Hypomethylation at H19DMR in penile squamous cell carcinoma is not related to HPV infection

References

• Douglawi A, Masterson TA. Updates on the epidemiology and risk factors for penile cancer. Transl Androl Urol. 2017;6(5):785–12. doi: 10.21037/tau.2017.05.19
   PubMed Web of Science ®Google Scholar
• Yanagawa N, Osakabe M, Hayashi M, et al. Detection of HPV-DNA, p53 alterations, and methylation in penile squamous cell carcinoma in Japanese men. Pathol Int. 2008;58(8):477–482. doi: 10.1111/j.1440-1827.2008.02259.x
   PubMed Web of Science ®Google Scholar
• Santos S, Hirth CG, Pinheiro DP, et al. HPV infection and 5mC/5hmC epigenetic markers in penile squamous cell carcinoma: new insights into prognostics. Clin Epigenetics. 2022;1–12. [Internet]. BioMed Central. doi:10.1186/s13148-022-01360-1
   PubMed Web of Science ®Google Scholar
• Feinberg AP, Ohlsson R, Henikoff S. The epigenetic progenitor origin of human cancer. Nat Rev Genet. 2006;7(1):21–33. doi: 10.1038/nrg1748
   PubMed Web of Science ®Google Scholar
• Lozano-Ureña A, Jiménez-Villalba E, Pinedo-Serrano A, et al. Aberrations of Genomic Imprinting in Glioblastoma Formation. Front Oncol. 2021;11:1–10. doi: 10.3389/fonc.2021.630482
   Web of Science ®Google Scholar
• Monk D, Mackay DJG, Eggermann T, et al. Genomic imprinting disorders: lessons on how genome, epigenome, and environment interact. Nat Rev Genet. 2019;20:235–248. [Internet]. Springer US. doi: 10.1038/s41576-018-0092-0
   PubMed Web of Science ®Google Scholar
• Sagi I, De Pinho JC, Zuccaro MV, et al. Distinct imprinting signatures and biased differentiation of human androgenetic and parthenogenetic embryonic stem cells. Cell Stem Cell. 2019;25(3):419–432.e9. doi: 10.1016/j.stem.2019.06.013
   PubMed Web of Science ®Google Scholar
• Cleaton MAM, Edwards CA, Ferguson-Smith AC. Phenotypic outcomes of imprinted gene models in mice: elucidation of pre- and postnatal functions of imprinted genes. Annu Rev Genomics Hum Genet. 2014;15(1):93–126. doi: 10.1146/annurev-genom-091212-153441
   PubMedGoogle Scholar
• Uribe-Lewis S, Woodfine K, Stojic L, et al. Molecular mechanisms of genomic imprinting and clinical implications for cancer. Expert Rev Mol Med. 2011;13:1–22. doi: 10.1017/S1462399410001717
   Web of Science ®Google Scholar
• Zhou J, Cheng T, Li X, et al. Epigenetic imprinting alterations as effective diagnostic biomarkers for early-stage lung cancer and small pulmonary nodules. Clin Epigenetics. 2021;13(1):1–14. doi: https://doi.org/10.1186/s13148-021-01203-5 [Internet]. BioMed Central
   PubMed Web of Science ®Google Scholar
• Tian F, Tang Z, Song G, et al. Loss of imprinting of IGF2 correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients. Mol Med Rep. 2012;5(6):1536–1540. doi: 10.3892/mmr.2012.833
   PubMed Web of Science ®Google Scholar
• Zhu YF, Guo YB, Zhang HY, et al. Prognostic significance of contactin 3 expression and associated genes in glioblastoma multiforme. Oncol Lett. 2019;18:1863–1871. doi: 10.3892/ol.2019.10482
   PubMed Web of Science ®Google Scholar
• Yang MY, Lin PM, Yang CH, et al. Loss of ZNF215 imprinting is associated with poor five-year survival in patients with cytogenetically abnormal-acute myeloid leukemia. Blood Cells Mol Dis. 2021;90:102577. doi: 10.1016/j.bcmd.2021.102577 [Internet]Elsevier Inc.
   PubMed Web of Science ®Google Scholar
• Byun HM, Wong HL, Birnstein EA, et al. Examination of IGF2 and H19 loss of imprinting in bladder cancer. Cancer Res. 2007;67(22):10753–10758. doi: 10.1158/0008-5472.CAN-07-0329
   PubMed Web of Science ®Google Scholar
• Nordin M, Bergman D, Halje M, et al. Epigenetic regulation of the Igf2/H19 gene cluster. Cell Prolif. 2014;47(3):189–199. doi: 10.1111/cpr.12106
   PubMed Web of Science ®Google Scholar
• Yoshimizu T, Miroglio A, Ripoche MA, et al. The H19 locus acts in vivo as a tumor suppressor. Proc Natl Acad Sci U S A. 2008;105(34):12417–12422. doi: 10.1073/pnas.0801540105
   PubMed Web of Science ®Google Scholar
• Tietze L, Kessler SM. The good, the bad, the question– H19 in hepatocellular carcinoma. Cancers (Basel). 2020;12(5):16. doi: 10.3390/cancers12051261
   Web of Science ®Google Scholar
• Ong CT, Corces VG. CTCF: an architectural protein bridging genome topology and function. Nat Rev Genet Nature Publishing Group. 2014;15(4):234–246. doi: 10.1038/nrg3663
   PubMed Web of Science ®Google Scholar
• Yang Z, Zhang T, Han S, et al. Long noncoding RNA H19 – a new player in the pathogenesis of liver diseases. Transl Res. 2021;230:139–150. doi: 10.1016/j.trsl.2020.11.010
   PubMed Web of Science ®Google Scholar
• Vohra M, Sharma AR, Prabhu BN, et al. SNPs in sites for DNA methylation, transcription factor binding, and miRNA targets leading to allele-specific gene expression and contributing to complex disease risk: a systematic review. Public Health Genomics. 2021;23(5–6):155–170. doi: 10.1159/000510253
   Web of Science ®Google Scholar
• Zhong R, Liu L, Tian Y, et al. Genetic variant in SWI/SNF complexes influences hepatocellular carcinoma risk: a new clue for the contribution of chromatin remodeling in carcinogenesis. Sci Rep. 2014;4(1):1–6. doi: 10.1038/srep04147
   Google Scholar
• Do C, Dumont E, Salas M, et al. Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs. Genome Biol Genome Biology. 2020;21(1):1–39. doi: 10.1186/s13059-020-02059-3
   Web of Science ®Google Scholar
• Shilpi A, Bi Y, Jung S, et al. Identification of genetic and epigenetic variants associated with breast cancer prognosis by integrative bioinformatics analysis. Cancer Inform. 2017;16:1–13. doi: 10.4137/CIN.S39783
   PubMedGoogle Scholar
• Yamaguchi Y, Tayama C, Tomikawa J, et al. Placenta-specific epimutation at H19-DMR among common pregnancy complications: its frequency and effect on the expression patterns of H19 and IGF2. Clin Epigenetics Clinical Epigenetics. 2019;11(1):1–13. doi: 10.1186/s13148-019-0712-3
   PubMed Web of Science ®Google Scholar
• Wu J, Qin Y, Li B, et al. Hypomethylated and hypermethylated profiles of H19DMR are associated with the aberrant imprinting of IGF2 and H19 in human hepatocellular carcinoma. Genomics. 2008;91(5):443–450. doi: 10.1016/j.ygeno.2008.01.007
   PubMed Web of Science ®Google Scholar
• Gao T, He B, Pan Y, et al. H19 DMR methylation correlates to the progression of esophageal squamous cell carcinoma through IGF2 imprinting pathway. Clin Transl Oncol. 2014;16(4):410–417. doi: 10.1007/s12094-013-1098-x
   PubMed Web of Science ®Google Scholar
• Wang J, Ma X, Si H, et al. Role of long non-coding RNA H19 in therapy resistance of digestive system cancers. Mol Med. 2021;27:1–9. doi: 10.1186/s10020-020-00255-2 [Internet]. BioMed Central.
   PubMed Web of Science ®Google Scholar
• Cubilla AL, Lloveras B, Alejo M, et al. Value of p16INK4a in the pathology of invasive penile squamous cell carcinomas: a report of 202 cases. Am J Surg Pathol. 2011;35(2):253–261. doi: 10.1097/PAS.0b013e318203cdba
   PubMed Web of Science ®Google Scholar
• Vértesy Á, Arindrarto W, Roost MS, et al. Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells. Nat Commun. 2018;9(1):1–10. doi: http://dx.doi.org/10.1038/s41467-018-04215-7 [Internet]. Springer US
   PubMedGoogle Scholar
• Bolger AM, Lohse M, Usadel B. Trimmomatic: A flexible trimmer for Illumina sequence data. Bioinformatics. 2014;30:2114–2120.
   PubMed Web of Science ®Google Scholar
• Ziebarth JD, Bhattacharya A, Cui Y. CTCFBSDB 2.0: a database for CTCF-binding sites and genome organization. Nucleic Acids Res. 2013;41(D1):D188–D194. doi: 10.1093/nar/gks1165
   PubMed Web of Science ®Google Scholar
• Tang G, Cho M, Wang X. OncoDB: an interactive online database for analysis of gene expression and viral infection in cancer. Nucleic Acids Res. 2022;50(D1):D1334–9. doi: 10.1093/nar/gkab970 Oxford University Press.
   PubMed Web of Science ®Google Scholar
• da Silva Santos R, Pascoalino Pinheiro D, Pinheiro Rodrigues Teixeira L, et al. CRISPR/Cas9 small promoter deletion in H19 lncRNA is associated with altered cell morphology and proliferation. Sci Rep. 2021;11(1):11. doi: https://doi.org/10.1038/s41598-021-97058-0 [Internet]. Nature Publishing Group UK.
   PubMed Web of Science ®Google Scholar
• Bhusari S, Yang B, Kueck J, et al. Insulin-like growth factor-2 (IGF2) loss of imprinting marks a field defect within human prostates containing cancer. Prostate. 2011;185(4S):23. doi: 10.1016/j.juro.2011.02.1695
   Google Scholar
• Fu VX, Dobosy JR, Desotelle JA, et al. Aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate. Cancer Res. 2014;23:1–7.
   Google Scholar
• Belharazem D, Magdeburg J, Berton AK, et al. Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications. J Gastroenterol. 2016;51(10):971–984. doi: 10.1007/s00535-016-1181-5
   PubMed Web of Science ®Google Scholar
• Haluska P, Menefee M, Plimack ER, et al. Phase I dose-escalation study of MEDI-573, a bispecific, antiligand monoclonal antibody against IGFI and IGFII, in patients with advanced solid tumors. Physiol Behav. 2015;20:4747–4757. Internet Carolina/Desktop/Artigos para acrescentar na qualificação/The impact of birth weight on cardiovascular disease risk in the.pdf: https://pubmed.ncbi.nlm.nih.gov/27165699%0Ahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664198/%0Afile:///C:/Users/Carla
   Google Scholar
• Sanderson MP, Hofmann MH, Garin-Chesa P, et al. The IGF1R/INSR inhibitor BI 885578 selectively inhibits growth of IGF2-overexpressing colorectal cancer tumors and potentiates the efficacy of anti-VEGF therapy. Mol Cancer Ther. 2017;16(10):2223–2233. doi: 10.1158/1535-7163.MCT-17-0336
   PubMed Web of Science ®Google Scholar
• De Crescenzo A, Coppola F, Falco P, et al. A novel microdeletion in the IGF2/H19 imprinting centre region defines a recurrent mutation mechanism in familial Beckwith–Wiedemann syndrome. Eur J Med Genet. 2011;54(4):e451–4. doi: 10.1016/j.ejmg.2011.04.009 [Internet]. Elsevier Masson SAS
   PubMed Web of Science ®Google Scholar
• Lynch CA, Tycko B, Bestor TH, et al. Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation. Mol Cancer. 2002;1(1):2–9. doi: 10.1186/1476-4598-1-2
   PubMedGoogle Scholar
• Matouk IJ, Raveh E, Abu-Lail R, et al. Oncofetal H19 RNA promotes tumor metastasis. Biochim Biophys Acta Mol Cell Res. 2014;1843(7):1414–1426. doi: 10.1016/j.bbamcr.2014.03.023 [Internet]. Elsevier B.V.
   PubMed Web of Science ®Google Scholar
• Cui H, Onyango P, Brandenburg S, et al. Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res. 2002;2:6442–6446.
   Google Scholar
• Verhaegh GW, Verkleij L, Vermeulen SHHM, et al. Polymorphisms in the H19 Gene and the risk of bladder cancer. Eur Urol. 2008;54:1118–1126.
   PubMed Web of Science ®Google Scholar
• Ghafouri-Fard S, Esmaeili M, Taheri M. H19 lncRNA : Roles in tumorigenesis. Biomed Pharmacother. 2020;123:123. doi: 10.1016/j.biopha.2019.109774
   Web of Science ®Google Scholar
• Vidal AC, Henry NM, Murphy SK, et al. PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer. Clin Transl Oncol. 2014;16(3):266–272. doi: 10.1007/s12094-013-1067-4
   PubMed Web of Science ®Google Scholar
• Bosire C, Vidal AC, Smith JS, et al. Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia. Infect Agent Cancer. 2021;16(1):1–8. doi: 10.1186/s13027-021-00382-3
   PubMed Web of Science ®Google Scholar
• Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):115. doi: 10.1186/gb-2013-14-10-r115
   PubMed Web of Science ®Google Scholar
• Zou Q, Wang X, Ren D, et al. DNA methylation-based signature of CD8+ tumor-infiltrating lymphocytes enables evaluation of immune response and prognosis in colorectal cancer. J Immunother Cancer. 2021;9(9):1–13. doi: 10.1136/jitc-2021-002671
   Web of Science ®Google Scholar
• Zhang B, Wu Q, Li B, et al. M6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer. Mol Cancer Molecular Cancer. 2020;19(1):1–21. doi: 10.1186/s12943-020-01170-0
   PubMed Web of Science ®Google Scholar
• Wang B, Suen CW, Ma H, et al. The Roles of H19 in Regulating Inflammation and Aging. Front Immunol. 2020;11:1–11. doi: 10.3389/fimmu.2020.579687
   PubMed Web of Science ®Google Scholar
• Jiang Y, Zhu H, Chen Z, et al. Hepatic IGF2/H19 epigenetic alteration induced glucose intolerance in gestational diabetes mellitus offspring via FoxO1 mediation. Front Endocrinol. 2022;13:1–11. doi: 10.3389/fendo.2022.844707
   Web of Science ®Google Scholar
• Barnes KT, McDowell BD, Button A, et al. Obesity is associated with increased risk of invasive penile cancer. BMC Urol. 2016;16(1):7–10. doi: http://dx.doi.org/10.1186/s12894-016-0161-7 [Internet]. BMC Urology.
   PubMedGoogle Scholar
• Ball MW, Bezerra SM, Chaux A, et al. Overexpression of insulin-like growth factor-1 receptor is associated with penile cancer progression. Urology [Internet]. Elsevier Inc. 2016;92:51–56. doi: 10.1016/j.urology.2016.02.006
   PubMed Web of Science ®Google Scholar
• Faraj SF, Gonzalez-Roibon N, Munari E, et al. Strong association of insulin-like growth factor 1 receptor expression with histologic grade, subtype, and HPV status in penile squamous cell carcinomas: a tissue microarray study of 112 cases. Virchows Arch Virchows Archiv. 2017;470(6):695–701. doi: 10.1007/s00428-017-2110-6
   PubMed Web of Science ®Google Scholar
• Prati B, Marangoni B, Boccardo E. Human papillomavirus and genome instability: from productive infection to cancer. Clinics. 2018;73:1–9. doi: 10.6061/clinics/2018/e539s
   Web of Science ®Google Scholar
• Shoemaker R, Deng J, Wang W, et al. Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome. Genome Res. 2010;20(7):883–889. doi: 10.1101/gr.104695.109
   PubMed Web of Science ®Google Scholar
• Canto Do LM, da Silva JM, Castelo-Branco PV, et al. Mutational signature and integrative genomic analysis of human papillomavirus-associated penile squamous cell carcinomas from Latin American patients. Cancers (Basel). 2022;14(14):14. doi: 10.3390/cancers14143514
   Web of Science ®Google Scholar
• Nazha B, Zhuang T, Wu S, et al. Comprehensive genomic profiling of penile squamous cell carcinoma and the impact of human papillomavirus status on immune-checkpoint inhibitor-related biomarkers. Cancer. 2023;25(24):3884–3893. doi: 10.1002/cncr.34982 Springer US
   Google Scholar
• Khan Aroo MH, Khalil A, Rashid H. Evaluation of the p53 Arg72Pro polymorphism and its association with cancer risk: a HuGE review and meta-analysis. Genet Res (Camb). 2015;97:e7. doi: 10.1017/S0016672315000075
   PubMed Web of Science ®Google Scholar
• Stoehr R, Weisser R, Wendler O, et al. P53 codon 72 polymorphism and risk for squamous cell carcinoma of the penis: a Caucasian case-control study. J Cancer. 2018;9(22):4234–4241. doi: 10.7150/jca.26050
   PubMed Web of Science ®Google Scholar
• Ahmed ME, Falasiri S, Hajiran A, et al. Review the immune microenvironment in penile cancer and rationale for immunotherapy. J Clin Med. 2020;9(10):1–17. doi: 10.3390/jcm9103334
   Web of Science ®Google Scholar
• Huang T, Cheng X, Chahoud J, et al. Effective combinatorial immunotherapy for penile squamous cell carcinoma. Nat Commun. 2020;11(1):11. doi: http://dx.doi.org/10.1038/s41467-020-15980-9 [Internet]. Springer US
   PubMed Web of Science ®Google Scholar
• Smith AD, Lu C, Payne D, et al. Autocrine IL6-mediated activation of the STAT3–DNMT axis silences the TNFα–RIP1 necroptosis pathway to sustain survival and accumulation of myeloid-derived suppressor cells. Cancer Res. 2021;80(15):3145–3156. doi: 10.1158/0008-5472.CAN-19-3670
   Web of Science ®Google Scholar