SNX29, a new susceptibility gene shared with major mental disorders in Han Chinese population

References

• Alonso J, Petukhova M, Vilagut G, Chatterji S, Heeringa S, Ustun TB, Alhamzawi AO, Viana MC, Angermeyer M, Bromet E, et al. 2011. Days out of role due to common physical and mental conditions: results from the WHO World Mental Health surveys. Mol Psychiatry. 16:1234–1246.
   PubMed Web of Science ®Google Scholar
• Bao F, Deng Y, Du M, Ren Z, Zhang Q, Zhao Y, Suo J, Zhang Z, Wang M, Dai Q. 2018. Probabilistic natural mapping of gene-level tests for genome-wide association studies. Brief Bioinform. 19:545–553.
   PubMed Web of Science ®Google Scholar
• Borelli CM, Solari H. 2019. Schizophrenia. JAMA. 322:1322.
   PubMedGoogle Scholar
• Børglum AD, Demontis D, Grove J, Pallesen J, Hollegaard MV, Pedersen CB, Hedemand A, Mattheisen M, Uitterlinden A, Nyegaard M, et al.; GROUP investigators10. 2014. Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. Mol Psychiatry. 19:325–333.
   PubMed Web of Science ®Google Scholar
• Brainstorm C, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, et al. 2018. Analysis of shared heritability in common disorders of the brain. Science. 360:eaap8757.
   PubMed Web of Science ®Google Scholar
• Breen MS, Dobbyn A, Li Q, Roussos P, Hoffman GE, Stahl E, Chess A, Sklar P, Li JB, Devlin B, et al.; CommonMind Consortium. 2019. Global landscape and genetic regulation of RNA editing in cortical samples from individuals with schizophrenia. Nat Neurosci. 22:1402–1412.
   PubMed Web of Science ®Google Scholar
• Burmeister M, McInnis MG, Zollner S. 2008. Psychiatric genetics: progress amid controversy. Nat Rev Genet. 9:527–540.
   PubMed Web of Science ®Google Scholar
• Callebaut I, de Gunzburg J, Goud B, Mornon JP. 2001. RUN domains: a new family of domains involved in Ras-like GTPase signaling. Trends Biochem Sci. 26:79–83.
   PubMed Web of Science ®Google Scholar
• Cannon TD, Keller MC. 2006. Endophenotypes in the genetic analyses of mental disorders. Annu Rev Clin Psychol. 2:267–290.
   PubMed Web of Science ®Google Scholar
• Cao J, Zhao S, Wei W, Li X, Liu H, Dong Q. 2014. A genome-wide association study of five meat quality traits in Yorkshire pigs. Front Agr Sci Eng. 1:137–143.
   Google Scholar
• Consortium C. 2015. Sparse whole-genome sequencing identifies two loci for major depressive disorder. Nature. 523:588–591.
   PubMed Web of Science ®Google Scholar
• Craddock N, Sklar P. 2013. Genetics of bipolar disorder. Lancet (London, England). 381:1654–1662.
   PubMed Web of Science ®Google Scholar
• Cross-Disorder Group of the Psychiatric Genomics C. 2013. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet (London, England). 381:1371–1379.
   PubMed Web of Science ®Google Scholar
• Cross-Disorder Group of the Psychiatric Genomics C, Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, et al. 2013. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet. 45:984–994.
   PubMed Web of Science ®Google Scholar
• Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, et al. 2018. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun. 9:2098.
   PubMed Web of Science ®Google Scholar
• de Bakker PI, Burtt NP, Graham RR, Guiducci C, Yelensky R, Drake JA, Bersaglieri T, Penney KL, Butler J, Young S, et al. 2006. Transferability of tag SNPs in genetic association studies in multiple populations. Nat Genet. 38:1298–1303.
   PubMed Web of Science ®Google Scholar
• de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D. 2005. Efficiency and power in genetic association studies. Nat Genet. 37:1217–1223.
   PubMed Web of Science ®Google Scholar
• Flury C, Boschung C, Denzler M, Bapst B, Schnyder U, Gredler B, Signer-Hasler H. 2014. Genome-wide association study for 13 udder traits from linear type classification in cattle. Proceedings of the 10th World Congress on Genetics Applied to Livestock Production.
   Google Scholar
• Green EK, Rees E, Walters JT, Smith KG, Forty L, Grozeva D, Moran JL, Sklar P, Ripke S, Chambert KD, et al. 2016. Copy number variation in bipolar disorder. Mol Psychiatry. 21:89–93.
   PubMed Web of Science ®Google Scholar
• Harrison PJ. 2016. Molecular neurobiological clues to the pathogenesis of bipolar disorder. Curr Opin Neurobiol. 36:1–6.
   PubMed Web of Science ®Google Scholar
• Hill WD, Marioni RE, Maghzian O, Ritchie SJ, Hagenaars SP, McIntosh AM, Gale CR, Davies G, Deary IJ. 2019. A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence. Mol Psychiatry. 24:169–181.
   PubMed Web of Science ®Google Scholar
• Howard DM, Adams MJ, Shirali M, Clarke TK, Marioni RE, Davies G, Coleman JRI, Alloza C, Shen X, Barbu MC, et al.; 23andMe Research Team. 2018. Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways. Nat Commun. 9:1470.
   PubMedGoogle Scholar
• Huckins LM, Dobbyn A, Ruderfer DM, Hoffman G, Wang W, Pardiñas AF, Rajagopal VM, Als TD, T Nguyen H, Girdhar K, et al.; iPSYCH-GEMS Schizophrenia Working Group. 2019. Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nat Genet. 51:659–674.
   PubMed Web of Science ®Google Scholar
• International HapMap C. 2003. The International HapMap Project. Nature. 426:789–796.
   PubMed Web of Science ®Google Scholar
• Iossifov I, O'Roak BJ, Sanders SJ, Ronemus M, Krumm N, Levy D, Stessman HA, Witherspoon KT, Vives L, Patterson KE, et al. 2014. The contribution of de novo coding mutations to autism spectrum disorder. Nature. 515:216–221.
   PubMed Web of Science ®Google Scholar
• Kahn RS, Sommer IE, Murray RM, Meyer-Lindenberg A, Weinberger DR, Cannon TD, O'Donovan M, Correll CU, Kane JM, van Os J, et al. 2015. Schizophrenia. Nat Rev Dis Primers. 1:15067.
   PubMed Web of Science ®Google Scholar
• Karayiorgou M, Gogos JA. 1997. A turning point in schizophrenia genetics. Neuron. 19:967–979.
   PubMed Web of Science ®Google Scholar
• Kirov G, Rees E, Walters J. 2015. What a psychiatrist needs to know about copy number variants. BJPsych Advances. 21:157–163.
   Google Scholar
• Kudinov A, Mishina A, Smaragdov M. 2018. WPSII-4 Population structure and Holstein ancestry analysis of modern Russian Black and White cattle for accurate genetic evaluation in Leningrad region. J Anim Sci. 96:516–516.
   Web of Science ®Google Scholar
• Lam M, Chen CY, Li Z, Martin AR, Bryois J, Ma X, Gaspar H, Ikeda M, Benyamin B, Brown BC, et al.; Genetic REsearch on schizophreniA neTwork-China and the Netherlands (GREAT-CN). 2019. Comparative genetic architectures of schizophrenia in East Asian and European populations. Nat Genet. 51:1670–1678.
   PubMed Web of Science ®Google Scholar
• Langfelder P, Horvath S. 2008. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 9:559.
   PubMed Web of Science ®Google Scholar
• Lee JJ, Wedow R, Okbay A, Kong E, Maghzian O, Zacher M, Nguyen-Viet TA, Bowers P, Sidorenko J, Karlsson Linner R, et al.; Social Science Genetic Association Consortium. 2018. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nat Genet. 50:1112–1121.
   PubMed Web of Science ®Google Scholar
• Li Z, Chen J, Yu H, He L, Xu Y, Zhang D, Yi Q, Li C, Li X, Shen J, et al. 2017. Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia. Nat Genet. 49:1576–1583.
   PubMed Web of Science ®Google Scholar
• Li Z, Zhang Z, He Z, Tang W, Li T, Zeng Z, He L, Shi Y. 2009. A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://analysis.bio-x.cn). Cell Res. 19:519–523.
   PubMed Web of Science ®Google Scholar
• Liu M, Woodward-Greene J, Kang X, Pan MG, Rosen B, Van Tassell CP, Chen H, Liu GE. 2020. Genome-wide CNV analysis revealed variants associated with growth traits in African indigenous goats. Genomics. 112:1477–1480.
   PubMed Web of Science ®Google Scholar
• Nothen MM, Nieratschker V, Cichon S, Rietschel M. 2010. New findings in the genetics of major psychoses. Dialogues Clin Neurosci. 12:85–93.
   PubMedGoogle Scholar
• O'Donovan MC, Craddock NJ, Owen MJ. 2009. Genetics of psychosis; insights from views across the genome. Hum Genet. 126:3–12.
   PubMed Web of Science ®Google Scholar
• Owen MJ, Sawa A, Mortensen PB. 2016. Schizophrenia. Lancet (London, England). 388:86–97.
   PubMed Web of Science ®Google Scholar
• Pardinas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S, Cameron D, Hamshere ML, et al.; CRESTAR Consortium. 2018. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nat Genet. 50:381–389.
   PubMed Web of Science ®Google Scholar
• Schizophrenia Working Group of the Psychiatric Genomics C. 2014. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 511:421–427.
   PubMed Web of Science ®Google Scholar
• Schork AJ, Won H, Appadurai V, Nudel R, Gandal M, Delaneau O, Revsbech Christiansen M, Hougaard DM, Baekved-Hansen M, Bybjerg-Grauholm J, et al. 2019. A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment. Nat Neurosci. 22:353–361.
   PubMed Web of Science ®Google Scholar
• Shen J, Li Z, Chen J, Song Z, Zhou Z, Shi Y. 2016. SHEsisPlus, a toolset for genetic studies on polyploid species. Sci Rep. 6:24095.
   PubMed Web of Science ®Google Scholar
• Shi YY, He L. 2005. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 15:97–98.
   PubMed Web of Science ®Google Scholar
• Smoller JW, Finn CT. 2003. Family, twin, and adoption studies of bipolar disorder. Am J Med Genet C Semin Med Genet. 123C:48–58.
   PubMed Web of Science ®Google Scholar
• Steidl C, Shah SP, Woolcock BW, Rui L, Kawahara M, Farinha P, Johnson NA, Zhao Y, Telenius A, Neriah SB, et al. 2011. MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers. Nature. 471:377–381.
   PubMed Web of Science ®Google Scholar
• Tiihonen J, Koskuvi M, Storvik M, Hyotylainen I, Gao Y, Puttonen KA, Giniatullina R, Poguzhelskaya E, Ojansuu I, Vaurio O, et al. 2019. Sex-specific transcriptional and proteomic signatures in schizophrenia. Nat Commun. 10:3933.
   PubMed Web of Science ®Google Scholar
• Trifu SC, Kohn B, Vlasie A, Patrichi B-E. 2020. Genetics of schizophrenia (Review). Exp Ther Med. 20:3462–3468.
   PubMed Web of Science ®Google Scholar
• Wang Z, Ma H, Xu L, Zhu B, Liu Y, Bordbar F, Chen Y, Zhang L, Gao X, Gao H, et al. 2019. Genome-Wide Scan Identifies Selection Signatures in Chinese Wagyu Cattle Using a High-Density SNP Array. Animals (Basel). 9:296.
   Google Scholar
• Wishart MJ, Taylor GS, Dixon JE. 2001. Phoxy lipids: revealing PX domains as phosphoinositide binding modules. Cell. 105:817–820.
   PubMed Web of Science ®Google Scholar
• Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, et al.; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. 2018. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet. 50:668–681.
   PubMed Web of Science ®Google Scholar
• Xia L, Ou J, Li K, Guo H, Hu Z, Bai T, Zhao J, Xia K, Zhang F. 2020. Genome-wide association analysis of autism identified multiple loci that have been reported as strong signals for neuropsychiatric disorders. Autism Res. 13:382–396.
   PubMed Web of Science ®Google Scholar
• Zhu L, Hu Z, Liu J, Gao J, Lin B. 2015. Gene expression profile analysis identifies metastasis and chemoresistance-associated genes in epithelial ovarian carcinoma cells. Med Oncol. 32:426.
   PubMed Web of Science ®Google Scholar