Sonosynthesis and artificial intelligence-enhanced characterization of PEGylated Camellia sinensis-encapsulated zinc oxide nanoparticles: cytotoxicity capacity against cervical cancer and fibroblast cells

References

• Mohammadzadeh P, Ardestani MS, Mortazavi-Derazkola S, et al. PEG-Citrate dendrimer second generation: is this a good carrier for imaging agents In vitro and In vivo? IET Nanobiotechnol. 2019;13(6):560–564. doi: 10.1049/iet-nbt.2018.5360
   PubMed Web of Science ®Google Scholar
• Hashemi Z, Mizwari ZM, Mohammadi-Aghdam S, et al. Sustainable green synthesis of silver nanoparticles using Sambucus ebulus phenolic extract (AgNPs@SEE): Optimization and assessment of photocatalytic degradation of methyl orange and their in vitro antibacterial and anticancer activity. Arab J Chem. 2022;15:103525. doi: 10.1016/j.arabjc.2021.103525
   Web of Science ®Google Scholar
• Ebrahimzadeh MA, Hashemi Z, Mohammadyan M, et al. In vitro cytotoxicity against human cancer cell lines (MCF-7 and AGS), antileishmanial and antibacterial activities of green synthesized silver nanoparticles using Scrophularia striata extract. Surf Interfaces. 2021;23:100963. doi: 10.1016/j.surfin.2021.100963
   Web of Science ®Google Scholar
• Khormali K, Mizwari ZM, Masoumeh Ghoreishi S, et al. Novel Dy2O3/ZnO-Au ternary nanocomposites: green synthesis using pomegranate fruit extract, characterization and their photocatalytic and antibacterial properties. Bioorg Chem. 2021;115:105204. doi: 10.1016/j.bioorg.2021.105204
   PubMed Web of Science ®Google Scholar
• Hashemi Z, Shirzadi-Ahodashti M, Mortazavi-Derazkola S, et al. Sustainable biosynthesis of metallic silver nanoparticles using barberry phenolic extract: Optimization and evaluation of photocatalytic, in vitro cytotoxicity, and antibacterial activities against multidrug-resistant bacteria. Inorg Chem Commun. 2022;139:109320. doi: 10.1016/j.inoche.2022.109320
   Web of Science ®Google Scholar
• Fouladi-Fard R, Aali R, Mohammadi-Aghdam S, et al. The surface modification of spherical ZnO with Ag nanoparticles: a novel agent, biogenic synthesis, catalytic and antibacterial activities. Arab J Chem. 2022;15:103658. doi: 10.1016/j.arabjc.2021.103658
   Web of Science ®Google Scholar
• Shirzadi-Ahodashti M, Hashemi Z, Mortazavi Y, et al. Discovery of high antibacterial and catalytic activities against multi-drug resistant clinical bacteria and hazardous pollutants by biosynthesized of silver nanoparticles using Stachys inflata extract (AgNPs@SI). Colloids Surf A Physicochem Eng Asp. 2021;617:126383. doi: 10.1016/j.colsurfa.2021.126383
   Web of Science ®Google Scholar
• Dutta D, Das BM. Scope of green nanotechnology towards amalgamation of green chemistry for cleaner environment: a review on synthesis and applications of green nanoparticles. Environ Nanotechnol Monit Manag. 2021;15:100418. doi: 10.1016/J.ENMM.2020.100418
   Google Scholar
• Liu D, Liu L, Yao L, et al. Synthesis of ZnO nanoparticles using radish root extract for effective wound dressing agents for diabetic foot ulcers in nursing care. J Drug Deliv Sci Technol. 2020;55:101364. doi: 10.1016/j.jddst.2019.101364
   Web of Science ®Google Scholar
• Malathi S, Balashanmugam P, Devasena T, et al. Enhanced antibacterial activity and wound healing by a novel collagen blended ZnO nanoparticles embedded niosome nanocomposites. J Drug Deliv Sci Technol. 2021;63:102498. doi: 10.1016/j.jddst.2021.102498
   Web of Science ®Google Scholar
• Danışman-Kalındemirtaş F, Afşin Kariper İ, Erdemir G, et al. Evaluation of anticancer effects of carboplatin-gelatin nanoparticles in different sizes synthesized with newly self-assembly method by exposure to IR light. Sci Rep. 12(123AD):10686. doi: 10.1038/s41598-022-15051-7
   PubMedGoogle Scholar
• Rudramurthy GR, Swamy MK. Potential applications of engineered nanoparticles in medicine and biology: an update. J Biol Inorg Chem. 2018;23(8):1185–1204. doi: 10.1007/s00775-018-1600-6
   PubMed Web of Science ®Google Scholar
• Khan ST, Ahmad J, Ahamed M, et al. Zinc oxide and titanium dioxide nanoparticles induce oxidative stress, inhibit growth, and attenuate biofilm formation activity of Streptococcus mitis. J Biol Inorg Chem. 2016;21(3):295–303. doi: 10.1007/s00775-016-1339-x
   PubMed Web of Science ®Google Scholar
• Ahmad J, Wahab R, Siddiqui MA, et al. Cytotoxicity and cell death induced by engineered nanostructures (quantum dots and nanoparticles) in human cell lines. J Biol Inorg Chem. 2020;25(2):325–338. doi: 10.1007/s00775-020-01764-5
   PubMed Web of Science ®Google Scholar
• Ansari MA, Mousa S, Asiri M, et al. Biofabricated fatty acids-capped silver nanoparticles as potential antibacterial, antifungal, antibiofilm and anticancer agents. Pharmaceuticals. 2021;14(2):139. doi: 10.3390/ph14020139
   Web of Science ®Google Scholar
• Khan FA, Lammari N, Muhammad Siar AS, et al. Quantum dots encapsulated with curcumin inhibit the growth of colon cancer, breast cancer and bacterial cells. Nanomedicine (Lond). 2020;15(10):969–980. doi: 10.2217/nnm-2019-0429
   PubMed Web of Science ®Google Scholar
• Khan FA, Akhtar S, Almofty SA, et al. FMSP-Nanoparticles induced cell death on human breast adenocarcinoma cell line (MCF-7 cells): morphometric analysis. Biomolecules. 2018;8(2):32. doi: 10.3390/BIOM8020032
   PubMed Web of Science ®Google Scholar
• Thirupathi B, Pongen YL, Kaveriyappan GR, et al. Padina boergesenii mediated synthesis of Se-ZnO bimetallic nanoparticles for effective anticancer activity. Front Microbiol. 2024;15:1358467. doi: 10.3389/fmicb.2024.1358467
   PubMed Web of Science ®Google Scholar
• Hamdani AM, Wani IA, Bhat NA. Sources, structure, properties and health benefits of plant gums: a review. Int J Biol Macromol. 2019;135:46–61. doi: 10.1016/j.ijbiomac.2019.05.103
   PubMed Web of Science ®Google Scholar
• Li F, Qasim S, Li D, et al. Updated review on green tea polyphenol epigallocatechin-3-gallate as a cancer epigenetic regulator. Semin Cancer Biol. 2022;83:335–352. doi: 10.1016/J.SEMCANCER.2020.11.018
   PubMed Web of Science ®Google Scholar
• Su J, Liao T, Ren Z, et al. Polydopamine nanoparticles coated with a metal-polyphenol network for enhanced photothermal/chemodynamic cancer combination therapy. Int J Biol Macromol. 2023;238:124088. doi: 10.1016/j.ijbiomac.2023.124088
   PubMed Web of Science ®Google Scholar
• Ganesh Kumar A, Pugazhenthi E, Sankarganesh P, et al. Microfibrillated cellulose from pine cone: extraction, properties, and characterization. Biomass Convers Biorefin. 2023;13:1–8. doi: 10.1007/s13399-021-01794-2
   Web of Science ®Google Scholar
• Chen X, Li Y, Lin Q, et al. Tea polyphenols induced apoptosis of breast cancer cells by suppressing the expression of Survivin. Sci Rep. 2014;4(4). doi: 10.1038/srep04416
   Google Scholar
• Velsankar K, Parvathy G, Sankaranarayanan K, et al. Green synthesis of silver oxide nanoparticles using Panicum miliaceum grains extract for biological applications. Adv Powder Technol. 2022;33:103645. doi: 10.1016/j.apt.2022.103645
   Web of Science ®Google Scholar
• Taha KK, Modwi A, Elamin MR, et al. Impact of Hibiscus extract on the structural and activity of sonochemically fabricated ZnO nanoparticles. J Photochem Photobiol A Chem. 2020;390:112263. doi: 10.1016/j.jphotochem.2019.112263
   Web of Science ®Google Scholar
• Deshpande SS, Veeragoni D, Rachamalla HK, et al. Anticancer properties of ZnO-Curcumin nanocomposite against melanoma cancer and its genotoxicity profiling. J Drug Deliv Sci Technol. 2022;75:103703. doi: 10.1016/j.jddst.2022.103703
   Web of Science ®Google Scholar
• Umavathi S, Subash M, Gopinath K, et al. Facile synthesis and characterization of ZnO nanoparticles using Abutilon indicum leaf extract: An eco-friendly nano-drug on human microbial pathogens. J Drug Deliv Sci Technol. 2021;66:102917. doi: 10.1016/j.jddst.2021.102917
   Web of Science ®Google Scholar
• Deivanathan SK, Thomas J, Prakash J, et al. Bio-synthesis of silver nanoparticles using leaf extract of Rhaphidophora pertusa and its characterization, antimicrobial, antioxidant and cytotoxicity activities. Res Chem Intermed. 2023;49(2):423–439. doi: 10.1007/s11164-022-04888-2
   Web of Science ®Google Scholar
• Sivakumari G, Rajarajan M, Senthilvelan S. Microwave-assisted synthesis and characterization of activated carbon–zirconium-incorporated CeO2 nanocomposites for photocatalytic and antimicrobial activity. Res Chem Intermed. 2023;49:3539–3561. doi: 10.1007/s11164-023-04968-x
   Web of Science ®Google Scholar
• Shehata EMM, Gowayed MA, El-Ganainy SO, et al. Pectin coated nanostructured lipid carriers for targeted piperine delivery to hepatocellular carcinoma. Int J Pharm. 2022;619:121712. doi: 10.1016/j.ijpharm.2022.121712
   PubMedGoogle Scholar
• Shome S, Das Talukdar A, Nath R, et al. Curcumin-ZnO nanocomposite mediated inhibition of Pseudomonas aeruginosa biofilm and its mechanism of action. J Drug Deliv Sci Technol. 2023;81:104301. doi: 10.1016/j.jddst.2023.104301
   Web of Science ®Google Scholar
• Greeshma KP, Thamizselvi R. Phytogenic synthesis of ZnO nanoparticles from Catharanthus Roseus and Morinda Citrifolia leaf extract and its promising multifunctional biological applications. J Drug Deliv Sci Technol. 2023;87:104785. doi: 10.1016/j.jddst.2023.104785
   Web of Science ®Google Scholar
• Schröder L, Marahrens P, Koch JG, et al. Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF–7 and MDA-MB-231 breast carcinoma cells. Oncol Rep. 2018;41:387–396. doi: 10.3892/or.2018.6789
   PubMed Web of Science ®Google Scholar
• Devkota HP, Gaire BP, Hori K, et al. The science of matcha: Bioactive compounds, analytical techniques and biological properties. Trends Food Sci Technol. 2021;118:735–743. doi: 10.1016/j.tifs.2021.10.021
   Web of Science ®Google Scholar
• Kochman J, Jakubczyk K, Antoniewicz J, et al. Health benefits and chemical composition of matcha green Tea: a review. Molecules. 2021;26(1):85. doi: 10.3390/molecules26010085
   Web of Science ®Google Scholar
• Lizoňová D, Hládek F, Chvíla S, et al. Surface stabilization determines macrophage uptake, cytotoxicity, and bioactivity of curcumin nanocrystals. Int J Pharm. 2022;626:122133. doi: 10.1016/j.ijpharm.2022.122133
   PubMedGoogle Scholar
• Sekowski S, Terebka M, Veiko A, et al. Epigallocatechin gallate (EGCG) activity against UV light-induced photo damages in erythrocytes and serum albumin—theoretical and experimental studies. J Photochem Photobiol A Chem. 2018;356:379–388. doi: 10.1016/j.jphotochem.2018.01.018
   Web of Science ®Google Scholar
• Keckstein S, Tilgener C, Jeschke U, et al. Effects of matcha tea extract on cell viability and peroxisome proliferator-activated receptor γ expression on T47D breast cancer cells. Arch Gynecol Obstet. 2022;306:451–459. doi: 10.1007/s00404-021-06381-4
   PubMed Web of Science ®Google Scholar
• Farhan M. Green Tea catechins: nature’s Way of preventing and treating cancer. Int J Mol Sci. 2022;23(18):10713. doi: 10.3390/ijms231810713
   PubMed Web of Science ®Google Scholar
• Zhang W, Cho WC, Bloukh SH, et al. An overview on the exploring the interaction of inorganic nanoparticles with microtubules for the advancement of cancer therapeutics. Int J Biol Macromol. 2022;212:358–369. doi: 10.1016/j.ijbiomac.2022.05.150
   PubMed Web of Science ®Google Scholar
• Abed NN, Abou El-Enain IMM, El-Husseiny Helal E, et al. Novel biosynthesis of tellurium nanoparticles and investigation of their activity against common pathogenic bacteria. J Taibah Univ Med Sci. 2023;18(2):400–412. doi: 10.1016/J.JTUMED.2022.10.006
   PubMed Web of Science ®Google Scholar
• Tulbah AS. In vitro bio-characterization of solid lipid nanoparticles of favipiravir in A549 human lung epithelial cancer cells. J Taibah Univ Med Sci. 2023;18:1076–1086. doi: 10.1016/J.JTUMED.2023.02.014
   PubMed Web of Science ®Google Scholar
• Shakib P, Mirzaei SZ, Lashgarian HE, et al. Preparation of zinc oxide nanoparticles assisted by okra mucilage and Evaluation of its biological activities. Curr Drug Discov Technol. 2023;20; doi: 10.2174/1570163820666221201090006
   Google Scholar
• Karkhane M, Lashgarian HE, Mirzaei SZ, et al. Antifungal, antioxidant and photocatalytic activities of zinc nanoparticles synthesized by Sargassum vulgare extract. Biocatal Agric Biotechnol. 2020;29:101791. doi: 10.1016/j.bcab.2020.101791
   Web of Science ®Google Scholar
• Gilavand F, Saki R, Zahra Mirzaei S, et al. Green synthesis of zinc nanoparticles using aqueous extract of magnoliae officinalis and assessment of its bioactivity potentials. Biointerface Res Appl Chem. 2020;11(1):7765–7774. doi: 10.33263/BRIAC111.77657774
   Web of Science ®Google Scholar
• Cheraghipour K, Khalaf AK, Moradpour K, et al. Synthesis, characterization, and antiparasitic effects of zinc oxide nanoparticles-eugenol nanosuspension against Toxoplasma gondii infection. Heliyon. 2023;9(8):e19295. doi: 10.1016/j.heliyon.2023.e19295
   PubMed Web of Science ®Google Scholar
• Ullah A, Saadullah M, Alvi F, et al. Synergistic effect of silver doped ZnO nanomaterials enhances the anticancer potential against A459 lung cancer cells. J King Saud Univ Sci. 2022;34:101724. doi: 10.1016/j.jksus.2021.101724
   Web of Science ®Google Scholar
• Yadav S, Sadique MA, Pal M, et al. Cytotoxicity and DNA fragmentation-mediated apoptosis response of hexagonal ZnO nanorods against human prostate cancer cells. Appl Surf Sci Advan. 2022;9:100237. doi: 10.1016/j.apsadv.2022.100237
   Google Scholar
• Panigrahi G, Medhi H, Wasnik K, et al. Hollow mesoporous SiO2–ZnO nanocapsules and effective in vitro delivery of anticancer drugs against different cancers with low doses of drugs. Mater Chem Phys. 2022;287:126287. doi: 10.1016/j.matchemphys.2022.126287
   Web of Science ®Google Scholar
• Hussein BY, Mohammed AM. Green synthesis of ZnO nanoparticles in grape extract: their application as anti-cancer and anti-bacterial. Mater Today Proc. 2021;42:A18–A26. doi: 10.1016/j.matpr.2021.03.729
   Google Scholar
• AbuMousa RA, Baig U, Gondal MA, et al. Investigation of the survival viability of cervical cancer cells (HeLa) under visible light induced photo-catalysis with facile synthesized WO3/ZnO nanocomposite. Saudi J Biol Sci. 2020;27:1743–1752. doi: 10.1016/j.sjbs.2020.04.038
   PubMed Web of Science ®Google Scholar
• Murali M, Manjula S, Shilpa N, et al. Facile synthesis of ZnO-NPs from yellow creeping daisy (Sphagneticola trilobata L.) attenuates cell proliferation by inducing cellular level apoptosis against colon cancer. J King Saud Univ Sci. 2022;34:102084. doi:10.1016/j.jksus.2022.102084
   Web of Science ®Google Scholar
• Jevapatarakul D, T-Thienprasert J, Payungporn S, et al. Utilization of Cratoxylum formosum crude extract for synthesis of ZnO nanosheets: characterization, biological activities and effects on gene expression of nonmelanoma skin cancer cell. Biomed Pharmacother. 2020;130:110552. doi: 10.1016/j.biopha.2020.110552
   PubMed Web of Science ®Google Scholar
• Eswari KM, Asaithambi S, Karuppaiah M, et al. Green synthesis of ZnO nanoparticles using Abutilon Indicum and Tectona Grandis leaf extracts for evaluation of anti-diabetic, anti-inflammatory and in-vitro cytotoxicity activities. Ceram Int. 2022;48(22):33624–33634. doi: 10.1016/j.ceramint.2022.07.308
   Web of Science ®Google Scholar
• Nava OJ, Luque PA, Gómez-Gutiérrez CM, et al. Influence of Camellia sinensis extract on Zinc Oxide nanoparticle green synthesis. J Mol Struct. 2017;1134:121–125. doi: 10.1016/j.molstruc.2016.12.069
   Web of Science ®Google Scholar
• Çolak H. Siyah Çay (camellia sinensis) sulu ekstraktı kullanılarak nanotanecikli ZnO İnce filminin Üretilmesi ve karakterize edilmesi. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2018;8(4):163–170. doi: 10.21597/JIST.409028
   Google Scholar
• Gonzalez RC, Woods RE, Digital image processing third edition Pearson international edition prepared by Pearson Education. Upper Saddle River, NJ: Prentice Hall; n.d.
   Google Scholar
• Haralick RM, Dinstein I, Shanmugam K. Textural features for image classification. EEE Trans Syst Man Cybern. 1973;SMC-3(6):610–621. doi: 10.1109/TSMC.1973.4309314
   Web of Science ®Google Scholar
• Duran H, Alkan FÜ, Ulkay MB, et al. Investigation of the in vitro cytotoxic effects and wound healing activity of ternary composite substance (hollow silica sphere/gum arabic/methylene blue). Int J Biol Macromol. 2019;121:1194–1202. doi: 10.1016/j.ijbiomac.2018.10.098
   PubMed Web of Science ®Google Scholar
• Alamdari S, Mirzaee O, Nasiri Jahroodi F, et al. Green synthesis of multifunctional ZnO/chitosan nanocomposite film using wild Mentha pulegium extract for packaging applications. Surf Interfaces. 2022;34:102349. doi: 10.1016/j.surfin.2022.102349
   PubMed Web of Science ®Google Scholar
• Karakuş S, Baytemir G, Özeroğlu CN. An ultra-sensitive smartphone-integrated digital colorimetric and electrochemical Camellia sinensis polyphenols encapsulated CuO nanoparticles-based ammonia biosensor. Inorg Chem Commun. 2022;143:109733. doi: 10.1016/j.inoche.2022.109733
   Web of Science ®Google Scholar
• Goudarzi A, Zabihi E, Shahrampour D, et al. Eco-friendly synthesis of large band gap ZnO nanoparticles by trisodium citrate: investigation of annealing effect on structural and optical properties. J Mater Sci Mater Electron. 2022;33:22798–22809. doi: 10.1007/s10854-022-09047-2
   Google Scholar
• Aga KW, Efa T, Beyene TT. Effects of sulfur doping and temperature on the energy Bandgap of ZnO Nanoparticles and Their Antibacterial Activities. ACS Omega. 2022;7:10796–10803. doi: 10.1021/acsomega.2c00647
   PubMed Web of Science ®Google Scholar
• Xiao J, Zou C, Liu M, et al. Mixing in a soft-elastic reactor (SER) characterized using an RGB based image analysis method. Chem Eng Sci. 2018;181:272–285. doi: 10.1016/j.ces.2018.02.019
   Web of Science ®Google Scholar
• Guo G, Zheng Q, Li T, et al. 3D printed self-calibrating on-site sensing platform based on bimodal excitation carbon dots for visual 4-nitrophenol detection by means of the localization of inner filter effect and pH regulation. Chem Eng Sci. 2023;281:119201. doi: 10.1016/j.ces.2023.119201
   Web of Science ®Google Scholar
• Panckow RP, Bliatsiou C, Nolte L, et al. Characterisation of particle stress in turbulent impeller flows utilising photo-optical measurements of a flocculation system – PART 1. Chem Eng Sci. 2023;267:118333. doi: 10.1016/j.ces.2022.118333
   Web of Science ®Google Scholar
• Thomas S, Gunasangkaran G, Arumugam VA. Synthesis and characterization of zinc oxide nanoparticles of solanum nigrum and its anticancer activity via the induction of apoptosis in cervical cancer. Biol Trace Elem Res. 2022;200(6):2684–2697. doi: 10.1007/s12011-021-02898-6
   PubMed Web of Science ®Google Scholar
• Naiel B, Fawzy M, Halmy MWA, et al. Green synthesis of zinc oxide nanoparticles using Sea Lavender (Limonium pruinosum L. Chaz.) extract: characterization, evaluation of anti-skin cancer, antimicrobial and antioxidant potentials. Sci Rep. 2022;12(1):1–12. doi: 10.1038/s41598-022-24805-2
   PubMed Web of Science ®Google Scholar
• Ilangovan A, Venkatramanan A, Thangarajan P, et al. Green synthesis of zinc oxide nanoparticles (ZnO NPs) using aqueous extract of tagetes erecta flower and evaluation of its antioxidant, antimicrobial, and cytotoxic activities on HeLa cell line. Curr Biotechnol. 2021;10:61–76. doi: 10.2174/2211550109999201202123939
   Google Scholar
• El-Waseif AA, El-Ghwas DE. Anti-breast cancer and cytotoxicity of nano materials formed bacterial cellulose-ZnO-Ag composite. Mater Today Proc. 2022;60:1651–1655. doi: 10.1016/j.matpr.2021.12.193
   Google Scholar
• Anitha J, Selvakumar R, Hema S, et al. Facile green synthesis of nano-sized ZnO using leaf extract of Morinda tinctoria: MCF-7 cell cycle arrest, antiproliferation, and apoptosis studies. J Ind Eng Chem. 2022;105:520–529. doi: 10.1016/j.jiec.2021.10.008
   Web of Science ®Google Scholar
• Shahriary S, Tafvizi F, Khodarahmi P, et al. Phyto-mediated synthesis of CuO nanoparticles using aqueous leaf extract of Artemisia deserti and their anticancer effects on A2780-CP cisplatin-resistant ovarian cancer cells. Biomass Convers Biorefin. 2022;1:1–17. doi: 10.1007/S13399-022-02436-X/FIGURES/11
   Google Scholar
• Resmi R, Yoonus J, Beena B. A novel greener synthesis of ZnO nanoparticles from Nilgiriantusciliantus leaf extract and evaluation of its biomedical applications. Mater Today Proc. 2021;46:3062–3068. doi: 10.1016/j.matpr.2021.02.498
   Google Scholar
• Barreira S, Moutinho C, Silva AMN, et al. Phytochemical characterization and biological activities of green tea (Camellia sinensis) produced in the Azores, Portugal. Portugal, Phytomedicine Plus. 2021;1:100001. doi: 10.1016/j.phyplu.2020.100001
   Google Scholar
• Fan D-M, Fan K, Yu C-P, et al. Tea polyphenols dominate the short-term tea (Camellia sinensis) leaf litter decomposition. J Zhejiang Univ Sci B. 2017;18(2):99–108. doi: 10.1631/jzus.B1600044
   PubMed Web of Science ®Google Scholar
• Ravindranath MH, Saravanan TS, Monteclaro CC, et al. Epicatechins purified from green Tea (camellia sinensis) differentially suppress growth of gender-dependent human cancer cell lines. eCAM. 2006;3:237–247. doi: 10.1093/ecam/nel003
   Google Scholar
• Xiang L-P, Wang A, Ye J-H, et al. Suppressive effects of Tea catechins on breast cancer. Nutrients. 2016;8(8):458. doi: 10.3390/nu8080458
   PubMed Web of Science ®Google Scholar
• Wang Y, Jin HY, Fang MZ, et al. Epigallocatechin gallate inhibits dimethylhydrazine-induced colorectal cancer in rats. World J Gastroenterol. 2020;26:2064–2081. doi: 10.3748/wjg.v26.i17.2064
   PubMed Web of Science ®Google Scholar
• Hayakawa S, Ohishi T, Miyoshi N, et al. Anti-Cancer effects of green Tea epigallocatchin-3-gallate and coffee chlorogenic acid. Molecules. 2020;25(19):4553. doi: 10.3390/molecules25194553
   PubMed Web of Science ®Google Scholar
• Shirakami Y, Shimizu M. Possible mechanisms of green Tea and Its constituents against cancer. Molecules. 2018;23(9):2284. doi: 10.3390/molecules23092284
   PubMed Web of Science ®Google Scholar
• Sharifi-Rad M, Pezzani R, Redaelli M, et al. Preclinical activities of epigallocatechin gallate in signaling pathways in cancer. Molecules. 2020;25(3):467), doi: 10.3390/molecules25030467
   PubMed Web of Science ®Google Scholar
• Bisht G, Rayamajhi S. Zno nanoparticles: A promising anticancer agent. Nanobiomedicine (Rij). 2016;3. doi: 10.5772/63437/ASSET/IMAGES/LARGE/10.5772_63437-FIG3.JPEG
   PubMedGoogle Scholar
• Tabrez S, Khan AU, Hoque M, et al. Biosynthesis of ZnO NPs from pumpkin seeds’ extract and elucidation of its anticancer potential against breast cancer. Nanotechnol Rev. 2022;11:2714–2725. doi: 10.1515/ntrev-2022-0154
   Web of Science ®Google Scholar
• Al-Ghamdi SA, Alkathiri TA, Alfarraj AE. Green synthesis and characterization of zinc oxide nanoparticles using Camellia sinensis tea leaf extract and their antioxidant, anti-bactericidal and anticancer efficacy. Res Chem Intermed. 2022;48(11):4769–4783. doi: 10.1007/s11164-022-04845-z
   Web of Science ®Google Scholar
• Saeed F, Younas M, Fazal H. Green and chemically synthesized zinc oxide nanoparticles: effects on in-vitro seedlings and callus cultures ofSilybum marianumand evaluation of their antimicrobial and anticancer potential. Artif Cells Nanomed Biotechnol. 2021;49:450–460. doi: 10.1080/21691401.2021.1926274
   PubMed Web of Science ®Google Scholar
• Pavithra M, Jessie Raj MB. Synthesis of ultrasonic assisted co-precipitated Ag/ZnO nanorods and their profound anti-liver cancer and antibacterial properties. Mater Sci Eng B. 2022;278:115653. doi: 10.1016/j.mseb.2022.115653
   Web of Science ®Google Scholar
• Truong Hoang Q, Ravichandran V, Nguyen Cao TG, et al. Piezoelectric Au-decorated ZnO nanorods: Ultrasound-triggered generation of ROS for piezocatalytic cancer therapy. Chem Eng J. 2022;435:135039. doi: 10.1016/j.cej.2022.135039
   Web of Science ®Google Scholar
• Ali S, Govindaraj Sudha K, Karunakaran G, et al. Anticancer and photocatalytic activities of zinc oxide nanorods synthesized from Manilkara littoralis leaf extract. Mater Chem Phys. 2022;277:125541. doi: 10.1016/j.matchemphys.2021.125541
   Web of Science ®Google Scholar
• Wahab R, Khan F, Kaushik N, et al. L-cysteine embedded core-shell ZnO microspheres composed of nanoclusters enhances anticancer activity against liver and breast cancer cells. Toxicol in Vitro. 2022;85:105460. doi: 10.1016/j.tiv.2022.105460
   PubMed Web of Science ®Google Scholar