Tinnitus treatment: Are drugs effective?

References

• Sand PG, Langguth B, Kleinjung T, Eichhammer P. Genetics of chronic tinnitus. Prog Brain Res. 2007; 166: 159–68
   PubMed Web of Science ®Google Scholar
• Simpson JJ, Davies WE. Recent advances in the pharmacological treatment of tinnitus. Trends Pharmacol Sci. 1999; 20: 12–8
   PubMed Web of Science ®Google Scholar
• Pyykkö I ZJ, Toppila E, Kentala E. Pharmacotherapy of the inner ear. Genes, Hearing and Deafness, A Martini. Informa Healthcare, London 2007; 219–38
   Google Scholar
• Oestreicher E, Wolfgang A, Felix D. Neurotransmission of the cochlear inner hair cell synapse: implications for inner ear therapy. Adv Otorhinolaryngol. 2002; 59: 131–9
   PubMedGoogle Scholar
• Pujol R, Puel JL, Gervais d'Aldin C, Eybalin M. Pathophysiology of the glutamatergic synapses in the cochlea. Acta Otolaryngol. 1993; 113: 330–4
   PubMed Web of Science ®Google Scholar
• Puel JL, Ruel J, Guitton M, Wang J, Pujol R. The inner hair cell synaptic complex: physiology, pharmacology and new therapeutic strategies. Audiol Neurootol. 2002; 7: 49–54
   PubMed Web of Science ®Google Scholar
• Puel JL. Chemical synaptic transmission in the cochlea. Prog Neurobiol. 1995; 47: 449–76
   PubMed Web of Science ®Google Scholar
• Puel JL, Pujol R, Tribillac F, Ladrech S, Eybalin M. Excitatory amino acid antagonists protect cochlear auditory neurons from excitotoxicity. J Comparative Neurol. 1994; 341: 241–56
   PubMed Web of Science ®Google Scholar
• Jager W, Goiny M, Herrera-Marschitz M, Brundin L, Fransson A, Canlon B. Noise-induced aspartate and glutamate efflux in the guinea pig cochlea and hearing loss. Experimental brain research Experimentelle Hirnforschung. 2000; 134: 426–34
   PubMed Web of Science ®Google Scholar
• Bienkowski P, Scinska A, Kostowski W, Koros E, Kukwa A. Ototoxic mechanism of aminoglycoside antibiotics: role of glutaminergic NMDA receptors. Pol Merkur Lekarski. 2000; 9: 713–5
   PubMedGoogle Scholar
• Pulec JL. Cochlear nerve section for intractable tinnitus. Ear Nose Throat J. 1995; 74: 468, 470–6
   Google Scholar
• Wazen JJ, Foyt D, Sisti M. Selective cochlear neurectomy for debilitating tinnitus. Ann Otol Rhinol Laryngol. 1997; 106: 568–70
   PubMed Web of Science ®Google Scholar
• Potashner SJ, Suneja SK, Benson CG. Regulation of D-aspartate release and uptake in adult brainstem auditory nuclei after unilateral middle ear ossicle removal and cochlear ablation. Exp Neurol. 1997; 148: 222–35
   PubMed Web of Science ®Google Scholar
• Makoff A, Pilling C, Harrington K, Emson P. Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS. Brain Res. 1996; 40: 165–70
   Web of Science ®Google Scholar
• Langner G, Wallhäusser-Franke E, Mahlke C. Evidence for a central origin of tinnitus from activity labelling in the auditory system of the gerbil. Physiol Res. 1999; 48: 23
   Google Scholar
• Jastreboff PJ, Brennan JF, Coleman JK, Sasaki CT. Phantom auditory sensation in rats: an animal model for tinnitus. Behav Neurosci. 1988; 102: 811–22
   PubMed Web of Science ®Google Scholar
• Masugi M, Yokoi M, Shigemoto R, Muguruma K, Watanabe Y, Sansig G, et al. Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion. J Neurosci. 1999; 19: 955–63
   PubMed Web of Science ®Google Scholar
• Cryan JF, Kelly PH, Neijt HC, Sansig G, Flor PJ, van der Putten H. Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7. Eur J Neurosci. 2003; 17: 2409–17
   PubMed Web of Science ®Google Scholar
• Sasaki CT, Kauer JS, Babitz L. Differential [14C]2-deoxyglucose uptake after deafferentation of the mammalian auditory pathway: a model for examining tinnitus. Brain Res. 1980; 194: 511–6
   PubMed Web of Science ®Google Scholar
• Bilak M, Kim J, Potashner SJ, Bohne BA, Morest DK. New growth of axons in the cochlear nucleus of adult chinchillas after acoustic trauma. Exp Neurol. 1997; 147: 256–68
   PubMed Web of Science ®Google Scholar
• Ruan RS, Leong SK, Yeoh KH. Ototoxicity of sodium nitroprusside is not due to nitric oxide. Exp Neurol. 1999; 158: 192–201
   PubMed Web of Science ®Google Scholar
• Zdanski CJ, Prazma J, Petrusz P, Grossman G, Raynor E, Smith TL, et al. Nitric oxide synthase is an active enzyme in the spiral ganglion cells of the rat cochlea. Hear Res. 1994; 79: 39–47
   PubMed Web of Science ®Google Scholar
• Johnson KL, Carrasco V, Prazma J, Zdanski CJ, Durland WF, Pillsbury HC. Role of nitric oxide in kainic acid-induced elevation of cochlear compound action potential thresholds. Acta Otolaryngol. 1998; 118: 660–5
   PubMed Web of Science ®Google Scholar
• Amaee FR, Comis SD, Osborne MP, Drew S, Tarlow MJ. Possible involvement of nitric oxide in the sensorineural hearing loss of bacterial meningitis. Acta Otolaryngol. 1997; 117: 329–36
   PubMed Web of Science ®Google Scholar
• Barkdull GC, Vu C, Keithley EM, Harris JP. Cochlear microperfusion: experimental evaluation of a potential new therapy for severe hearing loss caused by inflammation. Otol Neurotol. 2005; 26: 19–26
   PubMed Web of Science ®Google Scholar
• Nakashima T, Naganawa S, Sone M, Tominaga M, Hayashi H, Yamamoto H, et al. Disorders of cochlear blood flow. Brain Res Rev. 2003; 43: 17–28
   PubMed Web of Science ®Google Scholar
• Lamm K, Arnold W. Successful treatment of noise-induced cochlear ischaemia, hypoxia, and hearing loss. Ann N Y Acad Sci. 1999; 884: 233–48
   PubMed Web of Science ®Google Scholar
• Lamm K, Arnold W. The effect of blood flow promoting drugs on cochlear blood flow, perilymphatic PO2 and auditory function in the normal and noise-damaged hypoxic and ischaemic guinea pig inner ear. Hear Res. 2000; 141: 199–219
   PubMed Web of Science ®Google Scholar
• Lamm K, Arnold W. Noise-induced cochlear hypoxia is intensity dependent, correlates with hearing loss and precedes reduction of cochlear blood flow. Audiol Neurootol. 1996; 1: 148–60
   PubMedGoogle Scholar
• Bennett, MH, Kertesz, T, Yeung, P. Hyperbaric oxygen for idiopathic sudden sensorineural hearing loss and tinnitus. Cochrane database of systematic reviews (Online). 2007: CD004739.
   Web of Science ®Google Scholar
• Rejali D, Sivakumar A, Balaji N. Ginkgo biloba does not benefit patients with tinnitus: a randomized placebo-controlled double-blind trial and meta-analysis of randomized trials. Clin Otolaryngol. 2004; 29: 226–31
   PubMed Web of Science ®Google Scholar
• Drew S, Davies E. Effectiveness of Ginkgo biloba in treating tinnitus: double-blind, placebo- controlled trial. Br Med J. (Clinical research ed) 2001; 322: 73
   PubMed Web of Science ®Google Scholar
• James, AL, Burton, MJ. Betahistine for Menière's disease or syndrome. Cochrane database of systematic reviews (Online). 2001: CD001873.
   PubMedGoogle Scholar
• van Campen LE, Murphy WJ, Franks JR, Mathias PI, Toraason MA. Oxidative DNA damage is associated with intense noise exposure in the rat. Hear Res. 2002; 164: 29–38
   PubMed Web of Science ®Google Scholar
• Rybak LP, Whitworth C, Somani S. Application of antioxidants and other agents to prevent cisplatin ototoxicity. Laryngoscope. 1999; 109: 1740–4
   PubMed Web of Science ®Google Scholar
• Wu WJ, Sha SH, Schacht J. Recent advances in understanding aminoglycoside ototoxicity and its prevention. Audiol Neurootol. 2002; 7: 171–4
   PubMed Web of Science ®Google Scholar
• Clerici WJ, Yang L. Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function. Hear Res. 1996; 101: 14–22
   PubMed Web of Science ®Google Scholar
• Neri S, Signorelli S, Pulvirenti D, Mauceri B, Cilio D, Bordonaro F, et al. Oxidative stress, nitric oxide, endothelial dysfunction and tinnitus. Free Radic Res. 2006; 40: 615–8
   PubMed Web of Science ®Google Scholar
• Sha SH, Schacht J. Antioxidants attenuate gentamicin-induced free radical formation in vitro and ototoxicity in vivo: D-methionine is a potential protectant. Hear Res. 2000; 142: 34–40
   PubMed Web of Science ®Google Scholar
• Kopke RD, Weisskopf PA, Boone JL, Jackson RL, Wester DC, Hoffer ME, et al. Reduction of noise-induced hearing loss using L-NAC and salicylate in the chinchilla. Hear Res. 2000; 149: 138–46
   PubMed Web of Science ®Google Scholar
• Zou J, Bretlau P, Pyykko I, Toppila E, Olovius NP, Stephanson N, et al. Comparison of the protective efficacy of neurotrophins and antioxidants for vibration-induced trauma. ORL J Otorhinolaryngol Relat Spec. 2003; 65: 155–61
   PubMed Web of Science ®Google Scholar
• Puka-Sundvall M, Eriksson P, Nilsson M, Sandberg M, Lehmann A. Neurotoxicity of cysteine: interaction with glutamate. Brain Res. 1995; 705: 65–70
   PubMed Web of Science ®Google Scholar
• Olzowy, B, Canis, M, Hempel, JM, Mazurek, B, Suckfull, M. Effect of atorvastatin on progression of sensorineural hearing loss and tinnitus in the elderly: results of a prospective, randomized, double-blind clinical trial. Otol Neurotol. 2007; Publish Ahead of Print.
   PubMed Web of Science ®Google Scholar
• Savastano M, Brescia G, Marioni G. Antioxidant therapy in idiopathic tinnitus: preliminary outcomes. Arch Med Res. 2007; 38: 456–9
   PubMed Web of Science ®Google Scholar
• Khan M, Gross J, Haupt H, Jainz A, Niklowitz P, Scherer H, et al. A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium. Otolaryngol Head Neck Surg. 2007; 136: 72–7
   PubMed Web of Science ®Google Scholar
• Puel J, Wang J, Rebillard G, Eybalin M, Lloyd R, Pujol R, et al. Physiology, pharmacology and plasticity at the inner hair cell synaptic complex. Hear Res. 2007; 227: 19–27
   PubMed Web of Science ®Google Scholar
• Puel JL, Pujol R, Ladrech S, Eybalin M. Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid electrophysiological and neurotoxic effects in the guinea-pig cochlea. Neuroscience. 1991; 45: 63–72
   PubMed Web of Science ®Google Scholar
• Denk DM, Heinzl H, Franz P, Ehrenberger K. Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol. 1997; 117: 825–30
   PubMed Web of Science ®Google Scholar
• Salembier L, De Ridder D, van de Heyning PH. The use of flupirtine in treatment of tinnitus. Acta Otolaryngol Suppl 2006; 126(Suppl 556)93–5
   Google Scholar
• Attias J, Weisz G, Almog S, Shahar A, Wiener M, Joachims Z, et al. Oral magnesium intake reduces permanent hearing loss induced by noise exposure. Am J Otolaryngol. 1994; 15: 26–32
   PubMed Web of Science ®Google Scholar
• Joachims Z, Netzer A, Ising H, Rebentisch E, Attias J, Weisz G, et al. Oral magnesium supplementation as prophylaxis for noise-induced hearing loss: results of a double-blind field study. Schriftenreihe des Vereins fur Wasser-, Boden- und Lufthygiene. 1993; 88: 503–16
   PubMedGoogle Scholar
• Araujo MF, Oliveira CA, Bahmad FM., Jr. Intratympanic dexamethasone injections as a treatment for severe, disabling tinnitus: does it work?. Arch Otolaryngol Head Neck Surg. 2005; 131: 113–7
   PubMed Web of Science ®Google Scholar
• Sakata E, Itoh A, Itoh Y. Treatment of cochlear tinnitus with dexamethasone infusion into the tympanic cavity. Int Tinnitus J. 1996; 2: 129–35
   PubMedGoogle Scholar
• Sakata E, Ito Y, Itoh A. Clinical experiences of steroid targeting therapy to inner ear for control of tinnitus. Int Tinnitus J. 1997; 3: 117–21
   PubMedGoogle Scholar
• Sennaroglu L, Dini FM, Sennaroglu G, Gursel B, Ozkan S. Transtympanic dexamethasone application in Menière's disease: an alternative treatment for intractable vertigo. J Laryngol Otol. 1999; 113: 217–21
   PubMed Web of Science ®Google Scholar
• Eklund S, Pyykko I, Aalto H, Ishizaki H, Vasama JP. Effect of intratympanic gentamicin on hearing and tinnitus in Menière's disease. Am J Otol. 1999; 20: 350–6
   PubMedGoogle Scholar
• Havia M, Kentala E, Pyykko I. Hearing loss and tinnitus in Menière's disease. Auris, nasus, larynx. 2002; 29: 115–9
   PubMed Web of Science ®Google Scholar
• Yetiser S, Kertmen M. Intratympanic gentamicin in Menière's disease: the impact on tinnitus. Int J Audiol. 2002; 41: 363–70
   PubMed Web of Science ®Google Scholar
• Johnson RM, Brummett R, Schleuning A. Use of alprazolam for relief of tinnitus. A double-blind study. Arch Otolaryngol Head Neck Surg. 1993; 119: 842–5
   PubMed Web of Science ®Google Scholar
• Vernon JA, Meikle MB. Masking devices and alprazolam treatment for tinnitus. Otolaryngol Clin North Am. 2003; 36: 307–20
   PubMed Web of Science ®Google Scholar
• Huynh L, Fields S. Alprazolam for tinnitus. Ann Pharmacother. 1995; 29: 311–2
   PubMed Web of Science ®Google Scholar
• Albertino S, Assuncao AR, Souza JA. Pulsatile tinnitus: treatment with clonazepam and propranolol. Revista brasileira de otorrinolaringologia (English edn) 2005; 71: 111–3
   PubMedGoogle Scholar
• Lopez-Gonzalez MA, Moliner-Peiro F, Alfaro-Garcia J, Esteban-Ortega F. Sulpiride plus hydroxyzine decrease tinnitus perception. Auris, nasus, larynx. 2007; 34: 23–7
   PubMed Web of Science ®Google Scholar
• Silverstein, H, Choo, D, Rosenberg, SI, Kuhn, J, Seidman, M, Stein, I. Intratympanic steroid treatment of inner ear disease and tinnitus (preliminary report). ENT J. 1996;75: 468–71, 474, 476 passim.
   Google Scholar
• Megwalu UC, Finnell JE, Piccirillo JF. The effects of melatonin on tinnitus and sleep. Otolaryngol Head Neck Surg. 2006; 134: 210–3
   PubMed Web of Science ®Google Scholar
• Bauer CA, Brozoski TJ. Gabapentin. Prog Brain Res. 2007; 166: 287–301
   PubMed Web of Science ®Google Scholar
• den Hartigh J, Hilders CG, Schoemaker RC, Hulshof JH, Cohen AF, Vermeij P. Tinnitus suppression by intravenous lidocaine in relation to its plasma concentration. Clin Pharmacol Ther. 1993; 54: 415–20
   PubMed Web of Science ®Google Scholar
• Sanchez TG, Balbani AP, Bittar RS, Bento RF, Camara J. Lidocaine test in patients with tinnitus: rationale of accomplishment and relation to the treatment with carbamazepine. Auris, nasus, larynx. 1999; 26: 411–7
   PubMedGoogle Scholar
• Shea JJ, Harell M. Management of tinnitus aurium with lidocaine and carbamazepine. Laryngoscope. 1978; 88: 1477–84
   PubMed Web of Science ®Google Scholar
• Piccirillo JF, Finnell J, Vlahiotis A, Chole RA, Spitznagel E, Jr. Relief of idiopathic subjective tinnitus: is gabapentin effective?. Arch Otolaryngol Head Neck Surg. 2007; 133: 390–7
   PubMed Web of Science ®Google Scholar
• Witsell DL, Hannley MT, Stinnet S, Tucci DL. Treatment of tinnitus with gabapentin: a pilot study. Otol Neurotol. 2007; 28: 11–5
   PubMed Web of Science ®Google Scholar
• Bauer CA, Brozoski TJ. Effect of gabapentin on the sensation and impact of tinnitus. Laryngoscope. 2006; 116: 675–81
   PubMed Web of Science ®Google Scholar
• Azevedo AA, Figueiredo RR. Tinnitus treatment with acamprosate: double-blind study. Revista brasileira de otorrinolaringologia. (English edn) 2005; 71: 618–23
   PubMedGoogle Scholar
• Bahmad FM, Jr, Venosa AR, Oliveira CA. Benzodiazepines and GABAergics in treating severe disabling tinnitus of predominantly cochlear origin. Int Tinnitus J. 2006; 12: 140–4
   PubMedGoogle Scholar
• Trellakis S, Lautermann J, Lehnerdt G. Lidocaine: neurobiological targets and effects on the auditory system. Prog Brain Res. 2007; 166: 303–22
   PubMed Web of Science ®Google Scholar
• Goodey RJ. Drugs in the treatment of tinnitus. Ciba Foundation symposium. 1981; 85: 263–78
   PubMedGoogle Scholar
• Pyykkö I, Padoan S, Schalen L, Lyttkens L, Magnusson M, Henriksson NG. The effects of TTS-scopolamine, dimenhydrinate, lidocaine and tocainide on motion sickness, vertigo and nystagmus. Aviat Space Environ Med. 1985; 56: 777–82
   PubMedGoogle Scholar
• Savastano M. Lidocaine intradermal injection: a new approach in tinnitus therapy, preliminary report. Adv Therapy. 2004; 21: 13–20
   PubMed Web of Science ®Google Scholar
• Emmett JR, Shea JJ. Treatment of tinnitus with tocainide hydrochloride. Otolaryngol Head Neck Surg. 1980; 88: 442–6
   PubMed Web of Science ®Google Scholar
• Kawamoto K, Ishimoto S, Minoda R, Brough DE, Raphael Y. Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo. J Neurosci. 2003; 23: 4395–4400
   PubMed Web of Science ®Google Scholar
• Zou, J, Saulnier, P, Perrier, T, Zhang, Y, Manninen, T, Toppila, E, Pyykkö, I. Distribution of lipid nanocapsules in different cochlear cell populations after round window membrane permeation. J Biomed Materials Res: Part B-Applied Biomaterials. 2008 ( in press).
   PubMed Web of Science ®Google Scholar
• Zenner HP, Ernst A. Cochlear-motor, transduction and signal-transfer tinnitus: models for three types of cochlear tinnitus. Eur Arch Otorhinolaryngol. 1993; 249: 447–54
   PubMed Web of Science ®Google Scholar
• Rask-Andersen H, Boström M, Gerdin B, Kinnefors A, Nyberg G, Engstrand T, Miller JM, Lindholm D. Regeneration of human auditory nerve. In vitro/in video demonstration of neural progenitor cells in adults human and guinea pig spiral ganglion. Hear Res. 2005; 203: 180–91
   PubMed Web of Science ®Google Scholar