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Research Articles

Antiplasmodial effect and sub-acute toxicity of alkaloid, flavonoid and phenolic extracts of Sida acuta leaf on Plasmodium berghei-infected animals

ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 943-953 | Received 28 Nov 2019, Accepted 17 Jun 2020, Published online: 13 Jul 2020

References

  • Ounjaijean S, Kotepui M, Somsak V. Antimalarial activity of Tinospora baenzigeri against Plasmodium berghei-infected mice. J Trop Med. 2019: 1–6. doi:10.1155/2019/5464519.
  • WHO. World Malaria Report, World Health Organization, Geneva, Switzerland, 2017, http://wwwwhoint/malaria/world_malaria_report_2017/en/indexhtml.
  • Mzena T, Swai H, Chacha M. Antimalarial activity of Cucumis metuliferus and Lippia kituiensis against Plasmodium berghei infection in mice. Res Rep Trop Med. 2018;9:81–88.
  • Ajayi EIO, Adeleke MA, Adewumia TY, et al. Antiplasmodial activities of ethanol extracts of Euphorbia hirta whole plant and Vernonia amygdalina leaves in Plasmodium berghei-infected mice. J Taibah Univ Sci. 2017;1:831–835.
  • Lawal B, Shittu OK, Abubakar A, et al. Human genetic markers and structural prediction of plasmodium falciparum multi-drug resistance gene (Pfmdr1) for ligand binding in pregnant women attending General Hospital Minna. J Environ pub Health. 2018;2018:1–13.
  • Rout S, Mahapatra RK. Plasmodium falciparum: multi-drug resistance. Chem Biol Drug Des. 2019;93:737–759.
  • Pan WH, Xu XY, Xu N, et al. Antimalarial activity of plant metabolites. Intern J Mol Sci. 2018;19(5):1382–1389.
  • Lawal B, Shittu OK, Kabiru AY, et al. Potential antimalarials from African natural products: A review. J. Intercult Ethnopharmacol. 2015;4(4):318–343.
  • Benjumea DM, Gómez-Betancur IC, Vásquez J, et al. Neuropharmacological effects of the ethanolic extract of Sida acuta. Revista Brasileira de Farmacognosia. 2016;26(2):209–215.
  • Mohideen S, Sasikala E, Gopal V. Pharmacognostic studies on Sida acuta Burm.f. Ancient sci of Life. 2002;22(1):57.
  • Khare M, Srivastava SK, Singh AK. Chemistry and pharmacology of genus Sida (Malvaceae); a review. J. Med. Aromatic Plant Sci. 2002;24:430–440.
  • Olivier TT, Armel JS, Francis NT. Ethnomedicinal uses, phytochemical and pharmacological profiles, and toxicity of Sida acuta Burm. F.: a review article. The Pharma Innovat J. 2017;6(6):1–6.
  • Aarthi A, Murugan K, Madhiyazhagan P, et al. Studies on the effect of sida acuta and Vetiveri azizanioides against the malarial vector, anopheles stephensi and malarial parasite, plasmodium berghei. Inter J Pure Appl Zool. 2014;2(1):51–60.
  • Konate K, Souza A, Coulibaly AY, et al. In vitro antioxidant, lipoxygenase and xanthine oxidase inhibitory activities of fractions from Cienfuegosia digitata Cav, Sida alba L. and Sida acutaBurn f. (Malvaceae). Pak J Biol Sci. 2010;13:1092–1098.
  • Malairajan P, Gopalakrishnan G, Narasimhan S, et al. Antiulcer activity of Sida acuta Burm. Nat Prod Sci. 2006;12:150–152.
  • Akilandeswari S, Senthamarai R, Valarmathi R, et al. Wound healing activity of Sida acuta in rats. Int J Pharm Technol. 2010;2:585–587.
  • Ramachandran AV. Cardioprotective effect of Sida rhomboidea. Roxb extract against isoproterenol induced myocardial necrosis in rats. Exp Toxicol Pathol. 2011;63:351–356.
  • Arciniegas A, Pérez-Castorena A, Nieto-Camacho A. Anti-hyperglycemic, antioxidant, and anti-inflammatory activities of extracts and metabolites from Sida acuta and Sida rhombifolia. Química. 2017;40:176–181.
  • Karou SD, Savadogo A, Canini A, et al. Antibacterial activity of alkaloids from Sida acuta. Afr J Biotechnol. 2005;4:1452–1457.
  • Jindal A, Kumar PA. Antibacterial activity of Sida acuta Burm. f. against human pathogens. Asian J Pharm Clin. Res. 2012;5:33–35.
  • Karou D, Mamoudou H, Sanon S, et al. Antimalarial activity of Sida acuta Burm. f. (Malvaceae) and Pterocarpus erinaceus Poir. (Fabaceae). J Ethnopharmacol. 2003;89:291–294.
  • Banzouzi JT, Prado R, Menan H, et al. Studies on medicinal plants of Ivory Coast: investigation of Sida acuta for in vitro antiplasmodial activities and identification of an active constituent. Phytomedicine. 2004;11:338–341.
  • Jigam AA, Mahmood F, Lawal B. Protective effects of crude and alkaloidal extracts of Tamarindus indica against acute inflammation andnociception in rats. J Acute Dis. 2017;6(2):78–81.
  • Umar SI, Lawal B, Mohammed BA, et al. Antioxidant and antimicrobial activities of naturally occurring flavonoids from M. heterophylla and the safety evaluation in Wistar rats. Iran J Toxicol. 2019;13(4):39–44.
  • Prakash A, Varma RK, Ghosal S. Alkaloid constituents of Sida acuta, Sida humilis, Sida. rhombifolia and Sida spinosa. Planta Med. 1981;43:384–388.
  • Gonzales MVM, Tolentino AG. Extraction and isolation of the alkaloids from the Samanea Saman (Acacia) Bark: its antiseptic potential. Inter J Sci Technol. 2014;3:1–6.
  • Yahaya MM. Isolation and purification of flavonoids from the leaves of locally produced Carica Papaya. Intern J Sci Technol Res. 2015;4(12):282–284.
  • Atansuyi K, Ibukun EO, Ogunmoyole T. Antioxidant properties of free and bound phenolic extract of the leaves of Jatropha tanjorensis In vitro. J Med Plants Res. 2012;6(31):4667–4674.
  • OECD. (2008). OECD guideline for testing of chemicals. Test No. 425: acute oral toxicity: up-and-down procedure. doi:10.1787/9789264071049-en.
  • Ryley JF, Peters W. The antimalarial activity of some Quinolone Esters. Annals of Trop Med Parasitol. 1970;64(2):209–222.
  • Organization for Economic Cooperation and Development. (1981). Repeated dose dermal toxicity: 21/28-day oral toxicity study in rodents. Guidelines for the Testing of Chemicals/Draft Updated Test Guideline 410.
  • Yusuf AA, Lawal B, Yusuf MA, et al. Free radical scavenging, antimicrobial activities and effect of sub-acute exposure to Nigerian Xylopia Aethiopica seed extract on liver and kidney functional indices of albino rat. Iran J Toxicol. 2018;12(3):51–58.
  • Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 1957;28:56–63.
  • Weatherburn MW. Phenol-hypochlorite reaction for determination of ammonia. Analyt Chem. 1967;39:971–974.
  • Bartels H, Bohmer M, Heierli C. Serum creatinine determination without protein precipitation. Clin Chem Acta. 1972;37:193–197.
  • Weichselbaum TE. An accurate and rapid method for the determination of proteins in small amounts of blood serum and plasma. Amer J Clin Pathol. 1946;10:40–49.
  • Doumas BT, Watson WA, Biggs HG. Albumin standards and the measurement of serum albumin with Bromcresol Green. Clin Chem Acta. 1971;31(1):87–96.
  • Maruna RFL. Quantitative estimation of sodium (Na), potassium (K) in human serum by colorimetric methods. Clin Chem Acta. 1958;2:581–585.
  • Tietz NW. Clinical guide to laboratory tests. 3rd ed. Philadelphia (PA): WB Saunders Company; 1996; pp. 286–288.
  • Dacie JV, Lewis SM. Practical Haematology. 11th Edn. London: Elsevier; 2002; pp: 380-382.
  • Igwebuike UM, Eze UU. Morphology of the caeca of the african pied crow (corvus albus). Anim Res Inter. 2010;7(1):1121–1124.
  • Sultana B, Anwar F, Ashraf M. Effect of extraction solvent/technique on the antioxidant activity of selected medicinal plants extracts. Molecules. 2009;14(6):2167–2180.
  • Konaté K, Bassolé I, Hilou A, et al. Toxicity assessment and analgesic activity investigation of aqueous acetone extracts of Sida acuta Burn f. and Sida cordifolia L. (Malvaceae), medicinal plantsof Burkina Faso. BMC complement. Altern. Med. 2012;12:120, doi:10.1186/1472-6882-12-120.
  • Carvalho LH, Brandao MGL, Santos-Filho D, et al. Antimalarial activity of crude extracts from Brazilian plants. Studied in vivo in Plasmodium berghei-infected mice and in vitro against Plasmodium falciparum in culture. Braz J Med Biol Res. 1991;24:1113–1123.
  • Noedl H, Wongsrichanalai C, Wernsdorfer WH. Malaria drug sensitivity testing: new assays, new perspectives. Trends in Parasitol. 2003;19:175–181.
  • Adebayo JO, Yakubu MT, Egwim EC, et al. Effect of ethanolic extract of Khaya senegalensis stem bark on some biochemical parameters on rat kidney. J Ethnopharmacol. 2003;88:69–72.
  • Builders M, Alemika T, Aguiyi J. Antimalarial activity and isolation of phenolic compound from Parkia biglobosa. J Pharm Biol Sci. 2014;9(3):78–85.
  • Awoke N, Arota A. Profiles of hematological parameters in Plasmodium falciparum and Plasmodium vivax malaria patients attending Tercha General Hospital, Dawuro Zone, South Ethiopia. Infect Drug Resist. 2019;12:521–527.
  • Chinchilla M, Guerrero OM, Abarca G, et al. An in vivo model to study the anti-malariac capacity of plant extracts. Rev Biol Trop. 1998;46(1):1–7.
  • Berinyuy EB, Lawal B, Olalekan AA, et al. Hematological status and organs/body-weight parameters in Wister rats during chronic administration of Cassia occidentalis. Inter Blood Res Rev. 2015;4(3):1–7.
  • Ozkan C, Kaya A, Akgul Y. Normal values of haematological and some biochemical parameters in serum and urine of New Zealand white rabbits. World Rab Sci. 2012;20:253–259.
  • Lawal B, Shittu OK, Rotimi AA, et al. Effect of methanol extract of Telfairia occcidentalis on haematological parameters in Wister rats. J Med Sci. 2015;15(5):246–250.
  • Mishra N, Tandon VL. Haematological effects of aqueous extract of ornamental plants in male Swiss albino mice. Vet World. 2012;5:19–23.
  • Umar SI, Ndako M, Jigam AA, et al. Anti-plasmodial, Anti-inflammatory, antinociceptive and safety profile of Maytenus senegalensis root bark extract on hepato-renal integrity in experimental animals. Comp Clin Pathol. 2019;28(8):1–8.
  • Shittu OK, Lawal B, Blessing Uchenna AB, et al. Alteration in biochemical indices following chronic administration of methanolic extract of Nigeria bee propolis in Wister rats. Asian Pac J Trop Dis. 2015;5(8):654–657.
  • Yusuf AA, Lawal B, Abubakar AN, et al. In-vitro antioxidants, antimicrobial and toxicological evaluation of Nigerian Zingiber officinale. Clin Phytosci. 2018;4(12):1–8.
  • Akanji MA, Salau AK, Yakubu MT. Safety evaluation of aqueous extract of Cratevaadansonii leaves on selected tissues of rats. Fount Nat Appl Sci. 2013;2(1):17–28.
  • Bashir L, Shittu OK, Busari MB, et al. Safety evaluation of giant African land snails (Archachatina marginata) Haemolymph on hematological and biochemical parameters of albino rats. J Adv Med Pharm Sci. 2015;3(3):122–130.
  • Ogunlana OO, Ogunlana OE, Ntube CA, et al. Phytochemical screening and in vivo antioxidant activity of ethanolic extract of Caesalpinia bonduc (L.) Roxb. Global Res J Pharm. 2012;1(1):1–4.
  • da Silva G, Tanica M, Rocha J. In vivo anti-inflammatory effect and toxicological screening of Maytenus heterophylla and Maytenus senegalensis extracts. Human and Exp Toxicol. 2010;30(7):693–700.