Histone demethylase KDM4B contributes to advanced clear cell renal carcinoma and association with copy number variations and cell cycle progression

References

• Haake SM, Rathmell WK. Renal cancer subtypes: should we be lumping or splitting for therapeutic decision making? Cancer. 2017;123(2):200–12.
   PubMed Web of Science ®Google Scholar
• Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. Ca A Cancer J Clinicians. 2016;66(2):115–132.
   PubMed Web of Science ®Google Scholar
• Joosten SC, Smits KM, Aarts MJ, et al. Epigenetics in renal cell cancer: mechanisms and clinical applications. Nat Rev Urol. 2018;15(7):430–451.
   PubMed Web of Science ®Google Scholar
• Nishida J, Momoi Y, Miyakuni K, et al. Epigenetic remodelling shapes inflammatory renal cancer and neutrophil-dependent metastasis. Nat Cell Biol. 2020;22(4):465–475.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Thakur C, Shi J, et al. New discoveries of mdig in the epigenetic regulation of cancers. Semin Cancer Biol. 2019;57:27–35.
   PubMed Web of Science ®Google Scholar
• Berry WL, Janknecht R. KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells. Cancer Res. 2013;73(10):2936–2942.
   PubMed Web of Science ®Google Scholar
• Sha J, Han Q, Chi C, et al. Upregulated KDM4B promotes prostate cancer cell proliferation by activating autophagy. J Cell Physiol. 2020;235(3):2129–2138.
   PubMed Web of Science ®Google Scholar
• Li H, Lan J, Wang G, et al. KDM4B facilitates colorectal cancer growth and glucose metabolism by stimulating TRAF6-mediated AKT activation. J Exp Clin Cancer Res. 2020;39(1):12.
   PubMed Web of Science ®Google Scholar
• Zhao L, Li W, Zang W, et al. JMJD2B promotes epithelial–mesenchymal transition by cooperating with β-catenin and enhances gastric cancer metastasis. Clin Cancer Res. 2013;19(23):6419–6429.
   PubMed Web of Science ®Google Scholar
• Shi L, Sun L, Li Q, et al. Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proc Natl Acad Sci U S A. 2011;108(18):7541–7546. DOI:10.1073/pnas.1017374108
   PubMed Web of Science ®Google Scholar
• Fu L, Chen L, Yang J, et al. HIF-1α-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism. Carcinogenesis. 2012;33(9):1664–1673.
   PubMed Web of Science ®Google Scholar
• Toyokawa G, Cho H-S, Iwai Y, et al. The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6. Cancer Prev Res (Phila). 2011;4:2051–2061.
   PubMed Web of Science ®Google Scholar
• Lee H-L, Yu B, Deng P, et al. Transforming growth factor-β-induced kdm4b promotes chondrogenic differentiation of human mesenchymal stem cells. Stem Cells. 2016;34(3):711–719.
   PubMed Web of Science ®Google Scholar
• M-J W, Chen C-J, Lin T-Y, et al. Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer. Theranostics. 2021;11(16):7779–7796. DOI:10.7150/thno.58729
   PubMed Web of Science ®Google Scholar
• Shi Y, Zhang Q, Bi H, et al. Decoding the multicellular ecosystem of vena caval tumor thrombus in clear cell renal cell carcinoma by single-cell RNA sequencing. Genome Biol. 2022;23(1):87. DOI:10.1186/s13059-022-02651-9
   PubMed Web of Science ®Google Scholar
• Dries R, Zhu Q, Dong R, et al. Giotto: a toolbox for integrative analysis and visualization of spatial expression data. Genome Bio. 2021;22(1):78. DOI:10.1186/s13059-021-02286-2
   PubMed Web of Science ®Google Scholar
• Zheng SC, Stein-O’brien G, Augustin JJ, et al. Universal prediction of cell-cycle position using transfer learning. Genome Bio. 2022;23(1):41.
   PubMed Web of Science ®Google Scholar
• Oh S, Shin S, Janknecht R. The small members of the JMJD protein family: enzymatic jewels or jinxes? Biochim Biophys Acta Rev Cancer. 2019;1871(2):406–418.
   PubMed Web of Science ®Google Scholar
• Magadum A, Singh N, Kurian AA, et al. Pkm2 regulates cardiomyocyte cell cycle and promotes cardiac regeneration. Circulation. 2020;141(15):1249–1265. DOI:10.1161/CIRCULATIONAHA.119.043067
   PubMed Web of Science ®Google Scholar
• Bao J, Shi Y, Tao M, et al. Pharmacological inhibition of autophagy by 3-MA attenuates hyperuricemic nephropathy. Clin Sci (Lond). 2018;132(21):2299–2322.
   PubMed Web of Science ®Google Scholar
• Hwang SY, Kang YJ, Sung B, et al. Folic acid is necessary for proliferation and differentiation of C2C12 myoblasts. J Cell Physiol. 2018;233(2):736–747. DOI:10.1002/jcp.25989
   PubMed Web of Science ®Google Scholar
• Zhao J, Lu P, Wan C, et al. Cell-fate transition and determination analysis of mouse male germ cells throughout development. Nat Commun. 2021;12(1):6839. DOI:10.1038/s41467-021-27172-0
   PubMed Web of Science ®Google Scholar
• Okugawa Y, Grady WM, Goel A. Epigenetic alterations in colorectal cancer: emerging Biomarkers. Gastroenterology. 2015;149(5):1204–1225.e12.
   PubMed Web of Science ®Google Scholar
• Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol. 2010;28(10):1057–1068.
   PubMed Web of Science ®Google Scholar
• Ricketts CJ, Hill VK, Linehan WM. Tumor-specific hypermethylation of epigenetic biomarkers, including SFRP1, predicts for poorer survival in patients from the TCGA Kidney Renal Clear Cell Carcinoma (KIRC) project. PLoS ONE. 2014;9(1):e85621.
   PubMed Web of Science ®Google Scholar
• van Vlodrop IJH, Joosten SC, De Meyer T, et al. A four-gene promoter methylation marker panel consisting of GREM1, NEURL, LAD1, and NEFH predicts survival of clear cell renal cell cancer patients. Clin Cancer Res. 2017;23(8):2006–2018. DOI:10.1158/1078-0432.CCR-16-1236
   PubMed Web of Science ®Google Scholar
• Bianco-Miotto T, Chiam K, Buchanan G, et al. Global levels of specific histone modifications and an epigenetic gene signature predict prostate cancer progression and development. Cancer Epidemiol Biomarkers Prev. 2010;19(10):2611–2622. DOI:10.1158/1055-9965.EPI-10-0555
   PubMed Web of Science ®Google Scholar
• Krieg AJ, Rankin EB, Chan D, et al. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1α enhances hypoxic gene expression and tumor growth. Mol Cell Biol. 2010;30(1):344–353.
   PubMed Web of Science ®Google Scholar
• Guo X, Shi M, Sun L, et al. The expression of histone demethylase JMJD1A in renal cell carcinoma. Neoplasma. 2011;58(2):153–157.
   PubMed Web of Science ®Google Scholar
• Deng W-W, Hu Q, Liu Z-R, et al. KDM4B promotes DNA damage response via STAT3 signaling and is a target of CREB in colorectal cancer cells. Mol Cell Biochem. 2018;449(1–2):81–90.
   PubMed Web of Science ®Google Scholar
• Kawazu M, Saso K, Tong KI, et al. Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS ONE. 2011;6(3):e17830.
   PubMed Web of Science ®Google Scholar
• Liu X, Zhang Q, Zhao Y, et al. Association of JMJD2B and Hypoxia-inducible factor 1 expressions with poor prognosis in osteosarcoma. Anal Cell Pathol (Amst). 2020;2020:2563208.
   PubMedGoogle Scholar
• Toyokawa G, Taguchi K, Edagawa M, et al. The prognostic impact of jumonji domain-containing 2B in patients with resected lung adenocarcinoma. Anticancer Res. 2016;36(9):4841–4846. DOI:10.21873/anticanres.11046
   PubMed Web of Science ®Google Scholar
• Xiang Y, Yan K, Zheng Q, et al. Histone demethylase KDM4B promotes DNA damage by activating long interspersed nuclear element-1. Cancer Res. 2019;79(1):86–98. DOI:10.1158/0008-5472.CAN-18-1310
   PubMed Web of Science ®Google Scholar
• Slee RB, Steiner CM, Herbert B-S, et al. Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability. Oncogene. 2012;31(27):3244–3253. DOI:10.1038/onc.2011.502
   PubMed Web of Science ®Google Scholar
• Yang J, Jubb AM, Pike L, et al. The histone demethylase JMJD2B is regulated by estrogen receptor α and Hypoxia, and is a key mediator of estrogen induced growth. Cancer Res. 2010;70(16):6456–6466.
   PubMed Web of Science ®Google Scholar
• Wen L, Chen Y, Zeng L, et al. Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B. Acta Pharmacol Sin. 2012;33(1):109–119.
   PubMed Web of Science ®Google Scholar