Preparation and characterization of a novel thermosensitive and bioadhesive cephalexin nanohydrogel: a promising platform for topical antibacterial delivery

References

• Tous S, El Sayed A, El Mohsen MA, et al. Novel formulation and clinical evaluation of nalidixic acid ointment in impetigo. J Drug Delivery Sci Technol. 2012;22(4):347–352.
   Web of Science ®Google Scholar
• Iovino SM, Krantz KD, Blanco DM, et al. NVC-422 topical gel for the treatment of impetigo. Int J Clin Exp Pathol. 2011;4(6):587.
   PubMed Web of Science ®Google Scholar
• Zusmanovich L, Charach L, Charach G. Current microbiological. Clin Thera Asp Impetigo Clin Med Rev Case Rep. 2018;5:205.
   Google Scholar
• Chaisri W, Hennink WE, Okonogi S. Preparation and characterization of cephalexin loaded PLGA microspheres. Curr Drug Deliv. 2009;6(1):69–75.
   PubMedGoogle Scholar
• Speight T, Brogden R, Avery G. Cephalexin: a review of its antibacterial, pharmacological and therapeutic properties. Drugs. 1972;3(1–2):9–78.
   PubMed Web of Science ®Google Scholar
• Salarian A, Mollamahale YB, Hami Z, et al. Cephalexin nanoparticles: synthesis, cytotoxicity and their synergistic antibacterial study in combination with silver nanoparticles. Mater Chem Phys. 2017;198:125–130.
   Web of Science ®Google Scholar
• Poulikakos P, Falagas ME. Aminoglycoside therapy in infectious diseases. Expert Opin Pharmacother. 2013;14(12):1585–1597.
   PubMed Web of Science ®Google Scholar
• Brown J, Shriner DL, Schwartz RA, et al. Impetigo: an update. Int J Dermatol. 2003;42(4):251–255.
   PubMed Web of Science ®Google Scholar
• Ruela ALM, Perissinato AG, Lino M, et al. Evaluation of skin absorption of drugs from topical and transdermal formulations. Braz J Pharm Sci. 2016;52(3):527–544.
   Web of Science ®Google Scholar
• Tsai M-J, Huang Y-B, Fang J-W, et al. Preparation and characterization of naringenin-loaded elastic liposomes for topical application. PloS One. 2015;10(7):e0131026.
   PubMed Web of Science ®Google Scholar
• Venuganti VVK, Perumal OP. Poly (amidoamine) dendrimers as skin penetration enhancers: influence of charge, generation, and concentration. J Pharm Sci. 2009;98(7):2345–2356.
   PubMed Web of Science ®Google Scholar
• Shatalebi M, Mostafavi S, Moghaddas A. Niosome as a drug carrier for topical delivery of N-acetyl glucosamine. Res Pharm Sci. 2010;5(2):107.
   PubMedGoogle Scholar
• Kakkar V, Kaur IP, Kaur AP, et al. Topical delivery of tetrahydrocurcumin lipid nanoparticles effectively inhibits skin inflammation: in vitro and in vivo study. Drug Dev Ind Pharm. 2018;44(10):1701–1712.
   PubMed Web of Science ®Google Scholar
• Azhdarzadeh M, Lotfipour F, Zakeri-Milani P, et al. Anti-bacterial performance of azithromycin nanoparticles as colloidal drug delivery system against different gram-negative and gram-positive bacteria. Adv Pharm Bull. 2012;2(1):17.
   PubMedGoogle Scholar
• Salatin S, Barar J, Barzegar-Jalali M, et al. An Alternative approach for improved entrapment efficiency of hydrophilic drug substance in PLGA nanoparticles by interfacial polymer deposition following solvent displacement. Jundishapur J Nat Pharm Prod. 2018;13(4). DOI:10.5812/jjnpp.12873
   Web of Science ®Google Scholar
• Salatin S. Nanoparticles as potential tools for improved antioxidant enzyme delivery. J Adv Chem Pharma Mater (JACPM). 2018;1(3):65–66.
   Google Scholar
• Badri W, Miladi K, Nazari QA, et al. Effect of process and formulation parameters on polycaprolactone nanoparticles prepared by solvent displacement. Colloids Surf, A. 2017;516:238–244.
   Google Scholar
• Badri W, Miladi K, Robin S, et al. Polycaprolactone based nanoparticles loaded with indomethacin for anti-inflammatory therapy: from preparation to ex vivo study. Pharm Res. 2017 Sept;34(9):1773–1783.
   PubMed Web of Science ®Google Scholar
• Zhao YZ, Jin RR, Yang W, et al. Using gelatin nanoparticle mediated intranasal delivery of neuropeptide substance p to enhance neuro-recovery in hemiparkinsonian rats. PLoS One. 2016;11(2):e0148848.
   PubMed Web of Science ®Google Scholar
• Cabana A, Aı̈t-Kadi A, Juhász J. Study of the gelation process of polyethylene oxidea–polypropylene oxideb–polyethylene oxideacopolymer (poloxamer 407) aqueous solutions. J Colloid Interface Sci. 1997;190(2):307–312.
   PubMed Web of Science ®Google Scholar
• Chaudhary B, Verma S. Preparation and evaluation of novel in situ gels containing acyclovir for the treatment of oral herpes simplex virus infections. Sci World J. 2014;2014:1-7.
   Google Scholar
• Adila SN, Suyatma NE, Firlieyanti AS, et al. editors. Antimicrobial and physical properties of chitosan film as affected by solvent types and glycerol as plasticizer. Advanced materials research. Trans Tech Publ; 2013.
   Google Scholar
• Banerjee M, Mallick S, Paul A, et al., Heightened reactive oxygen species generation in the antimicrobial activity of a three component iodinated chitosan− silver nanoparticle composite. Langmuir. 2010;26(8):5901–5908.
   PubMed Web of Science ®Google Scholar
• Schmolka IR. Artificial skin I. Preparation and properties of pluronic F‐127 gels for treatment of burns. J Biomed Mater Res. 1972;6(6):571–582.
   PubMed Web of Science ®Google Scholar
• Limón D, Jiménez‐Newman C, Rodrigues M, et al. Cationic supramolecular hydrogels for overcoming the skin barrier in drug delivery. ChemistryOpen. 2017;6(4):585–598.
   PubMed Web of Science ®Google Scholar
• Qin H, Wang J, Wang T, et al. Preparation and characterization of chitosan/β-glycerophosphate thermal-sensitive hydrogel reinforced by graphene oxide. Front Chem. 2018;6:565.
   PubMed Web of Science ®Google Scholar
• Djiobie Tchienou GE, Tsatsop Tsague RK, Mbam Pega TF, et al. Multi-response optimization in the formulation of a topical cream from natural ingredients. Cosmetics. 2018;5(1):7.
   Google Scholar
• Salatin S, Barar J, Barzegar-Jalali M, et al., Formulation and evaluation of eudragit RL-100 nanoparticles loaded in-situ forming gel for intranasal delivery of rivastigmine. Adv Pharm Bull. 2019;10(1):20–29.
   PubMed Web of Science ®Google Scholar
• Maleki Dizaj S, Lotfipour F, Barzegar-Jalali M, et al. Ciprofloxacin HCl-loaded calcium carbonate nanoparticles: preparation, solid state characterization, and evaluation of antimicrobial effect against Staphylococcus aureus. Artif Cells Nanomed Biotechnol. 2017;45(3):535–543.
   PubMed Web of Science ®Google Scholar
• Salatin S, Alami-Milani M, Daneshgar R, et al. Box–Behnken experimental design for preparation and optimization of the intranasal gels of selegiline hydrochloride. Drug Dev Ind Pharm. 2018;44(10):1613–1621.
   PubMed Web of Science ®Google Scholar
• Alami-Milani M, Zakeri-Milani P, Valizadeh H, et al., Evaluation of anti-inflammatory impact of dexamethasone-loaded PCL-PEG-PCL micelles on endotoxin-induced uveitis in rabbits. Pharm Dev Technol. 2019;24(6):680–688.
   PubMed Web of Science ®Google Scholar
• Kugelberg E, Norström T, Petersen TK, et al. Establishment of a superficial skin infection model in mice by using Staphylococcus aureus and Streptococcus pyogenes. Antimicrob Agents Chemother. 2005;49(8):3435–3441.
   PubMed Web of Science ®Google Scholar
• Mekkawy AI, El-Mokhtar MA, Nafady NA, et al. In vitro and in vivo evaluation of biologically synthesized silver nanoparticles for topical applications: effect of surface coating and loading into hydrogels. Int J Nanomedicine. 2017;12:759.
   PubMed Web of Science ®Google Scholar
• Nasrollahzadeh M, Ganji F, Taghizadeh S, et al. Development and optimization of cephalexin-loaded solid lipid nanoparticles using D-optimal design. Adv Sci Eng Med. 2016;8(9):695–704.
   Google Scholar
• Benkaddour A, Jradi K, Robert S, et al. Grafting of polycaprolactone on oxidized nanocelluloses by click chemistry. Nanomaterials. 2013;3(1):141–157.
   Web of Science ®Google Scholar
• Sahadevan J, Prabhakaran R, Vijay J, et al. Formulation and evaluation of cephalexin extended-release matrix tablets using hydroxy propyl methyl cellulose as rate-controlling polymer. J Young Pharm. 2012;4(1):3–12.
   PubMedGoogle Scholar
• Pereira ADF, Pereira LGR, Barbosa LADO, et al. Efficacy of methotrexate-loaded poly (ε-caprolactone) implants in Ehrlich solid tumor-bearing mice. Drug Deliv. 2013;20(3–4):168–179.
   PubMed Web of Science ®Google Scholar
• Quintanar-Guerrero D, Allémann E, Fessi H, et al. Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers. Drug Dev Ind Pharm. 1998;24(12):1113–1128.
   PubMed Web of Science ®Google Scholar
• Mahmoudian M, Salatin S, Khosroushahi AY. Natural low- and high-density lipoproteins as mighty bio-nanocarriers for anticancer drug delivery. Cancer Chemother Pharmacol. 2018 Sept;82(3):371–382.
   PubMed Web of Science ®Google Scholar
• Abdel-Mottaleb MM, Moulari B, Beduneau A, et al. Surface-charge-dependent nanoparticles accumulation in inflamed skin. J Pharm Sci. 2012 Nov;101(11):4231–4239.
   PubMed Web of Science ®Google Scholar
• Danafar H, Jaberizadeh H, Andalib S. In vitro and in vivo delivery of gliclazide loaded mPEG-PCL micelles and its kinetic release and solubility study. Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1625–1636.
   PubMed Web of Science ®Google Scholar
• Contri R, Fiel L, Alnasif N, et al. Skin penetration and dermal tolerability of acrylic nanocapsules: influence of the surface charge and a chitosan gel used as vehicle. Int J Pharm. 2016;507(1–2):12–20.
   PubMedGoogle Scholar
• Lambers H, Piessens S, Bloem A, et al. Natural skin surface pH is on average below 5, which is beneficial for its resident flora. Int J Cosmet Sci. 2006;28(5):359–370.
   PubMedGoogle Scholar
• Singh RM, Kumar A, Pathak K. Thermally triggered mucoadhesive in situ gel of loratadine: β-cyclodextrin complex for nasal delivery. AAPS PharmSciTech. 2013;14(1):412–424.
   PubMed Web of Science ®Google Scholar
• Soorbaghi FP, Isanejad M, Salatin S, et al. Bioaerogels: synthesis approaches, cellular uptake, and the biomedical applications. Biomed Pharmacother. 2019;111:964–975.
   PubMed Web of Science ®Google Scholar
• Shankar NB, Kumar RP, Kumar NU. et al. Development and characterization of bioadhesive gel of microencapsulated metronidazole for vaginal use. Iranian J Pharm Res. 2010;9(3):209.
   PubMed Web of Science ®Google Scholar
• Salatin S, Barar J, Barzegar-Jalali M, et al. Thermosensitive in situ nanocomposite of rivastigmine hydrogen tartrate as an intranasal delivery system: development, characterization, ex vivo permeation and cellular studies. Colloids Surf B Biointerfaces. 2017;159:629–638.
   PubMed Web of Science ®Google Scholar
• Salatin S, Lotfipour F, Jelvehgari M. A brief overview on nano-sized materials used in the topical treatment of skin and soft tissue bacterial infections. Expert Opin Drug Deliv. 2019 Dec;16(12):1313–1331.
   PubMed Web of Science ®Google Scholar
• Shaikh S, Nazam N, Rizvi SMD, et al. Mechanistic Insights into the antimicrobial actions of metallic nanoparticles and their implications for multidrug resistance. Int J Mol Sci. 2019;20(10):2468.
   Web of Science ®Google Scholar
• Fu X, Shen Y, Jiang X, et al. Chitosan derivatives with dual-antibacterial functional groups for antimicrobial finishing of cotton fabrics. Carbohydr Polym. 2011;85(1):221–227.
   Web of Science ®Google Scholar
• Hoeller S, Sperger A, Valenta C. Lecithin based nanoemulsions: a comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation. Int J Pharm. 2009;370(1–2):181–186.
   PubMed Web of Science ®Google Scholar
• Yah CS, Simate GS, Hlangothi P, et al. Nanotechnology and the future of condoms in the prevention of sexually transmitted infections. Ann Afr Med. 2018;17(2):49.
   PubMed Web of Science ®Google Scholar
• Das D, Das R, Ghosh P, et al. Dextrin cross linked with poly (HEMA): a novel hydrogel for colon specific delivery of ornidazole. RSC Adv. 2013;3(47):25340–25350.
   Web of Science ®Google Scholar