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Original Investigation

Depressive symptoms are not associated with long-term integrated testosterone concentrations in hair

ORCID Icon, , , , , , , & show all
Pages 288-300 | Received 07 Aug 2019, Accepted 06 Jul 2020, Published online: 27 Jul 2020

References

  • Akil H, Gordon J, Hen R, Javitch J, Mayberg H, McEwen B, Meaney MJ, Nestler EJ. 2018. Treatment resistant depression: a multi-scale, systems biology approach. Neurosci Biobehav Rev. 84:272–288.
  • Almeida OP, Yeap BB, Hankey GJ, Jamrozik K, Flicker L. 2008. Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men. Arch Gen Psychiatry. 65(3):283–289.
  • Antonio L, Wu FCW, O’Neill TW, Pye SR, Ahern TB, Laurent MR, Huhtaniemi IT, Lean MEJ, Keevil BG, Rastrelli G, et al. 2016. Low free testosterone is associated with hypogonadal signs and symptoms in men with normal total testosterone. J Clin Endocrinol Metab. 101(7):2647–2657.
  • Asselmann E, Kische H, Haring R, Hertel J, Schmidt C-O, Nauck M, Beesdo-Baum K, Grabe H-J, Pané-Farré CA. 2019. Prospective associations of androgens and sex hormone-binding globulin with 12-month, lifetime and incident anxiety and depressive disorders in men and women from the general population. J Affect Disord. 245:905–911.
  • Barrett-Connor E, Von Mühlen DG, Kritz-Silverstein D. 1999. Bioavailable testosterone and depressed mood in older men: the Rancho Bernardo study. J Clin Endocrinol Metab. 84(2):573–577.
  • Barrett-Connor E, Von Mühlen DG, Laughlin GA, Kripke A. 1999. Endogenous levels of dehydroepiandrosterone sulfate, but not other sex hormones, are associated with depressed mood in older women: the Rancho Bernardo study. J Am Geriatr Soc. 47(6):685–691.
  • Bhasin S, Brito JP, Cunningham GR, Hayes FJ, Hodis HN, Matsumoto AM, Snyder PJ, Swerdloff RS, Wu FC, Yialamas MA. 2018. Testosterone therapy in men with hypogonadism: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 103(5):1715–1744.
  • Bollen KA, Curran PJ. 2004. Autoregressive latent trajectory (ALT) models a synthesis of two traditions. Sociol Meth Res. 32(3):336–383.
  • Bromberger JT, Schott LL, Kravitz HM, Sowers M, Avis NE, Gold EB, Randolph JF, Matthews KA. 2010. Longitudinal change in reproductive hormones and depressive symptoms across the menopausal transition: results from the Study of Women’s Health Across the Nation (SWAN). Arch Gen Psychiatry. 67(6):598–607.
  • Carrier N, Saland SK, Duclot F, He H, Mercer R, Kabbaj M. 2015. The anxiolytic and antidepressant-like effects of testosterone and estrogen in gonadectomized male rats. Biol Psychiatry. 78(4):259–269.
  • Chambers KC, Phoenix CH. 1981. Diurnal patterns of testosterone, dihydrotestosterone, estradiol, and cortisol in serum of rhesus males: relationship to sexual behavior in aging males. Horm Behav. 15(4):416–426.
  • Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y. 2018. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. 391(10128):P1357–P1366.
  • Colangelo LA, Craft LL, Ouyang P, Liu K, Schreiner PJ, Michos ED, Gapstur SM. 2012. Association of sex hormones and SHBG with depressive symptoms in post-menopausal women: the multi-ethnic study of atherosclerosis. Menopause. 19(8):877–885.
  • Davis SR, van der Mooren MJ, van Lunsen RHW, Lopes P, Ribot C, Ribot J, Rees M, Moufarege A, Rodenberg C, Buch A, et al. 2006. Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Menopause. 13(3):387–396.
  • Dettenborn L, Hinkelmann K, Muhtz C, Gao W, Wingenfeld K, Spitzer C, Moritz S, Kirschbaum C, Otte C. 2013. Hair testosterone and visuospatial memory in middle-aged men and women with and without depressive symptoms. Psychoneuroendocrinology. 38(10):2373–2377.
  • Dettenborn L, Kirschbaum C, Gao W, Spitzer C, Roepke S, Otte C, Wingenfeld K. 2016. Increased hair testosterone but unaltered hair cortisol in female patients with borderline personality disorder. Psychoneuroendocrinology. 71:176–179.
  • Dias RS, Kerr-Corrêa F, Moreno RA, Trinca LA, Pontes A, Halbe HW, Gianfaldoni A, Dalben IS. 2006. Efficacy of hormone therapy with and without methyltestosterone augmentation of venlafaxine in the treatment of postmenopausal depression: a double-blind controlled pilot study. Menopause. 13(2):202–211.
  • Fiacco S, Walther A, Ehlert U. 2019. Steroid secretion in healthy aging. Psychoneuroendocrinology. 105:64–78.
  • Fischer S, Ehlert U, Amiel Castro R. 2019. Hormones of the hypothalamic-pituitary-gonadal (HPG) axis in male depressive disorders – a systematic review and meta-analysis. Front Neuroendocrinol. 55:100792.
  • Ford AH, Yeap BB, Flicker L, Hankey GJ, Chubb SAP, Handelsman DJ, Golledge J, Almeida OP. 2016. Prospective longitudinal study of testosterone and incident depression in older men: the Health In Men Study. Psychoneuroendocrinology. 64:57–65.
  • Gao W, Kirschbaum C, Grass J, Stalder T. 2016. LC-MS based analysis of endogenous steroid hormones in human hair. J Steroid Biochem Mol Biol. 162:92–99.
  • Gao W, Stalder T, Foley P, Rauh M, Deng H, Kirschbaum C. 2013. Quantitative analysis of steroid hormones in human hair using a column-switching LC-APCI-MS/MS assay. J Chromatogr B Analyt Technol Biomed Life Sci. 928:1–8.
  • Geniole SN, Bird BM, Ruddick EL, Carré JM. 2017. Effects of competition outcome on testosterone concentrations in humans: an updated meta-analysis. Horm Behav. 92:37–50.
  • Giltay EJ, Enter D, Zitman FG, Penninx BWJH, van Pelt J, Spinhoven P, Roelofs K. 2012. Salivary testosterone: associations with depression, anxiety disorders, and antidepressant use in a large cohort study. J Psychosom Res. 72(3):205–213.
  • Goldstat R, Briganti E, Tran J, Wolfe R, Davis SR. 2003. Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women. Menopause. 10(5):390–398.
  • Hammond GL, Wu T-S, Simard M. 2012. Evolving utility of sex hormone-binding globulin measurements in clinical medicine. Curr Opin Endocrinol Diabetes Obes. 19:183–189.
  • Hayes LD, Sculthorpe N, Herbert P, Baker JS, Hullin DA, Kilduff LP, Grace FM. 2015. Poor levels of agreement between serum and saliva testosterone measurement following exercise training in aging men. Aging Male. 18(2):67–70.
  • Hooper D, Coughlan J, Mullen M. 2008. Structural equation modelling: guidelines for determining model fit. Electronic J Business Res Meth. 6(1):53–60.
  • Jahangard L, Mikoteit T, Bahiraei S, Zamanibonab M, Haghighi M, Sadeghi Bahmani D, Brand S. 2019. Prenatal and postnatal hair steroid levels predict post-partum depression 12 weeks after delivery. J Clin Med. 8(9):1290.
  • Kapoor A, Schultz-Darken N, Ziegler TE. 2018. Radiolabel validation of cortisol in the hair of rhesus monkeys. Psychoneuroendocrinology. 97:190–195.
  • Kische H, Gross S, Wallaschofski H, Grabe HJ, Völzke H, Nauck M, Haring R. 2017. Associations of androgens with depressive symptoms and cognitive status in the general population. PLoS One 12(5):e0177272.
  • Kische H, Pieper L, Venz J, Klotsche J, März W, Koch-Gromus U, Pittrow D, Lehnert H, Silber S, Stalla GK, et al. 2018. Longitudinal change instead of baseline testosterone predicts depressive symptoms. Psychoneuroendocrinology. 89:7–12.
  • Korenman S, Grotts J, Bell D, Elashoff D. 2018. Depression in non-classical hypogonadism in young men. J Endocr Soc. 2(11):1306–1313.
  • Kranz GS, Wadsak W, Kaufmann U, Savli M, Baldinger P, Gryglewski G, Haeusler D, Spies M, Mitterhauser M, Kasper S, et al. 2015. High-dose testosterone treatment increases serotonin transporter binding in transgender people. Biol Psychiatry. 78(8):525–533.
  • Kroenke K, Spitzer RL. 2002. The PHQ-9: a new depression measure. Psychiatr Ann. 32:1–7.
  • Kroenke K, Spitzer RL, Williams J. 2001. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 16(9):606–613.
  • Lomax RG, Schumacker RE. 2012. A beginner’s guide to structural equation modeling. 4th ed. New York (NY): Routledge Academic.
  • Mahmoud R, Wainwright SR, Galea L. 2016. Sex hormones and adult hippocampal neurogenesis: regulation, implications, and potential mechanisms. Front Neuroendocrinol. 41:129–152.
  • Matsuzaka H, Maeshima H, Kida S, Kurita H, Shimano T, Nakano Y, Baba H, Suzuki T, Arai H. 2013. Gender differences in serum testosterone and cortisol in patients with major depressive disorder compared with controls. Int J Psychiatry Med. 46(2):203–221.
  • Miller KK, Perlis RH, Papakostas GI, Mischoulon D, Iosifescu DV, Brick DJ, Fava M. 2009. Low-dose transdermal testosterone augmentation therapy improves depression severity in women. CNS Spectr. 14(12):688–694.
  • Mitchell AJ, Yadegarfar M, Gill J, Stubbs B. 2016. Case finding and screening clinical utility of the Patient Health Questionnaire (PHQ-9 and PHQ-2) for depression in primary care: a diagnostic meta-analysis of 40 studies. BJPsych Open 2(2):127–138.
  • National Collaborating Centre for Mental Health UK. 2010. Depression: the treatment and management of depression in adults. Leicester (UK): British Psychological Society.
  • Penz M, Wekenborg MK, Pieper L, Beesdo-Baum K, Walther A, Miller R, Stalder T, Kirschbaum C. 2018. The Dresden Burnout Study: protocol of a prospective cohort study for the bio-psychological investigation of burnout. Int J Methods Psychiatr Res. 27(2):e1613.
  • R Core Team. 2013. R development core team. RA Lang Environ Stat Comput. 55:275–286.
  • Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, Niederehe G, Thase ME, Lavori PW, Lebowitz BD, et al. 2006. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR* D report. Am J Psychiatry. 163(11):1905–1917.
  • Schneider G, Zitzmann M, Gromoll J, Ladwig KH, Berger K. 2013. The relation between sex hormone levels, the androgen receptor CAGn-polymorphism and depression and mortality in older men in a community study. Psychoneuroendocrinology 38(10):2083–2090.
  • Sjöberg B, De La Torre B, Hedman M, Falkay G, Diczfalusy E. 1979. Circadian variation in systemic hormone levels in healthy men. J Endocrinol Invest. 2(2):131–137.
  • Stalder T, Kirschbaum C. 2012. Brain, behavior, and immunity analysis of cortisol in hair – state of the art and future directions. Brain, Behav Immun. 26(7):1019–1029.
  • T’Sjoen GG, De Vos S, Goemaere S, Van Pottelbergh I, Dierick M, Van Heeringen C, Kaufman J-M. 2005. Sex steroid level, androgen receptor polymorphism, and depressive symptoms in healthy elderly men. J Am Geriatr Soc. 53(4):636–642.
  • van Manen MJG, Wester VL, van Rossum EFC, van den Toorn LM, Dorst KY, de Rijke YB, Wijsenbeek MS. 2019. Scalp hair cortisol and testosterone levels in patients with sarcoidosis. PLoS One 14(6):e0215763.
  • Walther A, Breidenstein J, Miller R. 2019. Association of testosterone treatment with alleviation of depressive symptoms in men: a systematic review and meta-analysis. JAMA Psychiatry 76(1):31–40.
  • Walther A, Philipp M, Lozza N, Ehlert U. 2016. The rate of change in declining steroid hormones: a new parameter of healthy aging in men? Oncotarget 7(38):60844–60857.
  • Walther A, Seuffert J. 2020. Testosterone and dehydroepiandrosterone treatment in ageing men: are we all set? World J Mens Health. 38(2):178–190.
  • Walther A, Tsao C, Pande R, Kirschbaum C, Field E, Berkman L. 2019. Do dehydroepiandrosterone, progesterone, and testosterone influence women’s depression and anxiety levels? Evidence from hair-based hormonal measures of 2105 rural Indian women. Psychoneuroendocrinology. 109:104382.
  • Walther A, Wasielewska JM, Leiter O. 2019. The antidepressant effect of testosterone: an effect of neuroplasticity? Neurol Psychiatry Brain Res. 32:104–110.
  • Weber B, Lewicka S, Deuschle M, Colla M, Heuser I. 2000. Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depression. Psychoneuroendocrinology. 25(8):765–771.
  • Wennig R. 2000. Potential problems with the interpretation of hair analysis results. Forensic Sci Int. 107(1–3):5–12.
  • Westley CJ, Amdur RL, Irwig MS. 2015. High rates of depression and depressive symptoms among men referred for borderline testosterone levels. J Sex Med. 12(8):1753–1760.
  • Wierman ME, Arlt W, Basson R, Davis SR, Miller KK, Murad MH, Rosner W, Santoro N. 2014. Androgen therapy in women: a reappraisal: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 99(10):3489–3510.
  • World Health Organization. 2017. Depression and other common mental disorders global health estimates. Geneva (Switzerland): WHO.
  • Wu FCW, Tajar A, Beynon JM, Pye SR, Silman AJ, Finn JD, O’Neill TW, Bartfai G, Casanueva FF, Forti G, et al. 2010. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med. 363(2):123–135.

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