Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth

References

• Felitti VJ, Anda RF, Nordenberg D, et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: the adverse childhood experiences (ACE) study. Am J Prev Med. 1998;14(4):245–14. doi: 10.1016/S0749-3797(98)00017-8
   PubMed Web of Science ®Google Scholar
• Anda RF, Croft JB, Felitti VJ, et al. Adverse childhood experiences and smoking during adolescence and adulthood. JAMA. 1999;282(17):1652–1658. doi: 10.1001/jama.282.17.1652
   PubMed Web of Science ®Google Scholar
• Kendler KS, Bulik CM, Silberg J, et al. Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis. Arch Gen Psychiatry. 2000;57(10):953–959. doi: 10.1001/archpsyc.57.10.953
   PubMed Web of Science ®Google Scholar
• Molnar BE, Buka SL, Kessler RC. Child sexual abuse and subsequent psychopathology: results from the national comorbidity survey. Am J Public Health. 2001;91(5):753–760. doi: 10.2105/AJPH.91.5.753
   PubMed Web of Science ®Google Scholar
• Martin A, Volkmar FR, Lewis M. Lewis’s Child and adolescent Psychiatry: a comprehensive textbook. 2007.
   Google Scholar
• Danese A, Tan M. Childhood maltreatment and obesity: systematic review and meta-analysis. Mol Psychiatry. 2014;19(5):544–554. doi: 10.1038/mp.2013.54
   PubMed Web of Science ®Google Scholar
• Burke NJ, Hellman JL, Scott BG, et al. The impact of adverse childhood experiences on an urban pediatric population. Child Abuse Negl. 2011;35(6):408–413. doi: 10.1016/j.chiabu.2011.02.006
   PubMed Web of Science ®Google Scholar
• Jones CM, Merrick MT, Houry DE. Identifying and preventing adverse childhood experiences: implications for clinical practice. JAMA - J Am Med Assoc. 2020;323(1):25–26. doi: 10.1001/jama.2019.18499
   PubMed Web of Science ®Google Scholar
• Maner JK, Hasty CR, Martinez JL, et al. The role of childhood unpredictability in adult health. J Behav Med. 2022;46(3):417–428. doi: 10.1007/s10865-022-00373-8
   PubMed Web of Science ®Google Scholar
• Zarei K, Kahle L, Buckman DW, et al. Parent-Child nativity, race, ethnicity, and adverse childhood experiences among U.S. Children. J Paediatr. 2022;251:190–195.e4. doi: 10.1016/j.jpeds.2022.07.050
   PubMed Web of Science ®Google Scholar
• Cavanaugh C, Nelson T. A national study of the influence of adverse childhood experiences on depression among black adults in the United States. J Affect Disord. 2022;311:523–529. doi: 10.1016/j.jad.2022.05.112
   PubMed Web of Science ®Google Scholar
• Jaddoe VWV, Felix JF, Andersen AMN, et al. The LifeCycle Project-EU Child cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents. Eur J Epidemiol. 2020;35(7):709–724. doi: 10.1007/s10654-020-00662-z
   PubMed Web of Science ®Google Scholar
• Nader JL, López-Vicente M, Julvez J, et al. Measures of early-life Behavior and later psychopathology in the LifeCycle project - EU Child cohort Network: a cohort Description. J Epidemiol. 2023;33(6):321–331. Published online 2021. doi: 10.2188/jea.je20210241
   PubMed Web of Science ®Google Scholar
• Kelly-Irving M, Delpierre C. Framework for understanding health inequalities over the life course: the embodiment dynamic and biological mechanisms of exogenous and endogenous origin. J Epidemiol Community Health (1978). 2021;75(12):1181–1186. doi: 10.1136/jech-2021-216430
   PubMed Web of Science ®Google Scholar
• Santos HP, Nephew BC, Bhattacharya A, et al. Discrimination exposure and DNA methylation of stress-related genes in Latina mothers. Psychoneuroendocrinology. 2018;98:131–138. doi: 10.1016/j.psyneuen.2018.08.014
   PubMed Web of Science ®Google Scholar
• Zhu Y, Lussier AA, Smith ADAC, et al. Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach. Psychoneuroendocrinology. 2022;144:105854. doi: 10.1016/j.psyneuen.2022.105854
   PubMed Web of Science ®Google Scholar
• Beach SRH, Gibbons FX, Carter SE, et al. Childhood adversity predicts black young adults’ DNA methylation-based accelerated aging: a dual pathway model. Dev Psychopathol. 2022;34(2):689–703. doi: 10.1017/S0954579421001541
   PubMed Web of Science ®Google Scholar
• Brody GH, Miller GE, Yu T, et al. Supportive family environments ameliorate the link between racial discrimination and Epigenetic aging: a replication across two longitudinal cohorts. Psychol Sci. 2016;27(4):530–541. doi: 10.1177/0956797615626703
   PubMed Web of Science ®Google Scholar
• Clausing ES, Non AL. Epigenetics as a mechanism of developmental embodiment of stress, resilience, and Cardiometabolic risk across generations of Latinx Immigrant Families. Front Psychiatry. 2021;12:12. doi: 10.3389/fpsyt.2021.696827
   Web of Science ®Google Scholar
• Vidal AC, Neelon SEB, Liu Y, et al. Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans. Genet Epigenet. 2014;6(6):37–44. doi: 10.4137/GEG.S18067
   PubMedGoogle Scholar
• Liu Y, Hoyo C, Murphy S, et al. DNA methylation at imprint regulatory regions in preterm birth and infection. Am J Obstet Gynecol. 2013;208(5):.e395.1–.e395.7. doi: 10.1016/j.ajog.2013.02.006
   Web of Science ®Google Scholar
• King KE, Kane JB, Scarbrough P, et al. Neighborhood and family environment of expectant mothers May influence prenatal programming of adult cancer risk: discussion and an Illustrative DNA methylation example. Biodemography Soc Biol. 2016;62(1):87–104. doi: 10.1080/19485565.2015.1126501
   PubMed Web of Science ®Google Scholar
• King K, Murphy S, Hoyo C. Epigenetic regulation of newborns’ imprinted genes related to gestational growth: patterning by parental race/ethnicity and maternal socioeconomic status. J Epidemiol Community Health (1978). 2015;69(7):639–647. doi: 10.1136/jech-2014-204781
   PubMed Web of Science ®Google Scholar
• Tobi EW, Heijmans BT, Kremer D, et al. DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age. Epigenetics. 2011;6(2):171–176. doi: 10.4161/epi.6.2.13516
   PubMed Web of Science ®Google Scholar
• Murphy SK, Adigun A, Huang Z, et al. Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke. Gene. 2012;494(1):36–43. doi: 10.1016/j.gene.2011.11.062
   PubMed Web of Science ®Google Scholar
• Perkins E, Murphy SK, Murtha AP, et al. Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children. J Paediatr. 2012;161(1):31–39. doi: 10.1016/j.jpeds.2012.01.015
   PubMed Web of Science ®Google Scholar
• Cui H, Cruz-Correa M, Giardiello FM, et al. Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Sci (1979). 2003;299(5613):1753–1755. doi: 10.1126/science.1080902
   PubMed Web of Science ®Google Scholar
• Müller R, Charaf S, Scherer C, et al. Phenotypic and epigenetic effects of vinclozolin in the gastropod physella acuta. J Mollus Stud. 2016;82(2):320–327. doi: 10.1093/mollus/eyv069
   Google Scholar
• House JS, Mendez M, Maguire RL, et al. Periconceptional maternal Mediterranean diet is associated with favorable offspring behaviors and altered CpG methylation of imprinted genes. Front Cell Dev Biol. 2018;6(SEP):107. doi: 10.3389/fcell.2018.00107
   PubMedGoogle Scholar
• Lu X, Yang S, Jie M, et al. Folate deficiency disturbs PEG10 methylation modifications in human spina bifida. Pediatr Res. 2022;92(4):987–994. doi: 10.1038/s41390-021-01908-6
   PubMed Web of Science ®Google Scholar
• van Dokkum NH, Bao M, Verkaik-Schakel RN, et al. Neonatal stress exposure and DNA methylation of stress-related and neurodevelopmentally relevant genes: an exploratory study. Early Hum Dev. 2023;186:186. doi: 10.1016/j.earlhumdev.2023.105868
   Web of Science ®Google Scholar
• Pandit M, Akhtar MN, Sundaram S, et al. Termination codon readthrough of NNAT mRNA regulates calcium-mediated neuronal differentiation. J Biol Chem. 2023;299(9):105184. doi: 10.1016/j.jbc.2023.105184
   PubMed Web of Science ®Google Scholar
• Liao J, Song S, Gusscott S, et al. Establishment of paternal methylation imprint at the H19/Igf2 imprinting control region. Sci Adv. 2023;9(36):eadi2050. doi: 10.1126/SCIADV.ADI2050
   PubMed Web of Science ®Google Scholar
• Sun J, Shu J, Shi D, et al. Effects of methylation and imprinting expression of Insulin-like growth factor 2 gene in gastric cancer. Cancer Biomark. 2023;2023(3):1–12. Published online September 15. doi: 10.3233/CBM-230105
   Google Scholar
• Argentato PP, Marchesi JAP, Dejani NN, et al. The relationship between obesity-related H19DMR methylation and H19 and IGF2 gene expression on offspring growth and body composition. Front Nutr. 2023;10:10. doi: 10.3389/fnut.2023.1170411
   Web of Science ®Google Scholar
• Alhendi ASN, Gazdagh G, Lim D, et al. A case of mosaic deletion of paternally-inherited PLAGL1 and two cases of upd(6)mat add to evidence for PLAGL1 under-expression as a cause of growth restriction. Am J Med Genet A. 2023. Published online 2023. doi: 10.1002/AJMG.A.63448
   PubMed Web of Science ®Google Scholar
• Qiu T, Ding Y, Qin J, et al. Epigenetic reactivation of PEG3 by EZH2 inhibitors suppresses renal clear cell carcinoma progress. Cell Signal. 2023;107:110662. doi: 10.1016/J.CELLSIG.2023.110662
   PubMed Web of Science ®Google Scholar
• Habib WA, Brioude F, Azzi S, et al. Transcriptional profiling at the DLK1/MEG3 domain explains clinical overlap between imprinting disorders. Sci Adv. 2019;5(2). doi: 10.1126/SCIADV.AAU9425
   PubMed Web of Science ®Google Scholar
• Sellers ZP, Bolkun L, Kloczko J, et al. Increased methylation upstream of the MEG3 promotor is observed in acute myeloid leukemia patients with better overall survival. Clin Epigenetics. 2019;11(1). doi: 10.1186/S13148-019-0643-Z
   PubMedGoogle Scholar
• Hoyo C, Murtha AP, Schildkraut JM, et al. Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy. Epigenetics. 2011;6(7):928–936. doi: 10.4161/epi.6.7.16263
   PubMed Web of Science ®Google Scholar
• Murphy SK, Huang Z, Hoyo C, et al. Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues. PLoS One. 2012;7(7):e40924. doi: 10.1371/journal.pone.0040924
   PubMed Web of Science ®Google Scholar
• Pervjakova N, Kasela S, Morris AP, et al. Imprinted genes and imprinting control regions show predominant intermediate methylation in adult somatic tissues. Epigenomics. 2016;8(6):789–799. doi: 10.2217/epi.16.8
   PubMed Web of Science ®Google Scholar
• Woodfine K, Huddleston JE, Murrell A. Quantitative analysis of DNA methylation at all human imprinted regions reveals preservation of epigenetic stability in adult somatic tissue. Epigenet Chromatin. 2011;4(1):1. doi: 10.1186/1756-8935-4-1
   PubMed Web of Science ®Google Scholar
• Riis JL, Granger DA, Minkovitz CS, et al. Maternal distress and child neuroendocrine and immune regulation. Soc Sci Med. 2016;151:206–214. doi: 10.1016/j.socscimed.2015.12.043
   PubMed Web of Science ®Google Scholar
• Williams DR, Yu Y, Jackson JS, et al. Racial differences in physical and mental health. Socio-economic status, stress and discrimination. J Health Psychol. 1997;2(3):335–351. doi: 10.1177/135910539700200305
   PubMedGoogle Scholar
• Joubert BR, Felix JF, Yousefi P, et al. DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis. Am J Hum Genet. 2016;98(4):680–696. doi: 10.1016/j.ajhg.2016.02.019
   PubMed Web of Science ®Google Scholar
• Long JA Interactions: comprehensive, user-friendly toolkit for probing interactions. Published online 2019.
   Google Scholar
• Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc Ser B (Methodological). 1995;57(1):289–300. doi: 10.1111/j.2517-6161.1995.tb02031.x
   Google Scholar
• Grobman WA, Parker C, Wadhwa PD, et al. Racial/Ethnic disparities in measures of self-reported psychosocial states and traits during pregnancy. Am J Perinatol. 2016;33(14):1426–1432. doi: 10.1055/s-0036-1586510
   PubMed Web of Science ®Google Scholar
• Smith JD, Fu E, Kobayashi MA. Prevention and Management of childhood obesity and its psychological and health comorbidities. Annu Rev Clin Psychol. 2020;16(1):351–378. doi: 10.1146/annurev-clinpsy-100219-060201
   PubMedGoogle Scholar
• Ertel KA, Koenen KC, Rich-Edwards JW, et al. Antenatal and postpartum depressive symptoms are differentially associated with early childhood weight and adiposity. Paediatr Perinat Epidemiol. 2010;24(2):179–189. doi: 10.1111/j.1365-3016.2010.01098.x
   PubMed Web of Science ®Google Scholar
• Gentile S. Untreated depression during pregnancy: short- and long-term effects in offspring. A systematic review. Neuroscience. 2017;342:154–166. doi: 10.1016/j.neuroscience.2015.09.001
   PubMed Web of Science ®Google Scholar
• Dieter JNI, Field T, Hernandez-Reif M, et al. Maternal depression and increased fetal activity. J Obstet Gynaecol (Lahore). 2001;21(5):468–473. doi: 10.1080/01443610120072009
   Google Scholar
• Korhonen LS, Karlsson L, Scheinin NM, et al. Prenatal maternal psychological distress and offspring risk for recurrent respiratory infections. J Paediatr. 2019;208:229–235.e1. doi: 10.1016/j.jpeds.2018.12.050
   PubMed Web of Science ®Google Scholar
• Rogers A, Obst S, Teague SJ, et al. Association between maternal perinatal depression and anxiety and Child and adolescent development: a meta-analysis. JAMA Pediatr. 2020;174(11):1082–1092. doi: 10.1001/jamapediatrics.2020.2910
   PubMed Web of Science ®Google Scholar
• Liu Y, Murphy SK, Murtha AP, et al. Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. Epigenetics. 2012;7(7):735–746. doi: 10.4161/epi.20734
   PubMed Web of Science ®Google Scholar
• Scorza P, Duarte CS, Lee S, et al. Epigenetic intergenerational transmission: mothers’ adverse childhood experiences and DNA methylation. J Am Acad Child Adolesc Psychiatry. 2020;59(7):900–901. doi: 10.1016/j.jaac.2020.03.008
   PubMed Web of Science ®Google Scholar
• Moore SR, Merrill SM, Sekhon B, et al. Infant DNA methylation: an early indicator of intergenerational trauma? Early Hum Dev. 2022;164:105519. doi: 10.1016/j.earlhumdev.2021.105519
   PubMed Web of Science ®Google Scholar
• Lund RJ, Kyläniemi M, Pettersson N, et al. Placental DNA methylation marks are associated with maternal depressive symptoms during early pregnancy. Neurobiol Stress. 2021;15:15. doi: 10.1016/j.ynstr.2021.100374
   Web of Science ®Google Scholar
• Smedley A, Smedley BD. Race as biology is fiction, racism as a social problem is real: anthropological and historical perspectives on the social construction of race. American Psychologist. 2005;60(1):16–26. doi: 10.1037/0003-066X.60.1.16
   PubMed Web of Science ®Google Scholar
• DeLano K, Folger AT, Ding L, et al. Associations between maternal community deprivation and infant DNA methylation of the SLC6A4 gene. Front Public Health. 2020;8:557195. doi: 10.3389/fpubh.2020.557195
   PubMed Web of Science ®Google Scholar
• Devlin AM, Brain U, Austin J, et al. Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth. PLoS One. 2010;5(8):e12201. doi: 10.1371/journal.pone.0012201
   PubMed Web of Science ®Google Scholar
• Gijsman HJ, Verkes RJ, Schouten-Verhagen JCM, et al. A review of the role of serotonin receptors in psychiatric disorders. Hum Psychopharmacol. 2000;15(6):397–415. doi: 10.1002/1099-1077(200008)15:6<397::AID-HUP212>3.0.CO;2-L
   PubMed Web of Science ®Google Scholar
• Lam D, Ancelin ML, Ritchie K, et al. Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression. BMC Psychiatry. 2018;18(1):1–10. doi: 10.1186/s12888-018-1850-4
   PubMedGoogle Scholar
• Smith JA, Zhao W, Wang X, et al. Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: the multi-ethnic study of atherosclerosis. Epigenetics. 2017;12(8):662–673. doi: 10.1080/15592294.2017.1341026
   PubMed Web of Science ®Google Scholar
• Wrigglesworth J, Ryan J, Vijayakumar N, et al. Brain-derived neurotrophic factor DNA methylation mediates the association between neighborhood disadvantage and adolescent brain structure. Psychiatry Res Neuroimaging. 2019;285:51–57. doi: 10.1016/j.pscychresns.2018.12.012
   PubMed Web of Science ®Google Scholar
• Fransquet PD, Hjort L, Rushiti F, et al. DNA methylation in blood cells is associated with cortisol levels in offspring of mothers who had prenatal post-traumatic stress disorder. Stress And Health. 2022;38(4):755–766. doi: 10.1002/smi.3131
   PubMed Web of Science ®Google Scholar