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Research Article

Biomarkers of erythropoiesis response to intravenous iron in a crossover pilot study in unexplained anemia of the elderly

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Pages 1-8 | Received 17 Dec 2022, Accepted 15 Apr 2023, Published online: 28 Apr 2023

References

  • Guralnik JM, et al. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104(8):2263–2268.
  • Ble A, et al. Renal function, erythropoietin, and anemia of older persons. Arch Intern Med. 2005;165(19):2222–2227.
  • Artz AS, et al. Prevalence of anemia in skilled-nursing home residents. Arch Gerontol Geriatr. 2004;39(3):201–206.
  • Stauder R, Valent P, Theurl I. Anemia at older age: etiologies, clinical implications, and management. Blood. 2018;131(5):505–514.
  • Price EA, et al. Anemia in older persons: etiology and evaluation. Blood Cells Mol Dis. 2011;46(2):159–165.
  • Artz AS, Thirman MJ. Unexplained anemia predominates despite an intensive evaluation in a racially diverse cohort of older adults from a referral anemia clinic. J Gerontol A Biol Sci Med Sci. 2011;66(8):925–932.
  • Juarez-Cedillo T, et al. Prevalence of anemia and its impact on the state of frailty in elderly people living in the community: SADEM study. Ann Hematol. 2014;93(12):2057–2062.
  • Migone De Amicis M, et al. Anemia in elderly hospitalized patients: prevalence and clinical impact. Intern Emerg Med. 2015;10(5):581–586.
  • Artz AS. Anemia and the frail elderly. Semin Hematol. 2008;45(4):261–266.
  • Rohrig G. Anemia in the frail, elderly patient. Clin Interv Aging. 2016;11:319–326.
  • Punnonen K, Irjala K, Rajamaki A. Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood. 1997;89(3):1052–1057.
  • Tavenier J, Leng SX. Inflammatory pathways to anemia in the frail elderly. Clin Geriatr Med. 2019;35(3):339–348.
  • Ferrucci L, et al. Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers. Br J Haematol. 2007;136(6):849–855.
  • Artz AS, et al. Unexplained anaemia in the elderly is characterised by features of low grade inflammation. Br J Haematol 2014;167(2):286–289.
  • Makipour S, Kanapuru B, Ershler WB. Unexplained anemia in the elderly. Semin Hematol. 2008;45(4):250–254.
  • Pang WW, Schrier SL, Weissman IL. Age-associated changes in human hematopoietic stem cells. Semin Hematol 2017;54(1):39–42.
  • Sriram S, Xenocostas A, Lazo-Langner A. Erythropoietin in anemia of unknown etiology: a systematic review and meta-analysis. Hematology. 2016;21(4):234–240.
  • Gowanlock Z, et al. Erythropoietin levels in elderly patients with anemia of unknown etiology. PLoS One. 2016;11(6):e0157279.
  • Guyatt GH, et al. Laboratory diagnosis of iron-deficiency anemia. J Gen Intern Med. 1992;7(2):145–153.
  • Joosten E, et al. Serum transferrin receptor in the evaluation of the iron status in elderly hospitalized patients with anemia. Am J Hematol. 2002;69(1):1–6.
  • Anker SD, et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med. 2009;361(25):2436–2448.
  • Price E, et al. A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20–200ng/mL. Blood Cells Mol Dis. 2014;53(4):221–230.
  • Ganz T, et al. Immunoassay for human serum hepcidin. Blood. 2008;112(10):4292–4297.
  • Ganz, T., Anemia of Inflammation. N Engl J Med, 2019. 381(12): p. 1148–1157.
  • Kautz L, et al. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014;46(7):678–684.
  • Yoon D, et al. Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem. 2006;281(35):25703–25711.
  • Cazzola M, et al. Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis. Blood. 1996;87(11):4824–4830.
  • Suominen P, et al. Single values of serum transferrin receptor and transferrin receptor ferritin index can be used to detect true and functional iron deficiency in rheumatoid arthritis patients with anemia. Arthritis Rheum. 2000;43(5):1016–1020.
  • Huebers HA, et al. Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood. 1990;75(1):102–107.
  • Beguin Y. Soluble transferrin receptor for the evaluation of erythropoiesis and iron status. Clin Chim Acta. 2003;329(1–2):9–22.
  • Butterfield AM, et al. A dual-monoclonal sandwich ELISA specific for hepcidin-25. Clin Chem. 2010;56(11):1725–1732.
  • Artz AS, et al. Markers of iron flux during testosterone-mediated erythropoiesis in older Men with unexplained or iron-deficiency anemia. J Clin Endocrinol Metab. 2020;105(11):3396–3403.
  • Onken JE, et al. A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia. Transfusion. 2014;54(2):306–315.
  • Ganz T. Anemia of chronic disease. In: K. Kaushansky, et al., editors. Williams hematology, 10th ed. New York: McGraw-Hill Education; 2021.
  • Qunibi WY, et al. A randomized controlled trial comparing intravenous ferric carboxymaltose with oral iron for treatment of iron deficiency anaemia of non-dialysis-dependent chronic kidney disease patients. Nephrol Dial Transplant. 2011;26(5):1599–1607.