman DR, Marion DW, Cornatzer WE, et al. S-Adenosylmethionine and S-adenosylhomocystein metabolism in isolated rat liver. Effects of L-methionine, L-homocysteine, and adenosine. J Biol Chem. 1980;255:10822–10827.
  • Zhou J, Yi Z, Fu Q. Dynamic decreased expression and hypermethylation of secreted frizzled-related protein 1 and 4 over the course of pulmonary fibrosis in mice. Life Sci. 2019;218:241–252.
  • Chen T, Ueda Y, Xie S, et al. A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. J Biol Chem. 2002;277:38746–38754.
  • Armstrong VL, Rakoczy S, Rojanathammanee L, et al. Expression of DNA methyltransferases is influenced by growth hormone in the long-living Ames dwarf mouse in vivo and in vitro. J Gerontol A Biol Sci Med Sci. 2014;69:923–933.
  • Svedruzic ZM, Reich NO. DNA cytosine C5 methyltransferase Dnmt1: catalysis-dependent release of allosteric inhibition. Biochemistry. 2005;44:9472–9485.
  • Higgins LG, Kelleher MO, Eggleston IM, et al. Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents. Toxicol Appl Pharmacol. 2009;237:267–280.
  • Turcot V, Rouleau T, Tsopmo A, et al. Long-term impact of an antioxidant-deficient neonatal diet on lipid and glucose metabolism. Free Radic Biol Med. 2009;47:275–282.
  • Awazu M, Hida M, Bader M. Folic acid supplementation alleviates reduced ureteric branching, nephrogenesis, and global DNA methylation induced by maternal nutrient restriction in rat embryonic kidney. PLoS One. 2020;15:e0230289.
  • Jarmasz JS, Stirton H, Davie JR, et al. DNA methylation and histone post-translational modification stability in post-mortem brain tissue. Clin Epigenetics. 2019;11(5). DOI:10.1186/s13148-018-0596-7
  • Kronfol MM, Jahr FM, Dozmorov MG, et al. DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver. Geroscience. 2020;3:819–832. DOI:10.1007/s11357-020-00181-5
  • Lim U, Flood A, Choi SW, et al. Genomic methylation of leukocyte DNA in relation to colorectal adenoma among asymptomatic women. Gastroenterology. 2008;134:47–55.
  • Stach D, Schmitz OJ, Stilgenbauer S, et al. Capillary electrophoretic analysis of genomic DNA methylation levels. Nucleic Acids Res. 2003;31:E2.
  • Stach D, Schmitz OJ, Stilgenbauer S, Benner A, Dohner H, Wiessler M, Lyko F. Capillary electrophoretic analysis of genomic DNA methylation levels. Nucleic Acids Research. 2003;31:E2. 2 doi:10.1093/nar/gng002
  • Teng M, Chen X, Wang C, et al. Life cycle exposure to propiconazole reduces fecundity by disrupting the steroidogenic pathway and altering DNA methylation in zebrafish (Danio rerio). Environ Int. 2020;135:105384.
  • Parsanathan R, Jain SK. Glutathione deficiency induces epigenetic alterations of vitamin D metabolism genes in the livers of high-fat diet-fed obese mice. Sci Rep. 2019;9:14784.
  • Kleiber N, Chessex P, Rouleau T, et al. Neonatal exposure to oxidants induces later in life a metabolic response associated to a phenotype of energy deficiency in an animal model of total parenteral nutrition. Pediatr Res. 2010;68:188–192.
  • Maghdessian R, Cote F, Rouleau T. Ben Djoudi Ouadda A, Levy E, Lavoie JC. Ascorbylperoxide contaminating parenteral nutrition perturbs the lipid metabolism in newborn guinea pig. J Pharmacol Exp Ther. 2010;334:278–284.
  • Schafer FQ, Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med. 2001;30:1191–1212.
  • Uthus EO. Simultaneous detection of S-adenosylmethionine and S-adenosylhomocysteine in mouse and rat tissues by capillary electrophoresis. Electrophoresis. 2003;24(78):1221–1226.
  • Lykkesfeldt J. Ascorbate and dehydroascorbic acid as reliable biomarkers of oxidative stress: analytical reproducibility and long-term stability of plasma samples subjected to acidic deproteinization. Cancer Epidemiol Biomarkers Prev. 2007;16:2513–2516.
  • Sławomir Dresler WM. Capillary zone electrophoresis for determination of reduced and oxidised ascorbate and glutathione in roots and leaf segments of Zea mays plants exposed to Cd and Cu. Acta Scientiarum Polonorum - Hortorum Cultus. 2013;12:143–145.
  • Gorski K, Carneiro M, Schibler U. Tissue-specific in vitro transcription from the mouse albumin promoter. Cell. 1986;47(5):767–776.
  • Rose KM, Stetler DA, Jacob ST. Phosphorylation of RNA polymerases: specific association of protein kinase NII with RNA polymerase I. Philos Trans R Soc Lond B Biol Sci. 1983;302:135–142.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.