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Hematology Volume 24, 2019 - Issue 1
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Case Report

Etoposide combined with ruxolitinib for refractory hemophagocytic lymphohistiocytosis during pregnancy: a case report and literature review

Shuoshan Wanga Department of General Medicine, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People’s Republic of ChinaView further author information
,
Jingguo Wua Department of General Medicine, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People’s Republic of ChinaView further author information
,
Xiaoli Jinga Department of General Medicine, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People’s Republic of ChinaCorrespondence[email protected]
View further author information
,
Yongwei Zhanga Department of General Medicine, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People’s Republic of ChinaView further author information
,
Hao Tangb Department of Emergency, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People’s Republic of ChinaView further author information
&
Junlin Wub Department of Emergency, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People’s Republic of ChinaView further author information
Pages 751-756 | Published online: 02 Nov 2020

References

  • Brisse E, Wouters CH, Matthys P. Hemophagocytic lymphohistiocytosis (HLH): a heterogeneous spectrum of cytokine-driven immune disorders. Cytokine Growth Factor Rev. 2015;26(3):263–280.
  • Creput C, Galicier L, Buyse S, et al. Understanding organ dysfunction in hemophagocytic lymphohistiocytosis. Intensive Care Med. 2008;34(7):1177–1187.
  • Hayden A, Park S, Giustini D, et al. Hemophagocytic syndromes (HPSs) including hemophagocytic lymphohistiocytosis (HLH) in adults: a systematic scoping review. Blood Rev. 2016;30(6):411–420.
  • Tumian NR, Wong CL. Pregnancy-related hemophagocytic lymphohistiocytosis associated with cytomegalovirus infection: a diagnostic and therapeutic challenge. Taiwan J Obstet Gynecol. 2015;54(4):432–437.
  • Whitacre CC, Reingold SC, O'Looney PA. A gender gap in autoimmunity. Science. 1999;283(5406):1277–1278.
  • Teng CL, Hwang G-Y, Lee B-J, et al. Pregnancy-induced hemophagocytic lymphohistiocytosis combined with autoimmune hemolytic anemia. J Chin Med Assoc. 2009;72(3):156–159.
  • La Rosee P, Horne A, Hines M, et al. Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. Blood. 2019;133(23):2465–2477.
  • Samra B, Yasmin M, Arnaout S, et al. Idiopathic hemophagocytic lymphohistiocytosis during pregnancy treated with steroids. Hematol Rep. 2015;7(3):6100.
  • Rousselin A, Alavi Z, Le Moigne E, et al. Hemophagocytic syndrome in pregnancy: case report, diagnosis, treatment, and prognosis. Clin Case Rep. 2017;5(11):1756–1764.
  • Parrott J, Shilling A, Male HJ, et al. Hemophagocytic lymphohistiocytosis in pregnancy: a case series and review of the current literature. Case Rep Obstet Gynecol. 2019;2019:9695367.
  • Giard JM, Decker KA, Lai JC, et al. Acute liver failure secondary to hemophagocytic lymphohistiocytosis during pregnancy. ACG Case Rep J. 2016;3(4):e162.
  • Kerley RN, Kelly RM, Cahill MR, et al. Haemophagocytic lymphohistiocytosis presenting as HELLP syndrome: a diagnostic and therapeutic challenge. BMJ Case Rep. 2017;2017:bcr2017219516), doi: 10.1136/bcr-2017-219516.
  • He MZ, Jia J, Zhang JY, et al. Pregnancy-associated hemophagocytic lymphohistiocytosis secondary to NK/T cells lymphoma A case report and literature review. Medicine (Baltimore). 2017;96(47):6.
  • Yildiz H, Vandercam B, Thissen X, et al. Hepatitis during pregnancy: a case of hemophagocytic lymphohistiocytosis. Clin Res Hepatol Gastroenterol. 2018;42(3):e49–e55.
  • Cheng J, Niu J, Wang Y, et al. Hemophagocytic lymphohistiocytosis in pregnancy: a case report and review of the literature. J Obstet Gynaecol. 2020;40(2):153–159. doi: 10.1080/01443615.2019.1601168.Epub 2019 Jun 19
  • Larroche C. Hemophagocytic lymphohistiocytosis in adults: diagnosis and treatment. Joint Bone Spine. 2012;79(4):356–361.
  • Hayden A, Lin M, Park S, et al. Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH. Blood Adv. 2017;1(26):2529–2534.
  • Fardet L, Galicier L, Lambotte O, et al. Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheumatol. 2014;66(9):2613–2620.
  • Riviere S, Galicier L, Coppo P, et al. Reactive hemophagocytic syndrome in adults: a retrospective analysis of 162 patients. Am J Med. 2014;127(11):1118–1125.
  • Das R, Guan P, Sprague L, et al. Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis. Blood. 2016;127(13):1666–1675.
  • Ahmed A, Merrill SA, Alsawah F, et al. Ruxolitinib in adult patients with secondary haemophagocytic lymphohistiocytosis: an open-label, single-centre, pilot trial. Lancet Haematol. 2019;6(12):e630–e6e7.
  • Slostad J, Hoversten P, Haddox CL, et al. Ruxolitinib as first-line treatment in secondary hemophagocytic lymphohistiocytosis: a single patient experience. Am J Hematol. 2018;93(2):E47–EE9.
  • Dohner H, Estey E, Grimwade D, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017;129(4):424–447.
  • Song Y, Wang Z, Hao Z, et al. Requirement for etoposide in the treatment of pregnancy related hemophagocytic lymphohistiocytosis: a multicenter retrospective study. Orphanet J Rare Dis. 2019;14(1):50.
  • Wang J, Wang Y, Wu L, et al. Ruxolitinib for refractory/relapsed hemophagocytic lymphohistiocytosis. Haematologica. 2020 May;105(5):e210–e212. doi: 10.3324/haematol.2019.222471.Epub 2019 Sep 12

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