MDL 28170 Attenuates Gentamicin Ototoxicity

References

• Forge A, Schacht J. Aminoglycoside antibiotics. Audiol Neurootol 2000; 5: 3–22
   PubMed Web of Science ®Google Scholar
• Mulherin D, Fahy J, Grant W, Keogan M, Kavanagh B, FitzGerald M. Aminoglycoside induced ototoxicity in patients with cystic fibrosis. Ir J Med Sci 1991; 160: 173–5
   PubMed Web of Science ®Google Scholar
• Barton-Davis E R, Cordier L, Shoturma D I, Leland S E, Sweeney H L. Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice. J Clin Invest 1999; 104: 375–81
   PubMed Web of Science ®Google Scholar
• Howard M T, Anderson C B, Fass U, Khatri S, Gesteland R F, Atkins J F, Flanigan K M. Readthrough of dystrophin stop codon mutations induced by aminoglycosides. Ann Neurol 2004; 55: 422–6
   PubMed Web of Science ®Google Scholar
• Kerem E. Pharmacological therapy for stop mutations: how much CFTR activity is enough?. Curr Opin Pulm Med 2004; 10: 547–52
   PubMed Web of Science ®Google Scholar
• Ding D, Stracher A, Salvi R J. Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity. Hear Res 2002; 164: 115–26
   PubMed Web of Science ®Google Scholar
• Sha S, Taylor R, Forge A, Schacht J. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res 2001; 155: 1–8
   PubMed Web of Science ®Google Scholar
• Clerici W J, Hensley K, DiMartino D L, Butterfield D A. Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hear Res 1996; 98: 116–24
   PubMed Web of Science ®Google Scholar
• Hirose K, Westrum L E, Stone J S, Zirpel L, Rubel E W. Dynamic studies of ototoxicity in mature avian auditory epithelium. Ann N Y Acad Sci 1999; 884: 389–409
   PubMedGoogle Scholar
• Takumida M, Popa R, Anniko M. Free radicals in the guinea pig inner ear following gentamicin exposure. ORL J Otorhinolaryngol Relat Spec 1999; 61: 63–70
   PubMed Web of Science ®Google Scholar
• Clerici W J, Yang L. Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function. Hear Res 1996; 101: 14–22
   PubMed Web of Science ®Google Scholar
• Sha S H, Schacht J. Salicylate attenuates gentamicin-induced ototoxicity. Lab Invest 1999; 79: 807–13
   PubMed Web of Science ®Google Scholar
• McFadden S L, Ding D, Salvemini D, Salvi R J. M40403, a superoxide dismutase mimetic, protects cochlear hair cells from gentamicin, but not cisplatin toxicity. Toxicol Appl Pharmacol 2003; 186: 46–54
   PubMed Web of Science ®Google Scholar
• Forge A. Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment. Hear Res 1985; 19: 171–82
   PubMed Web of Science ®Google Scholar
• Nakagawa T, Yamane H, Takayama M, Sunami K, Nakai Y. Apoptosis of guinea pig cochlear hair cells following chronic aminoglycoside treatment. Eur Arch Otorhinolaryngol 1998; 255: 127–31
   PubMedGoogle Scholar
• Cheng A G, Cunningham L L, Rubel E W. Hair cell death in the avian basilar papilla: characterization of the in vitro model and caspase activation. J Assoc Res Otolaryngol 2003; 4: 91–105
   PubMedGoogle Scholar
• Bartus R T, Elliott P J, Hayward N J, Dean R L, Harbeson S, Straub J A, et al. Calpain as a novel target for treating acute neurodegenerative disorders. Neurol Res 1995; 17: 249–58
   PubMed Web of Science ®Google Scholar
• Nath R, Raser K J, McGinnis K, Nadimpalli R, Stafford D, Wang K K. Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis. Neuroreport 1996; 8: 249–55
   PubMed Web of Science ®Google Scholar
• Sorimachi H, Ishiura S, Suzuki K. Structure and physiological function of calpains. Biochem J 1997; 328: 721–32
   PubMed Web of Science ®Google Scholar
• Saito K, Elce J S, Hamos J E, Nixon R A. Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer's disease: a potential molecular basis for neuronal degeneration. Proc Natl Acad Sci USA 1993; 90: 2628–32
   PubMed Web of Science ®Google Scholar
• Richard I, Brenguier L, Dincer P, Roudaut C, Bady B, Burgunder J M, et al. Multiple independent molecular aetiology for limb-girdle muscular dystrophy type 2A patients from various geographical origins. Am J Hum Genet 1997; 60: 1128–38
   PubMed Web of Science ®Google Scholar
• Stracher A. Calpain inhibitors as neuroprotective agents in neurodegenerative disorders. Intern Tinnitus J 1997; 3: 71–5
   PubMedGoogle Scholar
• Bartus R T, Elliott P J, Hayward N J, Dean R L, Harbeson S, Straub J A, et al. Calpain as a novel target for treating acute neurodegenerative disorders. Neurol Res 1995a; 17: 249–58
   PubMed Web of Science ®Google Scholar
• Badalamente M A, Hurst L C, Stracher A. Neuromuscular recovery after peripheral nerve repair: effects of an orally-administered peptide in a primate model. J Reconstr Microsurg 1995; 11: 429–37
   PubMedGoogle Scholar
• Bartus R T, Elliott P J, Hayward N J, Dean R L, Harbeson S, Straub J A, et al. Calpain as a novel target for treating acute neurodegenerative disorders. Neurological Res 1995b; 17: 249–58
   PubMed Web of Science ®Google Scholar
• Saatman K E, Murai H, Bartus R T, Smith D H, Hayward N J, Perri B R, McIntosh T K. Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat. Proc Nat Acad Sci USA 1996; 93: 3428–33
   PubMed Web of Science ®Google Scholar
• Wang K KW, Nath R, Raser K J, Hajimohammadreza I. Maitotoxin induces calpain activation in SH-SY5Y neuroblastoma cells and cerebrocortical cultures. Arch Biochem Biophys 1996; 331: 208–14
   PubMedGoogle Scholar
• Jordan J, Galindo M F, Miller R J. Role of calpain- and interleukin-1 beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture. J Neurochem 1997; 68: 1612–21
   PubMed Web of Science ®Google Scholar
• Cheng A G, Huang T, Stracher A, Kim A, Liu W, Malgrange B, et al. Calpain inhibitors protect auditory sensory cells from hypoxia and neurotrophin-withdrawal induced apoptosis. Brain Res 1999; 850: 234–43
   PubMed Web of Science ®Google Scholar
• Wang J, Ding D, Shulman A, Stracher A, Salvi R J. Leupeptin protects sensory hair cells from acoustic trauma. Neuroreport 1999; 10: 811–6
   PubMed Web of Science ®Google Scholar
• Li Y, Huang Y, Luo S. Alternation of intracellular Ca2+ caused by streptomycin in the isolated cochlear OHC. Chung Hua Erh Pi Yen Hou Ko Tsa Chih 1995; 30: 227–9
   Google Scholar
• Shimizu A, Takumida M, Anniko M, Suzuki M. Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity. Acta Otolaryngol 2003; 123: 459–65
   PubMed Web of Science ®Google Scholar
• Aoyagi T, Takeuchi T, Matsuzaki A, Kawamura K, Kondo S. Leupeptins, new protease inhibitors from Actinomycetes. J Antibiot 1969; 22: 283–6
   PubMed Web of Science ®Google Scholar
• Takumida M, Anniko M, Shimizu A, Watanabe H. Neuroprotection of vestibular sensory cells from gentamicin ototoxicity obtained using nitric oxide synthase inhibitors, reactive oxygen species scavengers, brain-derived neurotrophic factors and calpain inhibitors. Acta Otolaryngol 2003; 123: 8–13
   PubMed Web of Science ®Google Scholar
• Kwak K B, Kambayashi J, Kang M S, Ha D B, Chung C H. Cell-penetrating inhibitors of calpain block both membrane fusion and filamin cleavage in chick embryonic myoblasts. FEBS Lett 1993; 323: 151–4
   PubMedGoogle Scholar
• Osanai T, Nagai Y. Suppression of experimental allergic encephalomyelitis (EAE) with liposome-encapsulated protease inhibitor: therapy through the blood-brain barrier. Neurochem Res 1984; 9: 1407–16
   PubMed Web of Science ®Google Scholar
• Li P A, Howlett W, He Q P, Miyashita H, Siddiqui M, Shuaib A. Postischaemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischaemia. Neurosci Lett 1998; 247: 17–20
   PubMed Web of Science ®Google Scholar
• Buki A, Farkas O, Doczi T, Povlishock J T. Preinjury administration of the calpain inhibitor MDL 28170 attenuates traumatically induced axonal injury. J Neurotrauma 2003; 20: 261–8
   PubMedGoogle Scholar
• Crocker S J, Smith P D, Jackson-Lewis V, Lamba W R, Hayley S P, Grimm E, et al. Inhibition of calpains prevents neuronal and behavioural deficits in an MPTP mouse model of Parkinson's disease. J Neurosci 2003; 23: 4081–91
   PubMed Web of Science ®Google Scholar
• Brorson J R, Marcuccilli C J, Miller R J. Delayed antagonism of calpain reduces excitotoxicity in cultured neurons. Stroke 1995; 26: 1259–66, discussion 1267
   PubMedGoogle Scholar
• Corbacella E, Lanzoni I, Ding D, Previati M, Salvi R. Minocycline attenuates gentamicin induced hair cell loss in neonatal cochlear cultures. Hear Res 2004; 197: 11–8
   PubMed Web of Science ®Google Scholar
• Nicotera T M, Ding D, McFadden S L, Salvemini D, Salvi R. Paraquat-induced hair cell damage and protection with the superoxide dismutase mimetic M40403. Audiol Neurootol 2004; 9: 353–62
   PubMedGoogle Scholar
• Chen Z F, Schottler F, Lee K S. Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL28170. Brain Res 1997; 769: 188–92
   PubMedGoogle Scholar
• Brana C, Benham C D, Sundstrom L E. Calpain activation and inhibition in organotypic rat hippocampal slice cultures deprived of oxygen and glucose. Eur J Neurosci 1999; 11: 2375–84
   PubMedGoogle Scholar
• DeRosier D J, Tilney L G. F-actin bundles are derivatives of microvilli: what does this tell us about how bundles might form?. J Cell Biol 2000; 148: 1–6
   PubMedGoogle Scholar
• Loomis P A, Zheng L, Sekerkova G, Changyaleket, Mugnaini E, Bartles J R. Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo. J Cell Biol 2003; 163: 1045–55
   PubMed Web of Science ®Google Scholar
• Kitajiri S, Fukumoto K, Hata M, Sasaki H, Katsuno T, Nakagawa T, et al. Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia. J Cell Biol. 2004; 166: 559–70
   PubMed Web of Science ®Google Scholar
• Pataky F, Pironkova R, Hudspeth A J. Radixin is a constituent of stereocilia in hair cells. Proc Natl Acad Sci USA 2004; 101: 2601–6
   PubMedGoogle Scholar
• Shcherbina A, Bretscher A, Kenney D M, Remold-O'Donnell E. Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain. FEBS Lett 1999; 443: 31–6
   PubMedGoogle Scholar
• Hoock T C, Newcomb P M, Herman I M. Beta actin and its mRNA are localized at the plasma membrane and the regions of moving cytoplasm during the cellular response to injury. J Cell Biol 1991; 112: 653–64
   PubMedGoogle Scholar
• Potter D A, Tirnauer J S, Janssen R, Croall D E, Hughes C N, Fiacco K A, et al. Calpain regulates actin remodelling during cell spreading. J Cell Biol 1998; 141: 647–62
   PubMed Web of Science ®Google Scholar
• Nakayama N, Eichhorst S, Muller M, Krammer PH. Ethanol-induced apoptosis in hepatoma cells proceeds via intracellular Ca2+ elevation, activation of TLCK-sensitive proteases, and cytochrome c release. Exp Cell Res 2001; 269: 202–13
   PubMed Web of Science ®Google Scholar
• Liu N, Wang Y, Ashton-Rickardt P G. Serine protease inhibitor 2A inhibits caspase-independent cell death. FEBS Lett 2004; 569: 49–53
   PubMedGoogle Scholar
• Potter D A, Srirangam A, Fiacco K A, Brocks D, Hawes J, Herndon C, et al. Calpain regulates enterocyte brush border actin assembly and pathogenic Escherichia coli-mediated effacement. J Biol Chem 2003; 278: 30403–12
   PubMedGoogle Scholar