585
Views
31
CrossRef citations to date
0
Altmetric
Original Investigations

Plasma and serum brain-derived neurotrophic factor (BDNF) levels and their association with neurocognition in at-risk mental state, first episode psychosis and chronic schizophrenia patients

, , ORCID Icon, ORCID Icon, , ORCID Icon, , ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 545-554 | Received 20 Dec 2017, Accepted 28 Mar 2018, Published online: 25 Jun 2018

References

  • Agnew-Blais JC, Buka SL, Fitzmaurice GM, Smoller JW, Goldstein JM, Seidman LJ. 2015. Early childhood IQ trajectories in individuals later developing schizophrenia and affective psychoses in the new england family studies. Schizophr Bull. 41:817–823.
  • Ahmed AO, Mantini AM, Fridberg DJ, Buckley PF. 2015. Brain-derived neurotrophic factor (BDNF) and neurocognitive deficits in people with schizophrenia: a meta-analysis. Psychiatry Res. 226:1–13.
  • Asevedo E, Gadelha A, Noto C, Mansur RB, Zugman A, Belangero SI, Berberian AA, Scarpato BS, Leclerc E, Teixeira AL, et al. 2013. Impact of peripheral levels of chemokines, BDNF and oxidative markers on cognition in individuals with schizophrenia. J Psychiatr Res. 47:1376–1382.
  • Begliuomini S, Casarosa E, Pluchino N, Lenzi E, Centofanti M, Freschi L, Pieri M, Genazzani AD, Luisi S, Genazzani AR. 2007. Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor. Hum Reprod. 22:995–1002.
  • Bekinschtein P, Cammarota M, Katche C, Slipczuk L, Rossato JI, Goldin A, Izquierdo I, Medina JH. 2008. BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci USA. 105:2711–2716.
  • Bhang SY, Choi SW, Ahn JH. 2010. Changes in plasma brain-derived neurotrophic factor levels in smokers after smoking cessation. Neurosci Lett. 468:7–11.
  • Bora E, Lin A, Wood SJ, Yung AR, McGorry PD, Pantelis C. 2014. Cognitive deficits in youth with familial and clinical high risk to psychosis: a systematic review and meta-analysis. Acta Psychiatr Scand. 130:1–15.
  • Bora E, Murray RM. 2014. Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first-episode psychosis: do the cognitive deficits progress over, or after, the onset of psychosis?. Schizophr Bull. 40:744–755.
  • Bora E, Yalincetin B, Akdede BB, Alptekin K. 2017. Duration of untreated psychosis and neurocognition in first-episode psychosis: a meta-analysis. Schizophr Res. 193:3–10.
  • Bozikas VP, Andreou C. 2011. Longitudinal studies of cognition in first episode psychosis: a systematic review of the literature. Aust NZ J Psychiatry. 45:93–108.
  • Buckley PF, Pillai A, Evans D, Stirewalt E, Mahadik S. 2007. Brain derived neurotropic factor in first-episode psychosis. Schizophr Res. 91:1–5.
  • Buckley PF, Pillai A, Howell KR. 2011. Brain-derived neurotrophic factor: findings in schizophrenia. Curr Opin Psychiatry. 24:122–127.
  • Carlino D, De Vanna M, Tongiorgi E. 2013. Is altered BDNF biosynthesis a general feature in patients with cognitive dysfunctions? Neuroscientist. 19:345–353.
  • Carlino D, Leone E, Di Cola F, Baj G, Marin R, Dinelli G, Tongiorgi E, De Vanna M. 2011. Low serum truncated-BDNF isoform correlates with higher cognitive impairment in schizophrenia. J Psychiatr Res. 45:273–279.
  • Cattaneo A, Cattane N, Begni V, Pariante CM, Riva MA. 2016. The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders. Transl Psychiatry. 6:e958.
  • Conner JM, Lauterborn JC, Yan Q, Gall CM, Varon S. 1997. Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport. J Neurosci. 17:2295–2313.
  • D’Souza DC, Pittman B, Perry E, Simen A. 2009. Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans. Psychopharmacology (Berl). 202:569–578.
  • Delis DC, Kramer JH, Kaplan E, Ober BA. 1987. California verbal learning test (CVLT). San Antonio (TX): Psychological Corporation.
  • Dinoff A, Herrmann N, Swardfager W, Lanctot KL. 2017. The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor in healthy adults: a meta-analysis. Eur J Neurosci. 46:1635–1646.
  • Durany N, Michel T, Zochling R, Boissl KW, Cruz-Sanchez FF, Riederer P, Thome J. 2001. Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses. Schizophr Res. 52:79–86.
  • Elfving B, Plougmann PH, Muller HK, Mathe AA, Rosenberg R, Wegener G. 2010. Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression. Int J Neuropsychopharmacol. 13:563–572.
  • Fernandes BS, Steiner J, Berk M, Molendijk ML, Gonzalez-Pinto A, Turck CW, Nardin P, Goncalves CA. 2014. Peripheral brain-derived neurotrophic factor in schizophrenia and the role of antipsychotics: meta-analysis and implications. Mol Psychiatry. 20:1108–1119.
  • Fisher M, Mellon SH, Wolkowitz O, Vinogradov S. 2016. Neuroscience-informed auditory training in schizophrenia: a final report of the effects on cognition and serum brain-derived neurotrophic factor. Schizophr Res Cogn. 3:1–7.
  • Fusar-Poli P, Deste G, Smieskova R, Barlati S, Yung AR, Howes O, Stieglitz RD, Vita A, McGuire P, Borgwardt S. 2012. Cognitive functioning in prodromal psychosis: a meta-analysis. Arch Gen Psychiatry. 69:562–571.
  • Gardner DM, Murphy AL, O'Donnell H, Centorrino F, Baldessarini RJ. 2010. International consensus study of antipsychotic dosing. Am J Psychiatry. 167:686–693.
  • Gedika G, Schöttke H. 2001. Der Turm von Hanoi – TvH. Hogrefe Testsystem (HTS). Göttingen: Hogrefe.
  • Giese M, Unternaehrer E, Brand S, Calabrese P, Holsboer-Trachsler E, Eckert A. 2013. The interplay of stress and sleep impacts BDNF level. PLoS One. 8:e76050.
  • Goto N, Yoshimura R, Kakeda S, Moriya J, Hayashi K, Ikenouchi-Sugita A, Umene-Nakano W, Hori H, Ueda N, Korogi Y, et al. 2009. Associations between plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and negative symptoms or cognitive impairments in early-stage schizophrenia. Hum Psychopharmacol. 24:639–645.
  • Green MJ, Matheson SL, Shepherd A, Weickert CS, Carr VJ. 2011. Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis. Mol Psychiatry. 16:960–972.
  • Guzman-Marin R, Ying Z, Suntsova N, Methippara M, Bashir T, Szymusiak R, Gomez-Pinilla F, McGinty D. 2006. Suppression of hippocampal plasticity-related gene expression by sleep deprivation in rats. J Physiol. 575:807–819.
  • Hauser M, Zhang JP, Sheridan EM, Burdick KE, Mogil R, Kane JM, Auther A, Carrion RE, Cornblatt BA, Correll CU. 2017. Neuropsychological test performance to enhance identification of subjects at clinical high risk for psychosis and to be most promising for predictive algorithms for conversion to psychosis: a meta-analysis. J Clin Psychiatry. 78:e28–e40.
  • Hori H, Yoshimura R, Katsuki A, Atake K, Igata R, Konishi Y, Beppu H, Tominaga H. 2017. Blood biomarkers predict the cognitive effects of aripiprazole in patients with acute schizophrenia. Int J Mol Sci. 18:E568.
  • Hori H, Yoshimura R, Katsuki A, Atake K, Igata R, Konishi Y, Nakamura J. 2016. Relationships between serum brain-derived neurotrophic factor, plasma catecholamine metabolites, cytokines, cognitive function and clinical symptoms in Japanese patients with chronic schizophrenia treated with atypical antipsychotic monotherapy. World J Biol Psychiatry. 18:401–408.
  • Horn W. 1983. Leistungsprüfsystem (LPS). Vol. 2. Göttingen, Toronto, Zürich: Verlag für Psychologie.
  • Irani F, Kalkstein S, Moberg EA, Moberg PJ. 2011. Neuropsychological performance in older patients with schizophrenia: a meta-analysis of cross-sectional and longitudinal studies. Schizophr Bull. 37:1318–1326.
  • Karege F, Schwald M, Cisse M. 2002. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci Lett. 328:261–264.
  • Klein AB, Williamson R, Santini MA, Clemmensen C, Ettrup A, Rios M, Knudsen GM, Aznar S. 2011. Blood BDNF concentrations reflect brain-tissue BDNF levels across species. Int J Neuropsychopharmacol. 14:347–353.
  • Kuipers SD, Bramham CR. 2006. Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapy. Curr Opin Drug Discov Devel. 9:580–586.
  • Lehrl S. 1977. MWT-B Mehrfachwahl-Wortschatz-Test Form B. Mehrfachwahl Wortschatz Intelligenztest. MWT.B., Straube.
  • Leucht S, Samara M, Heres S, Patel MX, Woods SW, Davis JM. 2014. Dose equivalents for second-generation antipsychotics: the minimum effective dose method. Schizophr Bull. 40:314–326.
  • Lukoff D, Nuechterlein KH, Ventura J. 1986. Symptom monitoring in the rehabilitation of schizophrenic patients – Appendix A. Manual for the Expanded Brief Psychiatric Rating Scale. Schizophr Bull. 12:578–603.
  • Man L, Lv X, Du XD, Yin G, Zhu X, Zhang Y, Soares JC, Yang XN, Chen X, Zhang XY. 2018. Cognitive impairments and low BDNF serum levels in first-episode drug-naive patients with schizophrenia. Psychiatry Res. 263:1–6.
  • Martinotti G, Di Iorio G, Marini S, Ricci V, De Berardis D, Di Giannantonio M. 2012. Nerve growth factor and brain-derived neurotrophic factor concentrations in schizophrenia: a review. J Biol Regul Homeost Agents. 26:347–356.
  • Molendijk ML, Spinhoven P, Polak M, Bus BA, Penninx BW, Elzinga BM. 2014. Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N = 9484). Mol Psychiatry. 19:791–800.
  • Mollon J, Reichenberg A. 2017. Cognitive development prior to onset of psychosis. Psychol Med. 48:1–12.
  • Niitsu T, Ishima T, Yoshida T, Hashimoto T, Matsuzawa D, Shirayama Y, Nakazato M, Shimizu E, Hashimoto K, Iyo M. 2014. A positive correlation between serum levels of mature brain-derived neurotrophic factor and negative symptoms in schizophrenia. Psychiatry Res. 215:268–273.
  • Niitsu T, Shirayama Y, Matsuzawa D, Hasegawa T, Kanahara N, Hashimoto T, Shiraishi T, Shiina A, Fukami G, Fujisaki M, et al. 2011. Associations of serum brain-derived neurotrophic factor with cognitive impairments and negative symptoms in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 35:1836–1840.
  • Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ. 1998. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37:1553–1561.
  • Pillai A, Bruno D, Sarreal AS, Hernando RT, Saint-Louis LA, Nierenberg J, Ginsberg SD, Pomara N, Mehta PD, Zetterberg H, et al. 2012. Plasma BDNF levels vary in relation to body weight in females. PLoS One. 7:e39358.
  • Pillai A, Kale A, Joshi S, Naphade N, Raju MS, Nasrallah H, Mahadik SP. 2010. Decreased BDNF levels in CSF of drug-naive first-episode psychotic subjects: correlation with plasma BDNF and psychopathology. Int J Neuropsychopharmacol. 13:535–539.
  • Polyakova M, Stuke K, Schuemberg K, Mueller K, Schoenknecht P, Schroeter ML. 2015. BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis. J Affect Disord. 174:432–440.
  • Rapp C, Studerus E, Bugra H, Aston J, Tamagni C, Walter A, Pflueger M, Borgwardt S, Riecher-Rössler A. 2013. Duration of untreated psychosis and cognitive functioning. Schizophr Res. 145:43–49.
  • Riecher-Rössler A, Aston J, Ventura J, Merlo M, Borgwardt S, Gschwandtner U, Stieglitz RD. 2008. Basel Screening Instrument for Psychosis (BSIP): development, structure, reliability and validity. Fortschr Neurol Psychiatr. 76:207–216.
  • Riecher-Rössler A, Gschwandtner U, Aston J, Borgwardt S, Drewe M, Fuhr P, Pflüger M, Radü W, Schindler C, Stieglitz RD. 2007. The Basel early-detection-of-psychosis (FePsy)-study - design and preliminary results. Acta Psychiatr Scand. 115:114–125.
  • Riecher-Rössler A, Pflueger MO, Aston J, Borgwardt SJ, Brewer WJ, Gschwandtner U, Stieglitz RD. 2009. Efficacy of using cognitive status in predicting psychosis: a 7-year follow-up. Biol Psychiatry. 66:1023–1030.
  • Riecher-Rössler A, Studerus E. 2017. Prediction of conversion to psychosis in individuals with an at-risk mental state. A brief update on recent developments. Curr Opin Psychiatry. 30:209–219.
  • Rosvold HE, Mirsky AF, Sarason I, Bransome EDJ, Beck LH. 1956. A continuous performance test of brain damage. J Cons Psychol. 20:343–350.
  • Ruiz de Azua S, Matute C, Stertz L, Mosquera F, Palomino A, de la Rosa I, Barbeito S, Vega P, Kapczinski F, Gonzalez-Pinto A. 2013. Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis. BMC Psychiatry. 13:27.
  • Sartorius A, Hellweg R, Litzke J, Vogt M, Dormann C, Vollmayr B, Danker-Hopfe H, Gass P. 2009. Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats. Pharmacopsychiatry. 42:270–276.
  • Studerus E, Riecher-Rössler A, Papmeyer M. 2016. Neurocognition and motor functioning in the prediction of psychosis. In: Riecher-Rössler AMP, editor. Early detection and intervention in psychosis. Basel: Karger; p. 116–132.
  • Sun ZL, Liu J, Guo W, Jiang T, Ma C, Li WB, Tang YL, Ling SH. 2016. Serum brain-derived neurotrophic factor levels associate with cognitive improvement in patients with schizophrenia treated with electroacupuncture. Psychiatry Res. 244:370–375.
  • Szoke A, Trandafir A, Dupont ME, Meary A, Schurhoff F, Leboyer M. 2008. Longitudinal studies of cognition in schizophrenia: meta-analysis. Br J Psychiatry. 192:248–257.
  • Theleritis C, Fisher HL, Shafer I, Winters L, Stahl D, Morgan C, Dazzan P, Breedvelt J, Sambath I, Vitoratou S, et al. 2014. Brain derived neurotropic factor (BDNF) is associated with childhood abuse but not cognitive domains in first episode psychosis. Schizophr Res. 159:56–61.
  • Toll A, Mane A. 2015. Brain-derived neurotrophic factor levels in first episode of psychosis: a systematic review. World J Psychiatry. 5:154–159.
  • Tsuchimine S, Sugawara N, Ishioka M, Yasui-Furukori N. 2014. Preanalysis storage conditions influence the measurement of brain-derived neurotrophic factor levels in peripheral blood. Neuropsychobiology. 69:83–88.
  • Ventura J, Lukoff D, Nuechterlein KH, Liberman RP, Green MJ, Shaner A. 1993. Training and quality assurance with the brief psychiatric rating scale: “The Drift Busters” – Appendix 1. The Brief Psychiatric Rating Scale (expanded version). Int J Meth Psychiatric Res. 3:221–224.
  • Vinogradov S, Fisher M, Holland C, Shelly W, Wolkowitz O, Mellon SH. 2009. Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia?. Biol Psychiatry. 66:549–553.
  • Weickert CS, Hyde TM, Lipska BK, Herman MM, Weinberger DR, Kleinman JE. 2003. Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia. Mol Psychiatry. 8:592–610.
  • World Health Organization (WHO). 1994. Internationale Klassifikation psychischer Störungen: ICD-10, Kapitel V (F); Forschungskriterien. Huber.
  • Xiao W, Ye F, Liu C, Tang X, Li J, Dong H, Sha W, Zhang X. 2017. Cognitive impairment in first-episode drug-naive patients with schizophrenia: relationships with serum concentrations of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. Prog Neuropsychopharmacol Biol Psychiatry. 76:163–168.
  • Yamada K, Nabeshima T. 2003. Brain-derived neurotrophic factor/TrkB signaling in memory processes. J Pharmacol Sci. 91:267–270.
  • Yung AR, Phillips LJ, McGorry PD, McFarlane CA, Francey S, Harrigan S, Patton GC, Jackson HJ. 1998. Prediction of psychosis. A step towards indicated prevention of schizophrenia. Br J Psychiatry Suppl. 172:14–20.
  • Zhang XY, Chen DC, Xiu MH, Haile CN, Luo X, Xu K, Zhang HP, Zuo L, Zhang Z, Zhang X, et al. 2012. Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls. Hum Genet. 131:1187–1195.
  • Zhang XY, Liang J, Chen DC, Xiu MH, Yang FD, Kosten TA, Kosten TR. 2012. Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia. Psychopharmacology (Berl). 222:277–284.
  • Zhang XY, Xiu MH, Chen DC, Yang FD, Wu GY, Lu L, Kosten TA, Kosten TR. 2010. Nicotine dependence and serum BDNF levels in male patients with schizophrenia. Psychopharmacology (Berl). 212:301–307.
  • Zhang Y, Fang X, Fan W, Tang W, Cai J, Song L, Zhang C. 2018. Brain-derived neurotrophic factor as a biomarker for cognitive recovery in acute schizophrenia: 12-week results from a prospective longitudinal study. Psychopharmacology (Berl). 235:1191–1198.
  • Zimmermann P, Fimm B. 2002. A test battery for attentional performance. In: Leclercq M, Zimmermann P, editors. Applied neuropsychology of attention: theory, diagnosis and rehabilitation. Psychology Press; p. 110–151.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.