Advanced search
Publication Cover
Hematology Volume 28, 2023 - Issue 1
Submit an article Journal homepage
2,199
Views
2
CrossRef citations to date
0
Altmetric
Research Article

A novel necroptosis-related gene signature in acute myeloid leukemia

Weiyue Fanga Department of Hematology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of ChinaView further author information
,
Hongdou Linb Department of Hematology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of ChinaView further author information
,
Junyi Chenb Department of Hematology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of ChinaView further author information
&
Wenjian Guoc Medical and Radiation Oncology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China;d Zhejiang Engineering Research Center for Innovation and Application of Intelligent Radiotherapy Technology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of ChinaCorrespondence[email protected]
View further author information
Article: 2227491 | Received 08 Apr 2023, Accepted 15 Jun 2023, Published online: 27 Jun 2023

References

  • Valk PJ, Verhaak RG, Beijen MA, et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med. 2004;350(16):1617–1628. doi:10.1056/NEJMoa040465
  • Konopleva M, Letai A. BCL-2 inhibition in AML: an unexpected bonus? Blood. 2018;132(10):1007–1012. doi:10.1182/blood-2018-03-828269
  • Galluzzi L, Kepp O, Chan FK, et al. Necroptosis: mechanisms and relevance to disease. Annu Rev Pathol. 2017;12:103–130. doi:10.1146/annurev-pathol-052016-100247
  • Grootjans S, Vanden Berghe T, Vandenabeele P. Initiation and execution mechanisms of necroptosis: an overview. Cell Death Differ. 2017;24(7):1184–1195. doi:10.1038/cdd.2017.65
  • Koo GB, Morgan MJ, Lee DG, et al. Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics. Cell Res. 2015;25(6):707–725. doi:10.1038/cr.2015.56
  • Feng X, Song Q, Yu A, et al. Receptor-interacting protein kinase 3 is a predictor of survival and plays a tumor suppressive role in colorectal cancer. Neoplasma. 2015;62(4):592–601. doi:10.4149/neo_2015_071
  • Gong Y, Fan Z, Luo G, et al. The role of necroptosis in cancer biology and therapy. Mol Cancer. 2019;18(1):100. doi:10.1186/s12943-019-1029-8
  • Hsu SK, Chang T, Lin IL, et al. The role of necroptosis in ROS-mediated cancer therapies and its promising applications. Cancers (Basel). 2020;12(8):2185. doi:10.3390/cancers12082185
  • Strilic B, Yang L, Albarran-Juarez J, et al. Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature. 2016;536(7615):215–258. doi:10.1038/nature19076
  • Seifert L, Werba G, Tiwari S, et al. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Nature. 2016;532(7598):245–249. doi:10.1038/nature17403
  • Hockendorf U, Yabal M, Herold T, et al. RIPK3 restricts myeloid leukemogenesis by promoting cell death and differentiation of leukemia initiating cells. Cancer Cell. 2016;30(1):75–91. doi:10.1016/j.ccell.2016.06.002
  • Nugues AL, El Bouazzati H, Hetuin D, et al. RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavage. Cell Death Dis. 2014;5:e1384. doi:10.1038/cddis.2014.347
  • Xin J, You D, Breslin P, et al. Sensitizing acute myeloid leukemia cells to induced differentiation by inhibiting the RIP1/RIP3 pathway. Leukemia. 2017;31(5):1154–1165. doi:10.1038/leu.2016.287
  • Degterev A, Hitomi J, Germscheid M, et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008;4(5):313–321. doi:10.1038/nchembio.83
  • Hockendorf U, Yabal M, Jost PJ. RIPK3-dependent cell death and inflammasome activation in FLT3-ITD expressing LICs. Oncotarget. 2016;7(36):57483–4. doi:10.18632/oncotarget.11195
  • Mouasni S, Tourneur L. FADD at the crossroads between cancer and inflammation. Trends Immunol. 2018;39(12):1036–1053. doi:10.1016/j.it.2018.10.005
  • Chien HT, Cheng S D, Chuang WY, et al. Clinical implications of FADD gene amplification and protein overexpression in Taiwanese oral cavity squamous cell carcinomas. PLoS One. 2016;11(10):e0164870. doi:10.1371/journal.pone.0164870
  • Nakanishi M, Rosenberg DW. Roles of cPLA2alpha and arachidonic acid in cancer. Biochim Biophys Acta. 2006;1761(11):1335–1343. doi:10.1016/j.bbalip.2006.09.005
  • Hassan JJ, Lieske A, Dorpmund N, et al. A multiplex CRISPR-screen identifies PLA2G4A as prognostic marker and druggable target for HOXA9 and MEIS1 dependent AML. Int J Mol Sci. 2021;22(17):9411. doi:10.3390/ijms22179411
  • Masumoto J, Taniguchi S, Ayukawa K, et al. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J Biol Chem. 1999;274(48):33835–8. doi:10.1074/jbc.274.48.33835
  • Deswaerte V, Nguyen P, West A, et al. Inflammasome adaptor ASC suppresses apoptosis of gastric cancer cells by an IL18-mediated inflammation-independent mechanism. Cancer Res. 2018;78(5):1293–1307. doi:10.1158/0008-5472.CAN-17-1887
  • Kuriakose T, Kanneganti TD. ZBP1: innate sensor regulating cell death and inflammation. Trends Immunol. 2018;39(2):123–134. doi:10.1016/j.it.2017.11.002
  • Baik JY, Liu Z, Jiao D, et al. ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer [J]. Nat Commun. 2021;12(1):2666, doi:10.1038/s41467-021-23004-3
  • Sun Y, Wang R, Xie S, et al. A novel identified necroptosis-related risk signature for prognosis prediction and immune infiltration indication in acute myeloid leukemia patients. Genes (Basel). 2022;13(10):1837. doi:10.3390/genes13101837
  • Ma J, Jin Y, Gong B, et al. Pan-cancer analysis of necroptosis-related gene signature for the identification of prognosis and immune significance. Discov Oncol. 2022;13(1):17. doi:10.1007/s12672-022-00477-2

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.