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Original Articles

A new route for the synthesis of pyrimido[2,1-b][1,3]thiazine ring system

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Pages 293-299 | Received 03 Jan 2015, Accepted 15 Feb 2015, Published online: 11 Mar 2015

References

  • Danel K, Pedersen EB, Nielsen C. Synthesis and anti-HIV-1 activity of novel 2,3-dihydro-7H-thiazolo[3,2-a]pyrimidin-7-ones. J Med Chem. 1998;41:191–198. doi: 10.1021/jm970443m
  • Tozkoparan B, Ertan M, Kelicen P, Demirdamar R. Synthesis and anti-inflammatory activities of some thiazolo[3,2-a]pyrimidine derivatives. Farmaco. 1999;54:588–593. doi: 10.1016/S0014-827X(99)00068-3
  • Nicolle EJ, Guyod MB, Namil A, Leclerc G. New thiazolo[3,2-a]-pyrimidine derivatives, synthesis and structure-activity relationships. Eur J Med Chem. 1992;27:115–120. doi: 10.1016/0223-5234(92)90099-M
  • Bekhit AA, Fahmy HTY, Rostom SAF, Baraka AM. Design and synthesis of some substituted 1H-pyrazolyl-thiazolo[4,5-d]pyrimidines as anti-inflammatory–antimicrobial agents. Eur J Med Chem. 2003;38:27–36. doi: 10.1016/S0223-5234(02)00009-0
  • Abu-Hashem AA, Youssef MM, Hussein HAR. Synthesis, antioxidant, antitumer activities of some new thiazolopyrimidines, dyrrolothiazolo-pyrimidines and triazolopyrrolothiazolopyrimidines derivatives. J Chin Chem Soc. 2011;58:41–48. doi: 10.1002/jccs.201190056
  • Mohamed SF, Flefel EM, Amr A, Abd EI-Shafy DN. Anti-HSV-1 activity and mechanism of action of some new synthesized substituted pyrimidine, thiopyrimidine and thiazolopyrimidine derivatives. Eur J Med Chem. 2010;45:1494–1501. doi: 10.1016/j.ejmech.2009.12.057
  • Liang Y, Fan S, Mo WY, He HW. A facile synthesis and herbicidal activities of novel fluorine-containing thiazolo[4,5-d]pyrimidin-7(6H)-ones. J Fluorine Chem. 2007;128:879–884. doi: 10.1016/j.jfluchem.2007.04.011
  • Kolb S, Mondésert O, Goddard ML, Jullien D, Villoutreix B, Ducommun B, Garbay C, Braud E. Development of novel thiazolopyrimidines as CDC25B phosphatase inhibitors. ChemMed Chem. 2009;4:633–648. doi: 10.1002/cmdc.200800415
  • Geist J, Lauw S, Illarionova V, Illarionov I, Fischer M, Gräwert T, Rohdich F, Eisenreich W, Kaiser J, Groll M, Scheurer C, Wittlin S, Alonso-Gómez J, Schweizer W, Bacher A, Diederich F. Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from mycobacterium tuberculosis and plasmodium falciparum. ChemMedChem. 2010;5:1092–1101. doi: 10.1002/cmdc.201000083
  • Gakhar HK, Khanna A, Baveja P. Synthesis of pyrimido[2,1-b]-thieno[2,3-d][1,3]thiazines. Indian J Chem Section B. 1978;16:305–306.
  • El-Shareif AMSh, Micky JAA, Shmeiss NAMM, El-Gharieb G. Synthesis and reactions of some tetrahydrobenzothieno[2,3-d]pyrimidine derivatives with biological interest. Phosphorus Sulfur, Silicon and Rel. Elements. 2003;178:439–451. doi: 10.1080/10426500307912
  • Kolb HC, Sharpless KB. The growing impact of click chemistry on drug discovery. Drug Discov Today. 2009;8:1128–1137. doi: 10.1016/S1359-6446(03)02933-7
  • Agalave SG, Maujan SR, Pore VS. Click chemistry: 1,2,3-triazoles as pharmacophores. Chem. Asian J. 2011;6:2696–2718. doi: 10.1002/asia.201100432
  • Rostovtsev VV, Green LG, Fokin VV, Sharpless KB. A stepwise Huisgen cycloaddition process: copper(I)-catalyzed regioselective “Ligation” of azides and terminal alkynes. Angew Chem Int Ed. 2002;41:2596–2599. doi: 10.1002/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4
  • Reddy DM, Srinivas J, Chashoo G, Saxena AK, Kumar HMS. 4β-[(4-Alkyl)-1,2,3-triazol-1-yl] podophyllotoxins as anticancer compounds: design, synthesis and biological evaluation. Eur J Med Chem. 2011;46:1983–1991. doi: 10.1016/j.ejmech.2011.02.016
  • Odlo K, Hentzen J, Chabert JFD, Ducki S, Gani OABSM, Sylte I. 1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin. Bioorg Med Chem. 2008;16:4829–4838. doi: 10.1016/j.bmc.2008.03.049
  • Ameen MA, Karsten S, Liebscher J. A convenient method for constructing novel tetrahydropyridothieno[2,3-d]pyrimidinones carbohydrate and amino acid conjugates via copper(I)-catalyzed alkyne-azide ‘Click Chemistry’. J Tetrahedron. 2010;66:2141–2147. doi: 10.1016/j.tet.2010.01.071
  • Ahmed EKh, Ameen MA. A straightforward and mild method of tethering monosaccharides to thieno[2,3-d]pyrimidinones via the copper(I)-catalyzed azide-alkyne ‘Click Chemistry’. Z Naturforsch. 2012;67b:1282–1288.
  • Urleb U, Neidlein R, Kramer W. Synthesis of thiazole and fused thiazolo derivatives. Helv Chim Acta. 1993;76:431–440. doi: 10.1002/hlca.19930760127

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