References
- Dudgeon BJ, Gerrard BC, Jensen MP, et al. Physical disability and the experience of chronic pain. Arch Phys Med Rehabil. 2002;83(2):229–235.
- Hairi NN, Cumming RG, Blyth FM, et al. Chronic pain, impact of pain and pain severity with physical disability in older people—Is there a gender difference? Maturitas. 2013;74(1):68–73.
- Moriarty O, McGuire BE, Finn DP. The effect of pain on cognitive function: a review of clinical and preclinical research. Prog Neurobiol. 2011;93(3):385–404.
- McGuire BE. Chronic pain and cognitive function. Pain. 2013;154(7):964–965.
- Patel K, Dansie E, Guralnik J, et al. Prevalence and impact of pain among older adults in the United States: findings from the national health and aging trends study. J Pain. 2013;14(4):S12.
- Karttunen NM, Turunen JH, Ahonen RS, et al. Persistence of noncancer-related musculoskeletal chronic pain among community-dwelling older people: a population-based longitudinal study in Finland. Clin J Pain. 2015;31(1):79–85.
- Elliott AM, Smith BH, Penny KI, et al. The epidemiology of chronic pain in the community. Lancet. 1999;354(9186):1248–1252.
- Smith BH, Elliott AM, Chambers WA, et al. The impact of chronic pain in the community. Fam Pract. 2001;18(3):292–299.
- Rodriguez-Raecke R, Niemeier A, Ihle K, et al. Brain gray matter decrease in chronic pain is the consequence and not the cause of pain. J Neurosci. 2009;29(44):13746–13750.
- Moayedi M, Weissman-Fogel I, Salomons TV, et al. Abnormal gray matter aging in chronic pain patients. Brain Res. 2012;1456:82–93.
- Cruz-Almeida Y, Fillingim RB, Riley JL 3rd, et al. Chronic pain is associated with a brain aging biomarker in community-dwelling older adults. Pain. 2019;160(5):1119–1130.
- Zhang J-M, An J. Cytokines, inflammation and pain. Int Anesthesiol Clin. 2007;45(2):27.
- Hassett AL, Epel E, Clauw DJ, et al. Pain is associated with short leukocyte telomere length in women with fibromyalgia. J Pain. 2012;13(10):959–969.
- Sibille KT, Chen H, Bartley EJ, et al. Accelerated aging in adults with knee osteoarthritis pain: consideration for frequency, intensity, time, and total pain sites. Pain Rep. 2017;2(3). DOI:10.1097/PR9.0000000000000591.
- Apkarian AV, Sosa Y, Sonty S. Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. J Neurosci. 2004;24(46):10410–10415.
- Cole JH, Franke K. Predicting age using neuroimaging: innovative brain ageing biomarkers. Trends Neurosci. 2017;40(12):681–690.
- Cole JH, Ritchie SJ, Bastin ME, et al. Brain age predicts mortality. Mol Psychiatry. 2018;23(5):1385–1392.
- Habes M, Janowitz D, Erus G, et al. Advanced brain aging: relationship with epidemiologic and genetic risk factors, and overlap with Alzheimer disease atrophy patterns. Transl Psychiatry. 2016;6(4):e775.
- Franke K, Gaser C. Longitudinal changes in individual brainage in healthy aging, mild cognitive impairment, and Alzheimer’s disease. GeroPsych. 2012;25(4):235
- Cole JH, Underwood J, Caan MW, et al. Increased brain-predicted aging in treated HIV disease. Neurology. 2017;88(14):1349–1357.
- Nenadic I, Dietzek M, Langbein K, et al. BrainAGE score indicates accelerated brain aging in schizophrenia, but not bipolar disorder. Psychiatry Res Neuroimaging. 2017;266:86–89.
- Cruz-Almeida Y, Cole J. Pain, aging, and the brain: new pieces to a complex puzzle. Pain. 2020;161(3):461–463.
- Lu AT, Quach A, Wilson JG, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging (Albany NY). 2019;11(2):303–327.
- Totsch SK, Sorge RE. Immune system involvement in specific pain conditions. Mol Pain. 2017;13:1744806917724559.
- Barter JD, Foster TC. Aging in the brain: new roles of epigenetics in cognitive decline. Neuroscientist. 2018;24(5):516–525.
- Peterson JA, Meng L, Rani A, et al. Epigenetic aging, knee pain and physical performance in community-dwelling middle-to-older age adults. Exp Gerontol. 2022;166:111861.
- Terry EL, Booker SQ, Cardoso JS, et al. Neuropathic-like pain symptoms in a community-dwelling sample with or at risk for knee osteoarthritis. Pain Med. 2020;21(1):125–137.
- Terry EL, Fullwood MD, Booker SQ, et al. Everyday discrimination in adults with knee pain: the role of perceived stress and pain catastrophizing. J Pain Res. 2020;13:883.
- Terry EL, Tanner JJ, Cardoso JS, et al. Associations of pain catastrophizing with pain-related brain structure in individuals with or at risk for knee osteoarthritis: sociodemographic considerations. Brain Imaging Behav. 2021;15(4):1769–1777.
- Von Korff M, Ormel J, Keefe FJ, et al. Grading the severity of chronic pain. Pain. 1992;50(2):133–149.
- Dahlhamer J, Lucas J, Zelaya C, et al. Prevalence of chronic pain and high-impact chronic pain among adults—United States, 2016. Morbidity Mortality Weekly Rep. 2018;67(36):1001.
- Pitcher MH, Von Korff M, Bushnell MC, et al. Prevalence and profile of high-impact chronic pain in the United States. J Pain. 2019;20(2):146–160.
- Nugraha B, Gutenbrunner C, Barke A, et al. The IASP classification of chronic pain for ICD-11: functioning properties of chronic pain. Pain. 2019;160(1):88–94.
- Clausen AN, Fercho KA, Monsour M, et al. Assessment of brain age in posttraumatic stress disorder: findings from the ENIGMA PTSD and brain age working groups. Brain Behav. 2021;12:e2413.
- Aryee MJ, Jaffe AE, Corrada-Bravo H, et al. Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics. 2014;30(10):1363–1369.
- Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):3156.
- Dou J, Schmidt RJ, Benke KS, et al. Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation. Epigenetics. 2018;13(1):108–116.
- Ghamrawi R, Velickovic I, Milicevic O, et al. Buffy coat DNA methylation profile is representative of methylation patterns in white blood cell types in normal pregnancy. Front Bioeng Biotechnol. 2022;9:782843.
- Johnson A, Buchanan T, Laffitte C, et al. Added “Age-like” brain patterns with increasing pain impact in persons with knee osteoarthritis pain: considerations by race. J Pain. 2022;23(5):42.
- Cruz-Almeida Y, Sinha P, Rani A, et al. Epigenetic aging is associated with clinical and experimental pain in community-dwelling older adults. Mol Pain. 2019;15:1744806919871819.
- Wettstein M, Eich W, Bieber C, et al. Pain intensity, disability, and quality of life in patients with chronic low back pain: does age matter? Pain Med. 2019;20(3):464–475.
- Mattson MP, Arumugam TV. Hallmarks of brain aging: adaptive and pathological modification by metabolic states. Cell Metab. 2018;27(6):1176–1199.
- Cruz-Almeida Y, Coombes S, Febo M. Pain differences in neurite orientation dispersion and density imaging measures among community-dwelling older adults. Exp Gerontol. 2021;154:111520.
- Yang S, Chang MC. Chronic pain: structural and functional changes in brain structures and associated negative affective states. Int J Mol Sci. 2019;20(13):3130.
- Cavalli G, Heard E. Advances in epigenetics link genetics to the environment and disease. Nature. 2019;571(7766):489–499.
- Akbarian S, Beeri MS, Haroutunian V. Epigenetic determinants of healthy and diseased brain aging and cognition. JAMA Neurol. 2013;70(6):711–718.
- Fjell AM, Walhovd KB. Structural brain changes in aging: courses, causes and cognitive consequences. Rev Neurosci. 2010;21(3):187–221.
- Tang B, Dean B, Thomas EA. Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders. Transl Psychiatry. 2011;1(12):e64–e.
- Descalzi G, Ikegami D, Ushijima T, et al. Epigenetic mechanisms of chronic pain. Trends Neurosci. 2015;38(4):237–246.