The 2012 University of Cape Town Faculty of Health Sciences centenary debate

References

• Cordain L, Miller JB, Eaton SB, et al. Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets. Am J Clin Nutr. 2000;71(3):682–692.
   Google Scholar
• Boyd Eaton S, Konner M. Paleolithic nutrition: a consideration of its nature and current implications. New Eng J Med. 1985;312(5):283–289.
   Google Scholar
• Konner M, Eaton SB. Paleolithic nutrition: twenty-five years later. Nutr Clin Pract. 2010;25(6):594–602.
   Google Scholar
• Heinrich B. Endurance predator. In: Sands RR, Sands LR, editors. The anthropology of sport and human movement. Maryland: Lexington Books, 2010; p. 95–101.
   Google Scholar
• Noakes TD. Thermoregulation and hydrating stategies in human evolution. In: Sands RR, Sands LR, editors. The anthropology of sport and human movement. Maryland: Lexington Books, 2010; p. 103–141.
   Google Scholar
• Sands RR. Homo cursor: running into the pleistocene. In: Sands RR, Sands LR, editors. The anthropology of sport and human movement. Maryland: Lexington Books, 2010; p. 143–181.
   Google Scholar
• Wrangham R. Catching fire: how cooking made us human. New York: Basic Books, 2009; p. 1–309.
   Google Scholar
• Wilkins J, Schoville BJ, Brown KS, Chazan M. Evidence for early hafted hunting technology. Science. 2012;338(6109): 942–946.
   Google Scholar
• Ben-Dor M, Gopher A, Hershkovitz I, Barkai R. Man the fat hunter: the demise of Homo erectus and the emergence of a new hominin lineage in the Middle Pleistocene (ca. 400 kyr) Levant. PLoS One. 2011;6(12):e28689.
   Google Scholar
• Steckel RH, Prince JM. Tallest in the world: native Americans of the Great Plains in the nineteenth century. Am Econ Rev. 2001;91(1):287–294.
   Google Scholar
• Catlin G. North American Indians. Philadelphia: Leary, Stuart and Company, 1913; p. 1–303.
   Google Scholar
• Story M, Evans M, Fabsitz RR, et al. The epidemic of obesity in American Indian communities and the need for childhood obesity-prevention programs. Am J Clin Nutr. 1999;69(4 Suppl): 747S-754S.
   Google Scholar
• Campbell GD. Diabetes in Asians and Africans in and around Durban. S Afr Med J. 1963;37:1195–1208.
   Google Scholar
• Campbell GD. Incidence of diabetes mellitus in one district of Basutoland. S Afr Med J. 1960;34:332.
   Google Scholar
• Campbell GD, Batchelor EL, Goldberg MD. Sugar intake and diabetes. Diabetes. 1967;16(1):62–63.
   Google Scholar
• Cohen AM, Bavly S, Poznanski R. Change of diet of Yemenite Jews in relation to diabetes and ischaemic heart-disease. Lancet. 1961;2(7217):1399–1401.
   Google Scholar
• Cohen AM. Fats and carbohydrates as factors in atheroclerosis and diabetes in Yemenite Jews. Am Heart J. 1963;65:291–293.
   Google Scholar
• Yam D, Eliraz A, Berry EM. Diet and disease: the Israeli paradox: possible dangers of a high omega-6 polyunsaturated fatty acid diet. Isr J Med Sci. 1996;32(11):1134–1143.
   Google Scholar
• Minger D. Death by food pyramid. New York: Primal Nutrition, 2014; p. 1–300.
   Google Scholar
• Teicholz N. The big fat surprise. New York: Simon & Schuster, 2014; p. 1–479.
   Google Scholar
• Taubes G. Good calories, bad calories. New York: Anchor Books, 2007; p. 1–609.
   Google Scholar
• Keys A. Atherosclerosis: a problem in newer public health. J Mt Sinai Hosp NY. 1953;20(2):118–139.
   Google Scholar
• Mayosi BM, Forrester T. Commentary: “Serum-cholesterol, diet, and coronary heart-disease in Africans and Asians in Uganda” by AG Shaper and KW Jones. Int J Epidemiol 2012;41(5):1233–1235.
   Google Scholar
• Yerushalmy J, Hilleboe HE. Fat in the diet and mortality from heart disease; a methodologic note. NY State J Med. 1957;57(14):2343–2354.
   Google Scholar
• Yudkin J. Diet and coronary thrombosis hypothesis and fact. Lancet. 1957;273(6987):155–162.
   Google Scholar
• Yudkin J, Roddy J. Levels of dietary sucrose in patients with occlusive atherosclerotic disease. Lancet. 1964;2(7349):6–8.
   Google Scholar
• Yudkin J. Dietary fat and dietary sugar in relation to ischaemic heart-disease and diabetes. Lancet. 1964;2(7349):4–5.
   Google Scholar
• Armstrong BK, Mann JI, Adelstein AM, Eskin F. Commodity consumption and ischemic heart disease mortality, with special reference to dietary practices. J Chronic Dis. 1975;28(9):455–469.
   Google Scholar
• Harper AE. Coronary heart disease: an epidemic related to diet? Am J Clin Nutr. 1983;37(4):669–681.
   Google Scholar
• Page IH, Stare FJ, Corcoran AC, et al. Atherosclerosis and the fat content of the diet. Circulation. 1957;16(2):163–178.
   Google Scholar
• Dietary fat and its relation to heart attacks and strokes. Report by the Central Committee for Medical and Community Program of the American Heart Association. JAMA. 1961;175:389–391.
   Google Scholar
• Michaels D. Doubt is their product. New York: Oxford Univ Press, 2008; p. 1–372.
   Google Scholar
• Taubes G, Couzens CK. Sweet little lies. Mother Jones. 2012;35-40,68–69.
   Google Scholar
• Cleave TL, Campbell GD. The saccharine disease. Am J Proctol. 1967;18(3):202–210.
   Google Scholar
• Cleave TL, Campbell GD. Diabetes, coronary thrombosis and the saccharine disease. Bristol: John Wright & Sons, 1966; p. 1–146.
   Google Scholar
• Yudkin J. Sugar and disease. Nature. 1972;239(5369):197–199.
   Google Scholar
• Yudkin J. Pure, white and deadly. London: Penguin Books, 1972; p. 1–200.
   Google Scholar
• Gillespie D. Sweet poison: why sugar makes us fat. Victoria: Viking, 2008; p. 1–208.
   Google Scholar
• Lustig RH, Schmidt LA, Brindis CD. Public health: the toxic truth about sugar. Nature. 2012;482(7383):27–29.
   Google Scholar
• Lustig RH. Fat chance: beating the odds against sugar, processed food, obesity and disease. New York: Hudson Street Press, 2013; p. 1–320.
   Google Scholar
• Basu S, Yoffe P, Hills N, Lustig RH. The relationship of sugar to population-level diabetes prevalence: an econometric analysis of repeated cross-sectional data. PLoS One. 2013;8(2):e57873.
   Google Scholar
• O’Connell J. Sugar nation. New York: Hyperion, 2011; p. 1–303.
   Google Scholar
• Hu FB, Stampfer MJ, Manson JE, et al. Trends in the incidence of coronary heart disease and changes in diet and lifestyle in women. N Engl J Med. 2000;343(8):530–537.
   Google Scholar
• Horowitz R. Putting meat on the American table. Baltimore: John Hopkins University Press, 2006; p. 1–160.
   Google Scholar
• Rose G, Marmot MG. Social class and coronary heart disease. Br Heart J. 1981;45(1):13–19.
   Google Scholar
• Peretti J. Why our food is making us fat. The Guardian [homepage on the Internet]. 2012. Available from: http://www.theguardian.com/business/2012/jun/11/why-our-food-is-making-us-fat
   Google Scholar
• Ahrens EH. Dietary fats and coronary heart disease: unfinished business. Lancet. 1979;2(8156-8157): 1345–1348.
   Google Scholar
• Responses to dietary goals for the United States. Nutrition Today. 1977;12(6):10-13, 20–27.
   Google Scholar
• Reiser R. Oversimplification of diet: coronary heart disease relationships and exaggerated diet recommendations. Am J Clin Nutr. 1978 May;31(5):865–875.
   Google Scholar
• Hite AH, Feinman RD, Guzman GE, et al. In the face of contradictory evidence: report of the Dietary Guidelines for Americans Committee. Nutrition. 2010;26(10): 915–924.
   Google Scholar
• Hoenselaar R. Further response from Hoenselaar. Br J Nutr. 2012;108(5):939–942.
   Google Scholar
• Puaschitz NG, Strand E, Norekval TM, et al. Dietary intake of saturated fat is not associated with risk of coronary events or mortality in patients with established coronary artery disease. J Nutr. 2015;145(2):299–305.
   Google Scholar
• Chowdhury R, Warnakula S, Kunutsor S, et al. Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann Intern Med. 2014;160(6):398–406.
   Google Scholar
• Malhotra A. Saturated fat is not the major issue. BMJ. 2013;347:f6340.
   Google Scholar
• Hooper L, Summerbell CD, Thompson R, et al. Reduced or modified dietary fat for preventing cardiovascular disease. Cochrane Review. In: The Cochrane Library, Issue 5, 2012. Oxford: Update Software.
   Google Scholar
• Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr. 2010;91(3):535–546.
   Google Scholar
• Hoenselaar R. Saturated fat and cardiovascular disease: the discrepancy between the scientific literature and dietary advice. Nutrition. 2012;28(2):118–123.
   Google Scholar
• Astrup A, Dyerberg J, Elwood P, et al. The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010? Am J Clin Nutr. 2011;93(4):684–688.
   Google Scholar
• Ravnskov U, DiNicolantonio JJ, Harcombe Z, et al. The questionable benefits of exchanging saturated fat with polyunsaturated fat. Mayo Clin Proc. 2014;89(4):451–453.
   Google Scholar
• Ramsden CE, Hibbeln JR, Majchrzak SF, Davis JM. n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. Br J Nutr. 2010;104(11):1586–1600.
   Google Scholar
• DiNicolantonio JJ. The cardiometabolic consequencwes of replacing saturated fats with carbohydrates or omega-6 polyunsaturated fats: do the dietary guidelines have it wrong? Open Heart. 2014;1(1):e00032.
   Google Scholar
• Ravnskov U. The fallacies of the lipid hypothesis. Scand Cardiovasc J. 2008;42(4):236–239.
   Google Scholar
• Castelli WP. Concerning the possibility of a nut. Arch Intern Med. 1992;152(7):1371–1372.
   Google Scholar
• Harvard. Fats and cholesterol: out with the bad, in with the good. The Nutrition Source [homepage on the Internet]. 2014. Available from: http://www.hsph.harvard.edu/nutritionsource/fats-full-story/
   Google Scholar
• Stock AL, Yudkin J. Nutrient intake of subjects on low carbohydrate diet used in treatment of obesity. Am J Clin Nutr. 1970;23(7):948–952.
   Google Scholar
• Willett WC. Is dietary fat a major determinant of body fat? Am J Clin Nutr. 1998;67(3 Suppl):556S-562S.
   Google Scholar
• Taubes G. Why we get fat: the diet/weight relationship: an alternative hypothesis. YouTube [homepage on the Internet]. c2015. Available from: https://www.youtube.com/watch?v=qEuIlQONcHw
   Google Scholar
• Petersen KF, Dufour S, Savage DB, et al. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci USA. 2007;104(31):12587–12594.
   Google Scholar
• Coulston AM, Hollenbeck CB, Swislocki AL, Reaven GM. Persistence of hypertriglyceridemic effect of low-fat high-carbohydrate diets in NIDDM patients. Diabetes Care. 1989;12(2):94–101.
   Google Scholar
• Kraemer FB, Ginsberg HN. Gerald M. Reaven, MD: Demonstration of the central role of insulin resistance in type 2 diabetes and cardiovascular disease. Diabetes Care. 2014;37(5):1178–1181.
   Google Scholar
• Reaven G. Insulin resistance and coronary heart disease in nondiabetic individuals. Arterioscler Thromb Vasc Biol. 2012;32(8):1754–1759.
   Google Scholar
• Schwarz JM, Linfoot P, Dare D, Aghajanian K. Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets. Am J Clin Nutr. 2003;77(1):43–50.
   Google Scholar
• Sattar N, Forrest E, Preiss D. Non-alcoholic fatty liver disease. BMJ. 2014;349:g4596.
   Google Scholar
• Bierman EL, Hamlin JT, III. The hyperlipemic effect of a low-fat, high-carbohydrate diet in diabetic subjects. Diabetes. 1961;10:432–437.
   Google Scholar
• Sevastianova K, Santos A, Kotronen A, et al. Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. Am J Clin Nutr. 2012;96(4):727–734.
   Google Scholar
• Guldbrand H, Dizdar B, Bunjaku B, et al. In type 2 diabetes, randomisation to advice to follow a low-carbohydrate diet transiently improves glycaemic control compared with advice to follow a low-fat diet producing a similar weight loss. Diabetologia. 2012;55(8):2118–2127.
   Google Scholar
• Sestoft L, Krarup T, Palmvig B, et al. High-carbohydrate, low-fat diet: effect on lipid and carbohydrate metabolism, GIP and insulin secretion in diabetics. Dan Med Bull. 1985;32(1):64–69.
   Google Scholar
• Garg A, Grundy SM, Unger RH. Comparison of effects of high and low carbohydrate diets on plasma lipoproteins and insulin sensitivity in patients with mild NIDDM. Diabetes. 1992;41(10):1278–1285.
   Google Scholar
• Frost G, Leeds AA, Dore CJ, et al. Glycaemic index as a determinant of serum HDLcholesterol concentration. Lancet. 1999;353(9158):1045–1048.
   Google Scholar
• Austin MA, Breslow JL, Hennekens CH, et al. Low-density lipoprotein subclass patterns and risk of myocardial infarction. JAMA. 1988;260(13):1917–1921.
   Google Scholar
• Griffin BA, Freeman DJ, Tait GW, et al. Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions: relative contribution of small, dense LDL to coronary heart disease risk. Atherosclerosis. 1994;106(2):241–253.
   Google Scholar
• Miselli MA, Nora ED, Passaro A, et al. Plasma triglycerides predict ten-years all-cause mortality in outpatients with type 2 diabetes mellitus: a longitudinal observational study. Cardiovasc Diabetol. 2014;13(1):135.
   Google Scholar
• De Graaf J, Hak-Lemmers HL, Hectors MP, et al. Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects. Arterioscler Thromb. 1991;11(2): 298–306.
   Google Scholar
• Freedman DS, Otvos JD, Jeyarajah EJ, et al. Sex and age differences in lipoprotein subclasses measured by nuclear magnetic resonance spectroscopy: the Framingham Study. Clin Chem. 2004;50(7):1189–1200.
   Google Scholar
• Liu S, Manson JE, Buring JE, et al. Relation between a diet with a high glycemic load and plasma concentrations of high-sensitivity C-reactive protein in middle-aged women. Am J Clin Nutr. 2002;75(3):492–498.
   Google Scholar
• Flannery C, Dufour S, Rabol R, et al. Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly. Diabetes. 2012;61(11):2711–2717.
   Google Scholar
• Ahmed N, Babaei-Jadidi R, Howell SK, et al. Glycated and oxidized protein degradation products are indicators of fasting and postprandial hyperglycemia in diabetes. Diabetes Care. 2005;28(10):2465–2471.
   Google Scholar
• Toma L, Stancu CS, Botez GM, et al. Irreversibly glycated LDL induce oxidative and inflammatory state in human endothelial cells; added effect of high glucose. Biochem Biophys Res Commun. 2009;390(3): 877–882.
   Google Scholar
• Yano M, Hasegawa G, Ishii M, et al. Short-term exposure of high glucose concentration induces generation of reactive oxygen species in endothelial cells: implication for the oxidative stress associated with postprandial hyperglycemia. Redox Rep. 2004;9(2):111–116.
   Google Scholar
• Dandona P, Aljada A, Chaudhuri A, Bandyopadhyay A. The potential influence of inflammation and insulin resistance on the pathogenesis and treatment of atherosclerosis-related complications in type 2 diabetes. J Clin Endocrinol Metab. 2003;88(6):2422–2429.
   Google Scholar
• Facchini F, Chen YD, Hollenbeck CB, Reaven GM. Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA. 1991;266(21):3008–3011.
   Google Scholar
• Bosse JD, Lin HY, Sloan C, et al. A low-carbohydrate/high-fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance. Am J Physiol Heart Circ Physiol. 2013;304(12):H1733-H1742.
   Google Scholar
• Cherbuin N, Sachdev P, Anstey KJ. Higher normal fasting plasma glucose is associated with hippocampal atrophy: the PATH Study. Neurology. 2012;79(10):1019–1026.
   Google Scholar
• Kerti L, Witte AV, Winkler A, et al. Higher glucose levels associated with lower memory and reduced hippocampal microstructure. Neurology. 2013;81(20):1746–1752.
   Google Scholar
• Seneff S, Wainwright G, Mascitelli L. Nutrition and Alzheimer’s disease: the detrimental role of a high carbohydrate diet. Eur J Intern Med. 2011;22(2):134–140.
   Google Scholar
• Kenyon C. The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing. Philos Trans R Soc Lond B Biol Sci. 2011;366(1561):9–16.
   Google Scholar
• Meyerhardt JA, Sato K, Niedzwiecki D, et al. Dietary glycemic load and cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Natl Cancer Inst. 2012;104(22):1702–1711.
   Google Scholar
• Romieu I, Ferrari P, Rinaldi S, et al. Dietary glycemic index and glycemic load and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Clin Nutr. 2012;96(2):345–355.
   Google Scholar
• Stattin P, Bjor O, Ferrari P, et al. Prospective study of hyperglycemia and cancer risk. Diabetes Care. 2007;30(3):561–567.
   Google Scholar
• Moynihan R, Cassels A. Selling sickness: how the world’s biggest pharmaceutical companies are turning us all into patients. New York: Nation Books, 2005; p. 1–254.
   Google Scholar
• Abramson JD, Rosenberg HG, Jewell N, Wright JM. Should people at low risk of cardiovascular disease take a statin? BMJ. 2013;347:f6123.
   Google Scholar
• Di AE, Gao P, Pennells L, et al. Lipid-related markers and cardiovascular disease prediction. JAMA. 2012;307(23):2499–2506.
   Google Scholar
• Sachdeva A, Cannon CP, Deedwania PC, et al. Lipid levels in patients hospitalized with coronary artery disease: an analysis of 136,905 hospitalizations in Get With The Guidelines. Am Heart J. 2009;157(1):111–117.
   Google Scholar
• Castelli WP, Garrison RJ, Wilson PW, et al. Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study. JAMA. 1986;256(20):2835–2838.
   Google Scholar
• Castelli WP. Lipids, risk factors and ischaemic heart disease. Atherosclerosis. 1996;124 Suppl:S1-S9.
   Google Scholar
• Ware WR. The mainstream hypothesis that LDL cholesterol drives atherosclerosis may have been falsified by non-invasive imaging of coronary artery plaque burden and progression. Med Hypotheses. 2009;73(4):596–600.
   Google Scholar
• Ravnskov U. Is atherosclerosis caused by high cholesterol? QJM. 2002;95(6):397–403.
   Google Scholar
• Criqui MH, Denenberg JO, Ix JH, et al. Calcium density of coronary artery plaque and risk of incident cardiovascular events. JAMA. 2014;311(3):271–278.
   Google Scholar
• West KM, Ahuja MM, Bennett PH, et al. The role of circulating glucose and triglyceride concentrations and their interactions with other “risk factors” as determinants of arterial disease in nine diabetic population samples from the WHO multinational study. Diabetes Care. 1983;6(4):361–369.
   Google Scholar
• Khaw KT, Wareham N, Luben R, et al. Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European prospective investigation of cancer and nutrition (EPIC-Norfolk). BMJ. 2001;322(7277):15–18.
   Google Scholar
• Khaw KT, Wareham N, Bingham S, et al. Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk. Ann Intern Med. 2004;141(6):413–420.
   Google Scholar
• Schilling S, Tzourio C, Dufouil C, et al. Plasma lipids and cerebral small vessel disease. Neurology. 2014;83(20):1844–1852.
   Google Scholar
• Feinman RD, Pogozelski WK, Astrup A, et al. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition. 2015;31(1):1–13.
   Google Scholar
• Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005;54(6):1615–1625.
   Google Scholar
• Benn M, Tybjaerg-Hansen A, McCarthy MI, et al. Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study. J Am Coll Cardiol. 2012;59(25):2356–2365.
   Google Scholar
• Shaye K, Amir T, Shlomo S, Yechezkel S. Fasting glucose levels within the high normal range predict cardiovascular outcome. Am Heart J. 2012;164(1):111–116.
   Google Scholar
• Westman EC, Phinney SD, Volek JS. The new Atkins for a new you. New York: Fireside, 2010; p. 1–330.
   Google Scholar
• Volek JS, Phinney SD. The art and science of low carbohydrate performance. Florida: Beyond Obesity LLC, 2012; p. 1–162.
   Google Scholar
• Volek JS, Phinney SD. The art and science of low carbohydrate living. Florida: Beyond Obesity LLC, 2011; p. 1–302.
   Google Scholar
• Gunnars K. 23 studies on low-carb and low-fat diets: time to retire the fad. Authority Nutrition [homepage on the Internet]. 2013. Available from: http://authoritynutrition.com/23-studies-on-low-carb-and-low-fat-diets/
   Google Scholar
• Foster GD, Wyatt HR, Hill JO, et al. A randomized trial of a low-carbohydrate diet for obesity. New Eng J Med. 2003;348(21):2082–2090.
   Google Scholar
• Samaha FF, Iqbal N, Seshadri P, et al. A low-carbohydrate as compared with a low-fat diet in severe obesity. New Eng J Med. 2003;348(21):2074–2081.
   Google Scholar
• Sondike SB, Copperman N, Jacobson MS. Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents. J Pediatr. 2003;142(3):253–258.
   Google Scholar
• Brehm BJ, Seeley RJ, Daniels SR, D’Alessio DA. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrinol Metab. 2003;88(4):1617–1623.
   Google Scholar
• Aude YW, Agatston AS, Lopez-Jimenez F, et al. The national cholesterol education program diet vs a diet lower in carbohydrates and higher in protein and monounsaturated fat: a randomized trial. Arch Intern Med. 2004;164(19):2141–2146.
   Google Scholar
• Yancy WS Jr, Olsen MK, Guyton JR, et al. A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. Ann Intern Med. 2004;140(10):769–777.
   Google Scholar
• Volek J, Sharman M, Gomez A, et al. Comparison of energy-restricted very low-carbohydrate and low-fat diets on weight loss and body composition in overweight men and women. Nutr Metab (Lond). 2004;1(1):13.
   Google Scholar
• Meckling KA, O’Sullivan C, Saari D. Comparison of a low-fat diet to a low-carbohydrate diet on weight loss, body composition, and risk factors for diabetes and cardiovascular disease in free-living, overweight men and women. J Clin Endocrinol Metab. 2004;89(6):2717–2723.
   Google Scholar
• Nickols-Richardson SM, Coleman MD, Volpe JJ, Hosig KW. Perceived hunger is lower and weight loss is greater in overweight premenopausal women consuming a lowcarbohydrate/high-protein vs high-carbohydrate/low-fat diet. J Am Diet Assoc. 2005;105(9):1433–1437.
   Google Scholar
• Daly ME, Paisey R, Paisey R, et al. Short-term effects of severe dietary carbohydraterestriction advice in type 2 diabetes: a randomized controlled trial. Diabet Med. 2006;23(1):15–20.
   Google Scholar
• McClernon FJ, Yancy WS Jr, Eberstein JA, et al. The effects of a low-carbohydrate ketogenic diet and a low-fat diet on mood, hunger, and other self-reported symptoms. Obesity (Silver Spring). 2007;15(1):182–187.
   Google Scholar
• Gardner CD, Kiazand A, Alhassan S, et al. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A to Z Weight Loss Study: a randomized trial. JAMA. 2007;297(9):969–977.
   Google Scholar
• Halyburton AK, Brinkworth GD, Wilson CJ, et al. Low- and high-carbohydrate weightloss diets have similar effects on mood but not cognitive performance. Am J Clin Nutr. 2007;86(3):580–587.
   Google Scholar
• Dyson PA, Beatty S, Matthews DR. A low-carbohydrate diet is more effective in reducing body weight than healthy eating in both diabetic and non-diabetic subjects. Diabet Med. 2007;24(12):1430–1435.
   Google Scholar
• Westman EC, Yancy WS Jr, Mavropoulos JC, et al. The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus. Nutr Metab (Lond). 2008;5:36.
   Google Scholar
• Shai I, Schwarzfuchs D, Henkin Y, et al. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med. 2008;359(3):229–241.
   Google Scholar
• Keogh JB, Brinkworth GD, Noakes M, et al. Effects of weight loss from a very-lowcarbohydrate diet on endothelial function and markers of cardiovascular disease risk in subjects with abdominal obesity. Am J Clin Nutr. 2008;87(3):567–576.
   Google Scholar
• Tay J, Brinkworth GD, Noakes M, et al. Metabolic effects of weight loss on a very-lowcarbohydrate diet compared with an isocaloric high-carbohydrate diet in abdominally obese subjects. J Am Coll Cardiol. 2008;51(1):59–67.
   Google Scholar
• Volek JS, Phinney SD, Forsythe CE, et al. Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat diet. Lipids. 2009;44(4):297–309.
   Google Scholar
• Brinkworth GD, Noakes M, Buckley JD, et al. Long-term effects of a very-lowcarbohydrate weight loss diet compared with an isocaloric low-fat diet after 12 mo. Am J Clin Nutr. 2009;90(1):23–32.
   Google Scholar
• Hernandez TL, Sutherland JP, Wolfe P, et al. Lack of suppression of circulating free fatty acids and hypercholesterolemia during weight loss on a high-fat, low-carbohydrate diet. Am J Clin Nutr. 2010;91(3):578–585.
   Google Scholar
• Krebs NF, Gao D, Gralla J, et al. Efficacy and safety of a high protein, low carbohydrate diet for weight loss in severely obese adolescents. J Pediatr. 2010;157(2):252–258.
   Google Scholar
• Volek JS, Fernandez ML, Feinman RD, Phinney SD. Dietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning, and metabolic syndrome. Prog Lipid Res. 2008;47(5):307–318.
   Google Scholar
• Bazzano LA, Hu T, Reynolds K, et al. Effects of low-carbohydrate and low-fat diets: a randomized trial. Ann Intern Med. 2014;161(5):309–318.
   Google Scholar
• Dreon DM, Fernstrom HA, Campos H, et al. Change in dietary saturated fat intake is correlated with change in mass of large low-density-lipoprotein particles in men. Am J Clin Nutr. 1998;67(5):828–836.
   Google Scholar
• Krauss RM, Blanche PJ, Rawlings RS, et al. Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia. Am J Clin Nutr. 2006;83(5):1025–1031.
   Google Scholar
• Krauss RM. Atherogenic lipoprotein phenotype and diet-gene interactions. J Nutr. 2001;131(2):340S-343S.
   Google Scholar
• Faghihnia N, Tsimikas S, Miller ER, et al. Changes in lipoprotein (a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet. J Lipid Res. 2010;51(11):3324–3330.
   Google Scholar
• Volk BM, Kunces LJ, Freidenreich DJ, et al. Effects of step-wise increases in dietary carbohydrate on circulating saturated fatty acids and palmitoleic acid in adults with metabolic syndrome. PLoS One. 2014;9(11):e113605.
   Google Scholar
• Santos FL, Esteves SS, da Costa PA, et al. Systematic review and meta-analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factors. Obes Rev. 2012;13(11):1048–1066.
   Google Scholar
• Hu T, Mills KT, Yao L, et al. Effects of low-carbohydrate diets versus low-fat diets on metabolic risk factors: a meta-analysis of randomized controlled clinical trials. Am J Epidemiol. 2012;176 Suppl 7:S44-S54.
   Google Scholar
• Reaven GM. The metabolic syndrome: requiescat in pace. Clin Chem. 2005;51(6):931–938.
   Google Scholar
• Howard BV, Van HL, Hsia J, et al. Low-fat dietary pattern and risk of cardiovascular disease: the Women;s Health Initiative Randomized Controlled Dietary Modification Trial. JAMA. 2006;295(6):655–666.
   Google Scholar
• Bartsch H, Nair J, Owen RW. Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers. Carcinogenesis. 1999;20(12):2209–2218.
   Google Scholar
• Michels KB, Willett WC. The Women’s Health Initiative Randomized Controlled Dietary Modification Trial: a post-mortem. Breast Cancer Res Treat. 2009;114(1):1–6.
   Google Scholar
• Noakes TD. The Women’s Health Initiative Randomized Controlled Dietary Modification Trial: an inconvenient finding and the diet-heart hypothesis. S Afr Med J. 2013;103(11):824–825.
   Google Scholar
• Noakes TD. WHIDMT: Rossouw and Howard blatantly miss the point. S Afr Med J. 2014;104(4):261–262.
   Google Scholar
• Rossouw JE, Howard BV. Noakes misses the point. S Afr Med J. 2013,103(123):882 [homepage on the Internet. Available from: http://www.samj.org.za/index.php/samj/article/view/7709/5668
   Google Scholar
• Mozaffarian D, Rimm EB, Herrington DM. Dietary fats, carbohydrate, and progression of coronary atherosclerosis in postmenopausal women. Am J Clin Nutr. 2004;80(5):1175–1184.
   Google Scholar
• Knopp RH, Retzlaff BM. Saturated fat prevents coronary artery disease? An American paradox. Am J Clin Nutr. 2004;80(5):1102–1103.
   Google Scholar
• Westman EC, Yancy WS Jr, Olsen MK, et al. Effect of a low-carbohydrate, ketogenic diet program compared to a low-fat diet on fasting lipoprotein subclasses. Int J Cardiol 2006 Jun 16; 110(2): 212–216.
   Google Scholar
• Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem 1997 Aug 22; 272(34): 20963–20966.
   Google Scholar
• Shoji T, Hatsuda S, Tsuchikura S, Shinohara K, Kimoto E, Koyama H, et al. Small dense low-density lipoprotein cholesterol concentration and carotid atherosclerosis. Atherosclerosis. 2009;202(2):582–588.
   Google Scholar
• Hoogeveen RC, Gaubatz JW, Sun W, et al. Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the atherosclerosis Risk in Communities (ARIC) Study. Arterioscler Thromb Vasc Biol. 2014;34(5):1069–1077.
   Google Scholar
• St-Pierre AC, Cantin B, Dagenais GR, et al. Low-density lipoprotein subfractions and the long-term risk of ischemic heart disease in men: 13-year follow-up data from the Quebec Cardiovascular Study. Arterioscler Thromb Vasc Biol. 2005;25(3):553–559.
   Google Scholar
• Shikany JM, Margolis KL, Pettinger M, et al. Effects of a low-fat dietary intervention on glucose, insulin and insulin resistance in the Women’s Health Initiative (WHI) Dietary Modification trial. Am J Clin Nutr. 2011;94(1):75–85.
   Google Scholar
• Halton TL, Liu S, Manson JE, Hu FB. Low-carbohydrate-diet score and risk of type 2 diabetes in women. Am J Clin Nutr. 2008;87(2):339–346.
   Google Scholar
• Look AHEAD Research Group, Wing RR. Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Arch Intern Med. 2010;170(17):1566–1575.
   Google Scholar