Biochemical evaluation of Nigella sativa L. seeds on fluconazole toxicity in Wistar rats

References

• Wang J-L, Chang C-H, Young-Xu Y, et al. Systematic review and meta-analysis of the tolerability and hepatotoxicity of antifungals in empirical and definitive therapy for invasive fungal infection. Antimicrob Agents Chemother. 2010;54(6):2409–2419. doi: 10.1128/AAC.01657-09
   PubMed Web of Science ®Google Scholar
• Padda MS, Sanchez M, Akhtar AJ, et al. Drug-induced cholestasis. Hepatology. 2011;53(4):1377–1387. doi: 10.1002/hep.24229
   PubMed Web of Science ®Google Scholar
• Tverdek FP, Kofteridis D, Kontoyiannis DP. Antifungal agents and liver toxicity: a complex interaction. Expert Rev Anti Infect Ther. 2016;14(8):765–776. doi: 10.1080/14787210.2016.1199272
   PubMed Web of Science ®Google Scholar
• Debruyne D, Ryckelynck JP. Clinical pharmacokinetics of fluconazole. Clin Pharmacokinet. 1993;24:10–27. doi: 10.2165/00003088-199324010-00002
   PubMed Web of Science ®Google Scholar
• Tavakkoli A, Ahmadi A, Razavi BM, et al. Black seed (Nigella sativa) and its constituent thymoquinone as an antidote or a protective agent against natural or chemical toxicities. Iran J Pharm Res. 2017;16(Suppl):2–23.
   PubMedGoogle Scholar
• Alenzi FQ, El-Bolkiny Y-S, Salem ML. Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide. Br J Biomed Sci. 2010;67(1):20–28. doi: 10.1080/09674845.2010.11730285
   PubMed Web of Science ®Google Scholar
• Hosseinian S, Hadjzadeh MA, Roshan NM, et al. Renoprotective effect of Nigella sativa against Cisplatin induced nephrotoxicity and oxidative stress in rat. Saudi J Kidney Dis Transpl. 2018;29:19–29. doi: 10.4103/1319-2442.225208
   PubMed Web of Science ®Google Scholar
• Hagag AA, Badraia IM, El-Shehaby WA, et al. Protective role of black seed oil in doxorubicin-induced cardiac toxicity in children with acute lymphoblastic leukemia [published online ahead of print, 2020 Jan 21]. J Oncol Pharm Pract; 2020:1078155219897294.
   Web of Science ®Google Scholar
• Kushwah DS, Salman MT, Singh P, et al. Protective effects of ethanolic extract of Nigella sativa seed in paracetamol induced acute hepatotoxicity in vivo. Pak J Biol Sci. 2014;17(4):517–522. doi: 10.3923/pjbs.2014.517.522
   Google Scholar
• Spampinato C, Leonardi D. Candida infections, causes, targets, and resistance mechanisms: traditional and alternative antifungal agents. Biomed Res Int. 2013;2013:204237.
   PubMed Web of Science ®Google Scholar
• Galgiani JN, Ampel NM, Blair JE, et al. Infectious Diseases Society of America (IDSA) clinical practice guideline for the treatment of coccidioidomycosis. Clin Infect Dis. 2016;63(6):e112–e146. doi: 10.1093/cid/ciw360
   PubMed Web of Science ®Google Scholar
• Bellmann R, Smuszkiewicz P. Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients. Infection. 2017;45(6):737–779. doi: 10.1007/s15010-017-1042-z
   PubMed Web of Science ®Google Scholar
• Franklin I, Elias E, Hirsch C. Fluconazole-induced jaundice. Lancet (British Edition). 1990;336(8714).
   Web of Science ®Google Scholar
• Gayam V, Khalid M, Dahal S, et al. Hyperacute liver injury following intravenous fluconazole: A rare case of dose-independent hepatotoxicity. J Family Med Prim Care. 2018;7(2):451. doi: 10.4103/jfmpc.jfmpc_330_17
   Google Scholar
• Spernovasilis N, Kofteridis DP. Pre-existing liver disease and toxicity of antifungals. J Fungi. 2018;4(4):133. doi: 10.3390/jof4040133
   Web of Science ®Google Scholar
• Re VL III, Carbonari DM, Lewis JD, et al. Oral azole antifungal medications and risk of acute liver injury, overall and by chronic liver disease status. Am J Med. 2016;129(3):283–291. e285. doi: 10.1016/j.amjmed.2015.10.029
   Web of Science ®Google Scholar
• Javed A, Shahid A, Haider MS. Nutritional, phytochemical potential and pharmacological evaluation of Nigella sativa (Kalonji) and Trachyspermum ammi (Ajwain). J Med Plants Res. 2010;6(5):768–775.
   Google Scholar
• Yimer EM, Tuem KB, Karim A, et al. Nigella sativa L. (black Cumin): A promising natural remedy for wide range of illnesses. Evid-Based Complement Altern Med. 2019;2019:1–16. doi: 10.1155/2019/1528635
   Web of Science ®Google Scholar
• Bukhari AA. (2018). Sahih-ul-Bukhari. Available from: http://quranx.com/Search?q=Black+cumin&context=Hadith.
   Google Scholar
• Tariq M. Nigella sativa seeds: folklore treatment in modern day medicine. Saudi J Gastroenterol. 2008;14(3):105. doi: 10.4103/1319-3767.41725
   Google Scholar
• Sharma PC, Yelne MB, Dennis TJ. Database on medicinal plants used in Ayurveda. Vol. 3. New Delhi: CCRAS; 2005. p. 130–131.
   Google Scholar
• Kooti W, Hasanzadeh-Noohi Z, Sharafi-Ahvazi N, et al. Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa). Chinese J Natural Med. 2016;14(10):732–745. doi: 10.1016/S1875-5364(16)30088-7
   PubMed Web of Science ®Google Scholar
• Ulu R, Dogukan A, Tuzcu M, et al. Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury. Food Chem Toxicol. 2012;50:1675–1679. doi: 10.1016/j.fct.2012.02.082
   PubMed Web of Science ®Google Scholar
• Turkez H, Yousef MI, Geyikoglu F. Propolis prevents aluminium-induced genetic and hepatic damages in rat liver. Food Chem Toxicol. 2010;48:2741–2746. doi: 10.1016/j.fct.2010.06.049
   PubMed Web of Science ®Google Scholar
• Ghahramanloo KH, Kamalidehghan B, Javar HA, et al. Comparative analysis of essential oil composition of Iranian and Indian Nigella sativa L. Extracted using supercritical fluid extraction and solvent extraction. Drug Des Devel Ther. 2017;11:2221. doi: 10.2147/DDDT.S87251
   Web of Science ®Google Scholar
• Haseena S, Aithal M, Das KK, et al. Phytochemical analysis of Nigella sativa and its effect on reproductive system. J Pharm Sci Res. 2015;7(8):514.
   Google Scholar
• Mamun M, Absar N. Major nutritional compositions of black cumin seeds-cultivated in Bangladesh and the physicochemical characteristics of its oil. Int Food Res J. 2018;25(6):2634–2639.
   Web of Science ®Google Scholar
• Ong YS, Yazan LS, Ng WK, et al. Acute and subacute toxicity profiles of thymoquinone-loaded nanostructured lipid carrier in BALB/c mice. Int J Nanomed. 2016;11:5905–5915. doi: 10.2147/IJN.S114205
   PubMed Web of Science ®Google Scholar
• Ozdemir N, Kantekin-Erdogan MN, Tat T, et al. Effect of black cumin oil on the oxidative stability and sensory characteristics of mayonnaise. J Food Sci Technol. 2018;55(4):1562–1568. doi: 10.1007/s13197-018-3075-4
   Web of Science ®Google Scholar
• Mostafa RM, Moustafa YM, Mirghani Z, et al. Antioxidant effect of garlic (Allium sativum) and black seeds (Nigella sativa) in healthy postmenopausal women. SAGE Open Med. 2013;1:205031211351750. doi: 10.1177/2050312113517501
   Google Scholar
• Bensiameur-Touati K, Kacimi G, Haffaf E-M, et al. In vivo subacute toxicity and antidiabetic effect of aqueous extract of Nigella sativa. Evid-Based Complement Altern Med. 2017;2017:8427034. doi: 10.1155/2017/8427034
   Web of Science ®Google Scholar
• Daryabeygi-Khotbehsara R, Golzarand M, Ghaffari MP, et al. Nigella sativa improves glucose homeostasis and serum lipids in type 2 diabetes: A systematic review and meta-analysis. Complement Ther Med. 2017;35:6–13. doi: 10.1016/j.ctim.2017.08.016
   PubMed Web of Science ®Google Scholar
• Leong X-F, Rais Mustafa M, Jaarin K. Nigella sativa and its protective role in oxidative stress and hypertension. Evid-Based Complement Altern Med. 2013;2013:120732.
   PubMed Web of Science ®Google Scholar
• Boskabady MH, Vahedi N, Amery S, et al. The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed Guinea pigs. J Ethnopharmacol. 2011;137(2):1028–1034. doi: 10.1016/j.jep.2011.07.030
   PubMed Web of Science ®Google Scholar
• Kou B, Liu W, Zhao W, et al. Thymoquinone inhibits epithelial-mesenchymal transition in prostate cancer cells by negatively regulating the TGF-β/Smad2/3 signaling pathway. Oncol Rep. 2017;38(6):3592–3598.
   Web of Science ®Google Scholar
• Hassan AS, Ahmed JH, Al-Haroon SS. A study of the effect of Nigella sativa (black seeds) in isoniazid (INH)-induced hepatotoxicity in rabbits. Indian J. Pharmacol. 2012;44:678–682. doi: 10.4103/0253-7613.103239
   PubMed Web of Science ®Google Scholar
• Dollah MA, Parhizkar S, Latiff LA, et al. Toxicity effect of nigella sativa on the liver function of rats. Adv Pharm Bull. 2013;3(1):97–102.
   Google Scholar
• Al-Abbasi FA, Sadath S, Mushtaq G, et al. Vitamin B combination reduces fluconazole toxicity in Wistar rats. Daru. 2019;27(1):525–531. doi: 10.1007/s40199-019-00252-9
   Web of Science ®Google Scholar
• Zou W, Yang Y, Gu Y, et al. Repeated blood collection from tail vein of non-anesthetized rats with a vacuum blood collection system. J Vis Exp. 2017;130:55852.
   Google Scholar
• Rahman MK, Islam S, Ferdous J, et al. Determination of hematological and serum biochemical reference values for indigenous sheep (Ovies aries) in Dhaka and Chittagong Districts of Bangladesh. Vet World. 2018 Aug;11(8):1089–1093. doi: 10.14202/vetworld.2018.1089-1093
   Web of Science ®Google Scholar
• Subramaniam N, Kannan PKA, Thiruvengadam D. Hepatoprotective effect of boldine against diethylnitrosamine-induced hepatocarcinogenesis in wistar rats. J Biochem Mol Toxicol. 2019;8:e2240.
   Google Scholar
• AbuKhader MM. The effect of route of administration in thymoquinone toxicity in male and female rats. Indian J Pharm Sci. 2012;74(3):195–200. doi: 10.4103/0250-474X.106060
   PubMed Web of Science ®Google Scholar
• Tubesha Z, Imam MU, Mahmud R, et al. Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats. Molecules. 2013;18(7):7460–7472. doi: 10.3390/molecules18077460
   PubMed Web of Science ®Google Scholar
• Kao WY, Su CW, Huang YS, et al. Risk of oral antifungal agent-induced liver injury in Taiwanese. Br J Clin Pharmacol. 2014;77(1):180–189. doi: 10.1111/bcp.12178
   PubMed Web of Science ®Google Scholar
• Kemeir ME-HA. Hepatotoxic effect of itraconazole in experimental rats. Am J Animal Vet Sci. 2014;9(1):46–52. doi: 10.3844/ajavsp.2014.46.52
   Google Scholar
• Rezaei-Matehkolaei A, Khodavaisy S, Alshahni MM, et al. In vitro antifungal activity of novel triazole efinaconazole and five comparators against dermatophyte isolates. Antimicrob Agents Chemother. 2018;62(5):e02423–e02417. doi: 10.1128/AAC.02423-17
   Web of Science ®Google Scholar
• Erisgin Z, Atasever M, Cetinkaya K, et al. Protective effects of Nigella sativa oil against carboplatin-induced liver damage in rats. Biomed Pharmacother. 2019;110:742–747. doi: 10.1016/j.biopha.2018.12.037
   PubMed Web of Science ®Google Scholar
• Nguyen MT, Yang LE, Fletcher NK, et al. Effects of K+-deficient diets with and without NaCl supplementation on Na+, K+, and H2O transporters’ abundance along the nephron. Am J Physiol-Renal Physiol. 2012;303(1):F92–F104. doi: 10.1152/ajprenal.00032.2012
   Web of Science ®Google Scholar
• Bühler T, Medinger M, Bouitbir J, et al. Hepatotoxicity due to azole antimycotic agents in a HLA B* 35: 02-positive patient. Front Pharmacol. 2019;10. doi: 10.3389/fphar.2019.00645
   Web of Science ®Google Scholar
• Kurt H, Toprak O, Bülbül E. The possible efficacy of artichoke in fluconazole related hepatotoxicity. Case Reports Hepatol. 2014;2014:697359. doi: 10.1155/2014/697359
   Google Scholar
• Foo H, Gottlieb T. Lack of cross-hepatotoxicity between voriconazole and posaconazole. Clin Infect Dis. 2007;6:803–805. doi: 10.1086/521174
   Google Scholar
• Gazzin S, Vitek L, Watchko J, et al. A novel perspective on the biology of bilirubin in health and disease. Trends Mol Med. 2016;22(9):758–768. doi: 10.1016/j.molmed.2016.07.004
   PubMed Web of Science ®Google Scholar
• Newsome PN, Cramb R, Davison SM, et al. Guidelines on the management of abnormal liver blood tests. Gut. 2018;67(1):6–19. doi: 10.1136/gutjnl-2017-314924
   PubMed Web of Science ®Google Scholar
• Badar A, Kaatabi H, Bamosa A, et al. Effect of Nigella sativa supplementation over a one-year period on lipid levels, blood pressure and heart rate in type-2 diabetic patients receiving oral hypoglycemic agents: nonrandomized clinical trial. Ann Saudi Med. 2017;37(1):56–63. doi: 10.5144/0256-4947.2017.56
   Web of Science ®Google Scholar
• Artha IMJR, Bhargah A, Dharmawan NK, et al. High level of individual lipid profile and lipid ratio as a predictive marker of poor glycemic control in type-2 diabetes mellitus. Vasc Health Risk Manag. 2019;15:149. doi: 10.2147/VHRM.S209830
   PubMed Web of Science ®Google Scholar
• Matsue Y, van der Meer P, Damman K, et al. Blood urea nitrogen-to-creatinine ratio in the general population and in patients with acute heart failure. Heart. 2017;103(6):407–413. doi: 10.1136/heartjnl-2016-310112
   PubMed Web of Science ®Google Scholar
• Fisher BA, Brown RM, Bowman SJ, et al. A review of salivary gland histopathology in primary Sjögren’s syndrome with a focus on its potential as a clinical trials biomarker. Ann Rheum Dis. 2015;74(9):1645–1650. doi: 10.1136/annrheumdis-2015-207499
   Web of Science ®Google Scholar
• Cortes-Santiago N, Leung DH, Castro E, et al. Hepatic steatosis is prevalent following orthotopic liver transplantation in children with cystic fibrosis. J Pediatr Gastroenterol Nutr. 2019;68(1):96–103. doi: 10.1097/MPG.0000000000002154
   Web of Science ®Google Scholar
• Alsemeh AE, Moawad RS, Abdelfattah ER. Histological and biochemical changes induced by gibberellic acid in the livers of pregnant albino rats and their offspring: ameliorative effect of Nigella sativa. Anatom Sci Int. 2019;4:1–17.
   Google Scholar
• Kyriakidis I, Tragiannidis A, Munchen S, et al. Clinical hepatotoxicity associated with antifungal agents. Expert Opin Drug Saf. 2017;16(2):149–165.
   PubMed Web of Science ®Google Scholar