Childhood emotional neglect and oxytocin receptor variants: Association with limbic brain volumes

References

• Adhikari A, Topiwala MA, Gordon JA. 2010. Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety. Neuron. 65:257–269.
   PubMed Web of Science ®Google Scholar
• Baker SL, Heinrichs N, Kim H-J, Hofmann SG. 2002. The Liebowitz social anxiety scale as a self-report instrument: a preliminary psychometric analysis. Behav Res Ther. 40:701–715.
   PubMed Web of Science ®Google Scholar
• Bandelow B, Charimo Torrente A, Wedekind D, Broocks A, Hajak G, Rüther E. 2004. Early traumatic life events, parental rearing styles, family history of mental disorders, and birth risk factors in patients with social anxiety disorder. Eur Arch Psychiatry Clin Neurosci. 254:397–405.
   PubMed Web of Science ®Google Scholar
• Bernstein DP, Fink L. 1998. Manual for the childhood trauma questionnaire: a retrospective self-report. The Psychological Corporation. New York (NY): Harcourt Brace.
   Google Scholar
• Bickart KC, Wright CI, Dautoff RJ, Dickerson BC, Barrett LF. 2011. Amygdala volume and social network size in humans. Nat Neurosci. 14:163–164.
   PubMed Web of Science ®Google Scholar
• Brüne M. 2012. Does the oxytocin receptor polymorphism (rs2254298) confer “vulnerability” for psychopathology or “differential susceptibility”? insights from evolution. BMC Med. [Internet] 10. Available from: http://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-10-38.
   PubMed Web of Science ®Google Scholar
• Carpenter LL, Tyrka AR, Ross NS, Khoury L, Anderson GM, Price LH. 2009. Effect of childhood emotional abuse and age on cortisol responsivity in adulthood. Biol Psychiatry. 66:69–75.
   PubMed Web of Science ®Google Scholar
• Carr CP, Martins CMS, Stingel AM, Lemgruber VB, Juruena MF. 2013. The role of early life stress in adult psychiatric disorders: a systematic review according to childhood trauma subtypes. J. Nerv. Ment. Dis. 201:1007–1020.
   PubMed Web of Science ®Google Scholar
• de Carvalho HW, Pereira R, Frozi J, Bisol LW, Ottoni GL, Lara DR. 2015. Childhood trauma is associated with maladaptive personality traits. Child Abuse Negl. 44:18–25.
   PubMed Web of Science ®Google Scholar
• Chen FS, Barth ME, Johnson SL, Gotlib IH, Johnson SC. 2011. Oxytocin receptor (OXTR) polymorphisms and attachment in human infants. Front Psychol. [Internet] 2. Available from: http://journal.frontiersin.org/article/10.3389/fpsyg.2011.00200/abstract
   Web of Science ®Google Scholar
• Chen FS, Johnson SC. 2012. An oxytocin receptor gene variant predicts attachment anxiety in females and autism-spectrum traits in males. Soc Psychol Personal Sci. 3:93–99.
   Web of Science ®Google Scholar
• Dale AM, Fischl B, Sereno MI. 1999. Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage. 9:179–194.
   PubMed Web of Science ®Google Scholar
• Dale AM, Sereno MI. 1993. Improved localizadon of cortical activity by combining EEG and MEG with MRI cortical surface reconstruction: a linear approach. J Cogn Neurosci. 5:162–176.
   PubMed Web of Science ®Google Scholar
• Dannlowski U, Kugel H, Grotegerd D, Redlich R, Opel N, Dohm K, Zaremba D, Grögler A, Schwieren J, Suslow T, et al. 2016. Disadvantage of social sensitivity: interaction of oxytocin receptor genotype and child maltreatment on brain structure. Biol Psychiatry. 80:398–405.
   PubMed Web of Science ®Google Scholar
• De Bellis MD. 2005. The psychobiology of neglect. Child Maltreat. 10:150–172.
   PubMed Web of Science ®Google Scholar
• Domschke K, Tidow N, Kuithan H, Schwarte K, Klauke B, Ambrée O, Reif A, Schmidt H, Arolt V, Kersting A, et al. 2012. Monoamine oxidase A gene DNA hypomethylation – a risk factor for panic disorder?. Int J Neuropsychopharmacol. 15:1217–1228.
   PubMed Web of Science ®Google Scholar
• Domschke K, Tidow N, Schrempf M, Schwarte K, Klauke B, Reif A, Kersting A, Arolt V, Zwanzger P, Deckert J, et al. 2013. Epigenetic signature of panic disorder: a role of glutamate decarboxylase 1 (GAD1) DNA hypomethylation? Prog Neuropsychopharmacol Biol Psychiatry. 46:189–196.
   PubMed Web of Science ®Google Scholar
• Domschke K, Tidow N, Schwarte K, Deckert J, Lesch K-P, Arolt V, Zwanzger P, Baune BT. 2014. Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response. Int J Neuropsychopharmacol. 17:1167–1176.
   PubMed Web of Science ®Google Scholar
• Domschke K, Tidow N, Schwarte K, Ziegler C, Lesch K-P, Deckert J, Arolt V, Zwanzger P, Baune BT. 2015. Pharmacoepigenetics of depression: no major influence of MAO-A DNA methylation on treatment response. J Neural Transm. 122:99–108.
   PubMed Web of Science ®Google Scholar
• Dumais KM, Veenema AH. 2016. Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior. Front Neuroendocrinol. 40:1–23.
   PubMed Web of Science ®Google Scholar
• Feldman R, Monakhov M, Pratt M, Ebstein RP. 2016. Oxytocin pathway genes: evolutionary ancient system impacting on human affiliation, sociality, and psychopathology. Biol Psychiatry. 79:174–184.
   PubMed Web of Science ®Google Scholar
• Felix-Ortiz AC, Beyeler A, Seo C, Leppla CA, Wildes CP, Tye KM. 2013. BLA to vHPC inputs modulate anxiety-related behaviors. Neuron. 79:658–664.
   PubMed Web of Science ®Google Scholar
• Fischl B, Dale AM. 2000. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci USA. 97:11050–11055.
   PubMed Web of Science ®Google Scholar
• Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van der Kouwe A, Killiany R, Kennedy D, Klaveness S, et al. 2002. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron. 33:341–355.
   PubMed Web of Science ®Google Scholar
• Fischl B, Salat DH, van der Kouwe AJW, Makris N, Ségonne F, Quinn BT, Dale AM. 2004. Sequence-independent segmentation of magnetic resonance images. NeuroImage. 23: S69–S84.
   PubMed Web of Science ®Google Scholar
• Furman DJ, Chen MC, Gotlib IH. 2011. Variant in oxytocin receptor gene is associated with amygdala volume. Psychoneuroendocrinology. 36:891–897.
   PubMed Web of Science ®Google Scholar
• Gamble AL, Rapee RM. 2010. The time-course of attention to emotional faces in social phobia. J Behav Ther Exp Psychiatry. 41:39–44.
   PubMed Web of Science ®Google Scholar
• Gauthier L, Stollak G, Messé L, Aronoff J. 1996. Recall of childhood neglect and physical abuse as differential predictors of current psychological functioning. Child Abuse Negl. 20:549–559.
   PubMed Web of Science ®Google Scholar
• Gorka SM, Fitzgerald DA, Labuschagne I, Hosanagar A, Wood AG, Nathan PJ, Phan KL. 2015. Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder. Neuropsychopharmacology. 40:278–286.
   PubMed Web of Science ®Google Scholar
• Gouin JP, Zhou QQ, Booij L, Boivin M, Côté SM, Hébert M, et al. 2017. Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness. Sci Rep. [Internet] 7. Available from: http://www.nature.com/articles/s41598-017-07950-x
   Web of Science ®Google Scholar
• Harony-Nicolas H, Mamrut S, Brodsky L, Shahar-Gold H, Barki-Harrington L, Wagner S. 2014. Brain region-specific methylation in the promoter of the murine oxytocin receptor gene is involved in its expression regulation. Psychoneuroendocrinology. 39:121–131.
   PubMed Web of Science ®Google Scholar
• Hovens JGFM, Giltay EJ, Spinhoven P, van Hemert AM, Penninx BWJH. 2015. Impact of childhood life events and childhood trauma on the onset and recurrence of depressive and anxiety disorders. J Clin Psychiatry. 76:931–938.
   PubMed Web of Science ®Google Scholar
• Hunt X, Tomlinson M. 2018. Child developmental trajectories in adversity. In: Understanding uniqueness and diversity in child and adolescent mental health. Elsevier. p. 137–166. Available from: https://linkinghub.elsevier.com/retrieve/pii/B978012815310900006X
   Google Scholar
• Inoue H, Yamasue H, Tochigi M, Abe O, Liu X, Kawamura Y, Takei K, Suga M, Yamada H, Rogers MA, et al. 2010. Association between the oxytocin receptor gene and amygdalar volume in healthy adults. Biol Psychiatry. 68:1066–1072.
   PubMed Web of Science ®Google Scholar
• Jack A, Connelly JJ, Morris JP. 2012. DNA methylation of the oxytocin receptor gene predicts neural response to ambiguous social stimuli. Front Hum Neurosci. [Internet] 6. Available from: http://journal.frontiersin.org/article/10.3389/fnhum.2012.00280/abstract
   PubMed Web of Science ®Google Scholar
• Jaffee SR, Price TS. 2008. Genotype-environment correlations: implications for determining the relationship between environmental exposures and psychiatric illness. Psychiatry. 7:496–499.
   PubMedGoogle Scholar
• Jiang Y, Langley B, Lubin FD, Renthal W, Wood MA, Yasui DH, Kumar A, Nestler EJ, Akbarian S, Beckel-Mitchener AC, et al. 2008. Epigenetics in the nervous system. J Neurosci. 28:11753–11759.
   PubMed Web of Science ®Google Scholar
• Kim HS, Sherman DK, Sasaki JY, Xu J, Chu TQ, Ryu C, Suh EM, Graham K, Taylor SE. 2010. Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proc Natl Acad Sci USA. 107:15717–15721.
   PubMed Web of Science ®Google Scholar
• Klengel T, Pape J, Binder EB, Mehta D. 2014. The role of DNA methylation in stress-related psychiatric disorders. Neuropharmacology. 80:115–132.
   PubMed Web of Science ®Google Scholar
• Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E. 2005. Oxytocin increases trust in humans. Nature. 435:673–676.
   PubMed Web of Science ®Google Scholar
• Krueger F, Parasuraman R, Iyengar V, Thornburg M, Weel J, Lin M, et al. 2012. Oxytocin receptor genetic variation promotes human trust behavior. Front Hum Neurosci. [Internet] 6. Available from: http://journal.frontiersin.org/article/10.3389/fnhum.2012.00004/abstract
   Web of Science ®Google Scholar
• Kryski KR, Smith HJ, Sheikh HI, Singh SM, Hayden EP. 2014. Evidence for evocative gene–environment correlation between child oxytocin receptor (OXTR) genotype and caregiver behavior. Personal Individ Differ. 64:107–110.
   Web of Science ®Google Scholar
• Kumsta R, Hummel E, Chen FS, Heinrichs M. 2013. Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience. Front Neurosci. [Internet] 7. Available from: http://journal.frontiersin.org/article/10.3389/fnins.2013.00083/abstract
   PubMed Web of Science ®Google Scholar
• Kuo JR, Goldin PR, Werner K, Heimberg RG, Gross JJ. 2011. Childhood trauma and current psychological functioning in adults with social anxiety disorder. J Anxiety Disord. 25:467–473.
   PubMed Web of Science ®Google Scholar
• Kusui C, Kimura T, Ogita K, Nakamura H, Matsumura Y, Koyama M, Azuma C, Murata Y. 2001. DNA methylation of the human oxytocin receptor gene promoter regulates tissue-specific gene suppression. Biochem Biophys Res Commun. 289:681–686.
   PubMed Web of Science ®Google Scholar
• MacDonald KS. 2013. Sex, receptors, and attachment: a review of individual factors influencing response to oxytocin. Front Neurosci. [Internet] 6. Available from: http://journal.frontiersin.org/article/10.3389/fnins.2012.00194/abstract
   PubMed Web of Science ®Google Scholar
• Machado-de-Sousa JP, Osório F. d L, Jackowski AP, Bressan RA, Chagas MHN, Torro-Alves N, DePaula ALD, Crippa JAS, Hallak JEC. 2014. Increased amygdalar and hippocampal volumes in young adults with social anxiety. PLoS ONE. 9:e88523.
   PubMed Web of Science ®Google Scholar
• Mamrut S, Harony H, Sood R, Shahar-Gold H, Gainer H, Shi Y-J, Barki-Harrington L, Wagner S. 2013. DNA methylation of specific CpG sites in the promoter region regulates the transcription of the mouse oxytocin receptor. PLoS ONE. 8:e56869.
   PubMed Web of Science ®Google Scholar
• Maroun M, Wagner S. 2016. Oxytocin and memory of emotional stimuli: some dance to remember, some dance to forget. Biol Psychiatry. 79:203–212.
   PubMed Web of Science ®Google Scholar
• Marusak HA, Furman DJ, Kuruvadi N, Shattuck DW, Joshi SH, Joshi AA, Etkin A, Thomason ME. 2015. Amygdala responses to salient social cues vary with oxytocin receptor genotype in youth. Neuropsychologia. 79:1–9.
   PubMed Web of Science ®Google Scholar
• McCrory E, De Brito SA, Viding E. 2010. Research review: the neurobiology and genetics of maltreatment and adversity. J Child Psychol Psychiatry. 51:1079–1095.
   PubMed Web of Science ®Google Scholar
• McEwen BS. 2012. Brain on stress: how the social environment gets under the skin. Proc Natl Acad Sci USA. 109:17180–17185.
   PubMed Web of Science ®Google Scholar
• Michelini S, Urbanek M, Dean M, Goldman D. 1995. Polymorphism and genetic mapping of the human oxytocin receptor gene on chromosome 3. Am J Med Genet. 60:183–187.
   PubMed Web of Science ®Google Scholar
• Mogg K, Bradley BP. 2002. Selective orienting of attention to masked threat faces in social anxiety. Behav Res Ther. 40:1403–1414.
   PubMed Web of Science ®Google Scholar
• Mogg K, Philippot P, Bradley BP. 2004. Selective attention to angry faces in clinical social phobia. J Abnorm Psychol. 113:160–165.
   PubMed Web of Science ®Google Scholar
• Montag C, Sindermann C, Melchers M, Jung S, Luo R, Becker B, Xie J, Xu W, Guastella AJ, Kendrick KM, et al. 2017. A functional polymorphism of the OXTR gene is associated with autistic traits in Caucasian and Asian populations. Am J Med Genet B Neuropsychiatr Genet. 174:808–816.
   PubMed Web of Science ®Google Scholar
• Moore LD, Le T, Fan G. 2013. DNA methylation and its basic function. Neuropsychopharmacology. 38:23.
   PubMed Web of Science ®Google Scholar
• Müller LE, Bertsch K, Bülau K, Herpertz SC, Buchheim A. 2018. Emotional neglect in childhood shapes social dysfunctioning in adults by influencing the oxytocin and the attachment system: results from a population-based study. Int J Psychophysiol. 136:73–80. [Internet]. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0167876017307134
   PubMed Web of Science ®Google Scholar
• Myers AJ, Williams L, Gatt JM, McAuley-Clark EZ, Dobson-Stone C, Schofield PR, Nemeroff CB. 2014. Variation in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress. J Psychiatr Res. 59:93–100.
   PubMed Web of Science ®Google Scholar
• Neyazi A, Theilmann W, Brandt C, Rantamäki T, Matsui N, Rhein M, et al. 2018. P11 promoter methylation predicts the antidepressant effect of electroconvulsive therapy. Transl. Psychiatry. [Internet] 8. Available from: http://www.nature.com/articles/s41398-017-0077-3
   PubMed Web of Science ®Google Scholar
• Ngui EM, Khasakhala L, Ndetei D, Roberts LW. 2010. Mental disorders, health inequalities and ethics: a global perspective. Int Rev Psychiatry. 22:235–244.
   PubMed Web of Science ®Google Scholar
• Notzon S, Domschke K, Holitschke K, Ziegler C, Arolt V, Pauli P, Reif A, Deckert J, Zwanzger P. 2016. Attachment style and oxytocin receptor gene variation interact in influencing social anxiety. World J Biol Psychiatry. 17:76–83.
   PubMed Web of Science ®Google Scholar
• Olff M, Frijling JL, Kubzansky LD, Bradley B, Ellenbogen MA, Cardoso C, Bartz JA, Yee JR, van Zuiden M. 2013. The role of oxytocin in social bonding, stress regulation and mental health: An update on the moderating effects of context and interindividual differences. Psychoneuroendocrinology 38:1883–1894.
   PubMed Web of Science ®Google Scholar
• Opacka-Juffry J, Mohiyeddini C. 2012. Experience of stress in childhood negatively correlates with plasma oxytocin concentration in adult men. Stress. 15:1–10.
   PubMed Web of Science ®Google Scholar
• Paquola C, Bennett MR, Lagopoulos J. 2016. Understanding heterogeneity in grey matter research of adults with childhood maltreatment-A meta-analysis and review . Neurosci Biobehav Rev. 69:299–312.
   PubMed Web of Science ®Google Scholar
• Pechtel P, Lyons-Ruth K, Anderson CM, Teicher MH. 2014. Sensitive periods of amygdala development: the role of maltreatment in preadolescence. Neuroimage. 97:236–244.
   PubMed Web of Science ®Google Scholar
• Puglia MH, Lillard TS, Morris JP, Connelly JJ. 2015. Epigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brain. Proc Natl Acad Sci USA. 112:3308–3313.
   PubMed Web of Science ®Google Scholar
• R Development Core Team. 2018. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. Available from: https://www.R-project.org/
   Google Scholar
• Rees C. 2008. The influence of emotional neglect on development. Paediatr Child Health. 18:527–534.
   Google Scholar
• Reiner I, Frieling H, Beutel M, Michal M. 2016. Gene–environment interaction of the oxytocin receptor gene polymorphism (rs53576) and unresolved attachment status predict depersonalization symptoms: an exploratory study. Psychol Stud. 61:295–300.
   Google Scholar
• Reinius LE, Acevedo N, Joerink M, Pershagen G, Dahlén S-E, Greco D, Söderhäll C, Scheynius A, Kere J. 2012. Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility. PLoS ONE 7:e41361.
   PubMed Web of Science ®Google Scholar
• Reuter M, Rosas HD, Fischl B. 2010. Highly accurate inverse consistent registration: a robust approach. Neuroimage. 53:1181–1196.
   PubMed Web of Science ®Google Scholar
• Rodrigues SM, Saslow LR, Garcia N, John OP, Keltner D. 2009. Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc Natl Acad Sci USA. 106:21437–21441.
   PubMed Web of Science ®Google Scholar
• Rubin RD, Watson PD, Duff MC, Cohen NJ. 2014. The role of the hippocampus in flexible cognition and social behavior. Front Hum Neurosci. [Internet] 8. Available from: http://journal.frontiersin.org/article/10.3389/fnhum.2014.00742/abstract [CrossRef]
   PubMed Web of Science ®Google Scholar
• Sapolsky RM. 2000. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry. 57:925–935.
   PubMed Web of Science ®Google Scholar
• Schiele MA, Domschke K. 2018. Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders. Genes Brain Behav. 17:e12423
   PubMed Web of Science ®Google Scholar
• Schiele MA, Ziegler C, Kollert L, Katzorke A, Schartner C, Busch Y, et al. 2018. Plasticity of functional MAOA gene methylation in acrophobia. Int J Neuropsychopharmacol. [Internet]. Available from: https://academic.oup.com/ijnp/advance-article/doi/10.1093/ijnp/pyy050/5026103
   Web of Science ®Google Scholar
• Schneider-Hassloff H, Straube B, Jansen A, Nuscheler B, Wemken G, Witt SH, Rietschel M, Kircher T. 2016. Oxytocin receptor polymorphism and childhood social experiences shape adult personality, brain structure and neural correlates of mentalizing. Neuroimage. 134:671–684.
   PubMed Web of Science ®Google Scholar
• Schuebel K, Gitik M, Domschke K, Goldman D. 2016. Making sense of epigenetics. Int J Neuropsychopharmacol. 19.
   PubMed Web of Science ®Google Scholar
• Ségonne F, Dale AM, Busa E, Glessner M, Salat D, Hahn HK, Fischl B. 2004. A hybrid approach to the skull stripping problem in MRI. Neuroimage. 22:1060–1075.
   PubMed Web of Science ®Google Scholar
• Shamay-Tsoory SG, Abu-Akel A. 2016. The social salience hypothesis of oxytocin. Biol Psychiatry. 79:194–202.
   PubMed Web of Science ®Google Scholar
• Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. 1998. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 59(Suppl. 20):22–33. quiz 34–57.
   PubMed Web of Science ®Google Scholar
• Simon NM, Herlands NN, Marks EH, Mancini C, Letamendi A, Li Z, Pollack MH, Van Ameringen M, Stein MB. 2009. Childhood maltreatment linked to greater symptom severity and poorer quality of life and function in social anxiety disorder. Depress Anxiety. 26:1027–1032.
   PubMed Web of Science ®Google Scholar
• Sinwell JP, Schaid DJ. 2016. haplo.stats: Statistical analysis of haplotypes with traits and covariates when linkage phase is ambiguous. Available from: https://cran.r-project.org/web/packages/haplo.stats/
   Google Scholar
• Sled JG, Zijdenbos AP, Evans AC. 1998. A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging. 17:87–97.
   PubMed Web of Science ®Google Scholar
• Smearman EL, Almli LM, Conneely KN, Brody GH, Sales JM, Bradley B, Ressler KJ, Smith AK. 2016. Oxytocin receptor genetic and epigenetic variations: association with child abuse and adult psychiatric symptoms. Child Dev. 87:122–134.
   PubMed Web of Science ®Google Scholar
• Spielberger CD. 1983. Manual for the state-trait anxiety inventory STAI (form Y)(“self-evaluation questionnaire”).
   Google Scholar
• Spinhoven P, Elzinga BM, Hovens JGFM, Roelofs K, Zitman FG, van Oppen P, Penninx BWJH. 2010. The specificity of childhood adversities and negative life events across the life span to anxiety and depressive disorders. J Affect Disord. 126:103–112.
   PubMed Web of Science ®Google Scholar
• Stoltenborgh M, Bakermans-Kranenburg MJ, van Ijzendoorn MH. 2013. The neglect of child neglect: a meta-analytic review of the prevalence of neglect. Soc Psychiatry Psychiatr Epidemiol. 48:345–355.
   PubMed Web of Science ®Google Scholar
• Suzuki MM, Bird A. 2008. DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet. 9:465–476.
   PubMed Web of Science ®Google Scholar
• Tabak BA. 2013. Oxytocin and social salience: a call for gene-environment interaction research. Front Neurosci. [Internet] 7. Available from: http://journal.frontiersin.org/article/10.3389/fnins.2013.00199/abstract
   PubMed Web of Science ®Google Scholar
• Tadić A, Müller-Engling L, Schlicht KF, Kotsiari A, Dreimüller N, Kleimann A, Bleich S, Lieb K, Frieling H. 2014. Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression. Mol Psychiatry. 19:281–283.
   PubMed Web of Science ®Google Scholar
• Taillieu TL, Brownridge DA, Sareen J, Afifi TO. 2016. Childhood emotional maltreatment and mental disorders: results from a nationally representative adult sample from the United States. Child Abuse Negl. 59:1–12.
   PubMed Web of Science ®Google Scholar
• Tamnes CK, Bos MGN, van de Kamp FC, Peters S, Crone EA. 2018. Longitudinal development of hippocampal subregions from childhood to adulthood. Dev Cogn Neurosci. 30:212–222.
   PubMed Web of Science ®Google Scholar
• Teicher MH, Andersen SL, Polcari A, Anderson CM, Navalta CP, Kim DM. 2003. The neurobiological consequences of early stress and childhood maltreatment. Neurosci Biobehav Rev. 27:33–44.
   PubMed Web of Science ®Google Scholar
• Teicher MH, Anderson CM, Ohashi K, Khan A, McGreenery CE, Bolger EA, Rohan ML, Vitaliano GD. 2018. Differential effects of childhood neglect and abuse during sensitive exposure periods on male and female hippocampus. Neuroimage. 169:443–452.
   PubMed Web of Science ®Google Scholar
• Teicher MH, Samson JA. 2016. Annual Research Review: Enduring neurobiological effects of childhood abuse and neglect. J Child Psychol Psychiatry. 57:241–266.
   PubMed Web of Science ®Google Scholar
• Theodoridou A, Rowe AC, Penton-Voak IS, Rogers PJ. 2009. Oxytocin and social perception: oxytocin increases perceived facial trustworthiness and attractiveness. Horm Behav. 56:128–132.
   PubMed Web of Science ®Google Scholar
• Tost H, Kolachana B, Hakimi S, Lemaitre H, Verchinski BA, Mattay VS, Weinberger DR, Meyer-Lindenberg A. 2010. A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proc Natl Acad Sci USA. 107:13936–13941.
   PubMed Web of Science ®Google Scholar
• Tottenham N. 2009. A review of adversity, the amygdala and the hippocampus: a consideration of developmental timing. Front Hum Neurosci. [Internet]. Available from: http://journal.frontiersin.org/article/10.3389/neuro.09.068.2009/abstract
   PubMed Web of Science ®Google Scholar
• Tottenham N, Hare TA, Quinn BT, McCarry TW, Nurse M, Gilhooly T, Millner A, Galvan A, Davidson MC, Eigsti I-M, et al. 2010. Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulation: previous institutionalization. Dev Sci. 13:46–61.
   PubMed Web of Science ®Google Scholar
• Tyborowska A, Volman I, Niermann HCM, Pouwels JL, Smeekens S, Cillessen AHN, et al. 2018. Early-life and pubertal stress differentially modulate grey matter development in human adolescents. Sci Rep. [Internet] 8. Available from: http://www.nature.com/articles/s41598-018-27439-5
   PubMed Web of Science ®Google Scholar
• Unternaehrer E, Luers P, Mill J, Dempster E, Meyer AH, Staehli S, Lieb R, Hellhammer DH, Meinlschmidt G. 2012. Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress. Transl Psychiatry. 2:e150.
   PubMed Web of Science ®Google Scholar
• Vela RM. 2014. The effect of severe stress on early brain development, attachment, and emotions: a psychoanatomical formulation. Psychiatr Clin North Am. 37:519–534.
   PubMed Web of Science ®Google Scholar
• Verdolini N, Attademo L, Agius M, Ferranti L, Moretti P, Quartesan R. 2015. Traumatic events in childhood and their association with psychiatric illness in the adult. Psychiatr Danub. 27(Suppl 1):S60–S70.
   PubMedGoogle Scholar
• Wang J, Qin W, Liu B, Zhou Y, Wang D, Zhang Y, Jiang T, Yu C. 2014. Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament. Brain Struct Funct. 219:1543–1554.
   PubMed Web of Science ®Google Scholar
• Weber S, Jud A, Landolt MA. 2016. Quality of life in maltreated children and adult survivors of child maltreatment: a systematic review. Qual Life Res. 25:237–255.
   PubMed Web of Science ®Google Scholar
• Wu S, Jia M, Ruan Y, Liu J, Guo Y, Shuang M, Gong X, Zhang Y, Yang X, Zhang D, et al. 2005. Positive association of the oxytocin receptor gene (OXTR) with autism in the chinese han population. Biol Psychiatry. 58:74–77.
   PubMed Web of Science ®Google Scholar
• Young JC, Widom CS. 2014. Long-term effects of child abuse and neglect on emotion processing in adulthood. Child Abuse Negl. 38:1369–1381.
   PubMed Web of Science ®Google Scholar
• Ziegler C, Dannlowski U, Bräuer D, Stevens S, Laeger I, Wittmann H, Kugel H, Dobel C, Hurlemann R, Reif A, et al. 2015. Oxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety. Neuropsychopharmacology. 40:1528–1538.
   PubMed Web of Science ®Google Scholar
• Ziegler C, Richter J, Mahr M, Gajewska A, Schiele MA, Gehrmann A, Schmidt B, Lesch K-P, Lang T, Helbig-Lang S, et al. 2016. MAOA gene hypomethylation in panic disorder-reversibility of an epigenetic risk pattern by psychotherapy. Transl Psychiatry. 6:e773.
   PubMed Web of Science ®Google Scholar
• Ziegler C, Wolf C, Schiele MA, Feric Bojic E, Kucukalic S, Sabic Dzananovic E, et al. 2017. Monoamine oxidase A gene methylation and its role in posttraumatic stress disorder – first evidence from the south eastern europe (SEE)-PTSD study. Int J Neuropsychopharmacol. 21:423–432.
   Web of Science ®Google Scholar