242
Views
19
CrossRef citations to date
0
Altmetric
Original Research

Novel nicotinamide skin-adhesive hot melt extrudates for treatment of acne

ORCID Icon, , , &
Pages 1165-1173 | Received 27 Jun 2018, Accepted 06 Nov 2018, Published online: 15 Nov 2018

References

  • Karandikar H, Ambardekar R, Kelly A, et al. Systematic identification of thermal degradation products of HPMCP during hot melt extrusion process. Int J Pharm. 2015;486:252–258.
  • Maniruzzaman M, Boateng JS, Snowden MJ, et al. A review of hot-melt extrusion: process technology to pharmaceutical products. ISRN Pharmaceutics. 2012;article ID 436763. p. 1–9.
  • Malaquias LFB, Schulte HL, Chaker JA, et al. Hot melt extrudates formulated using design space: one simple process for both palatability and dissolution rate improvement. J Pharm Sci. 2018;107:286–296.
  • Alshahrani SM, Lu W, Park J-B, et al. Stability-enhanced hot-melt extruded amorphous solid dispersions via combinations of Soluplus and HPMCAS-HF. AAPS PharmSciTech. 2015;16:824–834.
  • Salah I, Abou Shamat M, Cook MT. Soluplus solutions as thermothickening materials for topical drug delivery. J Appl Polym Sci. 2018;46915:1–9.
  • Paaver U, Tamm I, Laidmae I, et al. Soluplus graft copolymer: potential novel carrier polymer in electrospinning of nanofibrous drug delivery systems for wound therapy. Biomed Res Int. 2014;article ID 789765. p. 1–7.
  • Osman N, Maibach H. Effects of occlusion on dermal drug delivery: implications for bioequivalence measurement. In: Shah V, Maibach H, Jenner J, editors. Topical drug bioavailability, bioequivalence, and penetration. New York (NY): Springer; 2015. p. 351–359.
  • Bhagurkar AM, Angamuthu M, Patil H, et al. Development of an ointment formulation using hot melt extrusion technology. AAPS PharmSciTech. 2016;17:158–166.
  • Pawar J, Narkhede R, Amin P, et al. Design and evaluation of topical diclofenac sodium gel using hot melt extrusion technology as a continuous manufacturing process with Kolliphor P407. AAPS PharmSciTech. 2017;18:2303–2315.
  • Feldman S, Careccia RE, Barham KL, et al. Diagnosis and treatment of acne. Am Fam Physician. 2004;69:2123–2130.
  • Niren NM. Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review. Cutis. 2006;77:11–16.
  • Walocko FM, Eber AE, Keri JE, et al. The role of nicotinamide in acne treatment. Dermatol Ther. 2017;30:1–7. Epub ahead of print.
  • Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol. 2004;3:88–93.
  • Draelos ZD, Matsubara A, Smiles K. The effect of 2% niacinamide on facial sebum production. J Cosmet Laser Ther. 2006;8:96–101.
  • Fivenson DP. The mechanisms of action of nicotinamide and zinc in inflammatory skin disease. Cutis. 2006;77:5–10.
  • Wohlrab J, Kreft D. Niacinamide—mechanisms of action and its topical use in dermatology. Skin Pharmacol Physiol. 2014;27:311–315.
  • Boonme P, Boonthingchuay C, Wongpoowarak W, et al. Evaluation of nicotinamide microemulsion on the skin penetration enhancement. Pharm Dev Technol. 2016;21:116–120.
  • Penumetcha SS, Gutta LN, Dhanala H, et al. Hot melt extrudates Aprepitant-Soluplus solid dispersion: preformulation considerations, stability and in vitro study. Drug Dev Ind Pharm. 2016;42:1609–1620.
  • Gabal YM, Kamel AO, Sammour OA, et al. Effect of surface charge on the brain delivery of nanostructured lipid carriers insitu gels via the nasal route. Int J Pharm. 2014;473:442–457.
  • Nasr M. Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery. Drug Deliv. 2016;23:1444–1452.
  • Barakat SS, Nasr M, Ahmed RF, et al. Intranasally administered in situ gelling nanocomposite system of dimenhydrinate: preparation, characterization and pharmacodynamic applicability in chemotherapy induced emesis model. Sci. Rep. 2017;7:9910.
  • Shalita AR, Smith JG, Parish LC, et al. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. Int J Dermatol. 1995;36:434–437.
  • Hathout RM, Nasr M. Transdermal delivery of betahistine hydrochloride using microemulsions: physical characterization, biophysical assessment, confocal imaging and permeation studies. Colloids Surf B Biointerfaces. 2013;110:254–260.
  • Bsieso EA, Nasr M, Moftah NH, et al. Could nanovesicles containing a penetration enhancer clinically improve the therapeutic outcome in skin fungal diseases? Nanomedicine (Lond). 2015;10:2017–2031.
  • Nasr M, Abdel-Hamid S. Optimizing the dermal accumulation of a tazarotene microemulsion using skin deposition modeling. Drug Dev Ind Pharm. 2016;42:636–643.
  • Abdelgawad R, Nasr M, Moftah NH, et al. Phospholipid membrane tabulation using ceramide doping “cerosomes”: characterization and clinical application in psoriasis treatment. Eur J Pharm. 2017;101:258–268.
  • Nasr M, Abdel-Hamid S, Moftah NH, et al. Jojoba soft colloidal nanocarrier of a synthetic retinoid: preparation, characterization and clinical efficacy in psoriatic patients. Curr Drug Deliv. 2017;14:426–432.
  • Hatem S, Nasr M, Moftah NH, et al. Clinical cosmeceutical repurposing of melatonin in androgenic alopecia using nanostructured lipid carriers prepared with antioxidant oils. Exp Opin Drug Deliv. 2018;15:927–935.
  • Hatem S, Nasr M, Moftah NH, et al. Melatonin vitamin C-based nanovesicles for treatment of androgenic alopecia: design, characterization and clinical appraisal. Eur J Pharm Sci. 2018;122:246–253.
  • Chaudhary AM, Modi J, Shaikh M. RP-HPLC method development and validation for simultaneous estimation of clindamycin phosphate and nicotinamide in pharmaceutical dosage form. IBDR. 2014;4:160–174.
  • NilFroushzadeh MA, Siadat AH, Baradaran EH, et al. Clindamycin lotion alone versus combination lotion of clindamycin phosphate plus tretinoin versus combination lotion of clindamycin phosphate plus salicylic acid in the topical treatment of mild to moderate acne vulgaris: A randomized control trial. Indian J Dermatol Venereol Leprol. 2009;75:279–282.
  • Mohanan S, Parveen B, Annie Malathy P, et al. Use of intense pulse light for acne vulgaris in Indian skin-a case series. Int J Dermatol. 2012;51:473–476.
  • Barakat MT, Moftah NH, El Khayyat MAM, et al. Significant reduction of inflammation and sebaceous glands size in acne vulgaris lesions after intense pulsed light treatment. Dermatol Ther. 2017;30:1-5.
  • Shewale S, Shete AS, Doijad RC, et al. Formulation and solid state characterization of nicotinamide-based co-crystals of fenofibrate. Indian J Pharm Sci. 2015;77:328–334.
  • Shi NQ, Lai HW, Zhang Y, et al. On the inherent properties of Soluplus and its application in ibuprofen solid dispersions generated by microwave-quench cooling technology. Pharm Dev Technol. 2016;16:1–14.
  • Zidan AS, Ahmed OA, Aliaeid BM. Nicotinamide polymeric nanoemulsified systems: a quality by design case study for a sustained antimicrobial activity. Int J Nanomedicine. 2016;11:1501–1516.
  • Albadarin AB, Potter CB, Davis MT, et al. Development of stability enhanced ternary solid dispersions via combinations of HPMCP and Soluplus processed by hot melt extrusion. Int J Pharm. 2017;532:603–611.
  • Shamma RV, Basha M. Soluplus: a novel polymeric solubilizer for optimization of carvedilol solid dispersions: formulation design and effect of method of preparation. Powder Technology. 2013;237:406–414.
  • Kathe K, Kathpalia H. Film forming systems for topical and transdermal drug delivery. Asian J Pharm. 2017;12:487–497.
  • Frederiksen K, Guy RH, Petersson K. Formulation considerations in the design of topical polymeric film-forming systems for sustained drug delivery to the skin. Eur J Pharm Biopharm. 2015;91:9–15.
  • Zhu C, Gong S, Ding J, et al. Supersaturated polymeric micelles for oral silybin delivery: the role of the Soluplus-PVPVA complex. Acta Pharm Sin B. 2018; Epub ahead of print.
  • Makhmalzade BS, Chavoshy F. Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders. J Adv Pharm Technol Res. 2018;9:2–8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.