Co-occurrence of injection drug use and hepatitis C increases epigenetic age acceleration that contributes to all-cause mortality among people living with HIV

References

• Amon JJ, Garfein RS, Ahdieh-Grant L, et al. Prevalence of hepatitis C virus infection among injection drug users in the United States, 1994-2004. Clin Infect Dis. 2008;46(12):1852–11. DOI:10.1086/588297
   PubMed Web of Science ®Google Scholar
• Blake A, Smith JE. Modeling hepatitis C elimination among people who inject drugs in new hampshire. JAMA Netw Open. 2021;4(8):e2119092.
   PubMed Web of Science ®Google Scholar
• Hagan H, Pouget ER, Des Jarlais DC, et al. Meta-regression of hepatitis C virus infection in relation to time since onset of illicit drug injection: the influence of time and place. Am J Epidemiol. 2008;168(10):1099–1109.
   PubMed Web of Science ®Google Scholar
• Nelson PK, Mathers BM, Cowie B, et al. Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews. Lancet. 2011;378(9791):571–583. DOI:10.1016/S0140-6736(11)61097-0
   PubMed Web of Science ®Google Scholar
• Strathdee SA, Hallett TB, Bobrova N, et al. HIV and risk environment for injecting drug users: the past, present, and future. Lancet. 2010;376(9737):268–284. DOI:10.1016/S0140-6736(10)60743-X
   PubMed Web of Science ®Google Scholar
• May MT, Justice AC, Birnie K, et al. Injection drug use and hepatitis C as risk factors for mortality in HIV-Infected individuals: the antiretroviral therapy cohort collaboration. J Acquir Immune Defic Syndr. 2015;69(3):348–354. DOI:10.1097/QAI.0000000000000603
   PubMed Web of Science ®Google Scholar
• Oursler KK, Marconi VC, Wang Z, et al. Epigenetic age acceleration markers are associated with physiologic frailty and all-cause mortality in people with HIV. Clin Infect Dis. 2022;76:e638–644.
   Web of Science ®Google Scholar
• Lagathu C, Cossarizza A, Bereziat V, et al. Basic science and pathogenesis of ageing with HIV: potential mechanisms and biomarkers. AIDS. 2017;31(2):S105–19.
   PubMedGoogle Scholar
• Lopez-Otin C, Blasco MA, Partridge L, et al. The hallmarks of aging. Cell. 2013;153(6):1194–1217.
   PubMed Web of Science ®Google Scholar
• Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115.
   PubMed Web of Science ®Google Scholar
• Hannum G, Guinney J, Zhao L, et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell. 2013;49(2):359–367. DOI:10.1016/j.molcel.2012.10.016
   PubMed Web of Science ®Google Scholar
• Levine ME, Lu AT, Quach A, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging. 2018;10(4):573–591. DOI:10.18632/aging.101414
   PubMedGoogle Scholar
• Lu AT, Quach A, Wilson JG, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging. 2019;11(2):303–327. DOI:10.18632/aging.101684
   PubMedGoogle Scholar
• Horvath S, Raj K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genet. 2018;19(6):371–384.
   PubMed Web of Science ®Google Scholar
• Liang X, Sinha R, Justice AC, et al. A new monocyte epigenetic clock reveals nonlinear effects of alcohol consumption on biological aging in three independent cohorts (N = 2242). Alcohol Clin Exp Res. 2022;46:736–748.
   PubMed Web of Science ®Google Scholar
• Horvath S, Levine AJ. HIV-1 infection accelerates age according to the epigenetic clock. J Infect Dis. 2015;212(10):1563–1573.
   PubMed Web of Science ®Google Scholar
• Boulias K, Lieberman J, Greer EL. An epigenetic clock measures accelerated aging in treated HIV infection. Mol Cell. 2016;62(2):153–155.
   PubMed Web of Science ®Google Scholar
• Nelson KN, Hui Q, Rimland D, et al. Identification of HIV infection-related DNA methylation sites and advanced epigenetic aging in HIV-positive, treatment-naive U.S. veterans. AIDS. 2017;31(4):571–575. DOI:10.1097/QAD.0000000000001360
   PubMed Web of Science ®Google Scholar
• Esteban-Cantos A, Rodriguez-Centeno J, Barruz P, et al. Epigenetic age acceleration changes 2 years after antiretroviral therapy initiation in adults with HIV: a substudy of the NEAT001/ANRS143 randomised trial. Lancet HIV. 2021;8(4):e197–205. DOI:10.1016/S2352-3018(21)00006-0
   PubMed Web of Science ®Google Scholar
• Zheng Y, Hlady RA, Joyce BT, et al. DNA methylation of individual repetitive elements in hepatitis C virus infection-induced hepatocellular carcinoma. Clin Epigenetics. 2019;11(1):145. DOI:10.1186/s13148-019-0733-y
   PubMed Web of Science ®Google Scholar
• Mekky MA, Salama RH, Abdel-Aal MF, et al. Studying the frequency of aberrant DNA methylation of APC, P14, and E-cadherin genes in HCV-related hepatocarcinogenesis. Cancer Biomark. 2018;22(3):503–509.
   PubMed Web of Science ®Google Scholar
• Cai C, Xie X, Zhou J, et al. Identification of TAF1, SAT1, and ARHGEF9 as DNA methylation biomarkers for hepatocellular carcinoma. J Cell Physiol. 2020;235(1):611–618.
   PubMed Web of Science ®Google Scholar
• Lambert MP, Paliwal A, Vaissiere T, et al. Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake. J Hepatol. 2011;54(4):705–715. DOI:10.1016/j.jhep.2010.07.027
   PubMed Web of Science ®Google Scholar
• Wu HC, Yang HI, Wang Q, et al. Plasma DNA methylation marker and hepatocellular carcinoma risk prediction model for the general population. Carcinogenesis. 2017;38(10):1021–1028.
   PubMed Web of Science ®Google Scholar
• Kuramoto J, Arai E, Tian Y, et al. Genome-wide DNA methylation analysis during non-alcoholic steatohepatitis-related multistage hepatocarcinogenesis: comparison with hepatitis virus-related carcinogenesis. Carcinogenesis. 2017;38(3):261–270.
   PubMed Web of Science ®Google Scholar
• Song MA, Kwee SA, Tiirikainen M, et al. Comparison of genome-scale DNA methylation profiles in hepatocellular carcinoma by viral status. Epigenetics. 2016;11(6):464–474.
   PubMed Web of Science ®Google Scholar
• Zhang X, Hu Y, Justice AC, et al. DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty. Nat Commun. 2017;8(1):2243.
   PubMedGoogle Scholar
• Gindin Y, Gaggar A, Lok AS, et al. DNA methylation and immune cell markers demonstrate evidence of accelerated aging in patients with chronic Hepatitis B virus or Hepatitis C virus, with or without human immunodeficienct virus co-infection. Clin Infect Dis. 2021;73(1):e184–90.
   PubMed Web of Science ®Google Scholar
• Justice AC, Dombrowski E, Conigliaro J, et al. Veterans Aging Cohort Study (VACS): overview and description. Med care. 2006;44(8 Suppl 2):S13–24.
   PubMed Web of Science ®Google Scholar
• Xu K, Zhang X, Wang Z, et al. Epigenome-wide association analysis revealed that SOCS3 methylation influences the effect of cumulative stress on obesity. Biol Psychol. 2018;131:63–71.
   PubMed Web of Science ®Google Scholar
• Zhang X, Justice AC, Hu Y, et al. Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals. Epigenetics. 2016;11(10):750–760.
   PubMed Web of Science ®Google Scholar
• Liang X, Justice AC, So-Armah K, et al. DNA methylation signature on phosphatidylethanol, not on self-reported alcohol consumption, predicts hazardous alcohol consumption in two distinct populations. Mol Psychiatry. 2021;26(6):2238–2253.
   PubMed Web of Science ®Google Scholar
• Cox DR. Regression models and life‐tables. J Royal Stat Soc Ser B (Methodological). 1972;34(2):187–202.
   Web of Science ®Google Scholar
• Therneau TM, Lumley, T. Package ‘survival’. R Top Doc. 2015;128(10):28–33.
   Google Scholar
• Edwards KD, Konold TR. Moderated mediation analysis: a review and application to school climate research. Pract Assess Res Eval. 2020;25(1):5.
   Google Scholar
• Saunders DR. Moderator variables in prediction. Educ Psychol Meas. 1956;16(2):209–222.
   Web of Science ®Google Scholar
• Conole ELS, Stevenson AJ, Munoz Maniega S, et al. DNA methylation and protein markers of chronic inflammation and their associations with brain and cognitive aging. Neurology. 2021;97(23):e2340–52.
   PubMed Web of Science ®Google Scholar
• Lupfer C, Kanneganti TD. The expanding role of NLRs in antiviral immunity. Immunol Rev. 2013;255(1):13–24.
   PubMed Web of Science ®Google Scholar
• Oursler KK, Marconi VC, Wang Z, et al. Epigenetic age acceleration markers are associated with physiologic frailty and all-cause mortality in people with human immunodeficiency virus. Clin Infect Dis. 2023;76(3):e638–44.
   PubMed Web of Science ®Google Scholar
• Bachi K, Sierra S, Volkow ND, et al. Is biological aging accelerated in drug addiction? Curr Opin Behav Sci. 2017;13:34–39.
   PubMed Web of Science ®Google Scholar
• Horvath, S, Lin DTS, Kobor MS, et al. HIV, pathology and epigenetic age acceleration in different human tissues. Geroscience. 2022
   Web of Science ®Google Scholar