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Short Communication

Further insights into the role of bHLH121 in the regulation of iron homeostasis in Arabidopsis thaliana

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Article: 1795582 | Received 06 Jun 2020, Accepted 30 Jun 2020, Published online: 21 Jul 2020

References

  • Hänsch R, Mendel RR. Physiological functions of mineral micronutrients (Cu, Zn, Mn, Fe, Ni, Mo, B, Cl). Curr Opin Plant Biol. 2009;12:1–5. doi:10.1016/j.pbi.2009.05.006.
  • Touraine B, Vignols F, Przybyla-Toscano J, Ischebeck T, Dhalleine T, Wu H-C, Magno C, Berger N, Couturier J, Dubos C, et al. Iron–sulfur protein NFU2 is required for branched-chain amino acid synthesis in Arabidopsis roots. J Exp Bot. 2019;70(6):1875–1889. doi:10.1093/jxb/erz050.
  • Berger N, Vignols F, Przybyla-Toscano J, Roland M, Rofidal V, Touraine B, Zienkiewicz K, Couturier J , Feussner I, Santoni V, et al. Identification of client iron-sulfur proteins of the chloroplastic NFU2 transfer protein in Arabidopsis thaliana. J Exp Bot. 2020;71(14):4171–4187.doi: 10.1093/jxb/eraa166.
  • Muckenthaler MU, Galy B, Hentze MW. Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu Rev Nutr. 2008;28:197–213. doi:10.1146/annurev.nutr.28.061807.155521.
  • Samira R, Li B, Kliebenstein D, Li C, Davis E, Gillikin JW, Long TA. The bHLH transcription factor ILR3 modulates multiple stress responses in Arabidopsis. Plant Mol Biol. 2018;97(4–5):297–309. doi:10.1007/s11103-018-0735-8.
  • Tsai -H-H, Schmidt W. One way. Or another? Iron uptake in plants. New Phytol. 2017;214:500–505. doi:10.1111/nph.14477.
  • Santi S, Schmidt W. Dissecting iron deficiency‐induced proton extrusion in Arabidopsis roots. New Phytol. 2009;183:1072–1084. doi:10.1111/j.1469-8137.2009.02908.x.
  • Brumbarova T, Bauer P, Ivanov R. Molecular mechanisms governing Arabidopsis iron uptake. Trends Plant Sci. 2015;20:124–133. doi:10.1016/j.tplants.2014.11.004.
  • Briat J-F, Duc C, Ravet K, Gaymard F. Ferritins and iron storage in plants. Biochimica Et Biophysica Acta (Bba)-gen Subj. 2010;1800:806–814. doi:10.1016/j.bbagen.2009.12.003.
  • Tissot N, Robe K, Gao F, Grant‐Grant S, Boucherez J, Bellegarde F, Maghiaoui A, Marcelin R, Izquierdo E, Benhamed M, et al. Transcriptional integration of the responses to iron availability in Arabidopsis by the bHLH factor ILR3. New Phytol. 2019;223(3):1433–1446. doi:10.1111/nph.15753.
  • Ravet K, Touraine B, Kim SA, Cellier F, Thomine S, Guerinot ML, Briat J-F, Gaymard F. Post-translational regulation of AtFER2 ferritin in response to intracellular iron trafficking during fruit development in Arabidopsis. Mol Plant. 2009;2:1095–1106. doi:10.1093/mp/ssp041.
  • Connorton JM, Balk J, Rodríguez-Celma J. Iron homeostasis in plants–a brief overview. Metallomics. 2017;9:813–823. doi:10.1039/C7MT00136C.
  • Gao F, Robe K, Gaymard F, Izquierdo E, Dubos C. The transcriptional control of iron homeostasis in plants: a tale of bHLH transcription factors? Front Plant Sci. 2019;10:6. doi:10.3389/fpls.2019.00006.
  • Zhang J, Liu B, Li M, Feng D, Jin H, Wang P, Liu J, Xiong F, Wang J, Wang H-B, et al. The bHLH transcription factor bHLH104 interacts with IAA-LEUCINE RESISTANT3 and modulates iron homeostasis in Arabidopsis. Plant Cell. 2015;27(3):787–805. doi:10.1105/tpc.114.132704.
  • Kim SA, LaCroix IS, Gerber SA, Guerinot ML. The iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI. Proc National Acad Sci. 2019;116:24933–24942. doi:10.1073/pnas.1916892116.
  • Gao F, Robe K, Bettembourg M, Navarro N, Rofidal V, Santoni V, Gaymard F, Vignols F, Roschzttardtz H, Izquierdo E, et al. The transcription factor bHLH121 interacts with bHLH105 (ILR3) and its closest homologs to regulate iron homeostasis in Arabidopsis. Plant Cell. 2020;32(2):508–524. doi:10.1105/tpc.19.00541.
  • Lei R, Li Y, Cai Y, Li C, Pu M, Lu C, Yang Y, Liang G. bHLH121 functions as a direct link that facilitates the activation of FIT by bHLH IVc transcription factors for maintaining Fe homeostasis in arabidopsis. Mol Plant. 2020;3:634–649. doi:10.1016/j.molp.2020.01.006.
  • Lockhart J. Personal trainer: BHLH121 functions upstream of a transcriptional network of heavy lifters involved in balancing iron levels. Plant Cell. 2020;32:293. doi:10.1105/tpc.19.00918.
  • Briat J-F, Ravet K, Arnaud N, Duc C, Boucherez J, Touraine B, Cellier F, Gaymard F. New insights into ferritin synthesis and function highlight a link between iron homeostasis and oxidative stress in plants. Ann Bot. 2010;105(5):811–822. doi:10.1093/aob/mcp128.
  • Reyt G, Boudouf S, Boucherez J, Gaymard F, Briat J-F. Iron-and ferritin-dependent reactive oxygen species distribution: impact on Arabidopsis root system architecture. Mol Plant. 2015;8:439–453. doi:10.1016/j.molp.2014.11.014.
  • Long TA, Tsukagoshi H, Busch W, Lahner B, Salt DE, Benfey PN. The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots. Plant Cell. 2010;22:2219–2236. doi:10.1105/tpc.110.074096.
  • Rampey RA, Woodward AW, Hobbs BN, Tierney MP, Lahner B, Salt DE, Bartel B. An Arabidopsis basic helix-loop-helix leucine zipper protein modulates metal homeostasis and auxin conjugate responsiveness. Genetics. 2006;174(4):1841–1857. doi:10.1534/genetics.106.061044.
  • Gratz R, Manishankar P, Ivanov R, Köster P, Mohr I, Trofimov K, Steinhorst L, Meiser J, Mai H-J, Drerup M, et al. CIPK11-dependent phosphorylation modulates FIT activity to promote Arabidopsis iron acquisition in response to calcium signaling. Dev Cell. 2019;48(5):726–40. e10. doi:10.1016/j.devcel.2019.01.006.
  • Gratz R, Brumbarova T, Ivanov R, Trofimov K, Tünnermann L, Ochoa‐Fernandez R, Blomeier T, Meiser J, Weidtkamp-Peters S,  Zurbriggen MD, et al. Phospho‐mutant activity assays provide evidence for alternative phospho‐regulation pathways of the transcription factor FER‐LIKE IRON DEFICIENCY‐INDUCED TRANSCRIPTION FACTOR. New Phytol. 2020;225:250–267. doi:10.1111/nph.16168.

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