1,016
Views
11
CrossRef citations to date
0
Altmetric
EDITORIAL

Schizophrenia: an example of complex genetic disease

Pages 194-197 | Published online: 12 Jul 2009

References

  • Caspi A, Moffitt TE, Cannon M, McClay J, Murray R, Harrington HL, Taylor A, Arseneault L, Williams B, Braithwaite A, Poulton R, Craig LW. Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene x environment interaction. Biol Psychiatry 2005; 57: 1117–1127
  • Delisi LE, Faraone SV. When is a ‘positive’ association truly a ‘positive’ in psychiatric genetics?. Am J Med Genet 2006; 141B: 319–322
  • Gershon ES, Cloninger RC. Genetic approaches to mental disorders. American Psychiatric Press, Washington, DC 1994
  • Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003; 160: 636–645
  • Harrison PJ, Law AJ. Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biol Psychiatry 2006; 60: 132–140
  • Ioannidis JP, Gwinn M, Little J, Higgins JP, Bernstein JL, Boffetta P, Bondy M, Bray MS, Brenchley PE, Buffler PA, Casas JP, Chokkalingam A, Danesh J, Smith GD, Dolan S, Duncan R, Gruis NA, Hartge P, Hashibe M, Hunter DJ, Jarvelin MR, Malmer B, Maraganore DM, Newton-Bishop JA, O'Brien TR, Petersen G, Riboli E, Salanti G, Seminara D, Smeeth L, et al. A road map for efficient and reliable human genome epidemiology. Nat Genet 2006; 38: 3–5
  • Jacquet H, Berthelot J, Bonnemains C, Simard G, Saugier-Veber P, Raux G, Campion D, Bonneau D, Frébourg T. 2003. The severe form of type I hyperprolinaemia results from homozygous inactivation of the PRODH gene. J Med Genet 40((1)): e7.
  • Jacquet H, Demily C, Houy E, Hecketsweiler B, Bou J, Raux G, Lerond J, Allio G, Haouzir S, Tillaux A, Bellegou C, Fouldrin G, Delamilleure P, Ménard JF, Dollfus S, D'Amato T, Petit M, Thibaut F, Frébourg T, Campion D. Hyperprolinemia is a risk factor for schizoaffective disorder. Mol Psychiatry 2005; 10: 479–485
  • Leonard S, Freedman R. Genetics of chromosome 15q13–q14 in schizophrenia. Biol Psychiatry 2006; 60: 115–122
  • Liu H, Heath SC, Sobin C, Roos JL, Galke BL, Blundell ML, Lenane M, Robertson B, Wijsman EM, Rapoport JL, Gogos JA, Karayiourgou M. Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. Proc Natl Acad Sci USA 2002; 99: 3717–3722
  • Louchart-de la Chapelle S, Nkam I, Houy E, Belmont A, Ménard J-F, Roussignol AC, Siwek O, Mezerai M, Guillermou M, Fouldrin G, Levillain D, Dollfus S, Campion D, Thibaut F. A concordance study of three electrophysiological measures in schizophrenia. Am J Psychiatry 2005; 162: 466–474
  • Mirnics K, Levitt P, Lewis DA. Critical appraisal of DNA microarrays in psychiatric genomics. Biol Psychiatry 2006; 60: 163–176
  • Paterlini M, Zakharenko SS, Lai WS, Qin J, Zhang H, Mukai J, Westphal KG, Olivier B, Sulzer D, Pavlidis P, Siegelbaum SA, Karayiorgou M, Gogos JA. Transcriptional and behavioural interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. Nat Neurosci 2005; 8(11)1586–1594
  • Perkins DO, Jeffries C, Sullivan P. Expanding the ‘central dogma’: the regulatory role of non protein coding genes and implications for the genetic liability to schizophrenia. Mol Psychiatry 2005; 10(1)69–78
  • Porteous DJ, Thomson P, Brandon NJ, Millar JK. The genetics and biology of Disc1. An emerging role in psychosis and cognition. Biol Psychiatry 2006; 60: 123–131
  • Raux G, Bonnet-Brilhault F, Louchart S, Houy E, Gantier R, Levillain D, Allio G, Haouzir S, Martinez M, Frébourg T, Thibaut F, Campion D. The-2 bp deletion in exon 6 of ‘alpha 7-like’ nicotinic receptor subunit gene is a risk factor for the P50 sensory gating deficit. Mol Psychiatry 2002; 7: 1006–1011
  • Tunbridge EM, Harrison PJ, Weinberger DR. catechol-O-methyltransferase, cognition, and psychosis: Val158Met and beyond. Biol Psychiatry 2006; 60: 141–151
  • Williams NM, O'Donovan MC, Owen MJ. Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?. Schizophr Bull 2005; 31(4)800–805
  • Wong AH, Gottesman II, Petronis A. Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 2005; 14: R11–18

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.