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Review

Liposomes as multifaceted delivery system in the treatment of osteoporosis

, , &
Pages 761-775 | Received 25 Oct 2020, Accepted 18 Dec 2020, Published online: 06 Jan 2021

References

  • Sözen T, Özışık L, Başaran N. An overview and management of osteoporosis. Eur J Rheumatol. 2017;4(1):46–56. PubMed PMID: 28293453; PubMed Central PMCID: PMCPmc5335887. Epub 2017/03/16.
  • Liu J, Curtis EM, Cooper C, et al. State of the art in osteoporosis risk assessment and treatment. J Endocrinol Invest. 2019;42(10):1149–1164. PubMed PMID: 30980341; PubMed Central PMCID: PMCPmc6751157. Epub 2019/04/14.
  • Holroyd C, Cooper C, Dennison E. Epidemiology of osteoporosis. Best Pract Res Clin Endocrinol Metab. 2008;22(5):671–685. PubMed PMID: 19028351. Epub 2008/11/26.
  • Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006;17(12):1726–1733. PubMed PMID: 16983459. Epub 2006/09/20.
  • Kanis JA, Johnell O, Oden A, et al. Long-term risk of osteoporotic fracture in Malmö. Osteoporos Int. 2000;11(8):669–674. PubMed PMID: 11095169. Epub 2000/11/30.
  • Sims NA, Martin TJ. Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit. Bonekey Rep. 2014;3:481. PubMed PMID: 24466412; PubMed Central PMCID: PMCPmc3899560. Epub 2014/01/28.
  • Lecart MP, Reginster JY. Current options for the management of postmenopausal osteoporosis. Expert Opin Pharmacother. 2011;12(16):2533–2552. PubMed PMID: 21916810. Epub 2011/09/16.
  • Khajuria DK, Razdan R, Mahapatra DR. Drugs for the management of osteoporosis: a review. Rev Bras Reumatol Engl Ed. 2011;51(4):365–71, 79–82. Epub 2011/07/23. PubMed PMID: 21779712
  • Cremers SC, Pillai G, Papapoulos SE. Pharmacokinetics/pharmacodynamics of bisphosphonates: use for optimisation of intermittent therapy for osteoporosis. Clin Pharmacokinet. 2005;44(6):551–570. PubMed PMID: 15932344. Epub 2005/06/04.
  • Goldberg M, Gomez-Orellana I. Challenges for the oral delivery of macromolecules. Nat Rev Drug Discov. 2003;2(4):289–295. PubMed PMID: 12669028. Epub 2003/04/02.
  • De Jong WH, Borm PJ. Drug delivery and nanoparticles:applications and hazards. Int J Nanomedicine. 2008;3(2):133–149. PubMed PMID: 18686775; PubMed Central PMCID: PMCPmc2527668. Epub 2008/08/09.
  • Cosman F. Anabolic and antiresorptive therapy for osteoporosis: combination and sequential approaches. Curr Osteoporos Rep. 2014;12(4):385–395. PubMed PMID: 25341476. Epub 2014/10/25.
  • Choi SW, Kim JH. Design of surface-modified poly(D,L-lactide-co-glycolide) nanoparticles for targeted drug delivery to bone. J Control Release. 2007;122(1):24–30. PubMed PMID: 17628158. Epub 2007/07/14.
  • Bobo D, Robinson KJ, Islam J, et al. Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date. Pharm Res. 2016;33(10):2373–2387. PubMed PMID: 27299311. Epub 2016/06/15.
  • Dang L, Liu J, Li F, et al. Targeted delivery systems for molecular therapy in skeletal disorders. Int J Mol Sci. 2016;17(3):428. PubMed PMID: 27011176; PubMed Central PMCID: PMCPmc4813278. Epub 2016/03/25.
  • Asafo-Adjei TA, Chen AJ, Najarzadeh A, et al. Advances in controlled drug delivery for treatment of osteoporosis. Curr Osteoporos Rep. 2016;14(5):226–238. PubMed PMID: 27502334; PubMed Central PMCID: PMCPmc5035217. Epub 2016/08/10.
  • Chang M, Lu S, Zhang F, et al. RGD-modified pH-sensitive liposomes for docetaxel tumor targeting. Colloids Surf B Biointerfaces. 2015;129:175–182. PubMed PMID: 25851582. Epub 2015/04/09.
  • Madni A, Sarfraz M, Rehman M, et al. Liposomal drug delivery: a versatile platform for challenging clinical applications. J Pharm Pharm Sci. 2014;17(3):401–426. PubMed PMID: 25224351. Epub 2014/09/17.
  • Zhang J, Li X, Huang L. Non-viral nanocarriers for siRNA delivery in breast cancer. J Control Release. 2014;190:440–450. PubMed PMID: 24874288; PubMed Central PMCID: PMCPmc4142098. Epub 2014/05/31.
  • Akbarzadeh A, Rezaei-Sadabady R, Davaran S, et al. Liposome: classification, preparation, and applications. Nanoscale Res Lett. 2013;8(1):102. PubMed PMID: 23432972; PubMed Central PMCID: PMCPmc3599573. Epub 2013/02/26.
  • Qadir A, Gao Y, Suryaji P, et al. Non-viral delivery system and targeted bone disease therapy. Int J Mol Sci. 2019;20(3). PubMed PMID: 30699924. DOI:10.3390/ijms20030565.
  • Simões S, Filipe A, Faneca H, et al. Cationic liposomes for gene delivery. Expert Opin Drug Deliv. 2005;2(2):237–254. PubMed PMID: 16296751. Epub 2005/11/22.
  • Ramamoorth M, Narvekar A. Non viral vectors in gene therapy- an overview. J Clin Diagn Res. 2015;9(1):Ge01–6. PubMed PMID: 25738007; PubMed Central PMCID: PMCPmc4347098. Epub 2015/03/05.
  • Hengst V, Oussoren C, Kissel T, et al. Bone targeting potential of bisphosphonate-targeted liposomes. Preparation, characterization and hydroxyapatite binding in vitro. Int J Pharm. 2007;331(2):224–227. PubMed PMID: 17150316. Epub 2006/12/08.
  • Pezzoli D, Kajaste-Rudnitski A, Chiesa R, et al. Lipid-based nanoparticles as nonviral gene delivery vectors. Methods Mol Biol. 2013;1025:269–279. PubMed PMID: 23918345. Epub 2013/08/07.
  • Vhora I, Lalani R, Bhatt P, et al. Colloidally Stable Small Unilamellar Stearyl Amine Lipoplexes for Effective BMP-9 Gene Delivery to Stem Cells for Osteogenic Differentiation. AAPS PharmSciTech. 2018;19(8):3550–3560. PubMed PMID: 30187446.
  • Murphy MB, Moncivais K, Caplan AI. Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med. 2013;45(11):e54. PubMed PMID: 24232253; PubMed Central PMCID: PMCPmc3849579. Epub 2013/11/16.
  • Ghadge SK, Mühlstedt S, Ozcelik C, et al. SDF- 1α as a therapeutic stem cell homing factor in myocardial infarction. Pharmacol Ther. 2011;129(1):97–108. PubMed PMID: 20965212. Epub 2010/10/23.
  • Vhora I, Lalani R, Bhatt P, et al. Lipid-nucleic acid nanoparticles of novel ionizable lipids for systemic BMP-9 gene delivery to bone-marrow mesenchymal stem cells for osteoinduction. Int J Pharm. 2019;563:324–336. PubMed PMID: 30954673. Epub 2019/04/08.
  • Lien CY, Chih-Yuan Ho K, Lee OK, et al. Restoration of bone mass and strength in glucocorticoid-treated mice by systemic transplantation of CXCR4 and cbfa-1 co-expressing mesenchymal stem cells. J Bone Miner Res. 2009;24(5):837–848. PubMed PMID: 19113920. Epub 2008/12/31.
  • Chen Q, Zheng C, Li Y, et al. Bone targeted delivery of SDF-1 via alendronate functionalized nanoparticles in guiding stem cell migration. ACS Applied Materials & Interfaces. 2018;10(28):23700–23710. PubMed PMID: 29939711.
  • Liu HC, Zhao H, Chen J, et al. Role of recombinant plasmid pEGFP-N1-IGF-1 transfection in alleviating osteoporosis in ovariectomized rats. J Mol Histol. 2013;44(5):535–544. PubMed PMID: 23508541. Epub 2013/03/20.
  • Hu Z, Zhang L, Wang H, et al. Targeted silencing of miRNA-132-3p expression rescues disuse osteopenia by promoting mesenchymal stem cell osteogenic differentiation and osteogenesis in mice. Stem Cell Res Ther 2020;11(1):58. PubMed PMID: 32054528.
  • Zhang G, Guo B, Wu H, et al. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nat Med. 2012;18(2):307–314. ubMed PMID: 22286306. Epub 2012/01/31.
  • Leucht P, Jiang J, Cheng D, et al. Wnt3a reestablishes osteogenic capacity to bone grafts from aged animals. J Bone Joint Surg Am Vol. 2013;95(14):1278–1288. PubMed PMID: 23864176; PubMed Central PMCID: PMCPmc3748990. Epub 2013/07/19.
  • Liu Y, Li Z, Arioka M, et al. WNT3A accelerates delayed alveolar bone repair in ovariectomized mice. Osteoporos Int. 2019;30(9):1873–1885. PubMed PMID: 31338519; PubMed Central PMCID: PMCPmc7007703. Epub 2019/07/25.
  • Fu R, Lv WC, Xu Y, et al. Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis. Nat Commun. 2020;11(1):460. PubMed PMID: 31974363; PubMed Central PMCID: PMCPMC6978338 other authors declare no competing interests. Epub 2020/01/25.
  • Li Y, Ma S, Guo J, et al. Effect of local hIL-10 gene therapy on experimental periodontitis in ovariectomized rats. Acta Odontol Scand. 2017;75(4):268–279. PubMed PMID: 28358289. Epub 2017/03/31.
  • Kofron MD, Laurencin CT. Bone tissue engineering by gene delivery. Adv Drug Deliv Rev. 2006;58(4):555–576. PubMed PMID: 16790291. Epub 2006/06/23.
  • Lyons JG, Plantz MA, Hsu WK, et al. Nanostructured biomaterials for bone regeneration. Front Bioeng Biotechnol. 2020;8(922). . DOI:10.3389/fbioe.2020.00922..
  • Roohani-Esfahani SI, Zreiqat H. Nanoparticles: a promising new therapeutic platform for bone regeneration? Nanomedicine (Lond). 2017;12(5):419–422. PubMed PMID: 28181460. Epub 2017/02/10.
  • Liu L, Xiang Y, Wang Z, et al. Adhesive liposomes loaded onto an injectable, self-healing and antibacterial hydrogel for promoting bone reconstruction. NPG Asia Mater. 2019;11:1–18.
  • Ma Y, Yang J, Li B, et al. Biodegradable and injectable polyme’ liposome hydrogel: a promising cell carrier. Polym Chem. 2016;7:2037–2044.
  • Mohammadi M, Alibolandi M, Abnous K, et al. Fabrication of hybrid scaffold based on hydroxyapatite-biodegradable nanofibers incorporated with liposomal formulation of BMP-2 peptide for bone tissue engineering. Nanomed. 2018;14(7):1987–1997. PubMed PMID: 29933024. Epub 2018/06/23.
  • Cattalini JP, Boccaccini AR, Lucangioli S, et al. Bisphosphonate-based strategies for bone tissue engineering and orthopedic implants. Tissue Eng Part B, Rev. 2012;18(5):323–340. PubMed PMID: 22440082; PubMed Central PMCID: PMCPmc3458621. Epub 2012/03/24.
  • Park J, Ries J, Gelse K, et al. Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes. Gene Ther. 2003;10(13):1089–1098. PubMed PMID: 12808439. Epub 2003/06/17.
  • Sun X, Wei J, Lyu J, et al. Bone-targeting drug delivery system of biomineral-binding liposomes loaded with icariin enhances the treatment for osteoporosis. J Nanobiotechnol. 2019;17(1):10. PubMed PMID: 30670021; PubMed Central PMCID: PMCPmc6341739. Epub 2019/01/24.
  • Stapleton M, Sawamoto K, Alméciga-Díaz CJ, et al. Development of bone targeting drugs. Int J Mol Sci. 2017;18(7):1345. PubMed PMID: 28644392; PubMed Central PMCID: PMCPmc5535838. Epub 2017/06/24.
  • Sun Y, Ye X, Cai M, et al. Osteoblast-targeting-peptide modified nanoparticle for siRNA/microRNA delivery. ACS Nano. 2016;10(6):5759–5768. PubMed PMID: 27176123. Epub 2016/05/14.
  • Farrell KB, Karpeisky A, Thamm DH, et al. Bisphosphonate conjugation for bone specific drug targeting. Bone Rep. 2018;9:47–60. PubMed PMID: 29992180; PubMed Central PMCID: PMCPmc6037665. Epub 2018/07/12.
  • Wu D, Wan M. Methylene diphosphonate-conjugated adriamycin liposomes: preparation, characteristics, and targeted therapy for osteosarcomas in vitro and in vivo. Biomed Microdevices. 2012;14(3):497–510. PubMed PMID: 22278099. Epub 2012/01/27.
  • Chupeerach C, Harnroongroj T, Phonrat B, et al. Decreased retinol transport proteins in Thai post-menopausal women with osteoporosis. Southeast Asian J Trop Med Public Health. 2011;42(6):1515–1520. PubMed PMID: 22299423. Epub 2012/02/04.
  • Sachaniya J, Savaliya R, Goyal R, et al. Liposomal formulation of vitamin A for the potential treatment of osteoporosis. Int J Nanomedicine. 2018;13(T–NANO 2014 Abstracts):51–53. PubMed PMID: 29593395; PubMed Central PMCID: PMCPmc5863641. Epub 2018/03/30.
  • Luo S, Yang Y, Chen J, et al. Tanshinol stimulates bone formation and attenuates dexamethasone-induced inhibition of osteogenesis in larval zebrafish. J Orthop Translat. 2016;4:35–45. PubMed PMID: 30035064; PubMed Central PMCID: PMCPmc5986998. Epub 2015/09/02.
  • Liu Y, Jia Z, Akhter MP, et al. Bone-targeting liposome formulation of Salvianic acid A accelerates the healing of delayed fracture Union in Mice. Nanomed. 2018;14(7):2271–2282. PubMed PMID: 30076934. Epub 2018/08/05.
  • Bigi A, Boanini E. Calcium phosphates as delivery systems for bisphosphonates. J Functional Biomater. 2018;9(1). PubMed PMID: 29342839. DOI:10.3390/jfb9010006.
  • Anada T, Takeda Y, Honda Y, et al. Synthesis of calcium phosphate-binding liposome for drug delivery. Bioorg Med Chem Lett. 2009;19(15):4148–4150. PubMed PMID: 19523821. Epub 2009/06/16.
  • Liu XM, Zhang Y, Chen F, et al. Prevention of orthopedic device-associated osteomyelitis using oxacillin-containing biomineral-binding liposomes. Pharm Res. 2012;29(11):3169–3179. PubMed PMID: 22733150; PubMed Central PMCID: PMCPmc3601903. Epub 2012/06/27.
  • Wu Z, Ma HM, Kukita T, et al. Phosphatidylserine-containing liposomes inhibit the differentiation of osteoclasts and trabecular bone loss. J Immunol. 2010;184(6):3191–3201. PubMed PMID: 20176740. Epub 2010/02/24.
  • Khachane P, Date AA, Nagarsenker MS. Eudragit EPO nanoparticles: application in improving therapeutic efficacy and reducing ulcerogenicity of meloxicam on oral administration. J Biomed Nanotechnol. 2011;7(4):590–597. PubMed PMID: 21870464. Epub 2011/08/30.
  • Raffin RP, Lima A, Lorenzoni R, et al. Natural lipid nanoparticles containing nimesulide: synthesis, characterization and in vivo antiedematogenic and antinociceptive activities. J Biomed Nanotechnol. 2012;8(2):309–315. PubMed PMID: 22515082. Epub 2012/04/21.
  • Vural I, Sarisozen C, Olmez SS. Chitosan coated furosemide liposomes for improved bioavailability. J Biomed Nanotechnol. 2011;7(3):426–430. PubMed PMID: 21830483. Epub 2011/08/13.
  • Teong B, Kuo SM, Tsai WH, et al. Liposomal encapsulation for systemic delivery of propranolol via transdermal iontophoresis improves bone microarchitecture in ovariectomized rats. Int J Mol Sci. 2017;18(4):822. PubMed PMID: 28406442; PubMed Central PMCID: PMCPmc5412406. Epub 2017/04/14.
  • Lu T, Ma Y, Hu H, et al. Ethinylestradiol liposome preparation and its effects on ovariectomized rats’ osteoporosis. Drug Deliv. 2011;18(7):468–477. PubMed PMID: 21688973. Epub 2011/06/22.
  • Cai Y, Gao T, Fu S, et al. Development of zoledronic acid functionalized hydroxyapatite loaded polymeric nanoparticles for the treatment of osteoporosis. Exp Ther Med. 2018;16(2):704–710. PubMed PMID: 30116324; PubMed Central PMCID: PMCPmc6090242. Epub 2018/08/18.
  • Law SL, Shih CL. Characterization of calcitonin-containing liposome formulations for intranasal delivery. J Microencapsul. 2001;18(2):211–221. PubMed PMID: 11253938. Epub 2001/03/20.
  • Gaspar M, Bakowsky U, Ehrhardt C. Inhaled liposomes current strategies and future challenges. J Biomed Nanotechnol. 2008;4:245–257.
  • Gaspar MM, Gobbo O, Ehrhardt C. Generation of liposome aerosols with the aeroneb pro and the aeroprobe nebulizers. J Liposome Res. 2010;20(1):55–61. PubMed PMID: 19580376. Epub 2009/07/08.
  • Nasr M, Taha I, Hathout RM. Suitability of liposomal carriers for systemic delivery of risedronate using the pulmonary route. Drug Deliv. 2013;20(8):311–318. PubMed PMID: 24079347. Epub 2013/10/02.
  • Aghazadeh-Habashi A, Yang Y, Tang K, et al. Transdermal drug delivery: feasibility for treatment of superficial bone stress fractures. Drug Deliv Transl Res. 2015;5(6):540–551. PubMed PMID: 26350235. Epub 2015/09/10.
  • Mahmood S, Taher M, Mandal UK. Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application. Int J Nanomedicine. 2014;9:4331–4346. PubMed PMID: 25246789; PubMed Central PMCID: PMCPmc4168883. Epub 2014/09/24.
  • Pandit AP, Omase SB, Mute VM. A chitosan film containing quercetin-loaded transfersomes for treatment of secondary osteoporosis. Drug Deliv Transl Res. 2020;10:1495–1506. PubMed PMID: 31942700. Epub 2020/01/17.
  • Daeihamed M, Dadashzadeh S, Haeri A, et al. Potential of liposomes for enhancement of oral drug absorption. Curr Drug Deliv. 2017;14(2):289–303. PubMed PMID: 26768542. Epub 2016/01/16.
  • Song KH, Chung SJ, Shim CK. Preparation and evaluation of proliposomes containing salmon calcitonin. J Control Release. 2002;84(1–2):27–37. PubMed PMID: 12399165. Epub 2002/10/26.
  • Yamabe K, Kato Y, Onishi H, et al. Potentiality of double liposomes containing salmon calcitonin as an oral dosage form. J Control Release. 2003;89(3):429–436. PubMed PMID: 12737845. Epub 2003/05/10.
  • Hosny KM, Ahmed OA, Al-Abdali RT. Enteric-coated alendronate sodium nanoliposomes: a novel formula to overcome barriers for the treatment of osteoporosis. Expert Opin Drug Deliv. 2013;10(6):741–746. PubMed PMID: 23656470. Epub 2013/05/10.
  • Han HK, Shin HJ, Ha DH. Improved oral bioavailability of alendronate via the mucoadhesive liposomal delivery system. Eur J Pharm Sci. 2012;46(5):500–507. PubMed PMID: 22522117. Epub 2012/04/24.
  • Marra M, Salzano G, Leonetti C, et al. Nanotechnologies to use bisphosphonates as potent anticancer agents: the effects of zoledronic acid encapsulated into liposomes. Nanomed. 2011;7(6):955–964. PubMed PMID: 21453789. Epub 2011/04/02.
  • Epstein H, Gutman D, Cohen-Sela E, et al. Preparation of alendronate liposomes for enhanced stability and bioactivity: in vitro and in vivo characterization. Aaps J. 2008;10(4):505–515. PubMed PMID: 18937071; PubMed Central PMCID: PMCPmc2628204. Epub 2008/10/22.
  • Maria J. Ramalho,Manuel A.N. Coelho and Maria C. Pereira. preface. In: Firestein GS, Budd RC, Gabriel SE, et al., editors. Kelley and firestein’s textbook of rheumatology. Tenth ed. Elsevier;  London (UK): Intechopen publishers; 2017. p. xxv.
  • Malekar SA, Sarode AL, Bach AC 2nd, et al. Radio frequency-activated nanoliposomes for controlled combination drug delivery. AAPS PharmSciTech. 2015;16(6):1335–1343. PubMed PMID: 25899799; PubMed Central PMCID: PMCPmc4666254. Epub 2015/04/23.
  • Turjeman K, Yanay N, Elbaz M, et al. Liposomal steroid nano-drug is superior to steroids as-is in mdx mouse model of Duchenne muscular dystrophy. Nanomed. 2019;16:34–44. PubMed PMID: 30529791. Epub 2018/12/12.
  • van der Goes MC, Strehl C, Buttgereit F, et al. Can adverse effects of glucocorticoid therapy be prevented and treated? Expert Opin Pharmacother. 2016;17(16):2129–2133. PubMed PMID: 27590884. Epub 2016/10/21.
  • Kundu SK, Sharma AR. Recent trends of polymer mediated liposomal gene delivery system. Biomed Res Int. 2014. PubMed PMID: 25250340. 2014;2014:934605.
  • Khan AA, Allemailem KS, Almatroodi SA, et al. Recent strategies towards the surface modification of liposomes: an innovative approach for different clinical applications. 3 Biotech. 2020;10(4):163. PubMed PMID: 32206497; PubMed Central PMCID: PMCPmc7062946. Epub 2020/03/25.
  • Çağdaş M, Sezer AD, Bucak S. (July 25th 2014). Liposomes as potential drug carrier systems for drug delivery, Application of Nanotechnology in Drug Delivery, Ali Demir Sezer, IntechOpen, London DOI: 10.5772/58459..
  • Kelly C, Jefferies C, Cryan SA. Targeted liposomal drug delivery to monocytes and macrophages. J Drug Deliv. 2011;2011:727241. PubMed PMID: 21512579; PubMed Central PMCID: PMCPmc3065850. Epub 2011/04/23.
  • Yetisgin AA, Cetinel S, Zuvin M. Therapeutic nanoparticles and their targeted delivery applications. Molecules (Basel, Switzerland). 2020;25(9). PubMed PMID: 32397080. DOI:10.3390/molecules25092193.
  • He H, Lu Y, Qi J, et al. Adapting liposomes for oral drug delivery. Acta Pharm Sin B. 2019;9(1):36–48. PubMed PMID: 30766776; PubMed Central PMCID: PMCPmc6362257. Epub 2019/02/16.
  • Glover DJ, Lipps HJ, Jans DA. Towards safe, non-viral therapeutic gene expression in humans. Nat Rev Genet. 2005;6(4):299–310. PubMed PMID: 15761468. Epub 2005/03/12.
  • Ahad A, Aqil M, Kohli K, et al. Formulation and optimization of nanotransfersomes using experimental design technique for accentuated transdermal delivery of valsartan. Nanomed. 2012;8(2):237–249. PubMed PMID: 21704600. Epub 2011/06/28.
  • Zeb A, Qureshi OS, Kim HS, et al. Improved skin permeation of methotrexate via nanosized ultradeformable liposomes. Int J Nanomedicine. 2016;11:3813–3824. PubMed PMID: 27540293; PubMed Central PMCID: PMCPmc4982511. Epub 2016/08/20.
  • Elnaggar YSR, Omran S, Hazzah HA, et al. Anionic versus cationic bilosomes as oral nanocarriers for enhanced delivery of the hydrophilic drug risedronate. Int J Pharm. 2019;564:410–425. PubMed PMID: 31029657. Epub 2019/04/29.
  • Antimisiaris SG, Mourtas S, Marazioti A. Exosomes and exosome-inspired vesicles for targeted drug delivery. Pharmaceutics. 2018;10(4):218. PubMed PMID: 30404188; PubMed Central PMCID: PMCPmc6321407. Epub 2018/11/09.
  • Xie Y, Hu JH, Wu H, et al. Bone marrow stem cells derived exosomes improve osteoporosis by promoting osteoblast proliferation and inhibiting cell apoptosis. Eur Rev Med Pharmacol Sci. 2019;23(3):1214–1220. PubMed PMID: 30779091. Epub 2019/02/20.
  • Li Y, Jin D, Xie W, et al. Mesenchymal stem cells-derived exosomes: a possible therapeutic strategy for osteoporosis. Curr Stem Cell Res Ther. 2018;13(5):362–368. PubMed PMID: 29623851. Epub 2018/04/07.
  • Chindamo G, Sapino S, Peira E. Bone diseases: current approach and future perspectives in drug delivery systems for bone targeted therapeutics. Nanomaterials (Basel, Switzerland). 2020;10(5). PubMed PMID: 32370009. DOI:10.3390/nano10050875..
  • Gong T, Chen Y, Zhang Y, et al. Osteogenic and anti-osteoporotic effects of risedronate-added calcium phosphate silicate cement. Biomed Mater. 2016;11(4):045002. PubMed PMID: 27388334. Epub 2016/07/09.
  • Li M, Liu X, Liu X, et al. Calcium phosphate cement with BMP-2-loaded gelatin microspheres enhances bone healing in osteoporosis: a pilot study. Clin Orthop Relat Res. 2010;468(7):1978–1985. PubMed PMID: 20306162; PubMed Central PMCID: PMCPmc2881991. Epub 2010/03/23.
  • Pyo SW, Kim YM, Kim CS, et al. Bone formation on biomimetic calcium phosphate-coated and zoledronate-immobilized titanium implants in osteoporotic rat tibiae. Int J Oral Maxillofac Implants. 2014;29(2):478–484. PubMed PMID: 24683577. Epub 2014/04/01.
  • Orellana BR, Hilt JZ, Puleo DA. Drug release from calcium sulfate-based composites. J Biomed Mater Res Part B Appl Biomater. 2015;103(1):135–142. PubMed PMID: 24788686; PubMed Central PMCID: PMCPmc4302276. Epub 2014/05/03.
  • Wang D, Miller SC, Kopecková P, et al. Bone-targeting macromolecular therapeutics. Adv Drug Deliv Rev. 2005;57(7):1049–1076. PubMed PMID: 15876403. Epub 2005/05/07.
  • Kim CW, Yun YP, Lee HJ, et al. In situ fabrication of alendronate-loaded calcium phosphate microspheres: controlled release for inhibition of osteoclastogenesis. J Control Release. 2010;147(1):45–53. PubMed PMID: 20600398. Epub 2010/07/06.

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