The rebirth of the cool: a narrative review of the clinical outcomes of cold stored low titer group O whole blood recipients compared to conventional component recipients in trauma

References

• Leeper CM, Yazer MH, Cladis FP, et al. Use of uncrossmatched cold-stored whole blood in injured children with hemorrhagic shock. JAMA Pediatr. 2018;172:491–492.
   PubMed Web of Science ®Google Scholar
• Zielinski MD, Stubbs JR, Berns KS, et al. Prehospital blood transfusion programs: capabilities and lessons learned. J Trauma Acute Care Surg. 2017;82:S70–SS8.
   PubMed Web of Science ®Google Scholar
• Pidcoke HF, McFaul SJ, Ramasubramanian AK, et al. Primary hemostatic capacity of whole blood: a comprehensive analysis of pathogen reduction and refrigeration effects over time. Transfusion. 2013;53(Suppl 1):137S–149S.
   PubMedGoogle Scholar
• Reddoch KM, Pidcoke HF, Montgomery RK, et al. Hemostatic function of apheresis platelets stored at 4 degrees c and 22 degrees c. Shock. 2014;41(Suppl 1):54–61.
   PubMed Web of Science ®Google Scholar
• Nair PM, Pandya SG, Dallo SF, et al. Platelets stored at 4 degrees C contribute to superior clot properties compared to current standard-of-care through fibrin-crosslinking. Br J Haematol. 2017;178:119–129.
   PubMed Web of Science ®Google Scholar
• US Secretary of Health and Human Services. Adequcy of the national blood supply report to Congress 2020. [cited 2021 Jun]. Available from: https://www.hhs.gov/sites/default/files/hhs-adequacy-national-blood-supply-report-congress-2020.pdf.
   Google Scholar
• Cannon JW, Khan MA, Raja AS, et al. Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the eastern association for the surgery of trauma. J Trauma Acute Care Surg. 2017;82:605–617.
   PubMed Web of Science ®Google Scholar
• Kaufman RM, Dinh A, Cohn CS, et al. Electronic patient identification for sample labeling reduces wrong blood in tube errors. Transfusion. 2019;59:972–980.
   PubMed Web of Science ®Google Scholar
• Narayan S, Poles D, et al. on behalf of the Serious Hazards of Transfusion (SHOT) Steering Group. The 2019 Annual SHOT Report (2020).
   Google Scholar
• Fatalities Reported to FDA Following Blood Collection and Transfusion Annual Summary for Fiscal Year 2018. Available from: https://www.fda.gov/media/136907/download.
   Google Scholar
• Yazer MH, Cap AP, Spinella PC. Raising the standards on whole blood. J Trauma Acute Care Surg. 2018;84:S14–SS7.
   PubMed Web of Science ®Google Scholar
• Standards for blood banks and transfusion services. 32nd ed. Bethesda, Maryland: AABB, 2020.
   Google Scholar
• Seheult JN, Anto V, Alarcon LH, et al. Clinical outcomes among low-titer group O whole blood recipients compared to recipients of conventional components in civilian trauma resuscitation. Transfusion. 2018;58:1838–1845.
   PubMed Web of Science ®Google Scholar
• Yazer MH, Spinella PC. The use of low-titer group O whole blood for the resuscitation of civilian trauma patients in 2018. Transfusion. 2018;58:2744–2746.
   PubMed Web of Science ®Google Scholar
• Yazer MH, Spinella PC. Review of low titer group O whole blood use for massively bleeding patients around the world in 2019. ISBT Sci Ser. 2019;14:276–281.
   Google Scholar
• Yazer MH, Spinella PC. An international survey on the use of low titer group O whole blood for the resuscitation of civilian trauma patients in 2020. Transfusion. 2020;60(Suppl 3):S176–S1S9.
   PubMedGoogle Scholar
• Yazer MH, Spinella PC, Anto V, et al. Survey of group A plasma and low-titer group O whole blood use in trauma resuscitation at adult civilian level 1 trauma centers in the US. Transfusion. 2021;61:1757–1763.
   PubMed Web of Science ®Google Scholar
• Yazer MH, Cap AP, Spinella PC, et al. How do I implement a whole blood program for massively bleeding patients? Transfusion. 2018;58:622–628.
   PubMed Web of Science ®Google Scholar
• Hashmi ZG, Chehab M, Nathens AB, et al. Whole truths but half the blood: addressing the gap between the evidence and practice of pre-hospital and in-hospital blood product use for trauma resuscitation. Transfusion. 2021 Jul;61 Suppl 1:S348–S353.
   PubMedGoogle Scholar
• Nadler R, Tsur AM, Yazer MH, et al. Early experience with transfusing low titer group O whole blood in the pre-hospital setting in Israel. Transfusion. 2020;60(Suppl 3):S10–SS6.
   PubMedGoogle Scholar
• Apelseth TO, Strandenes G, Kristoffersen EK, et al. How do I implement a whole blood-based blood preparedness program in a small rural hospital? Transfusion. 2020;60:2793–2800.
   PubMed Web of Science ®Google Scholar
• Bjerkvig C, Sivertsen J, Braathen H, et al. Cold-stored whole blood in a Norwegian emergency helicopter service: an observational study on storage conditions and product quality. Transfusion. 2020;60:1544–1551.
   PubMed Web of Science ®Google Scholar
• Crowe E, DeSantis SM, Bonnette A, et al. Whole blood transfusion versus component therapy in trauma resuscitation: a systematic review and meta-analysis. J Am Coll Emerg Physicians Open. 2020;1:633–641.
   PubMedGoogle Scholar
• Cid J, Harm SK, Yazer MH. Platelet transfusion - the art and science of compromise. Transfus Med Hemother. 2013;40:160–171.
   PubMed Web of Science ®Google Scholar
• Berseus O, Boman K, Nessen SC, et al. Risks of hemolysis due to anti-A and anti-B caused by the transfusion of blood or blood components containing ABO-incompatible plasma. Transfusion. 2013;53(Suppl 1):114S–123S.
   PubMedGoogle Scholar
• Yazer MH, Jackson B, Sperry JL, et al. Initial safety and feasibility of cold-stored uncrossmatched whole blood transfusion in civilian trauma patients. J Trauma Acute Care Surg. 2016;81:21–26.
   PubMed Web of Science ®Google Scholar
• Seheult JN, Bahr M, Anto V, et al. Safety profile of uncrossmatched, cold-stored, low-titer, group O+ whole blood in civilian trauma patients. Transfusion. 2018;58:2280–2288.
   PubMed Web of Science ®Google Scholar
• Harrold IM, Seheult JN, Alarcon LH, et al. Hemolytic markers following the transfusion of uncrossmatched, cold-stored, low-titer, group O+ whole blood in civilian trauma patients. Transfusion. 2020;60(Suppl 3):S24–S30.
   PubMedGoogle Scholar
• Seheult JN, Triulzi DJ, Alarcon LH, et al. Measurement of haemolysis markers following transfusion of uncrossmatched, low-titre, group O+ whole blood in civilian trauma patients: initial experience at a level 1 trauma centre. Transfus Med. 2017;27:30–35.
   PubMed Web of Science ®Google Scholar
• Williams J, Merutka N, Meyer D, et al. Safety profile and impact of low-titer group O whole blood for emergency use in trauma. J Trauma Acute Care Surg. 2020;88:87–93.
   PubMed Web of Science ®Google Scholar
• Gallaher JR, Dixon A, Cockcroft A, et al. Large volume transfusion with whole blood is safe compared with component therapy. J Trauma Acute Care Surg. 2020;89:238–245.
   PubMed Web of Science ®Google Scholar
• Condron M, Scanlan M, Schreiber M. Massive transfusion of low-titer cold-stored O-positive whole blood in a civilian trauma setting. Transfusion. 2019;59:927–930.
   PubMed Web of Science ®Google Scholar
• Yazer MH, Spinella PC, Doyle L, et al. Transfusion of uncrossmatched group O erythrocyte-containing products does Not interfere with most ABO typings. Anesthesiology. 2020;132:525–534.
   PubMed Web of Science ®Google Scholar
• Dunbar NM, Yazer MH. Biomedical excellence for safer transfusion C, et al. safety of the use of group A plasma in trauma: the STAT study. Transfusion. 2017;57:1879–1884.
   PubMed Web of Science ®Google Scholar
• Seheult JN, Dunbar NM, Hess JR, et al. Transfusion of blood components containing ABO-incompatible plasma does not lead to higher mortality in civilian trauma patients. Transfusion. 2020;60:2517–2528.
   PubMed Web of Science ®Google Scholar
• Holcomb JB, Tilley BC, Baraniuk S, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015;313:471–482.
   PubMed Web of Science ®Google Scholar
• Hanna K, Bible L, Chehab M, et al. Nationwide analysis of whole blood hemostatic resuscitation in civilian trauma. J Trauma Acute Care Surg. 2020;89:329–335.
   PubMed Web of Science ®Google Scholar
• Shea SM, Staudt A, Thomas KA, et al. The use of low-titer group o whole blood is independently associated with improved survival compared to component therapy in adults with severe traumatic hemorrhage. Transfusion. 2020;60:S2–S9.
   PubMed Web of Science ®Google Scholar
• Duchesne J, Smith A, Lawicki S, et al. Single institution trial comparing whole blood vs balanced component therapy: 50 years later. J Am Coll Surg. 2021;232:433–442.
   PubMedGoogle Scholar
• Hazelton JP, Cannon JW, Zatorski C, et al. Cold-stored whole blood: A better method of trauma resuscitation? J Trauma Acute Care Surg. 2019;87:1035–1041.
   PubMedGoogle Scholar
• Jones AR, Frazier SK. Increased mortality in adult patients with trauma transfused with blood components compared with whole blood. J Trauma Nurs. 2014;21:22–29.
   PubMed Web of Science ®Google Scholar
• Yazer MH, Freeman A, Harrold IM, et al. Injured recipients of low titer group O whole blood have similar clinical outcomes compared to recipients of conventional component therapy: a single-center, retrospective study. Transfusion. 2021;61:1710–1720.
   PubMed Web of Science ®Google Scholar
• Martinaud C, Tiberghien P, Begue S, et al. Rational and design of the T-STORHM study: A prospective randomized trial comparing fresh whole blood to blood components for acutely bleeding trauma patients. Transfus Clin Biol. 2019;26:198–201.
   PubMed Web of Science ®Google Scholar
• Cotton BA, Podbielski J, Camp E, et al. A randomized controlled pilot trial of modified whole blood versus component therapy in severely injured patients requiring large volume transfusions. Ann Surg. 2013;258:527–532.; discussion 32–3.
   PubMed Web of Science ®Google Scholar
• Morgan K, Yazer MH, Triulzi DJ, et al. Safety profile of Low titer group O whole blood in pediatric patients with massive hemorrhage. Transfusion. 2021 Jul;Suppl 1:S8–S14.
   Google Scholar
• Anand T, Obaid O, Nelson A, et al. Whole blood hemostatic resuscitation in pediatric trauma: a nationwide propensity-matched analysis. J Trauma Acute Care Surg. 2021.
   Web of Science ®Google Scholar
• Leeper CM, Yazer MH, Morgan KM, et al. Adverse events after low titer group O whole blood versus component product transfusion in pediatric trauma patients: A propensity-matched cohort study. Transfusion. 2021.
   Web of Science ®Google Scholar
• Leeper CM, Yazer MH, Triulzi DJ, et al. Whole blood is superior to component transfusion for injured children: a propensity matched analysis. Ann Surg. 2020;272:590–594.
   PubMed Web of Science ®Google Scholar
• Leonard JC, Josephson CD, Luther JF, et al. Life-Threatening bleeding in children: A prospective observational study. Crit Care Med. 2021.
   PubMed Web of Science ®Google Scholar
• Roberts I, Shakur H, Coats T, et al. The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Health Technol Assess. 2013;17:1–79.
   Web of Science ®Google Scholar
• Woolley T, Thompson P, Kirkman E, et al. Trauma hemostasis and oxygenation research network position paper on the role of hypotensive resuscitation as part of remote damage control resuscitation. J Trauma Acute Care Surg. 2018;84:S3–S13.
   PubMed Web of Science ®Google Scholar
• Wray JP, Bridwell RE, Schauer SG, et al. The diamond of death: hypocalcemia in trauma and resuscitation. Am J Emerg Med. 2021;41:104–109.
   PubMed Web of Science ®Google Scholar
• Sperry JL, Guyette FX, Brown JB, et al. Prehospital plasma during air medical transport in trauma patients at risk for hemorrhagic shock. N Engl J Med 2018;379: 315–326.
   PubMed Web of Science ®Google Scholar
• Cap AP, Pidcoke HF, Spinella P, et al. Damage control resuscitation. Mil Med. 2018;183:36–43.
   PubMed Web of Science ®Google Scholar
• Kemp Bohan PM, McCarthy PM, Wall ME, et al. Safety and efficacy of low-titer O whole blood resuscitation in a civilian level I trauma center. J Trauma Acute Care Surg. 2021 Aug 1;91(2S Suppl 2):S62–S168.
   Google Scholar