701
Views
12
CrossRef citations to date
0
Altmetric
Original Investigations

The relationship between physical activity, clinical and cognitive characteristics and BDNF mRNA levels in patients with severe mental disorders

, , , , , , , , , & show all
Pages 567-576 | Received 28 Sep 2018, Accepted 04 Dec 2018, Published online: 15 Jan 2019

References

  • Aas M, Dazzan P, Mondelli V, Melle I, Murray RM, Pariante CM. 2014. A systematic review of cognitive function in first-episode psychosis, including a discussion on childhood trauma, stress, and inflammation. Front Psych. 4:182.
  • Aas M, Dieset I, Morch R, Steen NE, Hope S, Reponen EJ, Laskemoen JF, Ueland T, Aukrust P, Melle I, et al. 2018. Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders. Schizophr Res. doi: 10.1016/j.schres.2018.08.007
  • Aas M, Haukvik UK, Djurovic S, Tesli M, Athanasiu L, Bjella T, Hansson L, Cattaneo A, Agartz I, Andreassen OA, Melle I. 2014. Interplay between childhood trauma and BDNF val66met variants on blood BDNF mRNA levels and on hippocampus subfields volumes in schizophrenia spectrum and bipolar disorders. J Psychiatr Res.59:14–21.
  • Aas M, Henry C, Andreassen OA, Bellivier F, Melle I, Etain B. 2016. The role of childhood trauma in bipolar disorders. Int J Bipolar Disord. 4:2.
  • Allen DN, Huegel SG, Gurklis JA Jr, Kelley ME, Barry EJ, van Kammen DP. 1997. Utility of WAIS-R short forms in schizophrenia. Schizophr Res. 26:163–172.
  • Archer T, Josefsson T, Lindwall M. 2014. Effects of physical exercise on depressive symptoms and biomarkers in depression. CNS Neurol Disord Drug Targets. 13:1640–1653.
  • Bitter I, Czobor P, Borsi A, Feher L, Nagy BZ, Bacskai M, Rakonczai P, Hegyi R, Nemeth T, Varga P, et al. 2017. Mortality and the relationship of somatic comorbidities to mortality in schizophrenia. A nationwide matched-cohort study. Eur Psych. 45:97–103.
  • Bourne C, Aydemir O, Balanza-Martinez V, Bora E, Brissos S, Cavanagh JT, Clark L, Cubukcuoglu Z, Dias VV, Dittmann S, et al. 2013. Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis. Acta Psychiatr Scand. 128:149–162.
  • Bozikas VP, Andreou C. 2011. Longitudinal studies of cognition in first episode psychosis: a systematic review of the literature. Aust N Z J Psychiatry. 45:93–108.
  • Buckley PF, Pillai A, Howell KR. 2011. Brain-derived neurotrophic factor: findings in schizophrenia. Curr Opin Psych. 24:122–127.
  • Church CAOA, Lorentzen S, Melle I, Aas M. 2017. Childhood trauma and minimization/denial in people with and without a severe mental disorder. Front Psychol. 8,1276.
  • Cohen J. 1977. Statistical power analysis for the behavioral sciences. New York: Academic Press.
  • Collins A, Hill LE, Chandramohan Y, Whitcomb D, Droste SK, Reul JM. 2009. Exercise improves cognitive responses to psychological stress through enhancement of epigenetic mechanisms and gene expression in the dentate gyrus. PLoS One. 4:e4330.
  • Correll CU, Solmi M, Veronese N, Bortolato B, Rosson S, Santonastaso P, Thapa-Chhetri N, Fornaro M, Gallicchio D, Collantoni E, et al. 2017. Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls. World Psychiatry. 16:163–180.
  • Cyr JJ, Brooker BH. 1984. Use of appropriate formulas for selecting WAIS-R short forms. (ed. B. H. Brooker). J Consult Clin Psychol. 52:903–905.
  • Deuster PA, Silverman MN. 2013. Physical fitness: a pathway to health and resilience. US Army Med Dep J. (Oct-Dec): 24–35.
  • Djurovic S, Gustafsson O, Mattingsdal M, Athanasiu L, Bjella T, Tesli M, Agartz I, Lorentzen S, Melle I, Morken G, Andreassen OA. 2010. A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample. J Affect Disord. 126:312–316.
  • Durany N, Michel T, Zochling R, Boissl KW, Cruz-Sanchez FF, Riederer P, Thome J. 2001. Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses. Schizophr Res. 52:79–86.
  • Evans VC, Iverson GL, Yatham LN, Lam RW. 2014. The relationship between neurocognitive and psychosocial functioning in major depressive disorder. J Clin Psych. 75:1359–1370.
  • Fernandes BS, Steiner J, Berk M, Molendijk ML, Gonzalez-Pinto A, Turck CW, Nardin P, Goncalves CA. 2015. Peripheral brain-derived neurotrophic factor in schizophrenia and the role of antipsychotics: meta-analysis and implications. Mol Psychiatry. 20:1108–1119.
  • Firth J, Cotter J, Elliott R, French P, Yung AR. 2015. A systematic review and meta-analysis of exercise interventions in schizophrenia patients. Psychol Med. 1:19.
  • Firth J, Firth JA, Stubbs B, Vancampfort D, Schuch FB, Hallgren M, Veronese N, Yung AR, Sarris J. 2018. Association between muscular strength and cognition in people with major depression or bipolar disorder and healthy controls. JAMA Psychiatry. 75:740–746.
  • Firth J, Stubbs B, Rosenbaum S, Vancampfort D, Malchow B, Schuch F, Elliott R, Nuechterlein KH, Yung AR. 2017. Aerobic exercise improves cognitive functioning in people with schizophrenia: a systematic review and meta-analysis. Schizophr Bull. 43:546–556.
  • Firth J, Stubbs B, Vancampfort D, Schuch FB, Rosenbaum S, Ward PB, Firth JA, Sarris J, Yung AR. 2018. The Validity and value of self-reported physical activity and accelerometry in people with schizophrenia: a population-scale study of the UK Biobank. Schizophr Bull. 44(6):1293–1300.
  • Flashman LA, Green MF. 2004. Review of cognition and brain structure in schizophrenia: profiles, longitudinal course, and effects of treatment. Psychiatr Clin North Am. 27:1–18.
  • Goldstein G. 1990. Neuropsychological heterogeneity in schizophrenia: a consideration of abstraction and problem-solving abilities. Arch Clin Neuropsychol. 5:251–264.
  • Green MF, Kern RS, Heaton RK. 2004. Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophr Res. 72:41–51.
  • Heinrichs RW, Awad AG. 1993. Neurocognitive subtypes of chronic schizophrenia. Schizophr Res. 9:49–58.
  • Ikeda Y, Yahata N, Ito I, Nagano M, Toyota T, Yoshikawa T, Okubo Y, Suzuki H. 2008. Low serum levels of brain-derived neurotrophic factor and epidermal growth factor in patients with chronic schizophrenia. Schizophr Res. 101:58–66.
  • Kerling A, Kuck M, Tegtbur U, Grams L, Weber-Spickschen S, Hanke A, Stubbs B, Kahl KG. 2017. Exercise increases serum brain-derived neurotrophic factor in patients with major depressive disorder. J Affect Disord. 215:152–155.
  • Kim YM, Ji ES, Kim SH, Kim TW, Ko IG, Jin JJ, Kim CJ, Kim TW, Kim DH. 2015. Treadmill exercise improves short-term memory by enhancing hippocampal cell proliferation in quinolinic acid-induced Huntington's disease rats. J Exerc Rehabil. 11:5–11.
  • Klein AB, Williamson R, Santini MA, Clemmensen C, Ettrup A, Rios M, Knudsen GM, Aznar S. 2011. Blood BDNF concentrations reflect brain-tissue BDNF levels across species. Int J Neuropsychopharmacol. 14:347–353.
  • Kurtze N, Rangul V, Hustvedt BE, Flanders WD. 2008. Reliability and validity of self-reported physical activity in the Nord-Trøndelag Health Study: HUNT 1. Scand J Public Health. 36:52–61.
  • Lewandowski KE, Cohen BM, Ongur D. 2011. Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder. Psychol Med. 41:225–241.
  • Lystad JU, Falkum E, Mohn C, Haaland VO, Bull H, Evensen S, Rund BR, Ueland T. 2014. The MATRICS Consensus Cognitive Battery (MCCB): performance and functional correlates. Psychiatry Res. 220:1094–1101.
  • Mangalore R, Knapp M. 2007. Cost of schizophrenia in England. J Ment Health Policy Econ. 10:23–41.
  • McClintock SM, Husain MM, Greer TL, Cullum CM. 2010. Association between depression severity and neurocognitive function in major depressive disorder: a review and synthesis. Neuropsychology. 24:9–34.
  • McDermott LM, Ebmeier KP. 2009. A meta-analysis of depression severity and cognitive function. J Affect Disord. 119:1–8.
  • Mondelli V, Cattaneo A, Belvederi MM, Di FM, Handley R, Hepgul N, Miorelli A, Navari S, Papadopoulos AS, Aitchison KJ, et al. 2011. Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume. J Clin Psychiatry. 72:1677–1684.
  • Nordentoft M, Mortensen PB, Pedersen CB. 2011. Absolute risk of suicide after first hospital contact in mental disorder. Arch Gen Psychiatry. 68:1058–1064.
  • Osby U, Westman J, Hallgren J, Gissler M. 2016. Mortality trends in cardiovascular causes in schizophrenia, bipolar and unipolar mood disorder in Sweden 1987-2010. Eur J Public Health. 26:867–871.
  • Park JK, Lee SJ, Kim TW. 2014. Treadmill exercise enhances NMDA receptor expression in schizophrenia mice. J Exerc Rehabil. 10:15–21.
  • Pedersen G, Hagtvet KA, Karterud S. 2007. Generalizability studies of the Global Assessment of Functioning-Split version. Compr Psych. 48:88–94.
  • Piepmeier AT, Etnier JL. 2015. Brain-derived neurotrophic factor (BDNF) as a potential mechanism of the effects of acute exercise on cognitive performance. J Sport Health Sci. 4:9.
  • Pruessner M, Cullen AE, Aas M, Walker EF. 2017. The neural diathesis-stress model of schizophrenia revisited: an update on recent findings considering illness stage and neurobiological and methodological complexities. Neurosci Biobehav Rev. 73:191–218.
  • Reichenberg A, Harvey PD, Bowie CR, Mojtabai R, Rabinowitz J, Heaton RK, Bromet E. 2009. Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders. Schizophr Bull. 35:1022–1029.
  • Ringen PA, Lagerberg TV, Birkenaes AB, Engn J, Faerden A, Jonsdottir H, Nesvag R, Friis S, Opjordsmoen S, Larsen F, et al. 2008. Differences in prevalence and patterns of substance use in schizophrenia and bipolar disorder. Psychol Med. 38:1241–1249.
  • Romm KL, Rossberg JI, Berg AO, Barrett EA, Faerden A, Agartz I, Andreassen OA, Melle I. 2010. Depression and depressive symptoms in first episode psychosis. J Nerv Ment Dis. 198:67–71.
  • Rosenthal R, Rosnow RL. 1984. Essentials of behavioural research: methods and data analysis. New York, NY: McGraw-Hill.
  • Rund BR, Melle I, Friis S, Johannessen JO, Larsen TK, Midboe LJ, Opjordsmoen S, Simonsen E, Vaglum P, McGlashan T. 2007. The course of neurocognitive functioning in first-episode psychosis and its relation to premorbid adjustment, duration of untreated psychosis, and relapse. Schizophr Res. 91:132–140.
  • Schuch FB, Vancampfort D, Richards J, Rosenbaum S, Ward PB, Stubbs B. 2016. Exercise as a treatment for depression: a meta-analysis adjusting for publication bias. J Psychiatr Res. 77:42–51.
  • Shimizu Y, Kitagawa N, Mitsui N, Fujii Y, Toyomaki A, Hashimoto N, Kako Y, Tanaka T, Asakura S, Kusumi I. 2013. Neurocognitive impairments and quality of life in unemployed patients with remitted major depressive disorder. Psychiatry Res. 210:913–918.
  • Silverstein ML, Zerwic MJ. 1985. Clinical psychopathologic symptoms in neuropsychologically impaired and intact schizophrenics. J Consult Clin Psychol. 53:267–268.
  • Sim K, Mahendran R, Siris SG, Heckers S, Chong SA. 2004. Subjective quality of life in first episode schizophrenia spectrum disorders with comorbid depression. Psychiatry Res. 129:141–147.
  • Simonsen C, Sundet K, Vaskinn A, Birkenaes AB, Engh JA, Faerden A, Jonsdottir H, Ringen PA, Opjordsmoen S, Melle I, et al. 2011. Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group. Schizophr Bull. 37:73–83.
  • Spitzer RL, Williams JB, Gibbon M, First MB. 1992. The structured clinical interview for DSM-III-R (SCID). I: history, rationale, and description. Arch Gen Psychiatry. 49:624–629.
  • Sonmez N, Romm KL, Andreasssen OA, Melle I, Rossberg JI. 2013. Depressive symptoms in first episode psychosis: a one-year follow-up study. BMC Psychiatry. 13:106.
  • Stubbs B, Firth J, Berry A, Schuch FB, Rosenbaum S, Gaughran F, Veronesse N, Williams J, Craig T, Yung AR, Vancampfort D. 2016. How much physical activity do people with schizophrenia engage in? A systematic review, comparative meta-analysis and meta-regression. Schizophr Res. 176:431–440.
  • Tandberg M, Sundet K, Andreassen OA, Melle I, Ueland T. 2013. Occupational functioning, symptoms and neurocognition in patients with psychotic disorders: investigating subgroups based on social security status. Soc Psychiatry Psychiatr Epidemiol. 48:863–874.
  • Van Os J, Kapur S. 2010. Psychosis: from diagnosis to syndrome. Ned Tijdschr Geneeskd. 154:A1874.
  • Vancampfort D, Correll CU, Galling B, Probst M, De Hert M, Ward PB, Rosenbaum S, Gaughran F, Lally J, Stubbs B. 2016. Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta-analysis. World Psychiatry. 15:166–174.
  • Vancampfort D, Firth J, Schuch FB, Rosenbaum S, Mugisha J, Hallgren M, Probst M, Ward PB, Gaughran F, De Hert M, et al. 2017. Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis. World Psychiatry. 16:308–315.
  • Vancampfort D, Rosenbaum S, Schuch F, Ward PB, Richards J, Mugisha J, Probst M, Stubbs B. 2017. Cardiorespiratory fitness in severe mental illness: a systematic review and meta-analysis. Sports Med. 47:343–352.
  • Varese F, Smeets F, Drukker M, Lieverse R, Lataster T, Viechtbauer W, Read J, van OJ, Bentall RP. 2012. Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies. Schizophr Bull. 38:661–671.
  • Vaskinn A, Hartberg CB, Sundet K, Westlye LT, Andreassen OA, Melle I, Agartz I. 2015. Brain structure characteristics in intellectually superior schizophrenia. Psychiatry Res. 232:123–129.
  • Vaskinn A, Sundet K. 2001. Estimering av premorbid IQ: en norsk versjon av National Adult Reading Test. Tidsskrift for Norsk Psykologforening 38:1133–1140.
  • Vaskinn A, Ueland T, Melle I, Agartz I, Andreassen OA, Sundet K. 2014. Neurocognitive decrements are present in intellectually superior schizophrenia. Front Psych. 5:45.
  • Wechsler D. 2003. Wechsler Adult Intelligence Scale: WAIS-III. Stockholm, Sweden: Pearson Assessment.
  • Wechsler D. 2007. Wechsler Appreviated Scale of Intelligence (WASI). Norwegian manual supplement. Stockholm: Pearson Assessment.
  • Zhou C, Zhong J, Zou B, Fang L, Chen J, Deng X, Zhang L, Zhao X, Qu Z, Lei Y, Lei T. 2017. Meta-analyses of comparative efficacy of antidepressant medications on peripheral BDNF concentration in patients with depression. PLoS One. 12:e0172270.
  • Zoladz JA, Pilc A. 2010. The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies. J Physiol Pharmacol. 61:533–541.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.