Continuous infusion aerosol delivery of prostacyclins during mechanical ventilation: challenges, limitations, and recent advances

References

• Dzierba AL, Abel EE, Buckley MS, et al. A review of inhaled nitric oxide and aerosolized epoprostenol in acute lung injury or acute respiratory distress syndrome. Pharmacotherapy. 2014;34(3):279–290.
   PubMed Web of Science ®Google Scholar
• Searcy RJ, Morales JR, Ferreira JA, et al. The role of inhaled prostacyclin in treating acute respiratory distress syndrome. Ther Adv Respir Dis. 2015;9(6):302–312.
   PubMed Web of Science ®Google Scholar
• Pacheco J, Arnold H, Skrupky L, et al. Predictors of outcome in 216 subjects with ARDS treated with inhaled epoprostenol. Respir Care. 2014;59(8):1178–1185.
   PubMed Web of Science ®Google Scholar
• Torbic H, Szumita PM, Anger KE, et al. Inhaled epoprostenol vs inhaled nitric oxide for refractory hypoxemia in critically ill patients. J Crit Care. 2013;28(5):844–848.
   PubMed Web of Science ®Google Scholar
• McPeck M, Ashraf S, Cuccia AD, et al. Factors determining continuous infusion aerosol delivery during mechanical ventilation. Respir Care. 2021;66(4):573–581.
   PubMed Web of Science ®Google Scholar
• Moler FW, Hurwitz ME, Custer JR. Improvement in clinical asthma score and PaCO2 in children with severe asthma treated with continuously nebulized terbutaline. J Allergy Clin Immunol. 1988;81(6):1101–1109.
   PubMed Web of Science ®Google Scholar
• Portnoy J, Aggarwal J. Continuous terbutaline nebulization for treatment of severe exacerbations of asthma in children. Ann Allergy. 1988;60(4):368–371.
   PubMedGoogle Scholar
• Voss KR, Willsie-Ediger SK, Pyszczynski DR, et al. Description of a delivery method for continuously aerosolized albuterol in status asthmaticus. J Asthma. 1990;27(1):37–39.
   PubMed Web of Science ®Google Scholar
• Colacone A, Wolkove N, Stern E, et al. Continuous nebulization of albuterol (salbutamol) in acute asthma. Chest. 1990;97(3):693–697.
   PubMed Web of Science ®Google Scholar
• Chipps BE, Blackney DA, Black LE, et al. Vortran High Output Extended Aerosol Respiratory Therapy (HEART) for delivery of continuously nebulized terbutaline for the treatment of acute bronchospasm. Pediatr Asthma Allergy Immunol. 1990;4(4):271–277.
   Google Scholar
• Moler FW, Johnson CE, Van Laanen C, et al. Continuous versus intermittent nebulized terbutaline: plasma levels and effects. Am J Respir Crit Care Med. 1995;151(3_pt_1):602–606.
   PubMed Web of Science ®Google Scholar
• McPeck M, Hughes K, Tandon R, et al. Aerosol delivery during continuous nebulization. Chest. 1997;111(5):1200–1205.
   PubMed Web of Science ®Google Scholar
• Raabe OG, Wong TM, Wong GB, et al. Continuous nebulization therapy for asthma with aerosols of β2 agonists. Ann Allergy Asthma Immunol. 1998;80(6):488–508.
   Web of Science ®Google Scholar
• Kelly HW, Keim KA, McWilliams BC. Comparison of two methods of delivering continuously nebulized albuterol. Ann Pharmacother. 2003;37(1):23–26.
   PubMed Web of Science ®Google Scholar
• Berlinski A, Willis JR, Leisenring T. In vitro comparison of 4 large-volume nebulizers in 8 hours of continuous nebulization. Respir Care. 2010;55(12):1671–1679.
   PubMed Web of Science ®Google Scholar
• NHLBI, National Asthma Education and Prevention Program. Expert Panel Report II. Guidelines for the diagnosis and management of asthma. Publication no. 97-4051. Bethesda MD: US Department of Health and Human Services; 1997.
   Google Scholar
• Khine H, Fuchs SM, Savile AL. Continuous vs intermittent nebulized albuterol for emergency management of asthma. Acad Emerg Med. 1996;3(11):1019–1024.
   PubMed Web of Science ®Google Scholar
• Tyvaso Inhalation System. Instructions for Use Manual. [cited 2022 Feb 28]. Available from: https://www.tyvaso.com/pdf/TD300_instructions_for_use.pdf
   Google Scholar
• Tips to Help Make the Most of Your Treatment with VENTAVIS/Mastering the ABCs of the I-neb Adaptive Aerosol Delivery (AAD®) System. [cited 2022 Feb 28]. Available from: https://www.janssencarepath.com/sites/www.janssencarepath-v1.com/files/ventavis-patient-brochure.pdf
   Google Scholar
• Siobal MS, Kallet RH, Pittet J-F, et al. Description and evaluation of a delivery system for aerosolized prostacyclin. Respir Care. 2003;48(8):742–753.
   PubMedGoogle Scholar
• Aerogen Solo System Instructions. P/N 30-674 Rev L, 2020, 24–26. [cited 2022 Feb 28]. Available from: https://www.aerogen.com/wp-content/uploads/2020/09/30-674-Rev-L-Aerogen-Solo-System-Instruction-Manual-US_WEB.pdf
   Google Scholar
• Anderson AC, Dubosky MN, Fiorino KA, et al., The effect of nebulizer position on aerosolized epoprostenol delivery in an adult lung model. Respir Care. 62(11): 1387–1395. 2017.
   PubMed Web of Science ®Google Scholar
• Smaldone GC. Drug delivery via aerosol systems: concept of “aerosol inhaled.” J Aerosol Med. 1991;4(3):229–235.
   PubMedGoogle Scholar
• Ari A, Atalay OT, Harwood R, et al. Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation. Respir Care. 2010;55(7):845–851.
   PubMed Web of Science ®Google Scholar
• McPeck M, Lee JA, Cuccia AD, et al. Real-time In Vitro assessment of aerosol delivery during mechanical ventilation. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2022;35(1):32–40.
   PubMed Web of Science ®Google Scholar
• Miller DD, Amin MM, Palmer LB, et al. Aerosol delivery and modern mechanical ventilation: in vitro/in vivo evaluation. Am J Respir Crit Care Med. 2003;168(10):1205–1209.
   PubMed Web of Science ®Google Scholar
• Sidler-Moix A-L, Di Paolo ER, Dolci U, et al. Physicochemical aspects and efficiency of albuterol nebulization: comparison of three aerosol types in an in vitro pediatric model. Respir Care. 2015;60(1):38–46.
   PubMed Web of Science ®Google Scholar
• McDermott K, Oakley JG. Droplet size and distribution of nebulized 3% sodium chloride, albuterol, and epoprostenol by phase Doppler particle analyzer. Curr Ther Res Clin Exp. 2021;82. doi:10.1016/j.curtheres.2021.100623.
   Google Scholar
• O’Riordan TG, Greco MJ, Perry RJ, et al. Nebulizer function during mechanical ventilation. Am Rev Respir Dis. 1992;145(5):1117–1122.
   PubMed Web of Science ®Google Scholar
• Walmrath D, Schneider T, Pilch J, et al. Aerosolized prostacyclin in adult respiratory distress syndrome. Lancet. 1993;342(8877):961–962.
   PubMed Web of Science ®Google Scholar