2,933
Views
3
CrossRef citations to date
0
Altmetric
Original Investigations

Inflammation biomarkers in suicide attempts and their relation to abuse, global functioning and cognition

ORCID Icon, , , , , , ORCID Icon, , , ORCID Icon & show all
Pages 307-317 | Received 22 Mar 2021, Accepted 30 Sep 2021, Published online: 03 Nov 2021

References

  • Achtyes E, Keaton SA, Smart L, Burmeister AR, Heilman PL, Krzyzanowski S, Nagalla M, Guillemin GJ, Escobar Galvis ML, Lim CK, et al. 2020. Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression. Brain Behav Immun. 83:239–247.
  • American Psychiatric Association. 2014. Manual diagnóstico y estadístico de los trastornos mentales (DSM-5). Ed. Madrid: Editorial Médica Panamericana.
  • Amitai M, Taler M, Lebow M, Ben-Baruch R, Apter A, Fennig S, Weizman A, Chen A. 2020. An increase in IL-6 levels at 6-month follow-up visit is associated with SSRI-emergent suicidality in high-risk children and adolescents treated with fluoxetine. Eur Neuropsychopharmacol. 40:61–69.
  • Ásgeirsdóttir HG, Valdimarsdóttir UA, Þorsteinsdóttir ÞK, Lund SH, Tomasson G, Nyberg U, Ásgeirsdóttir TL, Hauksdóttir A. 2018. The association between different traumatic life events and suicidality. Eur J Psychotraumatol. 9(1):1510279.
  • Batty GD, Bell S, Stamatakis E, Kivimaki M. 2016. Association of systemic inflammation with risk of completed suicide in the general population. JAMA Psychiatry. 73(9):993–995.
  • Bay-Richter C, Linderholm KR, Lim CK, Samuelsson M, Traskman-Bendz L, Guillemin GJ, Erhardt S, Brundin L. 2015. A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality. Brain Behav Immun. 43:110–117.
  • Beurel E, Toups M, Nemeroff CB. 2020. The bidirectional relationship of depression and inflammation: double trouble. Neuron. 107(2):234–256.
  • Björkenstam C, Kosidou K, Björkenstam E. 2017. Childhood adversity and risk of suicide: cohort study of 548 721 adolescents and young adults in Sweden. BMJ. 357:j1334.
  • Bobes J, Bulbena A, Luque A, Dal-Ré R, Ballesteros J, Ibarra N. 2003. Evaluación psicométrica comparativa de las versiones en español de 6, 17 y 21 ítems de la Escala de valoración de Hamilton para la evaluación de la depresión. Medicina Clínica. 120(18):693–700.
  • Borsini A, Zunszain PA, Thuret S, Pariante CM. 2015. The role of inflammatory cytokines as key modulators of neurogenesis. Trends Neurosci. 38(3):145–157.
  • Brown GL, Goodwin FK, Ballenger JC, Goyer PF, Major LF. 1979. Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res. 1(2):131–139.
  • Brundin L, Bryleva EY, Thirtamara Rajamani K. 2017. Role of inflammation in suicide: from mechanisms to treatment. Neuropsychopharmacology. 42(1):271–283.
  • Buitron V, Hartley CM, Pettit JW, Hatkevich C, Sharp C. 2018. Aggressive behaviors and suicide ideation in inpatient adolescents: the moderating roles of internalizing symptoms and stress. Suicide Life Threat Behav. 48(5):580–588.
  • Caravaca Sánchez F, Ignatyev Y, Mundt AP. 2019. Associations between childhood abuse, mental health problems, and suicide risk among male prison populations in Spain. Crim Behav Ment Health. 29(1):18–30.
  • Coccaro EF. 2006. Association of C-reactive protein elevation with trait aggression and hostility in personality disordered subjects: a pilot study. J Psychiatr Res. 40(5):460–465.
  • Colasanto M, Madigan S, Korczak DJ. 2020. Depression and inflammation among children and adolescents: a meta-analysis. J Affect Disord. 277:940–948.
  • Coryell W, Wilcox H, Evans SJ, Pandey GN, Jones-Brando L, Dickerson F, Yolken R. 2018. Aggression, impulsivity and inflammatory markers as risk factors for suicidal behavior. J Psychiatr Res. 106:38–42.
  • Coryell W, Wilcox H, Evans SJ, Pandey GN, Jones-Brando L, Dickerson F, Yolken R. 2020. Latent infection, inflammatory markers and suicide attempt history in depressive disorders. J Affect Disord. 270:97–101.
  • Courtet P, Giner L, Seneque M, Guillaume S, Olie E, Ducasse D. 2016. Neuroinflammation in suicide: toward a comprehensive model. World J Biol Psychiatry. 17(8):564–586.
  • Courtet P, Jaussent I, Genty C, Dupuy AM, Guillaume S, Ducasse D, Olié E. 2015. Increased CRP levels may be a trait marker of suicidal attempt. Eur Neuropsychopharmacol. 25(10):1824–1831.
  • Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. 2008. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 9(1):46–56.
  • Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctôt KL. 2010. A meta-analysis of cytokines in major depression. Biol Psychiatry. 67(5):446–457.
  • Ducasse D, Olié E, Guillaume S, Artéro S, Courtet P. 2015. A meta-analysis of cytokines in suicidal behavior. Brain Behav Immun. 46:203–211.
  • Dunn AJ. 2006. Effects of cytokines and infections on brain neurochemistry. Clin Neurosci Res. 6(1–2):52–68.
  • Enache D, Pariante CM, Mondelli V. 2019. Markers of central inflammation in major depressive disorder: a systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue. Brain Behav Immun. 81:24–40.
  • Engel GL. 1978. The biopsychosocial model and the education of health professionals. Ann NY Acad Sci. 310:169–187.
  • Fässberg MM, Cheung G, Canetto SS, Erlangsen A, Lapierre S, Lindner R, Draper B, Gallo JJ, Wong C, Wu J, et al. 2016. A systematic review of physical illness, functional disability, and suicidal behaviour among older adults. Aging Ment Health. 20(2):166–194.
  • FDA-NIH Biomarker Working Group. 2016. BEST (Biomarkers, EndpointS, and other Tools) Resource. Silver Spring (MD): Food and Drug Administration (US); Bethesda (MD): National Institutes of Health (US).
  • Fernández-Sevillano J, González-Pinto A, Rodríguez-Revuelta J, Alberich S, Gónzalez-Blanco L, Zorrilla I, Velasco Á, López MP, Abad I, Sáiz PA. 2021. Suicidal behaviour and cognition: a systematic review with special focus on prefrontal deficits. J Affect Disord. 278:488–496.
  • Friedberg A, Malefakis D. 2018. Resilience, trauma, and coping. Psychodyn Psychiatry. 46(1):81–113.
  • Gabbay V, Klein RG, Guttman LE, Babb JS, Alonso CM, Nishawala M, Katz Y, Gaite MR, Gonzalez CJ. 2009. A preliminary study of cytokines in suicidal and nonsuicidal adolescents with major depression. J Child Adolesc Psychopharmacol. 19(4):423–430.
  • Ganança L, Galfalvy HC, Cisneros-Trujillo S, Basseda Z, Cooper TB, Ren X, Figueira ML, Oquendo MA, Mann JJ, Sublette ME. 2021. Relationships between inflammatory markers and suicide risk status in major depression. J Psychiatr Res. 134:192–199.
  • Ganança L, Oquendo MA, Tyrka AR, Cisneros-Trujillo S, Mann JJ, Sublette ME. 2016. The role of cytokines in the pathophysiology of suicidal behavior. Psychoneuroendocrinology. 63:296–310.
  • García-Nieto R, Uribe IP, Palao D, Lopez-Castroman J, Sáiz PA, García-Portilla MP, Ruiz JS, Ibañez A, Tiana T, Sindreu SD, et al. 2012. Brief suicide questionnaire. Inter-rater reliability. Revista de Psiquiatría y Salud Mental. 5(1):24–36.
  • Golden C. 2001. Test de Colores y palabras Stroop. Madrid: TEA Ediciones.
  • González-Castro TB, Tovilla-Zárate CA, López-Narváez ML, Genis-Mendoza AD, Juárez-Rojop IE. 2021. Interleukin-6 levels in serum, plasma, and cerebral spinal fluid in individuals with suicide behavior: systematic review and meta-analysis with meta-regression. J Interferon Cytokine Res. 41(7):258–267.
  • Hamilton M. 1967. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol. 6(4):278–296.
  • Hartley CM, Pettit JW, Castellanos D. 2018. Reactive aggression and suicide-related behaviors in children and adolescents: a review and preliminary meta-analysis. Suicide Life Threat Behav. 48(1):38–51.
  • Hoyo-Becerra C, Huebener A, Trippler M, Lutterbeck M, Liu ZJ, Truebner K, Bajanowski T, Gerken G, Hermann DM, Schlaak JF. 2013. Concomitant interferon alpha stimulation and TLR3 activation induces neuronal expression of depression-related genes that are elevated in the brain of suicidal persons. PLOS One. 8(12):e83149.
  • Huang M-H, Chen M-H, Hsu J-W, Huang K-L, Tsai S-J, Su T-P, Bai Y-M. 2021. Inflammation, cognitive dysfunction, and suicidal ideation among patients with major depression. CNS Spectrums. :1–25. https://doi.org/10.1017/S1092852921000729
  • Huang T-L, Lee C-T. 2007. T-helper 1/T-helper 2 cytokine imbalance and clinical phenotypes of acute-phase major depression. Psychiatry Clin Neurosci. 61(4):415–420.
  • Isung J, Aeinehband S, Mobarrez F, Nordstrom P, Runeson B, Asberg M, Piehl F, Jokinen J. 2014. High interleukin-6 and impulsivity: determining the role of endophenotypes in attempted suicide. Transl Psychiatry. 4:e470.
  • Isung J, Mobarrez F, Nordstrom P, Asberg M, Jokinen J. 2012. Low plasma vascular endothelial growth factor (VEGF) associated with completed suicide. World J Biol Psychiatry. 13(6):468–473.
  • Janelidze S, Mattei D, Westrin A, Traskman-Bendz L, Brundin L. 2011. Cytokine levels in the blood may distinguish suicide attempters from depressed patients. Brain Behav Immun. 25(2):335–339.
  • Jeon SW, Yoon H, Kim Y-K. 2019. Role of inflammation in psychiatric disorders. In Y.-K. Kim (Ed.), Frontiers in psychiatry: artificial intelligence, precision medicine, and other paradigm shifts. Singapore: Springer; p. 491–501.
  • Jia C-X, Zhang J. 2012. Global functioning and suicide among Chinese rural population aged 15-34 years: a psychological autopsy case-control study. J Forensic Sci. 57(2):391–397.
  • Keaton SA, Madaj ZB, Heilman P, Smart L, Grit J, Gibbons R, Postolache TT, Roaten K, Achtyes ED, Brundin L. 2019. An inflammatory profile linked to increased suicide risk. J Affect Disord. 247:57–65.
  • Keilp JG, Gorlyn M, Oquendo MA, Burke AK, Mann JJ. 2008. Attention deficit in depressed suicide attempters. Psychiatry Res. 159(1–2):7–17.
  • Keilp JG, Gorlyn M, Russell M, Oquendo MA, Burke AK, Harkavy-Friedman J, Mann JJ. 2013. Neuropsychological function and suicidal behavior: attention control, memory and executive dysfunction in suicide attempt. Psychol Med. 43(3):539–551.
  • Keilp JG, Wyatt G, Gorlyn M, Oquendo MA, Burke AK, John Mann J. 2014. Intact alternation performance in high lethality suicide attempters. Psychiatry Res. 219(1):129–136.
  • Kim H, Jung AH, Nam S, Kim JW. 2017. Inflammatory and neurotrophic markers and the pathogenesis of major depressive disorder in youth: a preliminary analysis. J Am Acad Child Adolesc Psychiatry. 56 (10):S196–S197.
  • Kim Y-K, Lee S-W, Kim S-H, Shim S-H, Han S-W, Choi S-H, Lee B-H. 2008. Differences in cytokines between non-suicidal patients and suicidal patients in major depression. Prog Neuro-Psychopharmacol Biol Psychiatry. 32(2):356–361.
  • Lara E, Olaya B, Garin N, Ayuso-Mateos JL, Miret M, Moneta V, Haro JM. 2015. Is cognitive impairment associated with suicidality? A population-based study. Eur Neuropsychopharmacol. 25(2):203–213.
  • Lengvenyte A, Conejero I, Courtet P, Olié E. 2019. Biological bases of suicidal behaviours: a narrative review. Eur J Neurosci. 53:330–351.
  • Lewis VM, Williams K, KoKo C, Woolmore J, Jones C, Powell T. 2017. Disability, depression and suicide ideation in people with multiple sclerosis. J Affect Disord. 208:662–669.
  • Lindqvist D, Janelidze S, Erhardt S, Träskman‐Bendz L, Engström G, Brundin L. 2011. CSF biomarkers in suicide attempters-a principal component analysis. Acta Psychiatr Scand. 124(1):52–61.
  • Lindqvist D, Janelidze S, Hagell P, Erhardt S, Samuelsson M, Minthon L, Hansson O, Björkqvist M, Träskman-Bendz L, Brundin L. 2009. Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity. Biol Psychiatry. 66(3):287–292.
  • Lippard ETC, Nemeroff CB. 2020. The devastating clinical consequences of child abuse and neglect: increased disease vulnerability and poor treatment response in mood disorders. Am J Psychiatry. 177(1):20–36.
  • Liu CS, Adibfar A, Herrmann N, Gallagher D, Lanctôt KL. 2017. Evidence for inflammation-associated depression. Curr Top Behav Neurosci. 31:3–30.
  • Lutz J, Fiske A. 2018. Functional disability and suicidal behavior in middle-aged and older adults: a systematic critical review. J Affect Disord. 227:260–271.
  • Martinez JM, Garakani A, Yehuda R, Gorman JM. 2012. Proinflammatory and "resiliency" proteins in the CSF of patients with major depression. Depress Anxiety. 29(1):32–38.
  • McGirr A, Renaud J, Bureau A, Seguin M, Lesage A, Turecki G. 2008. Impulsive-aggressive behaviours and completed suicide across the life cycle: a predisposition for younger age of suicide. Psychol Med. 38(3):407–417.
  • Mendlovic S, Mozes E, Eilat E, Doron A, Lereya J, Zakuth V, Spirer Z. 1999. Immune activation in non-treated suicidal major depression. Immunol Lett. 67(2):105–108.
  • Miller AH, Maletic V, Raison CL. 2009. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 65(9):732–741.
  • Munkholm K, Braüner JV, Kessing LV, Vinberg M. 2013. Cytokines in bipolar disorder vs. healthy control subjects: a systematic review and meta-analysis. J Psychiatr Res. 47(9):1119–1133.
  • Nangle J-M, Clarke S, Morris DW, Schwaiger S, McGhee KA, Kenny N, Murphy K, Gill M, Corvin A, Donohoe G. 2006. Neurocognition and suicidal behaviour in an Irish population with major psychotic disorders. Schizophr Res. 85(1–3):196–200.
  • Nässberger L, & Träskman‐Bendz L. 1993. Increased soluble interleukin-2 receptor concentrations in suicide attempters. Acta Psychiatr Scand. 88(1):48–52.
  • Nehra D, Herrera-Escobar JP, Al Rafai SS, Havens J, Askari R, Nitzschke S, Velmahos G, Kasotakis G, Brasel KJ, Levy-Carrick N, et al. 2019. Resilience and long-term outcomes after trauma: an opportunity for early intervention? J Trauma Acute Care Surg. 87(4):782–789.
  • O’Donovan A, Rush G, Hoatam G, Hughes BM, McCrohan A, Kelleher C, O’Farrelly C, Malone KM. 2013. Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder. Depression Anxiety. 30(4):307–314.
  • Olie E, Seyller M, Beziat S, Loftus J, Bellivier F, Bougerol T, Belzeaux R, Azorin JM, Gard S, Kahn JP, et al. 2015. Clinical and neuropsychological characteristics of euthymic bipolar patients having a history of severe suicide attempt. Acta Psychiatr Scand. 131(2):129–138.
  • Pandey GN, Rizavi HS, Ren X, Fareed J, Hoppensteadt DA, Roberts RC, Conley RR, Dwivedi Y. 2012. Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims. J Psychiatr Res. 46(1):57–63.
  • Porter RJ. 2020. The biopsychosocial model in mental health. Aust N Z J Psychiatry. 54(8):773–774.
  • Priya PK, Rajappa M, Kattimani S, Mohanraj PS, Revathy G. 2016. Association of neurotrophins, inflammation and stress with suicide risk in young adults. Clinica Chimica Acta Int J Clin Chem. 457:41–45.
  • Richard-Devantoy S, Gorwood P, Annweiler C, Olié J-P, Le Gall D, Beauchet O. 2012. Suicidal behaviours in affective disorders: a deficit of cognitive inhibition? Can J Psychiatry. 57(4):254–262.
  • Rothenhäusler H-B, Stepan A, Kapfhammer H-P. 2006. Soluble interleukin 2 receptor levels, temperament and character in formerly depressed suicide attempters compared with normal controls. Suicide Life Threat Behav. 36(4):455–466.
  • Salokangas RKR, Luutonen S, Heinimaa M, From T, Hietala J. 2019. A study on the association of psychiatric diagnoses and childhood adversities with suicide risk. Nord J Psychiatry. 73(2):125–131.
  • Schiweck C, Claes S, Van Oudenhove L, Lafit G, Vaessen T, de Beeck GO, Berghmans R, Wijkhuijs A, Müller N, Arolt V, et al. 2020. Childhood trauma, suicide risk and inflammatory phenotypes of depression: insights from monocyte gene expression. Transl Psychiatry. 10(1):1–12.
  • Serafini G, Pompili M, Elena Seretti M, Stefani H, Palermo M, Coryell W, Girardi P. 2013. The role of inflammatory cytokines in suicidal behavior: a systematic review. Eur Neuropsychopharmacol. 23(12):1672–1686.
  • Su Y-A, Lin J-Y, Liu Q, Lv X-Z, Wang G, Wei J, Zhu G, Chen Q-L, Tian H-J, Zhang K-R, et al. 2020. Associations among serum markers of inflammation, life stress and suicide risk in patients with major depressive disorder. J Psychiatr Res. 129:53–60.
  • Szanto K. 2017. Cognitive deficits: underappreciated contributors to suicide. Am J Geriatr Psychiatry. 25(6):630–632.
  • Tanaka T, Narazaki M, Kishimoto T. 2014. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 6(10):a016295.
  • Thompson MP, Kingree JB, Lamis D. 2019. Associations of adverse childhood experiences and suicidal behaviors in adulthood in a U.S. nationally representative sample. Child Care Health Dev. 45(1):121–128.
  • Ting EY-C, Yang AC, Tsai S-J. 2020. Role of interleukin-6 in depressive disorder. Int J Mol Sci. 21(6):E2194.
  • Tonelli LH, Stiller J, Rujescu D, Giegling I, Schneider B, Maurer K, Schnabel A, Moller HJ, Chen HH, Postolache TT. 2008. Elevated cytokine expression in the orbitofrontal cortex of victims of suicide. Acta Psychiatr Scand. 117(3):198–206.
  • Turecki G. 2005. Dissecting the suicide phenotype: the role of impulsive-aggressive behaviours. J Psychiatry Neurosci. 30(6):398–408.
  • Turecki G, Brent DA, Gunnell D, O’Connor RC, Oquendo MA, Pirkis J, Stanley BH. 2019. Suicide and suicide risk. Nat Rev Dis Primers. 5(1):1–22.
  • Vargas HO, Vargas Nunes SO, de Castro MP, Bortolasci CC, Barbosa DS, Morimoto HK, Venugopal K, Dodd S, Maes M, Berk M. 2013. Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts. J Affect Disord. 150(3):923–930.
  • Vasupanrajit A, Jirakran K, Tunvirachaisakul C, Maes M. 2021. Suicide attempts are associated with activated immune-inflammatory, nitro-oxidative, and neurotoxic pathways: a systematic review and meta-analysis. J Affect Disord. 295:80–92.
  • Verma D, Srivastava MK, Singh SK, Bhatia T, Deshpande SN. 2016. Lifetime suicide intent, executive function and insight in schizophrenia and schizoaffective disorders. Schizophr Res. 178(1–3):12–16.
  • Wilson CJ, Finch CE, Cohen HJ. 2002. Cytokines and cognition-the case for a head-to-toe inflammatory paradigm. J Am Geriatr Soc. 50(12):2041–2056.
  • World Health Organization. 2019. Suicide in the world: Global health estimates (WHO/MSD/MER/19.3). World Health Organization.
  • World Medical Association. 2013. World Medical Association Declaration Of Helsinki: ethical principles for medical research involving human subjects. JAMA. 310(20):2191–2194.