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Hematology Volume 24, 2019 - Issue 1
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Articles

Diagnosis and treatment of juvenile myelomonocytic leukemia

Xiong-yu LiaoDepartment of Paediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China;Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaView further author information
,
Kun-yin QiuDepartment of Paediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China;Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-2865-4685View further author information
ORCID Icon,
Jian-pei FangDepartment of Paediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China;Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaView further author information
,
Ruo-hao WuDepartment of Paediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China;Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaView further author information
,
Shu-yi GuoDepartment of Paediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China;Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaView further author information
,
Ke HuangDepartment of Paediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China;Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaView further author information
&
Dun-hua ZhouDepartment of Paediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China;Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaCorrespondence[email protected]
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Pages 577-582 | Published online: 07 Aug 2019

References

  • Yan X, editor-in-chief. Pediatric hematology. Tianjin: Science and Technology Press; 2005. p. 466–468.
  • Chang TY, Dvorak CC, Loh ML. Bedside to bench in juvenile myelomonocytic leukemia: insights into leukemogenesis from a rare pediatric leukemia. Blood. 2014;124(16):2487–2497. doi: 10.1182/blood-2014-03-300319
  • Kang HJ, Shin HY, Choi HS, et al. Novel regimen for the treatment of juvenile myelomonocytic leukemia (JMML). Leuk Res. 2004;28(2):167–170. doi: 10.1016/S0145-2126(03)00217-0
  • Niemeyer CM, Loh ML, Cseh A, et al. Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia. Haematologica. 2015;100(1):17–22. doi: 10.3324/haematol.2014.109892
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  • Park HD, Lee SH, Sung KW, et al. Gene mutations in the Ras pathway and the prognostic implication in Korean patients with juvenile myelomonocytic leukemia. Ann Hematol. 2012;91(4):511–517. doi: 10.1007/s00277-011-1326-9
  • Wilhelm T, Lipka DB, Witte T, et al. Epigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia. Epigenetics. 2016;11(2):110–119. doi: 10.1080/15592294.2016.1145327
  • Fluhr S, Boerries M, Busch H, et al. CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia. Clin Epigenetics. 2016;8(1):50. doi: 10.1186/s13148-016-0216-3
  • Sakashita K, Matsuda K, Koike K. Diagnosis and treatment of juvenile myelomonocytic leukemia. Pediatr Int Off J Japan Pediatr Soc. 2016;58(8):681–690. doi: 10.1111/ped.13068
  • Matsuda K, Shimada A, Yoshida N, et al. Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. Blood. 2007;109(12):5477–5480. doi: 10.1182/blood-2006-09-046649
  • Niemeyer CM, Kang MW, Shin DH, et al. Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. Nat Genet. 2010;42(9):794–800. doi: 10.1038/ng.641
  • Locatelli F, Nöllke P, Zecca M, et al. Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial. Blood. 2005;105(1):410–419. doi: 10.1182/blood-2004-05-1944

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