1,316
Views
10
CrossRef citations to date
0
Altmetric
Research Paper

A genome-wide study of DNA methylation in white blood cells and asthma in Latino children and youth

, ORCID Icon, , ORCID Icon, , , , ORCID Icon, , , ORCID Icon, , , , , , & ORCID Icon show all
Pages 577-585 | Received 12 May 2020, Accepted 24 Jul 2020, Published online: 31 Aug 2020

References

  • Center for Disease Control and Prevention. Asthma. Data, statistics, and surveillance. [ cited 2020 Apr 9].
  • Demenais F, Margaritte-Jeannin P, Barnes KC, et al. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018;50(1):p. 42–53.
  • Forno E, Celedon JC. Epigenomics and transcriptomics in the prediction and diagnosis of childhood asthma: are we there yet? Front Pediatr. 2019;7:115.
  • Arathimos R, Suderman M, Sharp GC, et al. Epigenome-wide association study of asthma and wheeze in childhood and adolescence. Clin Epigenetics. 2017;9:112.
  • Davidson EJ, Yang IV. Role of epigenetics in the development of childhood asthma. Curr Opin Allergy Clin Immunol. 2018;18(2):132–138.
  • Reese SE, Xu CJ, Herman T, et al. Epigenome-wide meta-analysis of DNA methylation and childhood asthma. J Allergy Clin Immunol. 2019;143(6):2062–2074.
  • Xu CJ, Söderhäll C, Bustamante M, et al. DNA methylation in childhood asthma: an epigenome-wide meta-analysis. Lancet Respir Med. 2018;6(5):379–388.
  • Yang IV, Pedersen BS, Liu A, et al. DNA methylation and childhood asthma in the inner city. J Allergy Clin Immunol. 2015;136(1):69–80.
  • Forno E, Wang T, Qi C, et al. DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study. Lancet Respir Med. 2019;7(4):336–346.
  • Rosas-Salazar C, Ramratnam SK, Brehm JM, et al. Prematurity, atopy, and childhood asthma in Puerto Ricans. J Allergy Clin Immunol. 2014;133(2):357–362.
  • Brehm JM, Acosta-Pérez E, Klei L, et al. African ancestry and lung function in Puerto Rican children. J Allergy Clin Immunol. 2012;129(6):1484–90 e6.
  • Oh SS, Tcheurekdjian H, Roth LA, et al. Effect of secondhand smoke on asthma control among black and Latino children. J Allergy Clin Immunol. 2012;129(6):1478–83 e7.
  • Nishimura KK, Galanter JM, Roth LA, et al. Early-life air pollution and asthma risk in minority children. The GALA II and SAGE II studies. Am J Respir Crit Care Med. 2013;188(3):309–318.
  • Chen W, Wang T, Pino-Yanes M, et al. An epigenome-wide association study of total serum IgE in hispanic children. J Allergy Clin Immunol. 2017;140(2):571–577.
  • Xu Z, Niu L, Li L, et al. ENmix: a novel background correction method for illumina HumanMethylation450 BeadChip. Nucleic Acids Res. 2016;44(3):e20.
  • Leek JT, Johnson WE, Parker HS, et al. The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics. 2012;28(6):882–883.
  • Houseman EA, Accomando WP, Koestler DC, et al. DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics. 2012;13(1):86.
  • Price AL, Patterson NJ, Plenge RM, et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006;38(8):904–909.
  • Pedersen BS, Schwartz DA, Yang IV, et al. Comb-p: software for combining, analyzing, grouping and correcting spatially correlated P-values. Bioinformatics. 2012;28:2986–2988.
  • Gunawardhana LP, Gibson PG, Simpson JL, et al. Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma. Epigenetics. 2014;9(9):1302–1316.
  • Kourepini E, Paschalidis N, Simoes DC, et al. TIGIT enhances antigen-specific Th2 recall responses and allergic disease. J Immunol. 2016;196(9):3570–3580.
  • Yuan YP, Shi YH, Gu WC. Analysis of protein-protein interaction network in chronic obstructive pulmonary disease. Genet Mol Res. 2014;13(4):8862–8869.
  • Crespo-Lessmann A, Mateus E, Torrejón M, et al. Asthma with bronchial hypersecretion: expression of mucins and toll-like receptors in sputum and blood. J Asthma Allergy. 2017;10:269.
  • Shrine N, Portelli MA, John C, et al. Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. Lancet Respir Med. 2019;7(1):20–34.
  • Kuo C-HS, Pavlidis S, Loza M, et al. T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED. Eur Respir J. 2017;49(2):1602135.
  • Duvernelle C, Freund V, Frossard N. Transforming growth factor-beta and its role in asthma. Pulm Pharmacol Ther. 2003;16(4):181–196.
  • He L, Zhao X, He L. LINC01140 alleviates the oxidized low-density lipoprotein-induced inflammatory response in macrophages via suppressing miR-23b. Inflammation. 2020;43(1):66–73.
  • Breeze CE, Paul DS, van Dongen J, et al. eFORGE: a tool for identifying cell type-specific signal in epigenomic data. Cell Rep. 2016;17(8):2137–2150.
  • Gorska MM. Natural killer cells in asthma. Curr Opin Allergy Clin Immunol. 2017;17(1):50–54.
  • Lloyd CM, Hessel EM. Functions of T cells in asthma: more than just T(H)2 cells. Nat Rev Immunol. 2010;10(12):838–848.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.