Is there a link between stress and immune biomarkers and salivary opiorphin in patients with a restrictive-type of anorexia nervosa?

References

• Acres MJ, Heath JJ, Morris JA. 2012. Anorexia nervosa, autoimmunity and the hygiene hypothesis. Med Hypotheses. 78:772–775.
   PubMed Web of Science ®Google Scholar
• Ali N, Pruessner JC. 2012. The salivary alpha amylase over cortisol ratio as a marker to assess dysregulations of the stress systems. Physiol Behav. 106:65–72.
   PubMed Web of Science ®Google Scholar
• Almela M, Hidalgo V, Villada C, van der Meij L, Espín L, Gómez-Amor J, Salvador A. 2011. Salivary alpha-amylase response to acute psychosocial stress: the impact of age. Biol Psycho. 87:421–429.
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. 2013. Diagnostic and statistical manual of mental disorders. 5th ed. DSM V. Washington, DC: APA.
   Google Scholar
• Bellussi L, Cambi J, Passali D. 2013. Functional maturation of nasal mucosa: role of secretory immunoglobulin A (SIgA). Multidiscip Respir Med. 8:8–46.
   PubMed Web of Science ®Google Scholar
• Bishop NC, Gleeson M. 2009. Acute and chronic effects of exercise on markers of mucosal immunity. Front Biosci (Landmark Ed). 14:4444–4456.
   PubMed Web of Science ®Google Scholar
• Bosch JA, Brand H, Ligtenberg A, Bermond B, Hoogstraten J, Nieuw Amerongen AVN. 1998. The response of salivary protein levels and SIgA to an academic examination are associated with daily stress. J Psychophysiol. 12:384–391.
   Web of Science ®Google Scholar
• Bosch JA, Ring C, de Geus EJC, Veerman ECI, Amerongen A. 2002. Stress and secretory immunity. Int Rev Neurobiol. 52:213–253.
   PubMed Web of Science ®Google Scholar
• Brown AM, Lally ET, Frankel A, Harwick R, Davis LW, Rominger CJ. 1975. The association of the IGA levels of serum and whole saliva with the progression of oral cancer. Cancer. 35:1154–1162.
   PubMed Web of Science ®Google Scholar
• Campbell MJ, Scott J, Maecker HT, Park JW, Esserman LJ. 2005. Immune dysfunction and micrometastases in women with breast cancer. Breast Cancer Res Treat. 91:163–171.
   PubMed Web of Science ®Google Scholar
• Caregaro L, Alberino F, Angeli P, Gatta A. 1998. Insulin-like growth factor 1 (IGF-1) in liver cirrhosis: a marker of hepatocellular dysfunction? J Hepatol. 29:342–351.
   PubMed Web of Science ®Google Scholar
• Castagnola M, Scarano E, Passali GC, Messana I, Cabras T, Iavarone F, Di Cintio G, Fiorita A, De Corso E, Paludetti E. 2017. Salivary biomarkers and proteomics: future diagnostic and clinical utilities. Acta Otorhinolaryngol Ital. 37:94–101.
   PubMed Web of Science ®Google Scholar
• Challacombe SJ, Percival RS, Marsh PD. 1995. Age-related changes in immunoglobulin isotypes in whole and parotid saliva and serum in healthy individuals. Oral Microbiol Immunol. 10:202–207.
   PubMedGoogle Scholar
• Chiodini I, Torlontano M, Scillitani A, Arosio M, Bacci S, Di Lembo S, Epaminonda P, Augello G, Enrini R, Ambrosi B, et al. 2005. Association of subclinical hypercortisolism with type 2 diabetes mellitus: a case-control study in hospitalized patients. Eur J Endocrinol. 153:837–844.
   PubMed Web of Science ®Google Scholar
• Dorn LD, Lucke JF, Loucks TL, Berga SL. 2007. Salivary cortisol reflects serum cortisol: analysis of circadian profiles. Ann Clin Biochem. 44:281–284.
   PubMed Web of Science ®Google Scholar
• Douglas P, Dickinson MT. 1996. cDNA cloning of an abundant human lacrimal gland mRNA encoding a novel tear protein. Curr Eye Res. 15:377–386.
   PubMed Web of Science ®Google Scholar
• Dufour E, Villard-Saussine S, Mellon V, Leandri R, Jouannet P, Ungeheuer MN, Rougeot C, 2013. Opiorphin secretion pattern in healthy volunteers: gender difference and organ specificity. Biochem Anal Biochem. 2:2–11.
   Google Scholar
• Edgar WM, Dawes C, O’Mullane D. 2004. Saliva and oral health. London, UK: British Dental Association. 14–50.
   Google Scholar
• Engert V, Vogel S, Efanov SI, Duchesne A, Corbo V, Ali N, Pruessner JC. 2011. Investigation into the cross-correlation of salivary cortisol and alpha-amylase responses to psychological stress. Psychoneuroendocrinology. 36:1294–1302.
   PubMed Web of Science ®Google Scholar
• Gold PW, Loriaux DL, Roy A, Kling MA, Calabrese JR, Kellner CH, Nieman LK, Post RM, Pickar D, Gallucci W, et al. 1986. Responses to corticotrophin-releasing hormone in the hypercortisolism of depression and Cushing’s disease. Pathophysiologic and diagnostic implications. N Engl J Med. 314:1329–1335.
   PubMed Web of Science ®Google Scholar
• Gardner RV. 1999. Long term hematopoietic damage after chemotherapy and cytokine. Front Biosci. 4:e47–e57.
   PubMedGoogle Scholar
• Granger DA, Kivlighan KT, el–Sheikh M, Gordis EB, Stroud LR. 2007. Salivary alpha-amylase in biobehavioral research: recent developments and applications. Ann NY Acad Sci. 1098:122–144.
   PubMed Web of Science ®Google Scholar
• Hucklebridge F, Clow A, Evans P. 1998. The relationship between salivary secretory immunoglobulin A and cortisol: neuroendocrine response to awakening and the diurnal cycle. Int J Psychophysiol. 31:69–76.
   PubMed Web of Science ®Google Scholar
• Humphrey SP, Williamson RT. 2001. A review of saliva: normal composition, flow, and function. J Prosthet Dent. 85:162–169.
   PubMed Web of Science ®Google Scholar
• Javelot H, Messaoudi M, Garnier S, Rougeot C. 2010. Human opiorphin is a naturally occurring antidepressant acting selectively on enkephalin-dependent delta-opioid pathways. J Physiol Pharmacol. 61:355–362.
   PubMed Web of Science ®Google Scholar
• Jensen SB, Mouridsen HT, Reibel J, Brünner N, Nauntofte B. 2008. Adjuvant chemotherapy in breast cancer patients induces temporary salivary gland hypofunction. Oral Oncol. 44:162–173.
   PubMed Web of Science ®Google Scholar
• Jessop DS, Turner-Cobb JM. 2007. Measurement and meaning of salivary cortisol: a focus on health and disease in children. Stress. 11:1–14.
   PubMed Web of Science ®Google Scholar
• Kreipe RE, Goldstein B, DeKing DE, Tipton R, Kempski MH. 1994. Heart rate power spectrum analysis of autonomic dysfunction in adolescents with anorexia nervosa. Int J Eat Disord. 16:159–165.
   PubMed Web of Science ®Google Scholar
• Kirschbaum C, Hellhammer DH. 1989. Salivary cortisol in psychobiological research: an overview. Neuropsychobiology. 22:150–169.
   PubMed Web of Science ®Google Scholar
• Kirschbaum C, Hellhammer DH. 1994. Salivary cortisol in psychoneuroendocrine research: recent developments and applications. Psychoneuroendocrinology. 19:313–333.
   PubMed Web of Science ®Google Scholar
• Latiff AHA, Kerr MA. 2007. The clinical significance of immunoglobulin A deficiency. Ann Clin Biochem. 44:131–139.
   PubMed Web of Science ®Google Scholar
• Lawrence HP. 2002. Salivary markers of systemic disease: noninvasive diagnosis of disease and monitoring of general health. J Can Dent Assoc. 68:170–174.
   PubMedGoogle Scholar
• Lo Sauro C, Ravaldi C, Cabras PL, Faravelli C, Ricca V. 2008. Stress, hypothalamic-pituitary-adrenal axis and eating disorders. Neuropsychobiology. 57:95–115.
   PubMed Web of Science ®Google Scholar
• Maes M, Kubera M, Leunis J-C, Berk M. 2012. Increased IgA and IgM responses against gut commensals in chronic depression: further evidence for increased bacterial translocation or leaky gut. J Affect Disord. 141:55–62.
   PubMed Web of Science ®Google Scholar
• McEwen BS. 2008. Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol. 583:174–185.
   PubMed Web of Science ®Google Scholar
• McGirr A, Diaconu G, Berlim MT, Pruessner JC, Sablé R, Cabot S, Turecki G. 2010. Dysregulation of the sympathetic nervous system, hypothalamic-pituitary-adrenal axis and executive function in individuals at risk for suicide. J Psychiatry Neurosci. 35:399–408.
   PubMed Web of Science ®Google Scholar
• Moreira A, de Moura NR, Coutts A, Costa EC, Kempton T, Aoki MS. 2013. Monitoring internal training load and mucosal immune responses in futsal athletes. J Strength Cond Res. 27:1253–1259.
   PubMed Web of Science ®Google Scholar
• Monteleone P, Scognamiglio P, Canestrelli B, Serino I, Monteleone AM, Maj M. 2011. Asymmetry of salivary cortisol and α-amylase responses to psychosocial stress in anorexia nervosa but not in bulimia nervosa. Psychol Med. 41:1963–1969.
   PubMed Web of Science ®Google Scholar
• Monteleone P, Scognamiglio P, Monteleone AM, Mastromo D, Steardo L, Serino I, Maj M. 2011. Abnormal diurnal patterns of salivary α-amylase and cortisol secretion in acute patients with anorexia nervosa. World J Biol Psychiatry. 12:455–461.
   PubMed Web of Science ®Google Scholar
• Murialdo G, Casu M, Falchero M, Brugnolo A, Patrone V, Cerro PF, Ameri P, Andraghetti G, Briatore L, Copello F, et al. 2007. Alterations in the autonomic control of heart rate variability in patients with anorexia or bulimia nervosa: correlations between sympathovagal activity, clinical features, and leptin levels. J Endocrinol Invest. 30:356–362.
   PubMed Web of Science ®Google Scholar
• Müller F, Holberg-Petersen M, Rollag H, Degré M, Brandtzaeg P, Frøland SS. 1992. Nonspecific oral immunity in individuals with HIV infection. J Acquir Immune Defic Syndr. 5:46–51.
   PubMed Web of Science ®Google Scholar
• Nater UM, La Marca R, Florin L, Moses A, Langhans W, Koller MM, Ehlert MM. 2006. Stress –induced changes in human salivary alpha-amylase activity – associations with adrenergic activity. Psychoneuroendocrinology. 31:49–58.
   PubMed Web of Science ®Google Scholar
• Nater UM, Rohleder N. 2009. Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: current state of research. Psychoneuroendocrinology. 34:486–496.
   PubMed Web of Science ®Google Scholar
• Nater UM, Rohleder N, Schlotz W, Ehlert U, Kirschbaum C. 2007. Determinants of the diurnal course of salivary alpha-amylase. Psychoneuroendocrinology. 32:392–401.
   PubMed Web of Science ®Google Scholar
• Ozdogan MS, Gungormus M, Ince Yusufoglu S, Ertem SY, Sonmez C, Orhan M. 2018. Salivary opiorphin in dental pain: a potential biomarker for dental disease. Arch Oral Biol. 99:15–21.
   PubMed Web of Science ®Google Scholar
• Pandey S, Goel M, Nagpal R, Kar A, Rapsang E, Matani P. 2018. Evaluation of total salivary secretory immunoglobulin A and mi/fans-specific SIgA among children having dissimilarc caries status. J Contemp Dental Pract. 19:651–655.
   PubMedGoogle Scholar
• Parker KJ, Schatzberg AF, Lyons DM. 2003. Neuroendocrine aspects of hypercortisolism in major depression. Horm Behav. 43:60–66.
   PubMed Web of Science ®Google Scholar
• Peeke PM, Chrousos GP. 1995. Hypercortisolism and obesity. Ann N Y Acad Sci. 771:665–676.
   PubMedGoogle Scholar
• Paszynska E, Slopien A, Slebioda Z, Dyszkiewicz-Konwinska M, Weglarz M, Rajewski A. 2014. Macroscopic evaluation of the oral mucosa and analysis of salivary pH in patients with anorexia nervosa. Psychiat Pol. 48:453–464.
   PubMed Web of Science ®Google Scholar
• Paszynska E, Dmitrzak-Weglarz M, Roszak M, Boucher Y, Dutkiewicz A, Tyszkiewicz-Nwafor M, Gawriolek M, Otulakowska-Skrzynska J, Rzatowski S, Slopien A. 2018. Salivary opiorphin levels in anorexia nervosa: a case control study. World J Biol Psychiatry. doi:10.1080/15622975.2018.1517948
   PubMedGoogle Scholar
• Paszynska E, Dmitrzak-Weglarz M, Tyszkiewicz-Nwafor M, Slopien A. 2016. Salivary alpha-amylase, secretory IgA and free cortisol as neurobiological components of the stress response in the acute phase of anorexia nervosa. World J Biol Psychiatry. 17:266–267.
   PubMed Web of Science ®Google Scholar
• Paszynska E, Schlueter N, Slopien A, Dmitrzak-Weglarz M, Dyszkiewicz-Konwinska M, Hannig C. 2015. Salivary enzyme activity in anorexic persons – a controlled clinical trial. Clin Oral Invest. 19:1981–1989.
   PubMed Web of Science ®Google Scholar
• Paszynska E, Slopien A, Dmitrzak-Weglarz M, Hannig C. 2017. Enzyme activities in parotid saliva of patients with the restrictive type of anorexia nervosa. Arch Oral Biol. 76:7–13.
   PubMed Web of Science ®Google Scholar
• Petretta M, Bonaduce D, Themistoclakis S, Ianniciello A, Scalfi L, De Filippo E, Contaldo F, Marciano F, Migaux M-L. 1997. Heart rate variability as a measure of autonomic nervous system function in anorexia nervosa. Clin Cardiol. 20:219–224.
   PubMed Web of Science ®Google Scholar
• Popik P, Kamysz E, Kreczko J, Wróbel M. 2010. Human opiorphin: the lack of physiological dependence, tolerance to antinociceptive effects and abuse liability in laboratory mice. Behav Brain Res. 213:88–93.
   PubMed Web of Science ®Google Scholar
• Rasmussen AK, Nielsen H, Andersen V, Barington T, Bendtzen K, Hansen MB, Nielsen L, Pedersen BK, Wiik A. 1994. Chronic fatigue syndrome-a controlled cross sectional study. J Rheumatol. 21:1527–1531.
   PubMed Web of Science ®Google Scholar
• Rechlin T, Weis M, Ott C, Bleichner F, Joraschky P. 1998. Alterations of autonomic cardiac control in anorexia nervosa. Biol Psychiatry. 43:358–363.
   PubMed Web of Science ®Google Scholar
• Rohleder N, Nater U, Wolf JM, Ehlert U, Kirschbaum C. 2004. Psychosocial stress-induced activation of salivary alpha-amylase: an indicator of sympathetic activity? Ann N Y Acad Sci. 1032:258–263.
   PubMed Web of Science ®Google Scholar
• Sapolsky RM, Alberts SC, Altmann J. 1997. Hypercortisolism associated with social subordinance or social isolation among wild baboons. Arch Gen Psychiatry. 54:1137–1143.
   PubMed Web of Science ®Google Scholar
• Scheutzel P, Gerlach U. 1991. Alpha-amylase isoenzymes in serum and saliva of patients with anorexia and bulimia nervosa. Gastroenterol 29:339–345.
   Google Scholar
• Schlueter N, Ganss C, Pötschke S, Klimek J, Hannig C. 2012. Enzyme activities in the oral fluids of patients suffering from bulimia: a control clinical trial. Caries Res. 46:130–139.
   PubMed Web of Science ®Google Scholar
• Schumacher S, Kirschbaum K, Fydrich T, Strohle A. 2013. Is salivary alpha-amylase an indicator of autonomic nervous system dysregulations in mental disorders? - A review of preliminary findings and the interactions with cortisol. Psychoneuroendocrinology. 38:729–743.
   PubMed Web of Science ®Google Scholar
• Sikorska MHJ, Mielnik-Blaszczak M, Kapec E. 2002. The relationship between the levels of sIgA, lactoferrin and α1proteinaze inhibitor in saliva and permanent dentition caries in 15-year-old. Oral Microbiol Immunol. 17:272–276.
   PubMedGoogle Scholar
• Stone AA, Schwartz JE, Smyth J, Kirschbaum C, Cohen S, Hellhammer D, Grossman S. 2001. Individual differences in the diurnal cycle of salivary free cortisol: a replication of flattened cycles for some individuals. Psychoneuroendocrinology. 26:295–306.
   PubMed Web of Science ®Google Scholar
• Standish LJ, Torkelson C, Hamill FA, Yim D, Hill-Force A, Fitzpatrick A, Olsen M, Schildt S, Sweet E, Wenner CA, Martzen MR. 2008. Immune defects in breast cancer patients after radiotherapy. J Soc Integr Oncol. 6:110–121.
   PubMedGoogle Scholar
• Stanović S, Boranić M, Petrovečki M, Batinić D, Skodlar J, Nemet D, Labar B. 2000. Thiorphan, an inhibitor of neutral endopeptidase/enkephalinase (CD10/CALLA) enhances cell proliferation in bone marrow cultures of patients with acute leukemia in remission. Haematologia. 30:1–10.
   PubMedGoogle Scholar
• Sun H, Chen Y, Zou X, Li Q, Li H, Shu Y, Li X, Li W, Han L, Ge C. 2016. Salivary secretory immunoglobulin (SIgA) and lysozyme in malignant tumor patients. Biomed Res Int. 2016:1.
   Web of Science ®Google Scholar
• Teeuw W, Bosch JA, Veerman ECI, Amerongen AVN. 2004. Neuroendocrine regulation of salivary IgA synthesis and secretion: implications for oral health. Biol Chem. 385:1137–1146.
   PubMed Web of Science ®Google Scholar
• Tsujita S, Morimoto K. 1999. Secretory IgA in saliva can be a useful stress marker. Environ Health Prev Med. 4:1–8.
   PubMedGoogle Scholar
• Valdimarsdottir HB, Stone AA. 1997. Psychosocial factors and secretory immunoglobulin A. Crit Rev Oral Biol Med. 8:461–474.
   PubMed Web of Science ®Google Scholar
• Verma R, Foster RE, Horgan K, Mounsey K, Nixon H, Smalle N, Hughes TA, Carter CD. 2016. Lymphocyte depletion and repopulation after chemotherapy for primary breast cancer. Breast Cancer Res. 18:10.
   PubMed Web of Science ®Google Scholar
• Wan C, Couture-Lalande M-È, Narain TA, Lebel S, Bielajew C. 2016. Salivary alpha-amylase reactivity in breast cancer survivors. IJERPH,. 13:353.
   Google Scholar
• Wang D, Zhuo JQ, Zhao MP. 2010. A simple and rapid competitive enzyme-linked immunosorbent assay (cELISA) for high through-put measurement of secretory immunoglobulin A (sIgA) in saliva. Talanta. 82:432–436.
   PubMed Web of Science ®Google Scholar
• Wisner A, Dufour E, Messaoudi M, Nejdi A, Marcel A, Ungeheuer MN, Rougeot C. 2006. Human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways. PNAS. 103:17979–17984.
   PubMed Web of Science ®Google Scholar
• Wolf JM, Nicholls E, Chen E. 2008. Chronic stress, salivary cortisol, and alpha-amylase in children with asthma and healthy children. Biol Psychol. 78:20–28.
   PubMed Web of Science ®Google Scholar
• Yang QZ, Lu SS, Tian XZ, Yang AM, Ge WW, Chen Q. 2011. The antidepressant-like effect of human opiorphin via opioid-dependent pathways in mice. Neurosci Lett. 489:131–135.
   PubMed Web of Science ®Google Scholar