Characterization of glucocorticoid-induced loss of DNA methylation of the stress-response gene Fkbp5 in neuronal cells

References

• Klengel T, Mehta D, Anacker C, et al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci. 2013;16(1):33–41.
   Google Scholar
• Wu Y, Patchev AV, Daniel G, et al. Early-life stress reduces DNA methylation of the Pomc gene in male mice. Endocrinology. 2014;155(5):1751–1762.
   Google Scholar
• Webster MJ, Knable MB, O’Grady J, et al. Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. Mol Psychiatry. 2002;7(985–94):24.
   Google Scholar
• Binder EB, Nemeroff CB. The CRF system, stress, depression and anxiety-insights from human genetic studies. Mol Psychiatry. 2010;15(6):574–588.
   Google Scholar
• Raue S, Wedekind D, Wiltfang J, et al. The role of proopiomelanocortin and alpha-melanocyte-stimulating hormone in the metabolic syndrome in psychiatric disorders: a narrative mini-review. Front Psychiatry. 2019;10:834.
   Google Scholar
• Elliott E, Ezra-Nevo G, Regev L, Neufeld-Cohen A, Chen A. Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice. Nat Neurosci. 2010;13:1351–1353.
   Google Scholar
• Lee RS, Sawa A. Environmental stressors and epigenetic control of the hypothalamic-pituitary-adrenal axis. Neuroendocrinology. 2014;100(4):278–287.
   Google Scholar
• Niwa M, Jaaro-Peled H, Tankou S, et al. Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science. 2013;339(6117):335–339.
   Google Scholar
• Lee RS, Tamashiro KL, Yang X, et al. Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice. Endocrinology. 2010;151(9):4332–4343.
   Google Scholar
• Weaver IC, Cervoni N, Champagne FA, et al. Epigenetic programming by maternal behavior. Nat Neurosci. 2004;7(8):847–854.
   Google Scholar
• Yang X, Ewald ER, Huo Y, et al. Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5. Biochem Biophys Res Commun. 2012;420(3):570–575.
   Google Scholar
• Ramamoorthy S, Cidlowski JA. Ligand-induced repression of the glucocorticoid receptor gene is mediated by an NCoR1 repression complex formed by long-range chromatin interactions with intragenic glucocorticoid response elements. Mol Cell Biol. 2013;33(9):1711–1722.
   Google Scholar
• Binder EB. The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology. 2009;34(Suppl 1):S186–95.
   Google Scholar
• Binder EB, Salyakina D, Lichtner P, et al. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet. 2004;36(12):1319–1325. .
   Google Scholar
• Willour VL, Chen H, Toolan J, et al. Family-based association of FKBP5 in bipolar disorder. Mol Psychiatry. 2009;14(3):261–268. .
   Google Scholar
• Lee RS, Tamashiro KL, Yang X, et al. A measure of glucocorticoid load provided by DNA methylation of Fkbp5 in mice. Psychopharmacology (Berl). 2011;218(1):303–312.
   Google Scholar
• Conrad CD, McLaughlin KJ, Harman JS, et al. Chronic glucocorticoids increase hippocampal vulnerability to neurotoxicity under conditions that produce CA3 dendritic retraction but fail to impair spatial recognition memory. J Neurosci. 2007;27(31):8278–8285.
   Google Scholar
• Du J, Wang Y, Hunter R, et al. Dynamic regulation of mitochondrial function by glucocorticoids. Proc Natl Acad Sci U S A. 2009;106(9):3543–3548. .
   Google Scholar
• Gourley SL, Wu FJ, Kiraly DD, et al. Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression. Biol Psychiatry. 2008;63(4):353–359.
   Google Scholar
• Karatsoreos IN, Bhagat SM, Bowles NP, et al. Endocrine and physiological changes in response to chronic corticosterone: a potential model of the metabolic syndrome in mouse. Endocrinology. 2010;151(5):2117–2127.
   Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–408.
   Google Scholar
• Colella S, Shen L, Baggerly KA, et al. Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites. Biotechniques. 2003;35(1):146–150.
   Google Scholar
• Klug M, Rehli M. Functional analysis of promoter CpG methylation using a CpG-free luciferase reporter vector. Epigenetics. 2006;1(3):127–130.
   Google Scholar
• Lee RS, Pirooznia M, Guintivano J, et al. Search for common targets of lithium and valproic acid identifies novel epigenetic effects of lithium on the rat leptin receptor gene. Transl Psychiatry. 2015;5(7):e600.
   Google Scholar
• Bates D, Machler M, Bolker B, et al. Fitting linear mixed-effects models using lme4. J Stat Softw. 2015;67(1):1–48.
   Google Scholar
• Fong Y, Huang Y, Gilbert PB, et al. chngpt: threshold regression model estimation and inference. BMC Bioinformatics. 2017;18(1):454.
   Google Scholar
• Seifuddin F, Wand G, Cox O, et al. Genome-wide Methyl-Seq analysis of blood-brain targets of glucocorticoid exposure. Epigenetics. 2017;12(1):1–16. .
   Google Scholar
• Tomasz M. Mitomycin C: small, fast and deadly (but very selective). Chem Biol. 1995;2(9):575–579.
   Google Scholar
• Blajeski AL, Phan VA, Kottke TJ, et al. G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells. J Clin Invest. 2002;110(1):91–99.
   Google Scholar
• Murani E, Trakooljul N, Hadlich F, et al. Transcriptome responses to dexamethasone depending on dose and glucocorticoid receptor sensitivity in the liver. Front Genet. 2019;10:559.
   Google Scholar
• Ewald ER, Wand GS, Seifuddin F, et al. Alterations in DNA methylation of Fkbp5 as a determinant of blood-brain correlation of glucocorticoid exposure. Psychoneuroendocrinology. 2014;44:112–122.
   Google Scholar
• Lee RS, Mahon PB, Zandi PP, et al. DNA methylation and sex-specific expression of FKBP5 as correlates of one-month bedtime cortisol levels in healthy individuals. Psychoneuroendocrinology. 2018;97:164–173.
   Google Scholar
• Sawamura T, Klengel T, Armario A, et al. Dexamethasone treatment leads to enhanced fear extinction and dynamic Fkbp5 regulation in amygdala. Neuropsychopharmacology. 2016;41(3):832–846.
   Google Scholar
• Magee JA, Chang LW, Stormo GD, et al. Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element. Endocrinology. 2006;147(1):590–598.
   Google Scholar
• Hubler TR, Scammell JG. Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids. Cell Stress Chaperones. 2004;9(3):243–252.
   Google Scholar
• Datson NA, van den Oever JM, Korobko OB, et al. Previous history of chronic stress changes the transcriptional response to glucocorticoid challenge in the dentate gyrus region of the male rat hippocampus. Endocrinology. 2013;154(9):3261–3272.
   Google Scholar
• Provencal N, Arloth J, Cattaneo A, et al. Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation. Proc Natl Acad Sci U S A. 2019;117(38):23280–23285. .
   Google Scholar
• Lie DC, Colamarino SA, Song HJ, et al. Wnt signalling regulates adult hippocampal neurogenesis. Nature. 2005;437(7063):1370–1375. .
   Google Scholar
• Yang BZ, Zhang H, Ge W, et al. Child abuse and epigenetic mechanisms of disease risk. Am J Prev Med. 2013;44(2):101–107.
   Google Scholar
• Cao-Lei L, Veru F, Elgbeili G, et al. DNA methylation mediates the effect of exposure to prenatal maternal stress on cytokine production in children at age 13 (1/2)years: project Ice Storm. Clin Epigenetics. 2016;8(1):54.
   Google Scholar
• Duis J, Cox OH, Ji Y, et al. Effect of genotype and maternal affective disorder on intronic methylation of FK506 binding protein 5 in cord blood DNA. Front Genet. 2018;9:648.
   Google Scholar
• Urdinguio RG, Lopez-Serra L, Lopez-Nieva P, et al. Mecp2-null mice provide new neuronal targets for Rett syndrome. PLoS One. 2008;3(11):e3669.
   Google Scholar
• Nuber UA, Kriaucionis S, Roloff TC, et al. Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Hum Mol Genet. 2005;14(15):2247–2256. .
   Google Scholar
• McGill BE, Bundle SF, Yaylaoglu MB, et al. Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A. 2006;103(48):18267–18272.
   Google Scholar
• John S, Sabo PJ, Thurman RE, et al. Chromatin accessibility pre-determines glucocorticoid receptor binding patterns. Nat Genet. 2011;43(3):264–268.
   Google Scholar
• Surjit M, Ganti KP, Mukherji A, et al. Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor. Cell. 2011;145(2):224–241.
   Google Scholar
• Minelli A, Maffioletti E, Cloninger CR, et al. Role of allelic variants of FK506-binding protein 51 (FKBP5) gene in the development of anxiety disorders. Depress Anxiety. 2013;30(12):1170–1176. .
   Google Scholar
• Binder EB, Bradley RG, Liu W, et al. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA. 2008;299(11):1291–1305. .
   Google Scholar
• Scammell JG, Denny WB, Valentine DL, et al. Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates. Gen Comp Endocrinol. 2001;124(2):152–165.
   Google Scholar
• Niwa M, Lee RS, Tanaka T, et al. A critical period of vulnerability to adolescent stress: epigenetic mediators in mesocortical dopaminergic neurons. Hum Mol Genet. 2016;25(7):1370–1381.
   Google Scholar
• Smith MA, Makino S, Kvetnansky R, et al. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci. 1995;15(3):1768–1777.
   Google Scholar
• Glatz K, Mossner R, Heils A, et al. Glucocorticoid-regulated human serotonin transporter (5-HTT) expression is modulated by the 5-HTT gene-promotor-linked polymorphic region. J Neurochem. 2003;86(5):1072–1078.
   Google Scholar
• Ou XM, Chen K, Shih JC. Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1. J Biol Chem. 2006;281(30):21512–21525.
   Google Scholar