Microglia and HPA axis in depression: An overview of participation and relationship

References

• Ago Y, Arikawa S, Yata M, Yano K, Abe M, Takuma K, Matsuda T. 2008. Antidepressant-like effects of the glucocorticoid receptor antagonist RU-43044 are associated with changes in prefrontal dopamine in mouse models of depression. Neuropharmacology. 55(8):1355–1363.
   PubMed Web of Science ®Google Scholar
• Ahmed Z, Shaw G, Sharma VP, Yang C, Mcgowan E, Dickson DW. 2007. Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry. J Histochem Cytochem. 55(7):687–700.
   PubMed Web of Science ®Google Scholar
• Alzarea S, Rahman S. 2018. Effects of alpha-7 nicotinic allosteric modulator PNU 120596 on depressive-like behavior after lipopolysaccharide administration in mice. Prog Neuropsychopharmacol Biol Psychiatry. 86:218–228.
   PubMed Web of Science ®Google Scholar
• Anacker C, Zunszain PA, Carvalho LA, Pariante CM. 2011. The glucocorticoid receptor: pivot of depression and of antidepressant treatment? Psychoneuroendocrinology. 36(3):415–425.
   PubMed Web of Science ®Google Scholar
• Athira K, Mohanrao R, Chandran I, Lahkar M, Sinha S, Naidu VGM. 2018. Antidepressant activity of vorinostat is associated with amelioration of oxidative stress and inflammation in a corticosterone-induced chronic stress model in mice. Behav Brain Res. 344:73–84.
   PubMed Web of Science ®Google Scholar
• Béchade C, Cantaut-Belarif Y, Bessis A. 2013. Microglial control of neuronal activity. Front Cell Neurosci. 7:1–7.
   PubMed Web of Science ®Google Scholar
• Bellavance MA, Rivest S. 2014. The HPA - immune axis and the immunomodulatory actions of glucocorticoids in the brain. Front Immunol. 5:1–14.
   PubMed Web of Science ®Google Scholar
• Berkenbosch F, Van Oers JD, Rey A, Tilders F, Besedovsky H. 1987. Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science. 238:524–526.
   PubMed Web of Science ®Google Scholar
• Bhatia HS, Baron J, Hagl S, Eckert GP, Fiebich BL. 2016. Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway. J Neuroinflammation. 13:1–16.
   PubMed Web of Science ®Google Scholar
• Biber K, Neumann H, Inoue K, Boddeke HWGM. 2007. Neuronal ‘On’ and ‘Off’ signals control microglia. Trends Neurosci. 30(11):596–602.
   PubMed Web of Science ®Google Scholar
• Borsini A, Zunszain PA, Thuret S, Pariante CM. 2015. The role of inflammatory cytokines as key modulators of neurogenesis. Trends Neurosci. 38(3):145–157.
   PubMed Web of Science ®Google Scholar
• Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, Charney DS. 2000. Hippocampal volume reduction in major depression. Am J Psychiatry. 157(1):115–117.
   PubMed Web of Science ®Google Scholar
• Brites D, Fernandes A. 2015. Neuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulation. Front Cell Neurosci. 9:1–20.
   PubMed Web of Science ®Google Scholar
• Busillo JM, Azzam KM, Cidlowski JA. 2011. Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome. J Biol Chem. 286(44):38703–38713.
   PubMed Web of Science ®Google Scholar
• Caldeira Cáu, Oliveira AF, Cunha C, Vaz AR, FalcãO AS, Fernandes A, Brites D. 2014. Microglia change from a reactive to an age-like phenotype with the time in culture. Front Cell Neurosci. 8:1–16.
   PubMed Web of Science ®Google Scholar
• Carabotti M, Scirocco A, Maselli MA, Severi C. 2015. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 28(2):203–209.
   PubMed Web of Science ®Google Scholar
• Caraffa A, Gallenga CE, Kritas SK, Ronconi G, Conti P. 2019. Impact of mast cells in systemic lupus erythematosus: can inflammation be inhibited? J Biol Regul Homeost Agents. 33(3):669–673.
   PubMed Web of Science ®Google Scholar
• Carroll BJ, Cassidy F, Naftolowitz D, Tatham NE, Wilson WH, Iranmanesh A, Liu PY, Veldhuis JD. 2007. Pathophysiology of hypercortisolism in depression. Acta Psychiatr Scand. 115(s433):90–103.
   Google Scholar
• Chen M, Guilarte TR. 2008. Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair. Pharmacol Ther. 118(1):1–17.
   PubMed Web of Science ®Google Scholar
• Chiu WC, Su YP, Su KP, Chen PC. 2017. Recurrence of depressive disorders after interferon-induced depression. Transl Psychiatry. 7:1–9.
   Web of Science ®Google Scholar
• Chrousos GP, Gold PW. 1992. The concepts of stress and stress system disorders overview of homeostasis. Jama. 267(9):1244–1252.
   PubMed Web of Science ®Google Scholar
• Colonna M, Butovsky O. 2017. Microglia function in the central nervous system during health and neurodegeneration. Annu Rev Immunol. 35:441–468.
   PubMed Web of Science ®Google Scholar
• Conti P, Lauritano D, Caraffa A, Gallenga CE, Kritas SK, Ronconi G, Martinotti S. 2020. Microglia and mast cells generate proinflammatory cytokines in the brain and worsen inflammatory state: suppressor effect of IL-37. Eur J Pharmacol. 875:173035..
   PubMed Web of Science ®Google Scholar
• Cosgriff JP, Abbott RM, Oakley-Browne MA, Joyce PR. 1990. Cortisol hypersecretion predicts early depressive relapse after recovery with electroconvulsive therapy. Biol Psychiatry. 28(11):1007–1010.
   PubMed Web of Science ®Google Scholar
• Coutinho AE, Chapman KE. 2011. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol. 335(1):2–13.
   PubMed Web of Science ®Google Scholar
• Cruz-Topete D, Cidlowski JA. 2015. One hormone, two actions: Anti- and pro-inflammatory effects of glucocorticoids. Neuroimmunomodulation. 22(1-2):20–32.
   PubMed Web of Science ®Google Scholar
• David DJ, Samuels BA, Rainer Q, Wang J-W, Marsteller D, Mendez I, Drew M, Craig DA, Guiard BP, Guilloux J-P, et al. 2009. Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron. 62(4):479–493.
   PubMed Web of Science ®Google Scholar
• de Kloet ER, Sibug RM, Helmerhorst FM, Schmidt MV, Schmidt M. 2005. Stress, genes and the mechanism of programming the brain for later life. Neurosci Biobehav Rev. 29(2):271–281.
   PubMed Web of Science ®Google Scholar
• DeMorrow S. 2018. Role of the hypothalamic – pituitary – adrenal axis in health and disease. Int J Mol Sci. 19:1–5.
   Web of Science ®Google Scholar
• Di Filippo M, Chiasserini D, Gardoni F, Viviani B, Tozzi A, Giampà C, Costa C, Tantucci M, Zianni E, Boraso M, et al. 2013. Effects of central and peripheral inflammation on hippocampal synaptic plasticity. Neurobiol Dis. 52:229–236.
   PubMed Web of Science ®Google Scholar
• Dong H, Keegan JM, Hong E, Gallardo C, Montalvo-Ortiz J, Wang B, Rice KC, Csernansky J. 2018. Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress- induced behavioral changes and synapse loss in aged rats. Psychoneuroendocrinology. 90:92–101.
   PubMed Web of Science ®Google Scholar
• Doorn KJ, Brevé JJP, Drukarch B, Boddeke HW, Huitinga I, Lucassen PJ, van Dam A-M. 2015. Brain region-specific gene expression profiles in freshly isolated rat microglia. Front Cell Neurosci. 9:1–11.
   PubMed Web of Science ®Google Scholar
• Douma EH, de Kloet ER. 2020. Stress-induced plasticity and functioning of ventral tegmental dopamine neurons. Neurosci Biobehav Rev. 108:48–77.
   PubMed Web of Science ®Google Scholar
• Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctôt KL. 2010. A meta-analysis of cytokines in major depression. Biol Psychiatry. 67(5):446–457.
   PubMed Web of Science ®Google Scholar
• Duan C-M, Zhang J-R, Wan T-F, Wang Y, Chen H-S, Liu L. 2020. SRT2104 attenuates chronic unpredictable mild stress-induced depressive-like behaviors and imbalance between microglial M1 and M2 phenotypes in the mice. Behav Brain Res. 378:112296..
   PubMed Web of Science ®Google Scholar
• Dwivedi Y. 2014. Emerging role of microRNAs in major depressive disorder: diagnosis and therapeutic implications. Dialogues Clin Neurosci. 16(1):43–61.
   PubMed Web of Science ®Google Scholar
• Erny D, Hrabě de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, Keren-Shaul H, Mahlakoiv T, Jakobshagen K, Buch T, et al. 2015. Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 18(7):965–977.
   PubMed Web of Science ®Google Scholar
• Espinosa-Oliva AM, de Pablos RM, Villarán RF, Argüelles S, Venero JL, Machado A, Cano J. 2011. Stress is critical for LPS-induced activation of microglia and damage in the rat hippocampus. Neurobiol Aging. 32(1):85–102.
   PubMed Web of Science ®Google Scholar
• Farooq RK, Tanti A, Ainouche S, Roger S, Belzung C, Camus V. 2018. A P2X7 receptor antagonist reverses behavioural alterations, microglial activation and neuroendocrine dysregulation in an unpredictable chronic mild stress (UCMS) model of depression in mice. Psychoneuroendocrinology. 97:120–130.
   PubMed Web of Science ®Google Scholar
• Felger JC, Lotrich FE. 2013. Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience. 246:199–229.
   PubMed Web of Science ®Google Scholar
• Flores BH, Kenna H, Keller J, Solvason HB, Schatzberg AF. 2006. Clinical and biological effects of mifepristone treatment for psychotic depression. Neuropsychopharmacology. 31(3):628–636.
   PubMed Web of Science ®Google Scholar
• Franchimont D. 2004. Overview of the actions of glucocorticoids on the immune response: a good model to characterize new pathways of immunosuppression for new treatment strategies. Ann N Y Acad Sci. 1024:124–137.
   PubMed Web of Science ®Google Scholar
• Frank MG, Hershman SA, Weber MD, Watkins LR, Maier SF. 2014. Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus. Psychoneuroendocrinology 40:191–200.
   PubMed Web of Science ®Google Scholar
• Frank MG, Miguel ZD, Watkins LR, Maier SF. 2010. Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide. Brain Behav Immun. 24(1):19–30.
   PubMed Web of Science ®Google Scholar
• Freitas AE, Bettio LEB, Neis VB, Santos DB, Ribeiro CM, Rosa PB, Farina M, Rodrigues ALS. 2014. Agmatine abolishes restraint stress-induced depressive-like behavior and hippocampal antioxidant imbalance in mice. Prog Neuropsychopharmacol Biol Psychiatry 50:143–150.
   PubMed Web of Science ®Google Scholar
• Fu R, Shen Q, Xu P, Luo JJ, Tang Y. 2014. Phagocytosis of microglia in the central nervous system diseases. Mol Neurobiol. 49(3):1422–1434.
   PubMed Web of Science ®Google Scholar
• Gądek-Michalska A, Tadeusz J, Rachwalska P, Bugajski J. 2013. Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems. Pharmacol Reports. 65(6):1655–1662.
   PubMed Web of Science ®Google Scholar
• Gaffey AE, Bergeman CS, Clark LA, Wirth MM. 2016. Aging and the HPA axis: stress and resilience in older adults. Neurosci Biobehav Rev. 68:928–945.
   PubMed Web of Science ®Google Scholar
• Gallenga CE, Pandolfi F, Caraffa A, Kritas SK, Ronconi G, Toniato E, Martinotti S, Conti P. 2019. Interleukin-1 family cytokines and mast cells: activation and inhibition. J Biol Regul Homeost Agents. 33(1):1–6.
   PubMed Web of Science ®Google Scholar
• Gao M, Hu P, Cai Z, Wu Y, Wang D, Hu W, Xu X, Zhang Y, Lu X, Chen D, et al. 2019. Identification of a microglial activation-dependent antidepressant effect of amphotericin B liposome. Neuropharmacology. 151:33–44.
   PubMed Web of Science ®Google Scholar
• Gehrmann J, Matsumoto Y, Kreutzberg GW. 1995. Microglia: intrinsic immuneffector cell of the brain. Brain Res Brain Res Rev. 20(3):269–287.
   PubMedGoogle Scholar
• Gertig U, Hanisch U-K. 2014. Microglial diversity by responses and responders. Front Cell Neurosci. 8:1–9.
   PubMed Web of Science ®Google Scholar
• Gibbons JL, McHugh PR. 1962. Plasma cortisol in depressive illness. J Psychiatr Res. 1:162–171.
   PubMed Web of Science ®Google Scholar
• Ginhoux F, Lim S, Hoeffel G, Low D, Huber T. 2013. Origin and differentiation of microglia. Front Cell Neurosci. 7:1–14.
   PubMed Web of Science ®Google Scholar
• Gjerstad JK, Lightman SL, Spiga F. 2018. Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility. Stress. 21(5):403–416.
   PubMed Web of Science ®Google Scholar
• González H, Elgueta D, Montoya A, Pacheco R. 2014. Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases. J Neuroimmunol. 274(1–2):1–13.
   PubMed Web of Science ®Google Scholar
• Goshen I, Yirmiya R. 2009. Interleukin-1 (IL-1): a central regulator of stress responses. Front Neuroendocrinol. 30(1):30–45.
   PubMed Web of Science ®Google Scholar
• Greter M, Merad M. 2013. Regulation of microglia development and homeostasis. Glia. 61(1):121–127.
   PubMed Web of Science ®Google Scholar
• Hamadi N, Sheikh A, Madjid N, Lubbad L, Amir N, Shehab SA-DS, Khelifi-Touhami F, Adem A. 2016. Increased pro-inflammatory cytokines, glial activation and oxidative stress in the hippocampus after short‑term bilateral adrenalectomy. BMC Neurosci. 17(1):1–18.
   PubMedGoogle Scholar
• Han Y, Zhang L, Wang Q, Zhang D, Zhao Q, Zhang J, Xie L, Liu G, You Z. 2019. Minocycline inhibits microglial activation and alleviates depressive-like behaviors in male adolescent mice subjected to maternal separation. Psychoneuroendocrinology. 107:37–45.
   PubMed Web of Science ®Google Scholar
• Hanisch U-K. 2013. Functional diversity of microglia – how heterogeneous are they to begin with ? Front. Cell Neurosci. 7:1–18.
   Google Scholar
• Hansson PB, Murison R, Lund A, Hammar A. 2015. Cognitive functioning and cortisol profiles in first episode major depression. Scand J Psychol. 56(4):379–383.
   PubMed Web of Science ®Google Scholar
• Haque ME, Akther M, Jakaria M, Kim IS, Azam S, Choi DK. 2020. Targeting the microglial NLRP3 inflammasome and its role in Parkinson’s disease. Mov Disord. 35(1):20–33.
   PubMed Web of Science ®Google Scholar
• Harkness KL, Bruce AE, Lumley MN. 2006. The role of childhood abuse and neglect in the sensitization to stressful life events in adolescent depression. J Abnorm Psychol. 115(4):730–741.
   PubMed Web of Science ®Google Scholar
• Hendriksen E, van Bergeijk D, Oosting RS, Redegeld FA. 2017. Mast cells in neuroinflammation and brain disorders. Neurosci Biobehav Rev. 79:119–133.
   PubMed Web of Science ®Google Scholar
• Herman JP, Dolgas CM, Carlson SL. 1998. Ventral subiculum regulates hypothalamo-pituitary-adrenocortical and behavioural responses to cognitive stressors. Neuroscience. 86(2):449–459.
   PubMed Web of Science ®Google Scholar
• Herman JP, McKlveen JM, Solomon MB, Carvalho-Netto E, Myers B. 2012. Neural regulation of the stress response: glucocorticoid feedback mechanisms. Braz J Med Biol Res. 45(4):292–298.
   PubMed Web of Science ®Google Scholar
• Hermoso MA, Matsuguchi T, Smoak K, Cidlowski JA. 2004. Glucocorticoids and tumor necrosis factor alpha cooperatively regulate toll-like receptor 2 gene expression. Mol Cell Biol. 24(11):4743–4756.
   PubMed Web of Science ®Google Scholar
• Hinkelmann K, Moritz S, Botzenhardt J, Riedesel K, Wiedemann K, Kellner M, Otte C. 2009. Cognitive impairment in major depression: association with salivary cortisol. Biol Psychiatry 66(9):879–885.
   PubMed Web of Science ®Google Scholar
• Holsboer F, Ising M. 2008. Central CRH system in depression and anxiety-evidence from clinical studies with CRH1 receptor antagonists. Eur J Pharmacol. 583(2–3):350–357.
   PubMed Web of Science ®Google Scholar
• Horchar MJ, Wohleb ES. 2019. Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress. Brain Behav Immun. 81:329–340.
   PubMed Web of Science ®Google Scholar
• Iob E, Kirschbaum C, Steptoe A. 2019. Persistent depressive symptoms, HPA-axis hyperactivity, and inflammation: the role of cognitive-affective and somatic symptoms. Mol. Psychiatry:1–11.
   Web of Science ®Google Scholar
• Jankord R, Herman JP. 2008. Limbic regulation of hypothalamo-pituitary-adrenocortical function during acute and chronic stress. Ann N Y Acad Sci. 1148(1):64–73.
   PubMedGoogle Scholar
• Juruena MF, Cleare AJ, Papadopoulos AS, Poon L, Lightman S, Pariante CM. 2006. Different responses to dexamethasone and prednisolone in the same depressed patients. Psychopharmacology (Berl). 189(2):225–235.
   PubMed Web of Science ®Google Scholar
• Juruena MF, Cleare J, Pariante M. 2004. The hypothalamic pituitary adrenal axis, glucocorticoid receptor function and relevance to depression. Braz J Psychiatry. 26(3):189–201.
   PubMedGoogle Scholar
• Juruena MF. 2014. Early-life stress and HPA axis trigger recurrent adulthood depression. Epilepsy Behav. 38:148–159.
   PubMed Web of Science ®Google Scholar
• Kabba JA, Xu Y, Christian H, Ruan W, Chenai K, Xiang Y, Zhang L, Saavedra JM, Pang T. 2018. Microglia: housekeeper of the central nervous system. Cell Mol Neurobiol. 38(1):53–71.
   PubMed Web of Science ®Google Scholar
• Kato TA, Hayakawa K, Monji A, Kanba S. 2013. Missing and possible link between neuroendocrine factors, neuropsychiatric disorders, and microglia. Front Integr Neurosci. 7:1–16.
   PubMedGoogle Scholar
• Keller J, Gomez R, Williams G, Lembke A, Lazzeroni L, Murphy GM, Schatzberg AF. 2017. HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition. Mol Psychiatry. 22(4):527–536.
   PubMed Web of Science ®Google Scholar
• Kendler KS, Hettema JM, Butera F, Gardner CO, Prescott CA. 2003. Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety. Arch Gen Psychiatry. 60(8):789–796.
   PubMed Web of Science ®Google Scholar
• Kennis M, Gerritsen L, van Dalen M, Williams A, Cuijpers P, Bockting C. 2020. Prospective biomarkers of major depressive disorder: a systematic review and meta-analysis. Mol Psychiatry. 25(2):321–338.
   PubMed Web of Science ®Google Scholar
• Kitamura Y, Araki H, Gomita Y. 2002. Influence of ACTH on the effects of imipramine, desipramine and lithium on duration of immobility of rats in the forced swim test. Pharmacol Biochem Behav. 71(1–2):63–69.
   PubMed Web of Science ®Google Scholar
• Kreisel T, Frank MG, Licht T, Reshef R, Ben-Menachem-Zidon O, Baratta MV, Maier SF, Yirmiya R. 2014. Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. Mol Psychiatry. 19(6):699–709.
   PubMed Web of Science ®Google Scholar
• Lannan EA, Galliher-Beckley AJ, Scoltock AB, Cidlowski JA. 2012. Proinflammatory actions of glucocorticoids: glucocorticoids and TNFα coregulate gene expression in vitro and in vivo. Endocrinology. 153(8):3701–3712.
   PubMed Web of Science ®Google Scholar
• Lehnardt S, Massillon L, Follett P, Jensen FE, Ratan R, Rosenberg PA. 2003. Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci. 100:8514–8519.
   PubMed Web of Science ®Google Scholar
• Li X, Wu T, Yu Z, Li T, Zhang J, Zhang Z. 2018. Apocynum venetum leaf extract reverses depressive-like behaviors in chronically stressed rats by inhibiting oxidative stress and apoptosis. Biomed. Pharmacother. 100:394–406.
   PubMed Web of Science ®Google Scholar
• Liberman AC, Budziñski ML, Sokn C, Gobbini RP, Steininger A, Arzt E. 2018. Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells. Front Endocrinol. 9:1–14.
   PubMed Web of Science ®Google Scholar
• Littlefield AM, Setti SE, Priester C, Kohman RA. 2015. Voluntary exercise attenuates LPS-induced reductions in neurogenesis and increases microglia expression of a proneurogenic phenotype in aged mice. J Neuroinflammation. 12:1–12.
   Web of Science ®Google Scholar
• Liu D, Tang Q-Q, Yin C, Song Y, Liu Y, Yang J-X, Liu H, Zhang Y-M, Wu S-Y, Song Y, et al. 2018. Brain-derived neurotrophic factor-mediated projection-specific regulation of depressive-like and nociceptive behaviors in the mesolimbic reward circuitry. Pain. 159(1):175–188.
   PubMed Web of Science ®Google Scholar
• Liu Y, Wang Y, Jiang C. 2017. Inflammation: the common pathway of stress-related diseases. Front Hum Neurosci. 11:1–11.
   PubMed Web of Science ®Google Scholar
• Liu YU, Ying Y, Li Y, Eyo UB, Chen T, Zheng J, Umpierre AD, Zhu J, Bosco DB, Dong H, et al. 2019. Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling. Nat Neurosci. 22(11):1771–1781.
   PubMed Web of Science ®Google Scholar
• Machado MO, Oriolo G, Bortolato B, Köhler CA, Maes M, Solmi M, Grande I, Martín-Santos R, Vieta E, Carvalho AF, et al. 2017. Biological mechanisms of depression following treatment with interferon for chronic hepatitis C: a critical systematic review. J Affect Disord. 209:235–245.
   PubMed Web of Science ®Google Scholar
• Madry C, Kyrargyri V, Arancibia-Cárcamo IL, Jolivet R, Kohsaka S, Bryan RM, Attwell D. 2018. Microglial ramification, surveillance, and interleukin-1β release are regulated by the two-pore domain K + channel THIK-1. Neuron. 97(2):299–312.
   PubMed Web of Science ®Google Scholar
• Mahar I, Bambico FR, Mechawar N, Nobrega JN. 2014. Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neurosci Biobehav Rev. 38:173–192.
   PubMed Web of Science ®Google Scholar
• Majidi J, Kosari-Nasab M, Salari A-A. 2016. Developmental minocycline treatment reverses the effects of neonatal immune activation on anxiety- and depression-like behaviors, hippocampal inflammation, and HPA axis activity in adult mice. Brain Res Bull. 120:1–13.
   PubMed Web of Science ®Google Scholar
• Matthews SG. 2002. Early programming of the hypothalamo-pituitary-adrenal axis. Trends Endocrinol Metab. 13(9):373–380.
   PubMed Web of Science ®Google Scholar
• Mayer AMS, Murphy J, MacAdam D, Osterbauer C, Baseer I, Hall ML, Feher D, Williams P. 2016. Classical and alternative activation of Cyanobacterium oscillatoria sp. lipopolysaccharide-treated rat microglia in vitro. Toxicol Sci. 149(2):484–495.
   PubMed Web of Science ®Google Scholar
• McEwen BS, Morrison JH. 2013. The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course. Neuron. 79(1):16–29.
   PubMed Web of Science ®Google Scholar
• McEwen BS. 2000. Effects of adverse experiences for brain structure and function. Biol Psychiatry. 48(8):721–731.
   PubMed Web of Science ®Google Scholar
• McKim DB, Niraula A, Tarr AJ, Wohleb ES, Sheridan JF, Godbout JP. 2016. Neuroinflammatory dynamics underlie memory impairments after repeated social defeat. J Neurosci. 36(9):2590–2604.
   PubMed Web of Science ®Google Scholar
• Ménard C, Hodes GE, Russo SJ. 2016. Pathogenesis of depression: insights from human and rodent studies. Neuroscience. 321:138–162.
   PubMed Web of Science ®Google Scholar
• Ménard C, Pfau ML, Hodes GE, Russo SJ. 2017. Immune and neuroendocrine mechanisms of stress vulnerability and resilience. Neuropsychopharmacology. 42(1):62–80.
   PubMed Web of Science ®Google Scholar
• Miller AH, Maletic V, Raison CL. 2009. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 65(9):732–741.
   PubMed Web of Science ®Google Scholar
• Müller N, Weidinger E, Leitner B, Schwarz MJ. 2015. The role of inflammation in schizophrenia. Front Neurosci. 9:1–9.
   PubMedGoogle Scholar
• Munck A, Guyre PM, Holbrook NJ. 1984. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev. 5(1):25–44.
   PubMed Web of Science ®Google Scholar
• Munhoz CD, Lepsch LB, Kawamoto EM, Malta MB, Lima LDS, Avellar MCW. 2006. Chronic unpredictable stress exacerbates lipopolysaccharide-induced activation of nuclear factor-kB in the frontal cortex and hippocampus via glucocorticoid secretion. J Neurosci. 26(14):3813–3820.
   PubMed Web of Science ®Google Scholar
• Munhoz CD, Sorrells SF, Caso JR, Scavone C, Sapolsky RM. 2010. Glucocorticoids exacerbate lipopolysaccharide-induced signaling in the frontal cortex and hippocampus in a dose-dependent manner. J Neurosci. 30(41):13690–13698.
   PubMed Web of Science ®Google Scholar
• Belvederi Murri M, Pariante C, Mondelli V, Masotti M, Atti AR, Mellacqua Z, Antonioli M, Ghio L, Menchetti M, Zanetidou S, et al. 2014. HPA axis and aging in depression: systematic review and meta-analysis. Psychoneuroendocrinology. 41:46–62.
   PubMed Web of Science ®Google Scholar
• Nair A, Bonneau RH. 2006. Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation. J Neuroimmunol. 171(1-2):72–85.
   PubMed Web of Science ®Google Scholar
• Naseribafrouei A, Hestad K, Avershina E, Sekelja M, Linløkken A, Wilson R, Rudi K. 2014. Correlation between the human fecal microbiota and depression. Neurogastroenterol Motil. 26(8):1155–1162.
   PubMed Web of Science ®Google Scholar
• Neiva I, Malva JO, Valero J. 2014. Can we talk about microglia without neurons? A discussion of microglial cell autonomous properties in culture. Front Cell Neurosci. 8:1–5.
   PubMed Web of Science ®Google Scholar
• Nie X, Kitaoka S, Tanaka K, Segi-Nishida E, Imoto Y, Ogawa A, Nakano F, Tomohiro A, Nakayama K, Taniguchi M, et al. 2018. The innate immune receptors TLR2/4 mediate repeated social defeat stress-induced social avoidance through prefrontal microglial activation. Neuron. 99(3):464–479.e7.
   PubMed Web of Science ®Google Scholar
• Nimmerjahn A, Kirchhoff F, Helmchen F. 2005. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science. 308(5726):1314–1319.
   PubMed Web of Science ®Google Scholar
• Norden DM, Muccigrosso MM, Godbout JP. 2015. Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease. Neuropharmacology. 96:29–41.
   PubMed Web of Science ®Google Scholar
• Norman GJ, Karelina K, Zhang N, Walton JC, Morris JS, DeVries AC. 2010. Stress and IL-1 b contribute to the development of depressive-like behavior following peripheral nerve injury. Mol Psychiatry. 15(4):404–414.
   PubMed Web of Science ®Google Scholar
• O’Brien SM, Scully P, Fitzgerald P, Scott LV, Dinan TG. 2007. Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy. J. Psychiatr. Res. 41(3–4):326–331.
   PubMed Web of Science ®Google Scholar
• Oakley RH, Cidlowski JA. 2011. Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids . J Biol Chem. 286(5):3177–3184.
   PubMed Web of Science ®Google Scholar
• Osimo EF, Baxter LJ, Lewis G, Jones PB, Khandaker GM. 2019. Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels. Psychol Med. 49(12):1958–1970.
   PubMed Web of Science ®Google Scholar
• Pariante CM, Lightman SL. 2008. The HPA axis in major depression: classical theories and new developments. Trends Neurosci. 31(9):464–468.
   PubMed Web of Science ®Google Scholar
• Pariante CM. 2017. Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation. Eur Neuropsychopharmacol. 27(6):554–559.
   PubMed Web of Science ®Google Scholar
• Peng H, Long Y, Li J, Guo Y, Wu H, Yang Y, et al. 2014. Hypothalamic-pituitary-adrenal axis functioning and dysfunctional attitude in depressed patients with and without childhood neglect. BMC Psychiatry. 14:1–7.
   Web of Science ®Google Scholar
• Peixoto C, Grande AJ, Mallmann MB, Nardi AE, Cardoso A, Veras AB. 2018. Dehydroepiandrosterone (DHEA) for depression: a systematic review and meta-analysis. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders) 17:706–711.
   Google Scholar
• Qin D, Rizak J, Feng X, Yang S, Lü L, Pan L, et al. 2016. Prolonged secretion of cortisol as a possible mechanism underlying stress and depressive behaviour. Sci. Rep. 6:1–9.
   PubMed Web of Science ®Google Scholar
• Rainer Q, Xia L, Guilloux J-P, Gabriel C, Mocaër E, Hen R, Enhamre E, Gardier AM, David DJ. 2012. Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety. Int J Neuropsychopharm. 15(03):321–335.
   PubMedGoogle Scholar
• Reul JMHM, de Kloet ER. 1985. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology. 117(6):2505–2511.
   PubMed Web of Science ®Google Scholar
• Réus GZ, Fries GR, Stertz L, Badawy M, Passos IC, Barichello T, Kapczinski F, Quevedo J. 2015. The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders. Neuroscience. 300:141–154.
   PubMed Web of Science ®Google Scholar
• Rosenblat JD, McIntyre RS. 2018. Efficacy and tolerability of minocycline for depression: A systematic review and meta-analysis of clinical trials. J Affect Disord. 227:219–225.
   PubMed Web of Science ®Google Scholar
• Rupprecht R, Papadopoulos V, Rammes G, Baghai TC, Fan J, Akula N, Groyer G, Adams D, Schumacher M. 2010. Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders. Nat Rev Drug Discov. 9(12):971–988.
   PubMed Web of Science ®Google Scholar
• Saleh A, Potter GG, Mcquoid DR, Boyd B, Turner R, Macfall JR, et al. 2017. Effects of early life stress on depression, cognitive performance, and brain morphology. Psychol Med. 1:171–181.
   Google Scholar
• Salim S. 2017. Oxidative Stress and the Central Nervous System. J Pharmacol Exp Ther. 360(1):201–205.
   PubMed Web of Science ®Google Scholar
• Sandhu JK, Kulka M. 2021. Decoding mast cell-microglia communication in neurodegenerative diseases. IJMS. 22(3):1093.
   Google Scholar
• Schiepers OJG, Wichers MC, Maes M. 2005. Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry. 29(2):201–217.
   PubMed Web of Science ®Google Scholar
• Schnieder TP, Trencevska I, Rosoklija G, Stankov A, Mann JJ, Smiley J, Dwork AJ. 2014. Microglia of prefrontal white matter in suicide. J Neuropathol Exp Neurol. 73(9):880–890.
   PubMed Web of Science ®Google Scholar
• Setiawan E, Attwells S, Wilson AA, Mizrahi R, Rusjan PM, Miler L, Xu C, Sharma S, Kish S, Houle S, et al. 2018. Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study. Lancet Psychiatry. 5(4):339–347.
   PubMed Web of Science ®Google Scholar
• Setiawan E, Wilson AA, Mizrahi R, Rusjan PM, Miler L, Rajkowska G, Suridjan I, Kennedy JL, Rekkas PV, Houle S, et al. 2015. Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes. JAMA Psychiatry. 72(3):268–275.
   PubMed Web of Science ®Google Scholar
• Shechter R, Miller O, Yovel G, Rosenzweig N, London A, Ruckh J, Kim K-W, Klein E, Kalchenko V, Bendel P, et al. 2013. Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus. Immunity. 38(3):555–569.
   PubMed Web of Science ®Google Scholar
• Sierra A, Gottfried-Blackmore A, Milner TA, McEwen BS, Bulloch K. 2008. Steroid hormone receptor expression and function in microglia. Glia. 56(6):659–674.
   PubMed Web of Science ®Google Scholar
• Singhal G, Baune BT. 2017. Microglia: an interface between the loss of neuroplasticity and depression. Front Cell Neurosci. 11:1–16.
   PubMed Web of Science ®Google Scholar
• Soczynska JK, Mansur RB, Brietzke E, Swardfager W, Kennedy SH, Woldeyohannes HO, Powell AM, Manierka MS, McIntyre RS. 2012. Novel therapeutic targets in depression: minocycline as a candidate treatment. Behav Brain Res. 235(2):302–317.
   PubMed Web of Science ®Google Scholar
• Song C, Halbreich U, Han C, Leonard BE, Luo H. 2009. Imbalance between pro- and anti-inflammatory cytokines, and between Th1 and Th2 cytokines in depressed patients: the effect of electroacupuncture or fluoxetine treatment. Pharmacopsychiatry. 42(5):182–188.
   PubMed Web of Science ®Google Scholar
• Soria V, González-Rodríguez A, Huerta-Ramos E, Usall J, Cobo J, Bioque M, Barbero JD, García-Rizo C, Tost M, Monreal JA, et al. 2018. Targeting hypothalamic-pituitary-adrenal axis hormones and sex steroids for improving cognition in major mood disorders and schizophrenia: a systematic review and narrative synthesis. Psychoneuroendocrinology. 93:8–19.
   PubMed Web of Science ®Google Scholar
• Sorrells SF, Caso JR, Munhoz CD, Sapolsky RM. 2009. The stressed CNS: when glucocorticoids aggravate inflammation. Neuron. 64(1):33–39.
   PubMed Web of Science ®Google Scholar
• Sorrells SF, Sapolsky RM. 2007. An inflammatory review of glucocorticoid actions in the CNS. Brain Behav Immun. 21(3):259–272.
   PubMed Web of Science ®Google Scholar
• Spencer RL, Deak T. 2017. A users guide to HPA axis research. Physiol Behav. 178:43–65.
   PubMed Web of Science ®Google Scholar
• Srikumar BN, Paschapur M, Kalidindi N, Adepu B, Das ML, Sreedhara MV, Kuchibhotla VK, Pieschl RL, Li Y-W, Ega DSP, et al. 2017. Characterization of the adrenocorticotrophic hormone - induced mouse model of resistance to antidepressant drug treatment. Pharmacol Biochem Behav. 161:53–61.
   PubMed Web of Science ®Google Scholar
• Stárka L, Duskova M, Hill M. 2015. Dehydroepiandrosterone: a neuroactive steroid. J Steroid Biochem Mol Biol. 145:254–260.
   PubMed Web of Science ®Google Scholar
• Steiner J, Bielau H, Brisch R, Danos P, Ullrich O, Mawrin C, Bernstein H-G, Bogerts B. 2008. Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide. J Psychiatr Res. 42(2):151–157.
   PubMed Web of Science ®Google Scholar
• Stence N, Waite M, Dailey ME. 2001. Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia. 33(3):256–266.
   PubMed Web of Science ®Google Scholar
• Stetler C, Miller GE. 2011. Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research. Psychosom Med. 73(2):114–126.
   PubMed Web of Science ®Google Scholar
• Stratoulias V, Venero JL, Tremblay M-È, Joseph B. 2019. Microglial subtypes: diversity within the microglial community. Embo J. 38(17):1–18.
   Web of Science ®Google Scholar
• Streit WJ, Walter SA, Pennell NA. 1999. Reactive microgliosis. Prog Neurobiol. 57(6):563–581.
   PubMed Web of Science ®Google Scholar
• Su F, Yi H, Xu L, Zhang Z. 2015. Fluoxetine and S-citalopram inhibit M1 activation and promote M2 activation of microglia in vitro. Neuroscience. 294:60–68.
   PubMed Web of Science ®Google Scholar
• Subhramanyam CS, Wang C, Hu Q, Dheen ST. 2019. Microglia-mediated neuroinflammation in neurodegenerative diseases. Semin Cell Dev Biol. 94:112–120.
   PubMed Web of Science ®Google Scholar
• Sugama S, Takenouchi T, Fujita M, Conti B, Hashimoto M. 2009. Differential microglial activation between acute stress and lipopolysaccharide treatment. J Neuroimmunol. 207(1–2):24–31.
   PubMed Web of Science ®Google Scholar
• Sugama S, Takenouchi T, Fujita M, Kitani H, Conti B, Hashimoto M. 2013. Corticosteroids limit microglial activation occuring during acute stress. Neuroscience. 232:13–20.
   PubMed Web of Science ®Google Scholar
• Surget A, Tanti A, Leonardo ED, Laugeray A, Rainer Q, Touma C, Palme R, Griebel G, Ibarguen-Vargas Y, Hen R, et al. 2011. Antidepressants recruit new neurons to improve stress response regulation. Mol Psychiatry. 16(12):1177–1188.
   PubMed Web of Science ®Google Scholar
• Suzuki H, Ohgidani M, Kuwano N, Chrétien F, Lorin de la Grandmaison G, Onaya M, Tominaga I, Setoyama D, Kang D, Mimura M, et al. 2019. Suicide and microglia: recent findings and future perspectives based on human studies. Front Cell Neurosci. 13:1–10.
   PubMed Web of Science ®Google Scholar
• Suzumura A. 2013. Neuron-microglia interaction in neuroinflammation. Curr Protein Pept Sci. 14(1):16–20.
   PubMed Web of Science ®Google Scholar
• Tapp ZM, Godbout JP, Kokiko-Cochran ON. 2019. A tilted axis: maladaptive inflammation and HPA axis dysfunction contribute to consequences of TBI. Front Neurol. 10:1–19.
   PubMed Web of Science ®Google Scholar
• Thameem Dheen S, Kaur C, Ling E-A. 2007. Microglial activation and its implications in the brain diseases. Curr Med Chem. 14(11):1189–1197.
   PubMed Web of Science ®Google Scholar
• Theoharides TC, Tsilioni I, Bawazeer M. 2019. Mast cells, neuroinflammation and pain in fibromyalgia syndrome. Front Cell Neurosci. 13:1–8.
   PubMed Web of Science ®Google Scholar
• Thurgur H, Pinteaux E. 2019. Microglia in the neurovascular unit: blood-brain barrier-microglia interactions after central nervous system disorders. Neuroscience. 405:55–67.
   PubMed Web of Science ®Google Scholar
• Timmermans S, Souffriau J, Libert C. 2019. A General introduction to glucocorticoid biology. Front Immunol. 10:1545.
   PubMed Web of Science ®Google Scholar
• Torres-Platas SG, Cruceanu C, Chen GG, Turecki G, Mechawar N. 2014. Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides. Brain Behav Immun. 42:50–59.
   PubMed Web of Science ®Google Scholar
• Tracey KJ. 2009. Reflex control of immunity. Nat Rev Immunol. 9(6):418–428.
   PubMed Web of Science ®Google Scholar
• Tremblay MÈ, Stevens B, Sierra A, Wake H, Bessis A, Nimmerjahn A. 2011. The role of microglia in the healthy brain. J Neurosci. 31(45):16064–16069.
   PubMed Web of Science ®Google Scholar
• Tynan RJ, Naicker S, Hinwood M, Nalivaiko E, Buller KM, Pow DV, Day TA, Walker FR. 2010. Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions. Brain Behav Immun. 24(7):1058–1068.
   PubMed Web of Science ®Google Scholar
• Valvassori SS, Budni J, Varela RB, Quevedo J. 2013. Contributions of animal models to the study of mood disorders. Rev Bras Psiquiatr. 35(suppl 2):S121–S131.
   PubMed Web of Science ®Google Scholar
• van Bodegom M, Homberg JR, Henckens MJAG. 2017. Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure. Front Cell Neurosci. 11:1–33.
   PubMed Web of Science ®Google Scholar
• van der Meer MJM, Sweep CGJ, Rijnkels CEM, Pesman GJ, Tilders FJH, Kloppenborg PWC, Hermus ARMM. 1996. Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1B, TNFa and IL-6: A dose response study. J Endocrinol Invest. 19(3):175–182.
   PubMed Web of Science ®Google Scholar
• Verdonk F, Petit A-C, Abdel-Ahad P, Vinckier F, Jouvion G, de Maricourt P, De Medeiros GF, Danckaert A, Van Steenwinckel J, Blatzer M, et al. 2019. Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine. Brain Behav Immun. 81:361–373.
   PubMed Web of Science ®Google Scholar
• Villas Boas GR, Boerngen de Lacerda R, Paes MM, Gubert P, Almeida WLDC, Rescia VC, de Carvalho PMG, de Carvalho AAV, Oesterreich SA. 2019. Molecular aspects of depression: a review from neurobiology to treatment. Eur J Pharmacol. 851:99–121.
   PubMed Web of Science ®Google Scholar
• Wang Y, Han Q, Gong W, Pan D, Wang L, Hu W, et al. 2018. Microglial activation mediates chronic mild behavior in adult rats. J Neuroinflammation. 15:1–14.
   PubMed Web of Science ®Google Scholar
• Werneburg S, Feinberg PA, Johnson KM, Schafer DP. 2017. A microglia-cytokine axis to modulate synaptic connectivity and function. Curr Opin Neurobiol. 47:138–145.
   PubMed Web of Science ®Google Scholar
• West PK, Viengkhou B, Campbell IL, Hofer MJ. 2019. Microglia responses to interleukin-6 and type I interferons in neuroinflammatory disease. Glia. 67:1–21.
   Web of Science ®Google Scholar
• Wohleb ES. 2016. Neuron – microglia interactions in mental health disorders: “for better, and for worse”. Front Immunol. 7:1–13.
   PubMed Web of Science ®Google Scholar
• World Health Organization [WHO]. 2012. Depression and suicide. Available from: https://www.who.int/gho/publications/mdgs-sdgs/MDGs-SDGs2015_chapter7_snapshot_depression_suicide.pdf.
   Google Scholar
• World Health Organization [WHO]. 2018. Depression – fact sheets. Available from: https://www.who.int/news-room/fact-sheets/detail/depression.
   Google Scholar
• Xie Y, Zhou G, Wang C, Xu X, Li C. 2019. Specific microbiota dynamically regulate the bidirectional Gut-Brain Axis Communications in Mice Fed Meat Protein Diets. J Agric Food Chem. 67(3):1003–1017.
   PubMed Web of Science ®Google Scholar
• Yiallouris A, Tsioutis C, Agapidaki E, Zafeiri M, Agouridis AP, Ntourakis D, Johnson EO. 2019. Adrenal aging and its implications on stress responsiveness in humans. Front Endocrinol. 10:1–12.
   PubMed Web of Science ®Google Scholar
• Yirmiya R, Rimmerman N, Reshef R. 2015. Depression as a microglial disease. Trends Neurosci. 38(10):637–658.
   PubMed Web of Science ®Google Scholar
• Zhang C, Zhang Y-P, Li Y-Y, Liu B-P, Wang H-Y, Li K-W, Zhao S, Song C. 2019. Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat. Behav Brain Res. 356:348–357.
   PubMed Web of Science ®Google Scholar
• Zhang J, Li X, Ren Y, Zhao Y, Xing A, Jiang C, Chen Y, An L. 2018. Switching of the microglial activation phenotype is a possible treatment for depression disorder. Front Cell Neurosci. 12:1–13.
   PubMed Web of Science ®Google Scholar
• Zhang S, Zeng X, Yang H, Hu G, He S. 2012. Mast cell tryptase induces microglia activation via protease-activated receptor 2 signaling. Cell Physiol Biochem. 29(5–6):931–940.
   PubMedGoogle Scholar
• Zhang Y, Su WJ, Chen Y, Wu TY, Gong H, Shen XL. 2016. Effects of hydrogen-rich water on depressive-like behavior in mice. Sci. Rep. 6:1–7.
   PubMed Web of Science ®Google Scholar
• Zhang Y-P, Wang H-Y, Zhang C, Liu B-P, Peng Z-L, Li Y-Y, Liu F-M, Song C. 2018. Mifepristone attenuates depression-like changes induced by chronic central administration of interleukin-1β in ats. Behav. Brain Res. 347:436–445.
   PubMed Web of Science ®Google Scholar
• Zhao Q, Wu X, Yan S, Xie X, Fan Y, Zhang J, et al. 2016. The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPAR γ -mediated alteration of microglial activation phenotypes. J. Neuroinflammation. 13:1–17.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Wang Q, Jia M, Fu S, Pan J, Chu C, Liu X, Liu X, Liu Z. 2019. (+) Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation. J Nutr Biochem. 64:61–71.
   PubMed Web of Science ®Google Scholar
• Zheng X, Cheng Y, Chen Y, Yue Y, Li Yingchun, Xia S, et al. 2019. Ferulic acid improves depressive-like behavior in prenatally-stressed offspring rats via anti-inflammatory activity and HPA axis. Int J Mol Sci. 20:1–17.
   Web of Science ®Google Scholar
• Zheng P, Zeng B, Zhou C, Liu M, Fang Z, Xu X, et al. 2016. Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism. Mol Psychiatry. 21:1–11.
   PubMed Web of Science ®Google Scholar
• Zobel AW, Nickel T, Künzel HE, Ackl N, Sonntag A, Ising M, Holsboer F. 2000. Efects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. J Psychiatr Res. 34(3):171–181.
   PubMed Web of Science ®Google Scholar