The one-carbon metabolism as an underlying pathway for placental DNA methylation – a systematic review

References

• Gluckman PD, Hanson MA, Cooper C. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008;359(1):61–26. doi: 10.1056/NEJMra0708473
   PubMed Web of Science ®Google Scholar
• Barker DJP. The origins of the developmental origins theory. J Intern Med. 2007 May;261(5):412–7. doi: 10.1111/j.1365-2796.2007.01809.x
   PubMed Web of Science ®Google Scholar
• Bianco-Miotto TCJ, Craig JM, Gasser YP, et al. Epigenetics and DOHaD: from basics to birth and beyond. J Dev Orig Health Dis. 2017 Oct;8(5):513–519. doi: 10.1017/S2040174417000733
   PubMed Web of Science ®Google Scholar
• Moore LD, Le T, Fan G. DNA methylation and its basic function. Neuropsychopharmacology. 2013;38(1):23–38. doi: 10.1038/npp.2012.112
   PubMed Web of Science ®Google Scholar
• Jin B, Li Y, Robertson KD. DNA methylation: superior or subordinate in the epigenetic hierarchy? Genes & Cancer. 2011 Jun;2(6):607–617. doi: 10.1177/1947601910393957
   PubMedGoogle Scholar
• Greenberg MVC, Bourc’his D. The diverse roles of DNA methylation in mammalian development and disease. Nat Rev Mol Cell Biol. 2019 Oct;20(10):590–607. doi: 10.1038/s41580-019-0159-6
   PubMed Web of Science ®Google Scholar
• Steegers-Theunissen RP, Twigt J, Pestinger V. The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism. Human Reproduction Update. 2013 Nov-Dec;19(6):640–655. doi: 10.1093/humupd/dmt041
   PubMed Web of Science ®Google Scholar
• Zeng Y, Chen T. DNA methylation reprogramming during mammalian development. Genes (Basel). 2019 Mar 29;10(4):257. doi: 10.3390/genes10040257
   PubMed Web of Science ®Google Scholar
• Friso S, Udali S, De Santis D. One-carbon metabolism and epigenetics. Molecular Aspects Of Medicine. 2017 Apr;54:28–36. doi: 10.1016/j.mam.2016.11.007
   PubMed Web of Science ®Google Scholar
• Korsmo HW, Jiang X. One carbon metabolism and early development: a diet-dependent destiny. Trends In Endocrinology & Metabolism. 2021 Aug;32(8):579–593. doi: 10.1016/j.tem.2021.05.011
   PubMed Web of Science ®Google Scholar
• McGee MB, Bainbridge S, Fontaine-Bisson B. A crucial role for maternal dietary methyl donor intake in epigenetic programming and fetal growth outcomes. Nutrition Reviews. 2018; Jun 1;76(6):469–478. doi: 10.1093/nutrit/nuy006
   PubMed Web of Science ®Google Scholar
• James JP, Sajjadi AS, Tomar A, et al. EMPHASIS study group. Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism. Int J Epidemiol. 2018 Dec 1;47(6):1910–1937. doi: 10.1093/ije/dyy153
   PubMed Web of Science ®Google Scholar
• Anderson OS, Sant KE, Dolinoy DC. Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. J Nutr Biochem. 2012 Aug;23(8):853–859. doi: 10.1016/j.jnutbio.2012.03.003
   PubMed Web of Science ®Google Scholar
• Lee HS. Impact of maternal diet on the epigenome during in utero life and the developmental programming of diseases in childhood and adulthood. Nutrients. 2015 Nov 17;7(11):9492–507. doi: 10.3390/nu7115467
   PubMed Web of Science ®Google Scholar
• Steegers-Theunissen S-TR, Obermann-Borst SA, Kremer D, et al. Periconceptional maternal folic acid use of 400 µg per day is related to increased methylation of the IGF2 gene in the very young child. PloS One. 2009 Nov 16;4(11):e7845. doi: 10.1371/journal.pone.0007845
   PubMed Web of Science ®Google Scholar
• Sinclair KD, Allegrucci C, Singh R, et al. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19351–19356. doi: 10.1073/pnas.0707258104
   PubMed Web of Science ®Google Scholar
• Clare CE, Brassington AH, Kwong WY. One-Carbon Metabolism: linking nutritional biochemistry to epigenetic programming of long-term development. Ann Rev Anim Biosci. 2019; Feb 15;7(1):263–287. doi: 10.1146/annurev-animal-020518-115206
   PubMedGoogle Scholar
• Waterland RA, Travisano M, Tahiliani KG, et al. Methyl donor supplementation prevents transgenerational amplification of obesity. Int J Obes (Lond). 2008 Sep;32(9):1373–1379. doi: 10.1038/ijo.2008.100
   PubMed Web of Science ®Google Scholar
• Cooney CA, Dave AA, Wolff GL. Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring. J Nutr. 2002 Aug;132(8):2393S–2400S. doi: 10.1093/jn/132.8.2393S
   PubMed Web of Science ®Google Scholar
• Tobi EW, Slieker RC, Stein AD, et al. Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome. Int J Epidemiol. 2015 Aug;44(4):1211–1223. doi: 10.1093/ije/dyv043
   PubMed Web of Science ®Google Scholar
• Burton GJ, Jauniaux E. What is the placenta? Am J Obstet Gynecol. 2015 Oct;213(4):SS6.e1–S6.e4. doi: 10.1016/j.ajog.2015.07.050
   Web of Science ®Google Scholar
• Nelissen ECM, van Montfoort APA, Dumoulin JLH. Epigenetics and the placenta. Hum Reprod Update. 2011;17(3):397–417. doi: 10.1093/humupd/dmq052
   PubMed Web of Science ®Google Scholar
• Wong AIC, Lo YMD. Noninvasive fetal genomic, methylomic, and transcriptomic analyses using maternal plasma and clinical implications. Trends Mol Med. 2015;21(2):98–108. doi: 10.1016/j.molmed.2014.12.006
   PubMed Web of Science ®Google Scholar
• Liu H-Y, Liu S-M, Zhang Y-Z. Maternal folic acid supplementation mediates offspring health via DNA methylation. Reprod Sci. 2020 Apr;27(4):963–976. doi: 10.1007/s43032-020-00161-2
   PubMed Web of Science ®Google Scholar
• Mandaviya PR, Stolk L, Heil SG. Homocysteine and DNA methylation: a review of animal and human literature. Mol Genet Metab. 2014 Dec;113(4):243–252. doi: 10.1016/j.ymgme.2014.10.006
   PubMed Web of Science ®Google Scholar
• Thompson RP, Nilsson E, Skinner MK. Environmental epigenetics and epigenetic inheritance in domestic farm animals. Anim Reprod Sci. 2020 Sep;220:106316. doi: 10.1016/j.anireprosci.2020.106316
   PubMed Web of Science ®Google Scholar
• Campagna MP, Xavier A, Lechner-Scott J, et al. Epigenome-wide association studies: current knowledge, strategies and recommendations. Clin Epigenetics. 2021; Dec 4;13(1):214. doi: 10.1186/s13148-021-01200-8
   PubMed Web of Science ®Google Scholar
• Shamseer SL, Moher D, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015; Jan 2;349(jan02 1):g7647. doi: 10.1136/bmj.g7647
   Google Scholar
• Hamilton O. Quality assessment tool for quantitative studies: national collaborating centre for methods and tools 2008 [Updated 2020 Apr13]. Available from: https://dev.nccmt.ca/knowledge-repositories/search/14.
   Google Scholar
• Devi S, Mukhopadhyay A, Dwarkanath P, et al. Combined vitamin B-12 and balanced protein-energy supplementation affect homocysteine remethylation in the methionine cycle in pregnant south Indian women of low vitamin B-12 status. J Nutr. 2017;147(6):1094–103. doi: 10.3945/jn.116.241042
   PubMed Web of Science ®Google Scholar
• Dou JF, Middleton LYM, Zhu Y, et al. Prenatal vitamin intake in first month of pregnancy and DNA methylation in cord blood and placenta in two prospective cohorts. Epigenet Chromatin. 2022;15(1):28. doi: 10.1186/s13072-022-00460-9
   PubMed Web of Science ®Google Scholar
• Lecorguille M, Charles MA, Lepeule J, et al. Association between dietary patterns reflecting one-carbon metabolism nutrients intake before pregnancy and placental DNA methylation. Epigenetics. 2022;17(7):715–30. doi: 10.1080/15592294.2021.1957575
   PubMed Web of Science ®Google Scholar
• Castillo-Castrejon M, Yang IV, Davidson EJ, et al. Preconceptional lipid-based nutrient supplementation in 2 low-resource countries results in distinctly different IGF-1/mTOR placental responses. J Nutr. 2021;151(3):556–569. doi: 10.1093/jn/nxaa354
   PubMed Web of Science ®Google Scholar
• Jiang X, Yan J, West AA, et al. Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans. FASEB J. 2012;26(8):3563–74. doi: 10.1096/fj.12-207894
   PubMed Web of Science ®Google Scholar
• Liu J, Zhang Z, and Xu J, et al. Genome-wide DNA methylation changes in placenta tissues associated with small for gestational age newborns; cohort study in the Chinese population. Epigenomics. 2019;11(12):1399–412. doi: 10.2217/epi-2019-0004
   PubMed Web of Science ®Google Scholar
• Loke YJ, Galati JC, Morley R, et al. Association of maternal and nutrient supply line factors with DNA methylation at the imprinted IGF2/H19 locus in multiple tissues of newborn twins. Epigenetics. 2013;8(10):1069–1079. doi: 10.4161/epi.25908
   PubMed Web of Science ®Google Scholar
• Nakanishi M, Funahashi N, Fukuoka H, et al. Effects of maternal and fetal choline concentrations on the fetal growth and placental DNA methylation of 12 target genes related to fetal growth, adipogenesis, and energy metabolism. J Obstet Gynaecol Res. 2021;47(2):734–44. doi: 10.1111/jog.14599
   PubMed Web of Science ®Google Scholar
• Schmidt RJ, Schroeder DI, Crary-Dooley FK, et al. Self-reported pregnancy exposures and placental DNA methylation in the MARBLES prospective autism sibling study. Environ Epigenet. 2016;2(4):dvw024. doi: 10.1093/eep/dvw024
   PubMedGoogle Scholar
• Heil SG, Herzog EM, Griffioen PH, et al. Lower S-adenosylmethionine levels and DNA hypomethylation of placental growth factor (PlGF) in placental tissue of early-onset preeclampsia-complicated pregnancies. PloS One. 2019;14(12):e0226969. doi: 10.1371/journal.pone.0226969
   PubMed Web of Science ®Google Scholar
• Khot VV, Yadav DK, Shrestha S, et al. Hypermethylated CpG sites in the MTR gene promoter in preterm placenta. Epigenomics. 2017;9(7):985–996. doi: 10.2217/epi-2016-0173
   PubMed Web of Science ®Google Scholar
• Moeini N, Momeni AM, Zargar M, et al. The Effect of B9 and B12 Vitamins Deficiency on Hypomethylation of MMP-9 gene Promoter Among Women With Preterm Parturition. Biochem Genet. 2022;60(1):336–350. doi: 10.1007/s10528-021-10099-y
   PubMed Web of Science ®Google Scholar
• van Otterdijk SD, Klett H, Boerries, M, et al. The impact of pre-pregnancy folic acid intake on placental DNA methylation in a fortified cohort. FASEB J. 2023;37(1):e22698. doi: 10.1096/fj.202200476RR
   PubMed Web of Science ®Google Scholar
• Rahat B, Hamid A, Bagga R, et al. Folic acid levels during pregnancy regulate trophoblast invasive behavior and the possible development of preeclampsia. Front Nutr. 2022;9:847136. doi: 10.3389/fnut.2022.847136
   PubMed Web of Science ®Google Scholar
• Sletner L, Moen AEF, Yajnik CS, et al. Maternal glucose and LDL-Cholesterol levels are related to placental leptin gene methylation, and, together with nutritional factors, largely explain a higher methylation level among ethnic south asians. Front Endocrinol. 2021;12:809916. doi: 10.3389/fendo.2021.809916
   PubMed Web of Science ®Google Scholar
• Ge J, Wang J, Zhang F, et al. Correlation between MTHFR gene methylation and pre-eclampsia, and its clinical significance. Genet Mol Res. 2015;14:8021–8. doi: 10.4238/2015.July.17.10
   PubMed Web of Science ®Google Scholar
• Pinunuri R, Castano-Moreno E, Llanos MN, et al. Epigenetic regulation of folate receptor-α (FOLR1) in human placenta of preterm newborns. Placenta. 2020;94:202–25. doi: 10.1016/j.placenta.2020.03.009
   Web of Science ®Google Scholar
• Tserga A, Binder AM, Michels KB. Impact of folic acid intake during pregnancy on genomic imprinting of IGF2/H19 and 1-carbon metabolism. FASEB J. 2017;31(12):5149–58. doi: 10.1096/fj.201601214RR
   PubMed Web of Science ®Google Scholar
• Zhu Y, Mordaunt CE, Yasui DH, et al. Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study. Hum Mol Genet. 2019;28(16):2659–74. doi: 10.1093/hmg/ddz084
   PubMed Web of Science ®Google Scholar
• Kulkarni A, Chavan-Gautam P, Mehendale S, et al. Global DNA methylation patterns in placenta and its association with maternal hypertension in pre-eclampsia. DNA Cell Biol. 2011;30(2):79–84. doi: 10.1089/dna.2010.1084
   PubMed Web of Science ®Google Scholar
• Jiang X, Greenwald E, Jack-Roberts C. Effects of Choline on DNA Methylation and Macronutrient Metabolic Gene Expression in in Vitro Models of Hyperglycemia. Nutr Metab Insights. 2016;9:NMI.S29465. doi: 10.4137/NMI.S29465
   Google Scholar
• Rahat B, Mahajan A, Bagga R, et al. Epigenetic modifications at DMRs of placental genes are subjected to variations in normal gestation, pathological conditions and folate supplementation. Sci Rep. 2017;7(1):40774. doi: 10.1038/srep40774
   PubMedGoogle Scholar
• Pinunuri R, Castano-Moreno E, Llanos MN, et al. Epigenetic regulation of folate receptor-α (FOLR1) in human placenta of preterm newborns. Placenta. 2020;94:20–25. doi: 10.1016/j.placenta.2020.03.009
   PubMed Web of Science ®Google Scholar
• Nordin NM, Bergman D, Halje M, et al. Epigenetic regulation of the Igf2/H19 gene cluster. Cell Proliferation. 2014 Jun;47(3):189–199. doi: 10.1111/cpr.12106
   PubMed Web of Science ®Google Scholar
• Pauwels PS, Ghosh M, Duca RC, et al. Godderis L maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants. Clin Epigenetics. 2017 Feb 7;9(1):16. doi: 10.1186/s13148-017-0321-y
   PubMedGoogle Scholar
• Haggarty HP, Hoad G, Campbell DM, et al. Folate in pregnancy and imprinted gene and repeat element methylation in the offspring. Am J Clin Nutr. 2013 Jan;97(1):94–99. Epub Nov 14. PMID: 23151531. doi: 10.3945/ajcn.112.042572
   PubMed Web of Science ®Google Scholar
• Qadir MI, Ahmed Z. Lep expression and its role in obesity and type-2 diabetes. Crit Rev Eukaryot Gene Expr. 2017;27(1):47–51. doi: 10.1615/CritRevEukaryotGeneExpr.2017019386
   PubMed Web of Science ®Google Scholar
• Yabluchanskiy YA, Ma Y, Iyer RP, et al. Matrix metalloproteinase-9: many shades of function in cardiovascular disease. Physiology. 2013 Nov;28(6):391–403. doi: 10.1152/physiol.00029.2013
   PubMed Web of Science ®Google Scholar
• Tjwa TM, Luttun A, Autiero M. VEGF and PlGF: two pleiotropic growth factors with distinct roles in development and homeostasis. Cell Tissue Res. 2003 Oct;314(1):5–14. doi: 10.1007/s00441-003-0776-3
   PubMed Web of Science ®Google Scholar
• Maynard SE, Karumanchi SA. Angiogenic factors and preeclampsia. Semin Nephrol. 2011 Jan;31(1):33–46. doi: 10.1016/j.semnephrol.2010.10.004
   PubMed Web of Science ®Google Scholar
• Chavatte-Palmer C-P-P, Velazquez MA, Jammes H. Review: Epigenetics, developmental programming and nutrition in herbivores. Animal. 2018 Dec;12(s2):s363–s371. doi: 10.1017/S1751731118001337
   PubMedGoogle Scholar
• Rasmussen L, Knorr S, Antoniussen CS, et al. The impact of lifestyle, diet and physical activity on epigenetic changes in the offspring—A systematic review. Nutrients. 2021;13(8):2821. doi: 10.3390/nu13082821
   PubMed Web of Science ®Google Scholar
• Lapehn S, Paquette AG. The Placental Epigenome as a Molecular Link Between Prenatal Exposures and Fetal Health Outcomes Through the DOHaD Hypothesis. Curr Envir Health Rpt. 2022;9(3):490–501. doi: 10.1007/s40572-022-00354-8
   PubMedGoogle Scholar
• Herzog EM, Eggink AJ, Willemsen SP, et al. The tissue-specific aspect of genome-wide DNA methylation in newborn and placental tissues: implications for epigenetic epidemiologic studies. J Dev Orig Health Dis. 2021 Feb;12(1):113–123. doi: 10.1017/S2040174420000136
   PubMed Web of Science ®Google Scholar