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Original Investigation

Genes involved in glucocorticoid receptor signalling affect susceptibility to mood disorders

, , , , , , , , , , ORCID Icon, ORCID Icon, , , ORCID Icon, & ORCID Icon show all
Pages 149-160 | Received 09 Mar 2020, Accepted 02 May 2020, Published online: 26 May 2020

References

  • Anacker C, Zunszain PA, Carvalho LA, Pariante CM. 2011. The glucocorticoid receptor: pivot of depression and of antidepressant treatment? Psychoneuroendocrinology. 36(3):415–425.
  • Bekhbat M, Rowson SA, Neigh GN. 2017. Checks and balances: the glucocorticoid receptor and NFĸB in good times and bad. Front Neuroendocrinol. 46:15–31.
  • Blasey CM, Debattista C, Roe R, Block T, Belanoff JK. 2009. A multisite trial of mifepristone for the treatment of psychotic depression: a site-by-treatment interaction. Contemp Clin Trials. 30(4):284–288.
  • Breen ME, Gaynor SC, Monson ET, de Klerk K, Parsons MG, Braun TA, DeLuca AP, Zandi PP, Potash JB, Willour VL. 2016. Targeted sequencing of FKBP5 in suicide attempters with bipolar disorder. PLoS One. 11(12):e0169158.
  • Bustin SA. 2000. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol. 25(2):169–193.
  • Chen J, Wang ZZ, Zuo W, Zhang S, Chu SF, Chen NH. 2016. Effects of chronic mild stress on behavioral and neurobiological parameters - role of glucocorticoid. Horm Behav. 78:150–159.
  • Davies TH, Ning YM, Sanchez ER. 2002. A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. J Biol Chem. 277(7):4597–4600.
  • De Kloet ER, Vreugdenhil E, Oitzl MS, Joels M. 1998. Brain corticosteroid receptor balance in health and disease. Endocr Rev. 19(3):269–301.
  • DuBois DC, Sukumaran S, Jusko WJ, Almon RR. 2013. Evidence for a glucocorticoid receptor beta splice variant in the rat and its physiological regulation in liver. Steroids. 78(2):312–320.
  • First MB, Spitzer RL, Gibbon M, Williams J. 1996. Structured clinical interview for DSM-IV axis I disorders, clinician version (SCID-CV). Washington (DC): American Psychiatric Press.
  • Hauk PJ, Goleva E, Strickland I, Vottero A, Chrousos GP, Kisich KO, Leung DY. 2002. Increased glucocorticoid receptor Beta expression converts mouse hybridoma cells to a corticosteroid-insensitive phenotype. Am J Respir Cell Mol Biol. 27(3):361–367.
  • Havard HL, Buckland PR, O'Donovan MC, McGuffin P. 1991. The effects of antidepressant drugs on kainate receptor mRNA levels. Neuropharmacology. 30(6):675–677.
  • Hawkins GA, Lazarus R, Smith RS, Tantisira KG, Meyers DA, Peters SP, Weiss ST, Bleecker ER. 2009. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. J Allergy Clin Immunol. 123(6):1376–1383.
  • Holsboer F. 2000. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology. 23(5):477–501.
  • Islam MR, Islam MR, Ahmed I, Moktadir AA, Nahar Z, Islam MS, Shahid SFB, Islam SN, Islam MS, Hasnat A. 2018. Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: a case-control study. SAGE Open Med. 6:205031211877395. 2050312118773953.
  • Jain A, Wordinger RJ, Yorio T, Clark AF. 2012. Spliceosome protein (SRp) regulation of glucocorticoid receptor isoforms and glucocorticoid response in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 53(2):857–866.
  • Jindal A, Mahesh R, Bhatt S. 2013. Etazolate rescues behavioral deficits in chronic unpredictable mild stress model: modulation of hypothalamic-pituitary-adrenal axis activity and brain-derived neurotrophic factor level. Neurochem Int. 63(5):465–475.
  • Keller J, Gomez R, Williams G, Lembke A, Lazzeroni L, Murphy GM, Jr., Schatzberg AF. 2017. HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition. Mol Psychiatry. 22(4):527–536.
  • Ladd AN, Nguyen NH, Malhotra K, Cooper TA. 2004. CELF6, a member of the CELF family of RNA-binding proteins, regulates muscle-specific splicing enhancer-dependent alternative splicing. J Biol Chem. 279(17):17756–17764.
  • Lecrubier Y, Sheehan D, Weiller E, Amorim P, Bonora I, Sheehan K, Janavs J, Dunbar G. 1997. The MINI International Neuropsychiatric Interview (M.I.N.I.). A short diagnostic structured interview: reliability and validity according to the CIDI. Eur Psychiatr. 12(5):224–231.
  • Lee HH, Chang CH, Wang LJ, Wu CC, Chen HL, Lu T, Lu RB, Lee SY. 2018. The correlation between longitudinal changes in hypothalamic-pituitary-adrenal (HPA)-axis activity and changes in neurocognitive function in mixed-state bipolar II disorder. Neuropsychiatr Dis Treat. 14:2703–2713.
  • Li HB, Du YZ. 2013. Molecular cloning and characterization of an Hsp90/70 organizing protein gene from Frankliniella occidentalis (Insecta: Thysanoptera, Thripidae). Gene. 520(2):148–155.
  • McGuffin P, Farmer A, Harvey I. 1991. A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Arch Gen Psychiatry. 48(8):764–770.
  • Miller SA, Dykes DD, Polesky HF. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16(3):1215
  • Minelli A, Maffioletti E, Cloninger CR, Magri C, Sartori R, Bortolomasi M, Congiu C, Bignotti S, Segala M, Giacopuzzi M, et al. 2013. Role of allelic variants of FK506-binding protein 51 (FKBP5) gene in the development of anxiety disorders. Depress Anxiety. 30(12):1170–1176.
  • O’Donovan M, McGuffin P. 1991. Growing points in psychiatric genetics. Br J Hosp Med. 46(6):359–360.
  • Oomen CA, Mayer JL, de Kloet ER, Joels M, Lucassen PJ. 2007. Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress. Eur J Neurosci. 26(12):3395–3401.
  • Pae CU, Mandelli L, Serretti A, Patkar AA, Kim JJ, Lee CU, Lee SJ, Lee C, De Ronchi D, Paik IH. 2007. Heat-shock protein-70 genes and response to antidepressants in major depression. Prog Neuropsychopharmacol Biol Psychiatry. 31(5):1006–1011.
  • Pandey GN, Rizavi HS, Ren X, Dwivedi Y, Palkovits M. 2013. Region-specific alterations in glucocorticoid receptor expression in the postmortem brain of teenage suicide victims. Psychoneuroendocrinology. 38(11):2628–2639.
  • Papiol S, Arias B, Gasto C, Gutierrez B, Catalan R, Fananas L. 2007. Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment. J Affect Disord. 104(1-3):83–90.
  • Papp M. 2012. Models of affective illness: chronic mild stress in the rat. Curr Protoc Pharmacol. Chapter. 5:Unit 5 :9.
  • Pariante CM, Miller AH. 2001. Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol Psychiatry. 49(5):391–404.
  • Porsolt RD, Bertin A, Jalfre M. 1977. Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther. 229(2):327–336.
  • Raone A, Cassanelli A, Scheggi S, Rauggi R, Danielli B, De Montis MG. 2007. Hypothalamus-pituitary-adrenal modifications consequent to chronic stress exposure in an experimental model of depression in rats. Neuroscience. 146(4):1734–1742.
  • Ruksee N, Tongjaroenbuangam W, Mahanam T, Govitrapong P. 2014. Melatonin pretreatment prevented the effect of dexamethasone negative alterations on behavior and hippocampal neurogenesis in the mouse brain. J Steroid Biochem Mol Biol. 143:72–80.
  • Schmidt U, Wochnik GM, Rosenhagen MC, Young JC, Hartl FU, Holsboer F, Rein T. 2003. Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor. J Biol Chem. 278(7):4926–4931.
  • Sebbag-Sznajder N, Raitskin O, Angenitzki M, Sato TA, Sperling J, Sperling R. 2012. Regulation of alternative splicing within the supraspliceosome. J Struct Biol. 177(1):152–159.
  • Szczepankiewicz A, Leszczyńska-Rodziewicz A, Pawlak J, Narozna B, Rajewska-Rager A, Wilkosc M, Zaremba D, Maciukiewicz M, Twarowska-Hauser J. 2014. FKBP5 polymorphism is associated with major depression but not with bipolar disorder. J Affect Disord. 164:33–37.
  • Szczepankiewicz A, Leszczyńska-Rodziewicz A, Pawlak J, Rajewska-Rager A, Dmitrzak-Weglarz M, Wilkosc M, Skibinska M, Hauser J. 2011. Glucocorticoid receptor polymorphism is associated with major depression and predominance of depression in the course of bipolar disorder. J Affect Disord. 134(1-3):138–144.
  • Szczepankiewicz A, Narozna B, Rybakowski JK, Kliwicki S, Czerski P, Dmitrzak-Węglarz M, Skibińska M, Twarowska-Hauser J, Pawlak J. 2018. Genes involved in stress response influence lithium efficacy in bipolar patients. Bipolar Disord. 20(8):753–760.
  • Tatro ET, Everall IP, Masliah E, Hult BJ, Lucero G, Chana G, Soontornniyomkij V, Achim CL, Center H. 2009. Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder. J Neuroimmune Pharmacol. 4(2):218–226.
  • Wang Y, Jin S, Li N, Liu J, Shi H, Li Y. 2015. Systematic study of stress-inducible protein 1 (Stip1) in male reproductive system and its expression during stress response. Gene. 554(1):58–63.
  • Wang Q, Verweij EW, Krugers HJ, Joels M, Swaab DF, Lucassen PJ. 2014. Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients. Brain Struct Funct. 219(5):1615–1626.
  • Watanuki T, Funato H, Uchida S, Matsubara T, Kobayashi A, Wakabayashi Y, Otsuki K, Nishida A, Watanabe Y. 2008. Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients. J Affect Disord. 110(1–2):62–69.
  • Wei Q, Lu XY, Liu L, Schafer G, Shieh KR, Burke S, Robinson TE, Watson SJ, Seasholtz AF, Akil H. 2004. Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional lability. Proc Natl Acad Sci USA. 101(32):11851–11856.
  • Willner P, Bergman J, Vanderschuren L, Ellenbroek B. 2015. Pharmacological approaches to the study of social behaviour. Behav Pharmacol. 26(6):501–504.
  • Willour VL, Chen H, Toolan J, Belmonte P, Cutler DJ, Goes FS, Zandi PP, Lee RS, MacKinnon DF, Mondimore FM, Schweizer B. 2009. Family-based association of FKBP5 in bipolar disorder. Mol Psychiatry. 14(3):261–268.
  • Wochnik GM, Ruegg J, Abel GA, Schmidt U, Holsboer F, Rein T. 2005. FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells. J Biol Chem. 280(6):4609–4616.
  • Woo H, Hong CJ, Jung S, Choe S, Yu SW. 2018. Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling. Mol Brain. 11(1):37
  • Wulsin AC, Herman JP, Solomon MB. 2010. Mifepristone decreases depression-like behavior and modulates neuroendocrine and central hypothalamic-pituitary-adrenocortical axis responsiveness to stress. Psychoneuroendocrinology. 35(7):1100–1112.
  • Xu J, Wang R, Liu Y, Liu D, Jiang H, Pan F. 2017. FKBP5 and specific microRNAs via glucocorticoid receptor in the basolateral amygdala involved in the susceptibility to depressive disorder in early adolescent stressed rats. J Psychiatr Res. 95:102–113.
  • Yan XB, Tang CH, Huang Y, Fang H, Yu ZQ, Wu LM, Liu RY. 2010. Alternative splicing in exon 9 of glucocorticoid receptor pre-mRNA is regulated by SRp40. Mol Biol Rep. 37(3):1427–1433.
  • Yitzhaki S, Miriami E, Sperling R, Sperling J. 1996. Phosphorylated Ser/Arg-rich proteins: limiting factors in the assembly of 200S large nuclear ribonucleoprotein particles. Proc Natl Acad Sci USA. 93(17):8830–8835.
  • Young AH, Gallagher P, Watson S, Del-Estal D, Owen BM, Ferrier IN. 2004. Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. Neuropsychopharmacology. 29(8):1538–1545.
  • Zhou R, Gray NA, Yuan P, Li X, Chen J, Chen G, Damschroder-Williams P, Du J, Zhang L, Manji HK. 2005. The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers. J Neurosci. 25(18):4493–4502.
  • Zobel A, Schuhmacher A, Jessen F, Höfels S, von Widdern O, Metten M, Pfeiffer U, Hanses C, Becker T, Rietschel M, et al. 2010. DNA sequence variants of the FKBP5 gene are associated with unipolar depression. Int J Neuropsychopharmacol. 13(5):649–660.

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