Advanced search
Publication Cover
Expert Opinion on Drug Delivery Volume 13, 2016 - Issue 10
Submit an article Journal homepage
3,013
Views
21
CrossRef citations to date
0
Altmetric
Editorial

Will pulmonary drug delivery for systemic application ever fulfill its rich promise?

David CipollaR&D, Aradigm Corp., Hayward, CA, USACorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-5773-4721View further author information
ORCID Icon
Pages 1337-1340 | Received 16 Jun 2016, Accepted 21 Jul 2016, Published online: 05 Aug 2016

References

  • Cipolla D, Gonda I. Formulation technology to repurpose drugs for inhalation delivery. Drug Discov Today. 2011;8(3–4):123–130. doi:10.1016/j.ddstr.2011.07.001.
  • Patton J, Fishburn C, Weers J. The lungs as a portal of entry for systemic drug delivery. Proc Am Thorac Soc. 2004;1:338–344.
  • Siekmeier R, Scheuch G. Systemic treatment by inhalation of macromolecules – principles, problems and examples. J Physiol Pharmacol. 2008;59(6):53–79.
  • Weers JG, Bell J, Chan HK, et al. Pulmonary formulations: what remains to be done? J Aerosol Med Pulm Drug Deliv. 2010;23(S2):S5–S23.
  • Cipolla D, Shekunov B, Blanchard J, et al. Lipid-based carriers for pulmonary products: preclinical development and case studies in humans. Adv Drug Deliv Rev. 2014;75:53–80. doi:10.1016/j.addr.2014.05.001.
  • Edwards D, Hanes J, Caponetti G, et al. Large porous particles for pulmonary drug delivery. Science. 1997;276:1868–1871.
  • Cipolla D, Johansson E. AERx pulmonary drug delivery systems. In: Rathbone MJ, Hadgraft J, Roberts MS, et al. editors. Modified release drug delivery technology. 2nd ed. New York: Informa Healthcare; 2008. p. 563–571
  • Cipolla D, Chan H-K, Schuster J, et al. Personalized medicine: development of inhalation systems tailored to the individual. Ther Deliv. 2010;1(5):667–682.
  • Bitonti A, Dumont J. Pulmonary administration of therapeutic proteins using an immunoglobulin transport pathway. Adv Drug Deliv Rev. 2006;58(9–10):1106–1118.
  • Wolff R. Safety of inhaled proteins for therapeutic use. J Aerosol Med. 1998;11:197–219.
  • Cavaiola TS, Edelman S. Inhaled insulin: a breath of fresh air? A review of inhaled insulin. Clin Ther. 2014;36(8):1275–1289.
  • Patton JS, Porter L. Re-thinking inhaled insulin’s role in the global challenge to treat diabetes. In: Dalby RN, Byron PR, Peart J, et al., editors. Respiratory drug delivery Europe 2015. Vol. 2015. River Grove (IL): Davis Healthcare Int’l Publishing; 2013. p. 49–58, 237–242.
  • Hickey AJ. Back to the future: inhaled drug products. J Pharm Sci. 2013;102(4):1165–1171.
  • Angelo R, Rousseau K, Grant M, et al. Technosphere insulin: defining the role of technosphere particles at the cellular level. J Diabetes Sci Technol. 2009;3:545–554.
  • Kim ES, Plosker GL. AFREZZA® (insulin human) inhalation powder: a review in diabetes mellitus. Drugs. 2015;75:1679–1686.
  • Cipolla D, Gonda I. Inhaled nicotine replacement therapy. Asian J Pharm Sci. 2015;10(6):472–480. doi:10.1016/j.ajps.2015.07.004.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.