The do’s and don’ts of arginine supplementation

References

• Pharmaconutrition: a new emerging paradigm. Jones NE, Heyland DK. 2008, Current Opin Gastroenterol, Vol. 24, pp. 215–222.
   Google Scholar
• Use of Exogenous Arginine in Multiple Organ Dysfunction Syndrome and Sepsis. Barbul A, Uliyargoli A. 9 (Suppl), s.l. : Lippincott Williams & Wilkins, 2007, Critical Care Medicine, Vol. 35, pp. S564 – S567.
   Google Scholar
• Arginine: Biochemistry, Physiology and Therapeutic Implications. Barbul A. 1986, Journal of Parenteral and Enteral Nutrition, Vol. 10, pp. 227–238.
   Google Scholar
• Arginine Metabolism: Nitric Oxide and Beyond. Wu G, Morris SM Jr. 1998, Biochem J, Vol. 336, pp. 1–17.
   Google Scholar
• Agmatine: At the Crossroads of Arginine Pathways. Satriano J. 2003, Ann NY Acad Sci , Vol. 1009, pp. 34–43.
   Google Scholar
• Macrophage Syntehsis of Nitrite, Nitrate and N-nitrosamines: precursors and role of the respiratory burst. Iyengar R, Stuehr DJ, MArletta MA. 1987, Proc. Natl Acad. Sci, Vol. 84, pp. 6369–6373.
   Google Scholar
• Vascular endothelial cells synthesis of nitric oxide from L-argenine. Palmer RMJ , Ashton DS, Moncada S. Nature, Vol. 333, pp. 664–666.
   Google Scholar
• Arginine is a precursor of Endothelial derived Nitric Oxide. Schmidt HHHW, Nau H, Wittfoht W, Gerlach J, Prescher KE et al. European Journal of Pharmacology, Vol. 154, pp. 213 – 216.
   Google Scholar
• Nitric Oxide accounts for the biological activity of endothelium derived relaxing factor. Palmer RMJ, Ferrige AG, Moncada S. Nature, Vol. 327, pp. 524–526.
   Google Scholar
• An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Radomski MW, Palmer RMJ, Moncada S. Proc. Natl. Acad. Sci, Vol. 87, pp. 5193–5197.
   Google Scholar
• Nitric Oxide: an endogenous modulator of leukocyte adhesion. Kubes P, Suzuki M, Granger DN. Proc. Natl. Acad. Sci., Vol. 88, pp. 4651–4655.
   Google Scholar
• Nitric Oxide generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth mucscle cells. Garg UC, Hassid A. 1989, J Clin. Invest., Vol. 83, pp. 1774–1777.
   Google Scholar
• Nitric oxide modulates the expression of monocyte chemoattractant protein-1 in cultured human endothelial cells. Zeiher AM, Fisslthaler B, Schray-Utz B, Busse R. Circ Res, Vol. 76, pp. 980–86.
   Google Scholar
• The Clinical Pharmacology of L-Arginine. Boger RH, Bode-Boger SM. 2001, Annual Review of Pharmacology and Toxicology, Vol. 1, pp. 79–99.
   Google Scholar
• Characterisation of three inhibitors of endothelial nitric oxide synthase in vitri and in vivo. Rees DD, Palmer RMJ, Schulz R, Hodson HF, Moncada S. 1990, British Journal of Pharmacology, Vol. 101, pp. 746–752.
   Google Scholar
• Native low density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Pritchard KA, Groszek L, Smalley DM, Sessa WC, Wu M et al. Circ. Res., Vol. 77, pp. 510–518.
   Google Scholar
• Correction of Endothelial Dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Drexler H, Zeiher AM, Meinzer K, Just H. 1991, Lancet, Vol. 338, pp. 1546–1550.
   Google Scholar
• L-arginine improves endothelium-dependant vasodilation in hypercholesterolemic humans. Creager MA, Gallagher SJ, Girerd XJ, Coleman SM, Dzau VJ, Cooke JP. 1992, J. Clin. Invest., Vol. 90, pp. 1248–1253.
   Google Scholar
• Modulation of Coronary vasomotor tone in humans: progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Zeiher AM, Drexler H, Wollschlager H, Just H. 1991, Circulation, Vol. 83, pp. 391–401.
   Google Scholar
• Restoring vascular NO formation by L-arginine improves the sypmtoms of intermittent claudication in patients with peripheral arterial occlusive disease. Boger RH, Bode-Boger SM, Thiele W, Creutzig A, Alexander K, Frohlich JC. Journal of American College of Cardiology, Vol. 32, pp. 1336–1344.
   Google Scholar
• Dose related effect of intravenous L-arginine on muscular blood flowof the calf in patients with peripheral vascular disease. Schellong SM, Boger RH, Burchert W, Bode-Boger SM, Galland A et al. 1997, Clin. Sci, Vol. 93, pp. 159–165.
   Google Scholar
• Long term L-arginine supplementation improves small vessel coronary artery endothelial funtion in humans. Lerman A, Burnett JC, Higano ST, McKinely LJ, Holmes DR. Circulation, Vol. 97, pp. 2123–2128.
   Google Scholar
• Effect of Supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris. Ceremuzynski L, Chamiec T, Herbaczynska-Cedro K. 1997, American Journal of Cardiology, Vol. 80, pp. 331–333.
   Google Scholar
• Randomised, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Rector TS, Bank AL, Mullen KA, Tschumperlin LK, Sih R et al. 1996, Circulation, Vol. 93, pp. 2135–2141.
   Google Scholar
• Acute effect of nitric oxide on Raynaud’s phenomenon in scleroderma. Freedman GR, Girgis R, Mayes MD. 1999, Lancet, Vol. 354, p. 739.
   Google Scholar
• Plasma amino acids as predictors of the severity and outcome of sepsis. Freund H, Atamian S, Holroyde J et al. 1979, Ann. Surg., Vol. 190, pp. 571–576.
   Google Scholar
• Amino Acid Kinetics in patients with sepsis. Druml W, Heinzel G, Kleinberger G. 2001, Americal Journal of Clinical Nutrition, Vol. 73, pp. 908–913.
   Google Scholar
• Low Plasma Agrinine concentration in Septic Patients is related to diminished de novo arginine production from Citrulline. Luiking YC, Steens L, Poeze M et al. Supplement, 2003, Clinical Nutrition, Vol. 22, p. S26.
   Google Scholar
• Plasma Arginine Correlations in trauma and Sepsis. Chiarla C, Giovannini I, Siegel JH. 2006, Amino Acids, Vol. 30, pp. 81–86.
   Google Scholar
• L–agrinine infusion does not deteriorate the haemodynamic condition in patients with severe sepsis. Luiking YC, Poeze M, Hendrikx M et al. 2005, Clin Nutr., Vol. 24, pp. 612–613.
   Google Scholar
• Metabolic Support in Sepsis and Multiple Organ Failure: More Questions than Answers. Vincent JL. 9 (Suppl), 2007, Critical Care Medicine, Vol. 35, pp. S436–S440.
   Google Scholar