Magnetic hybrid nanovesicles for the precise diagnosis and treatment of central nervous system disorders

References

• Meyer AH, Feldsien TM, Mezler M, et al. Novel developments to enable treatment of CNS diseases with targeted drug delivery. Pharmaceutics. 2023;15(4):1100. doi: 10.3390/pharmaceutics15041100
   PubMed Web of Science ®Google Scholar
• Chaulagain B, Gothwal A, Lamptey RNL, et al. Experimental models of in vitro blood–brain barrier for CNS drug delivery: an evolutionary perspective. Int J Mol Sci. 2023;24(3):2710. doi: 10.3390/ijms24032710
   PubMed Web of Science ®Google Scholar
• Rajendran R, Kunnil A, Radhakrishnan A, et al. Current trends and future perspectives for enhanced drug delivery to central nervous system in treatment of stroke. Ther Deliv. 2023 Jan;14(1):61–85. doi: 10.4155/tde-2022-0064
   PubMed Web of Science ®Google Scholar
• Farhoudi M, Sadigh-Eteghad S, Mahmoudi J, et al. The therapeutic benefits of intravenously administrated nanoparticles in stroke and age-related neurodegenerative diseases. Curr Pharm Des. 2022;28(24):1985–2000. doi: 10.2174/1381612828666220608093639
   PubMed Web of Science ®Google Scholar
• Nguyen TT, Nguyen TTD, Vo TK, et al. Nanotechnology-based drug delivery for central nervous system disorders. Biomed Pharmacother. 2021;143:112117. doi: 10.1016/j.biopha.2021.112117
   PubMed Web of Science ®Google Scholar
• Virmani R, Virmani T, Pathak K. Nanovesicles for delivery of central nervous system drugs. Elsevier: Applications of Nanovesicular Drug Delivery; 2022. p. 315–339.
   Google Scholar
• Liang Y, Iqbal Z, Lu J, et al. Cell-derived nanovesicle-mediated drug delivery to the brain: principles and strategies for vesicle engineering. Mol Ther. 2023;31(5):1207–1224. doi: 10.1016/j.ymthe.2022.10.008
   PubMed Web of Science ®Google Scholar
• Chen Y, Hou S. Application of magnetic nanoparticles in cell therapy. Stem Cell Res Ther. 2022;13(1):135–143. doi: 10.1186/s13287-022-02808-0
   PubMed Web of Science ®Google Scholar
• Zhu M, Li Y, Huang C, et al. Magnetic nanoparticle-driven and exosome-mediated intelligent targeting nanovesicles for inducing ferroptosis to surmount breast cancer. ACS Appl Nano Mater. 2023;6(13):11269–11281. doi: 10.1021/acsanm.3c01304
   Web of Science ®Google Scholar
• Maghsoodi M, Rahmani M, Ghavimi H, et al. Fast dissolving sublingual films containing sumatriptan alone and combined with methoclopramide: evaluation in vitro drug release and mucosal permeation. Pharm Sci. 2022;22(3):153–163. doi: 10.15171/PS.2016.25
   Google Scholar
• Huang Q, Chen AT, Chan KY, et al. Targeting AAV vectors to the central nervous system by engineering capsid–receptor interactions that enable crossing of the blood–brain barrier. PLoS Biol. 2023;21(7):e3002112. doi: 10.1371/journal.pbio.3002112
   PubMed Web of Science ®Google Scholar
• van Lengerich B, Zhan L, Xia D, et al. A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models. Nat Neurosci. 2023;26(3):416–429. doi: 10.1038/s41593-022-01240-0
   PubMed Web of Science ®Google Scholar
• Chatterjee S, Deshpande AA, Shen H. Recent advances in the in vitro and in vivo methods to assess impact of P‐glycoprotein and breast cancer resistance protein transporters in central nervous system drug disposition. Biopharm Drug Dispos. 2023;44(1):7–25. doi: 10.1002/bdd.2345
   PubMed Web of Science ®Google Scholar
• Ahmadian E, Samiei M, Hasanzadeh A, et al. Monitoring of drug resistance towards reducing the toxicity of pharmaceutical compounds: past, present and future. J Pharm Biomed Anal. 2020;186:113265. doi: 10.1016/j.jpba.2020.113265
   PubMed Web of Science ®Google Scholar
• Diao X, Han H, Li B, et al. The rare marine bioactive compounds in neurological disorders and diseases: is the Blood-Brain Barrier an obstacle or a target? Mar Drugs. 2023;21(7):406. doi: 10.3390/md21070406
   PubMed Web of Science ®Google Scholar
• Alkahtani S, Al-Johani NS, Alarifi S. Mechanistic insights, treatment paradigms, and clinical progress in neurological disorders: Current and future prospects. IJMS. 2023;24(2):1340. doi: 10.3390/ijms24021340
   Google Scholar
• Villalba N, Ma Y, Gahan SA, et al. Lung infection by P. aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice. bioRxiv. 2023 Jan 23;20:1–18. doi: 10.1186/s12974-023-02817-7
   Google Scholar
• Panlilio LV, Goldberg SR. Self‐administration of drugs in animals and humans as a model and an investigative tool. Addiction. 2007;102(12):1863–1870. doi: 10.1111/j.1360-0443.2007.02011.x
   PubMed Web of Science ®Google Scholar
• ElShagea HN, Makar RR, Salama AH, et al. Investigating the targeting power to brain tissues of intranasal rasagiline mesylate-loaded transferosomal in situ gel for efficient treatment of Parkinson’s disease. Pharmaceutics. 2023;15(2):533. doi: 10.3390/pharmaceutics15020533
   PubMed Web of Science ®Google Scholar
• Nojoki F, Ebrahimi-Hosseinzadeh B, Hatamian-Zarmi A, et al. Design and development of chitosan-insulin-transfersomes (transfersulin) as effective intranasal nanovesicles for the treatment of Alzheimer’s disease: In vitro, in vivo, and ex vivo evaluations. Biomed Pharmacother. 2022 Sep;153:113450. doi: 10.1016/j.biopha.2022.113450
   PubMed Web of Science ®Google Scholar
• Shi J, Wang Y, Luo G. Ligustrazine phosphate ethosomes for treatment of Alzheimer’s disease, in vitro and in animal model studies. AAPS Pharm Sci Tech. 2012 Jun;13(2):485–492. doi: 10.1208/s12249-012-9767-6
   PubMed Web of Science ®Google Scholar
• Qu M, Lin Q, He S, et al. A brain targeting functionalized liposomes of the dopamine derivative N-3,4-bis(pivaloyloxy)-dopamine for treatment of Parkinson’s disease. J Control Release. 2018;277:173–182. doi: 10.1016/j.jconrel.2018.03.019
   PubMed Web of Science ®Google Scholar
• Zhu Y, Liang J, Gao C, et al. Multifunctional ginsenoside Rg3-based liposomes for glioma targeting therapy. J Control Release. 2021;330:641–657. doi: 10.1016/j.jconrel.2020.12.036
   PubMed Web of Science ®Google Scholar
• Kulkarni P, Rawtani D, Barot T. Design, development and in-vitro/in-vivo evaluation of intranasally delivered rivastigmine and N-Acetyl cysteine loaded bifunctional niosomes for applications in combinative treatment of Alzheimer’s disease. Eur J Pharm Biopharm. 2021;163:1–15. doi: 10.1016/j.ejpb.2021.02.015
   PubMed Web of Science ®Google Scholar
• Geng W, Tang H, Luo S, et al. Exosomes from miRNA-126-modified ADSCs promotes functional recovery after stroke in rats by improving neurogenesis and suppressing microglia activation. Am J Transl Res. 2019;11(2):780–792. doi: 10.1111/cns.13455
   PubMed Web of Science ®Google Scholar
• Bu N, Wu H, Zhang G, et al. Exosomes from dendritic cells loaded with chaperone-rich cell lysates elicit a potent T cell immune response against intracranial glioma in mice. J Mol Neurosci. 2015;56(3):631–643. doi: 10.1007/s12031-015-0506-9
   PubMed Web of Science ®Google Scholar
• Salatin S. Nanoparticles as potential tools for improved antioxidant enzyme delivery. J Adv Chem Pharm Mater (JACPM). 2018;1(3):65–66.
   Google Scholar
• Salatin S, Lotfipour F, Jelvehgari M. A brief overview on nano-sized materials used in the topical treatment of skin and soft tissue bacterial infections. Expert Opin Drug Deliv. 2019;16(12):1313–1331. doi: 10.1080/17425247.2020.1693998
   PubMed Web of Science ®Google Scholar
• Kenari AN, Cheng L, Hill AF. Methods for loading therapeutics into extracellular vesicles and generating extracellular vesicles mimetic-nanovesicles. Methods. 2020;177:103–113. doi: 10.1016/j.ymeth.2020.01.001
   PubMed Web of Science ®Google Scholar
• Grimaldi N, Andrade F, Segovia N, et al. Lipid-based nanovesicles for nanomedicine. Chem Soc Rev. 2016;45(23):6520–6545. doi: 10.1039/C6CS00409A
   PubMed Web of Science ®Google Scholar
• Rampado R, Biccari A, D’Angelo E, et al. Optimization of biomimetic, leukocyte-mimicking nanovesicles for drug delivery against colorectal cancer using a design of experiment approach. Front Bioeng Biotechnol. 2022;10:883034. doi: 10.3389/fbioe.2022.883034
   PubMed Web of Science ®Google Scholar
• Fan Z, Wang Y, Li L, et al. Tumor-homing and immune-reprogramming cellular nanovesicles for photoacoustic imaging-guided phototriggered precise chemoimmunotherapy. ACS Nano. 2022;16(10):16177–16190. doi: 10.1021/acsnano.2c04983
   PubMed Web of Science ®Google Scholar
• Bose R JC, Uday Kumar S, Zeng Y, et al. Tumor cell-derived extracellular vesicle-coated nanocarriers: an efficient theranostic platform for the cancer-specific delivery of anti-miR-21 and imaging agents. ACS Nano. 2018;12(11):10817–10832. doi: 10.1021/acsnano.8b02587
   PubMed Web of Science ®Google Scholar
• Omidi Y, Omidian H, Kwon Y, et al. Blood–brain barrier and nanovesicles for brain-targeting drug delivery. Elsevier: Applications of Nanovesicular Drug Delivery; 2022. p. 167–199. doi: 10.1016/B978-0-323-91865-7.00007-9
   Google Scholar
• Picone P, Palumbo FS, Federico S, et al. Nano-structured myelin: new nanovesicles for targeted delivery to white matter and microglia, from brain-to-brain. Mater Today Bio. 2021;12:100146. doi: 10.1016/j.mtbio.2021.100146
   PubMedGoogle Scholar
• Naguib MJ, Salah S, Halim SAA, et al. Investigating the potential of utilizing glycerosomes as a novel vesicular platform for enhancing intranasal delivery of lacidipine. Int J Pharm. 2020;582:119302. doi: 10.1016/j.ijpharm.2020.119302
   PubMed Web of Science ®Google Scholar
• Alami-Milani M, Salatin S, Rayeni FS, et al. Preparation and in vitro evaluation of thermosensitive and mucoadhesive hydrogels for intranasal delivery of phenobarbital sodium. Ther Deliv. 2021;12(6):461–475. doi: 10.4155/tde-2021-0022
   PubMed Web of Science ®Google Scholar
• Li J-Y, Li Q-Q, Sheng R. The role and therapeutic potential of exosomes in ischemic stroke. Neurochem Int. 2021;151:105194. doi: 10.1016/j.neuint.2021.105194
   PubMed Web of Science ®Google Scholar
• Wang Z, Zhao Y, Jiang Y, et al. Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. Sci Rep. 2015;5(1):12651. doi: 10.1038/srep12651
   PubMedGoogle Scholar
• Thomas RG, Kim J-H, Kim J-H, et al. Treatment of ischemic stroke by atorvastatin-loaded PEGylated liposome. Transl Stroke Res. 2023;2023:1–9. doi: 10.1007/s12975-023-01125-9
   Google Scholar
• Amin FU, Hoshiar AK, Do TD, et al. Osmotin-loaded magnetic nanoparticles with electromagnetic guidance for the treatment of Alzheimer’s disease. Nanoscale. 2017;9(30):10619–10632. doi: 10.1039/C7NR00772H
   PubMed Web of Science ®Google Scholar
• Tafoya MA, Madi S, Sillerud LO. Superparamagnetic nanoparticle-enhanced MRI of Alzheimer’s disease plaques and activated microglia in 3X transgenic mouse brains: contrast optimization. J Magn Reson Imaging. 2017;46(2):574–588. doi: 10.1002/jmri.25563
   PubMed Web of Science ®Google Scholar
• X-G L, Lu S, D-Q L, et al. ScFv-conjugated superparamagnetic iron oxide nanoparticles for MRI-based diagnosis in transgenic mouse models of Parkinson’s and Huntington’s diseases. Brain Res. 2019;1707:141–153. doi: 10.1016/j.brainres.2018.11.034
   PubMed Web of Science ®Google Scholar
• Wang L, Yang S, Li L, et al. A low-intensity repetitive transcranial magnetic stimulation coupled to magnetic nanoparticles loaded with scutellarin enhances brain protection against cerebral ischemia reperfusion injury. J Drug Deliv Sci Technol. 2022;74:103606. doi: 10.1016/j.jddst.2022.103606
   Web of Science ®Google Scholar
• Lu X, Zhang Y, Wang L, et al. Development of L-carnosine functionalized iron oxide nanoparticles loaded with dexamethasone for simultaneous therapeutic potential of blood brain barrier crossing and ischemic stroke treatment. Drug Deliv. 2021;28(1):380–389. doi: 10.1080/10717544.2021.1883158
   PubMed Web of Science ®Google Scholar
• Chen H-A, Ma Y-H, Hsu T-Y, et al. Preparation of peptide and recombinant tissue plasminogen activator conjugated poly (lactic-co-glycolic acid)(PLGA) magnetic nanoparticles for dual targeted thrombolytic therapy. Int J Mol Sci. 2020;21(8):2690. doi: 10.3390/ijms21082690
   PubMed Web of Science ®Google Scholar
• Afzalipour R, Khoei S, Khoee S, et al. Thermosensitive magnetic nanoparticles exposed to alternating magnetic field and heat-mediated chemotherapy for an effective dual therapy in rat glioma model. Nanomed Nanotechnol Biol Med. 2021;31:102319. doi: 10.1016/j.nano.2020.102319
   PubMed Web of Science ®Google Scholar
• Rego GNA, Mamani JB, Souza TKF, et al. Therapeutic evaluation of magnetic hyperthermia using Fe3O4-aminosilane-coated iron oxide nanoparticles in glioblastoma animal model. Einstein (Sao Paulo). 2019;17(4):eAO4786. doi: 10.31744/einstein_journal/2019AO4786
   PubMed Web of Science ®Google Scholar
• Pal A, Kumar S, Jain S, et al. Neuroregenerative effects of electromagnetic field and magnetic nanoparticles on spinal cord injury in rats. J Nanosci Nanotechnol. 2018 Oct 1;18(10):6756–6764. doi: 10.1166/jnn.2018.15820
   PubMed Web of Science ®Google Scholar
• Gkountas AA, Polychronopoulos ND, Sofiadis GN, et al. Simulation of magnetic nanoparticles crossing through a simplified blood-brain barrier model for glioblastoma multiforme treatment. Comput Methods Programs Biomed. 2021;212:106477. doi: 10.1016/j.cmpb.2021.106477
   PubMed Web of Science ®Google Scholar
• Aguilera G, Berry CC, West RM, et al. Carboxymethyl cellulose coated magnetic nanoparticles transport across a human lung microvascular endothelial cell model of the blood–brain barrier. Nanoscale Adv. 2019;1(2):671–685. doi: 10.1039/C8NA00010G
   PubMed Web of Science ®Google Scholar
• Wu Y, Lu Z, Li Y, et al. Surface modification of iron oxide-based magnetic nanoparticles for cerebral theranostics: application and prospection. Nanomaterials. 2020;10(8):1441. doi: 10.3390/nano10081441
   Web of Science ®Google Scholar
• Chan M-H, Li C-H, Chang Y-C, et al. Iron-based ceramic composite nanomaterials for magnetic fluid hyperthermia and drug delivery. Pharmaceutics. 2022;14(12):2584. doi: 10.3390/pharmaceutics14122584
   PubMed Web of Science ®Google Scholar
• Mamani JB, Souza TKF, Nucci MP, et al. In vitro evaluation of hyperthermia magnetic technique indicating the best strategy for internalization of magnetic nanoparticles applied in glioblastoma tumor cells. Pharmaceutics. 2021 1-21;13(8):1219. doi: 10.3390/pharmaceutics13081219
   PubMed Web of Science ®Google Scholar
• Choi M, Ryu J, Vu HD, et al. Transferrin-conjugated melittin-loaded l-arginine-coated iron oxide nanoparticles for mitigating beta-amyloid pathology of the 5XFAD mouse brain. Int J Mol Sci. 2023;24(19):14954. doi: 10.3390/ijms241914954
   PubMed Web of Science ®Google Scholar
• Azarmi M, Maleki H, Nikkam N, et al. Novel neurolisteriosis therapy using SPION as a drivable nanocarrier in gallic acid delivery to CNS. J Control Release. 2023;353:507–517. doi: 10.1016/j.jconrel.2022.12.006
   PubMed Web of Science ®Google Scholar
• Ucar A, Parlak V, Ozgeris FB, et al. Magnetic nanoparticles-induced neurotoxicity and oxidative stress in brain of rainbow trout: mitigation by ulexite through modulation of antioxidant, anti-inflammatory, and antiapoptotic activities. Sci Total Environ. 2022;838:155718. doi: 10.1016/j.scitotenv.2022.155718
   PubMed Web of Science ®Google Scholar
• Lotfipour F, Shahi S, Farjami F, et al. Safety and toxicity issues of therapeutically used nanoparticles from the oral route. BMC Res Int. 2021;2021:1–14. doi: 10.1155/2021/9322282
   Google Scholar
• Figueroa-Pizano M, Carvajal-Millan E. Nanovesicles for image-guided drug delivery. Elsevier: Systems of Nanovesicular Drug Delivery; 2022. p. 419–433.
   Google Scholar
• Hermann CA, Mayer M, Griesche C, et al. Microfluidic-enabled magnetic labelling of nanovesicles for bioanalytical applications. Analyst. 2021;146(3):997–1003. doi: 10.1039/D0AN02027C
   PubMed Web of Science ®Google Scholar
• Wang M, Li L, Zhang X, et al. Magnetic resveratrol liposomes as a new theranostic platform for magnetic resonance imaging guided Parkinson’s disease targeting therapy. ACS Sustain Chem Eng. 2018;6(12):17124–17133. doi: 10.1021/acssuschemeng.8b04507
   Web of Science ®Google Scholar
• Ji B, Wang M, Gao D, et al. Combining nanoscale magnetic nimodipine liposomes with magnetic resonance image for Parkinson’s disease targeting therapy. Nanomedicine. 2017;12(3):237–253. doi: 10.2217/nnm-2016-0267
   PubMed Web of Science ®Google Scholar
• Lu YJ, Hsu HL, Lan YH, et al. Thermosensitive cationic magnetic liposomes for thermoresponsive delivery of CPT-11 and SLP2 shRNA in glioblastoma treatment. Pharmaceutics. 2023;15(4):1169–1191. doi: 10.3390/pharmaceutics15041169
   PubMed Web of Science ®Google Scholar
• Saiyed ZM, Gandhi NH, Nair MP. Magnetic nanoformulation of azidothymidine 5’-triphosphate for targeted delivery across the blood-brain barrier. Int J Nanomedicine. 2010;5:157–166. doi: 10.2147/IJN.S8905
   PubMed Web of Science ®Google Scholar
• Dickinson PJ, LeCouteur RA, Higgins RJ, et al. Canine model of convection-enhanced delivery of liposomes containing CPT-11 monitored with real-time magnetic resonance imaging: laboratory investigation. J Neurosurg. 2008;108(5):989–998. doi: 10.3171/JNS/2008/108/5/0989
   PubMed Web of Science ®Google Scholar
• Saesoo S, Sathornsumetee S, Anekwiang P, et al. Characterization of liposome-containing SPIONs conjugated with anti-CD20 developed as a novel theranostic agent for central nervous system lymphoma. Colloids Surf B Biointerfaces. 2018 Jan 1;161:497–507. doi: 10.1016/j.colsurfb.2017.11.003
   PubMed Web of Science ®Google Scholar
• Sharifi S, Samani A, Ahmadian E, et al. Oral delivery of proteins and peptides by mucoadhesive nanoparticles. Biointerface Res Appl Chem. 2019;9(2):3849–3852.
   Web of Science ®Google Scholar
• Maleki Dizaj S, Rad AA, Safaei N, et al. The application of nanomaterials in cardiovascular diseases: a review on drugs and devices. J Pharm Pharm Sci. 2019;22(1):501–515. doi: 10.18433/jpps30456
   Google Scholar
• Pashirova TN, Zueva IV, Petrov KA, et al. Mixed cationic liposomes for brain delivery of drugs by the intranasal route: the acetylcholinesterase reactivator 2-PAM as encapsulated drug model. Colloids Surf B Biointerfaces. 2018;171:358–367. doi: 10.1016/j.colsurfb.2018.07.049
   PubMed Web of Science ®Google Scholar
• van der Koog L, Gandek TB, Nagelkerke A. Liposomes and extracellular vesicles as drug delivery systems: a comparison of composition, pharmacokinetics, and functionalization. Adv Healthc Mater. 2022;11(5):2100639. doi: 10.1002/adhm.202100639
   Web of Science ®Google Scholar
• Al-Jamal WT, Kostarelos K. Liposomes: from a clinically established drug delivery system to a nanoparticle platform for theranostic nanomedicine. Acc Chem Res. 2011 Oct 18;44(10):1094–1104. doi: 10.1021/ar200105p
   PubMed Web of Science ®Google Scholar
• Choi WI, Sahu A, Wurm FR, et al. Magnetoliposomes with size controllable insertion of magnetic nanoparticles for efficient targeting of cancer cells. RSC Adv. 2019;9(26):15053–15060. doi: 10.1039/C9RA02529D
   PubMed Web of Science ®Google Scholar
• Zhao M, Chang J, Fu X, et al. Nano-sized cationic polymeric magnetic liposomes significantly improves drug delivery to the brain in rats. J Drug Target. 2012 Jun;20(5):416–421. doi: 10.3109/1061186X.2011.651726
   PubMed Web of Science ®Google Scholar
• Cifuentes J, Cifuentes-Almanza S, Ruiz Puentes P, et al. Multifunctional magnetoliposomes as drug delivery vehicles for the potential treatment of Parkinson’s disease. Front Bioeng Biotechnol. 2023;11:1–10. doi: 10.3389/fbioe.2023.1181842
   Web of Science ®Google Scholar
• Jain S, Mishra V, Singh P, et al. RGD-anchored magnetic liposomes for monocytes/neutrophils-mediated brain targeting. Int J Pharm. 2003 Aug 11;261(1–2):43–55. doi: 10.1016/S0378-5173(03)00269-2
   PubMedGoogle Scholar
• Zhao M, Hu J, Zhang L, et al. Study of amphotericin B magnetic liposomes for brain targeting. Int J Pharm. 2014 Nov 20;475(1–2):9–16. doi: 10.1016/j.ijpharm.2014.08.035
   PubMedGoogle Scholar
• Lu Y-J, Chuang E-Y, Cheng Y-H, et al. Thermosensitive magnetic liposomes for alternating magnetic field-inducible drug delivery in dual targeted brain tumor chemotherapy. Chem Eng J. 2019;373:720–733. doi: 10.1016/j.cej.2019.05.055
   Web of Science ®Google Scholar
• Marie H, Lemaire L, Franconi F, et al. Superparamagnetic liposomes for MRI monitoring and external magnetic field‐induced selective targeting of malignant brain tumors. Adv Funct Mater. 2015;25(8):1258–1269. doi: 10.1002/adfm.201402289
   Web of Science ®Google Scholar
• Rivière C, Martina MS, Tomita Y, et al. Magnetic targeting of nanometric magnetic fluid loaded liposomes to specific brain intravascular areas: a dynamic imaging study in mice. Radiology. 2007 Aug;244(2):439–448. doi: 10.1148/radiol.2442060912
   PubMed Web of Science ®Google Scholar
• Ding H, Sagar V, Agudelo M, et al. Enhanced blood-brain barrier transmigration using a novel transferrin embedded fluorescent magneto-liposome nanoformulation. Nanotechnology. 2014 Feb 7;25(5):055101. doi: 10.1088/0957-4484/25/5/055101
   PubMed Web of Science ®Google Scholar
• Thomsen LB, Linemann T, Birkelund S, et al. Evaluation of targeted delivery to the brain using magnetic immunoliposomes and magnetic force. Materials. 2019 Oct 31;12(21):1–19. doi: 10.3390/ma12213576
   PubMed Web of Science ®Google Scholar
• Chen W, Xu Y, Yang D, et al. Preparation of liposomes coated superparamagnetic iron oxide nanoparticles for targeting and imaging brain glioma. Nano Biomed Eng. 2022;14(1):71–80. doi: 10.5101/nbe.v14i1.p71-80
   Google Scholar
• Shi D, Mi G, Shen Y, et al. Glioma-targeted dual functionalized thermosensitive Ferri-liposomes for drug delivery through an in vitro blood–brain barrier. Nanoscale. 2019;11(32):15057–15071. doi: 10.1039/C9NR03931G
   PubMed Web of Science ®Google Scholar
• Xu HL, Yang JJ, ZhuGe DL, et al. Glioma-targeted delivery of a theranostic Liposome Integrated with quantum dots, superparamagnetic iron oxide, and cilengitide for dual-imaging guiding cancer surgery. Adv Healthc Mater. 2018 May;7(9):e1701130. doi: 10.1002/adhm.201701130
   PubMed Web of Science ®Google Scholar
• Liu Y, Wang CY, Kong XH, et al. Novel multifunctional polyethylene glycol-transactivating-transduction protein-modified liposomes cross the blood-spinal cord barrier after spinal cord injury. J Drug Target. 2010 Jul;18(6):420–429. doi: 10.3109/10611860903434001
   PubMed Web of Science ®Google Scholar
• Scarpa E, Bailey JL, Janeczek AA, et al. Quantification of intracellular payload release from polymersome nanoparticles. Sci Rep. 2016;6(1):29460. doi: 10.1038/srep29460
   PubMedGoogle Scholar
• He C, Zhang Z, Ding Y, et al. LRP1-mediated pH-sensitive polymersomes facilitate combination therapy of glioblastoma in vitro and in vivo. J Nanobiotechnol. 2021;19(1):29. doi: 10.1186/s12951-020-00751-x
   PubMed Web of Science ®Google Scholar
• Kotha R, Kara DD, Roychowdhury R, et al. Polymersomes based versatile nanoplatforms for controlled drug delivery and imaging. Adv Pharm Bull. 2023;13(2):218. doi: 10.34172/apb.2023.028
   PubMed Web of Science ®Google Scholar
• Duan X, Lu L, Wang Y, et al. The long-term fate of mesenchymal stem cells labeled with magnetic resonance imaging-visible polymersomes in cerebral ischemia. Int J Nanomedicine. 2017;12:6705–6719. doi: 10.2147/IJN.S146742
   PubMed Web of Science ®Google Scholar
• Duan X, Wang Y, Zhang F, et al. Superparamagnetic iron oxide-loaded cationic polymersomes for cellular MR imaging of therapeutic stem cells in stroke. J Biomed Nanotechnol. 2016 Dec;12(12):2112–2124. doi: 10.1166/jbn.2016.2321
   PubMed Web of Science ®Google Scholar
• Carvalho SM, Leonel AG, Mansur AAP, et al. Bifunctional magnetopolymersomes of iron oxide nanoparticles and carboxymethylcellulose conjugated with doxorubicin for hyperthermo-chemotherapy of brain cancer cells. Biomater Sci. 2019 Apr 23;7(5):2102–2122. doi: 10.1039/C8BM01528G
   PubMed Web of Science ®Google Scholar
• DB G, VL P. Recent advances of non-ionic surfactant-based nano-vesicles (niosomes and proniosomes): a brief review of these in enhancing transdermal delivery of drug. Future J Pharm Sci. 2020;6(1):1–18. doi: 10.1186/s43094-020-00117-y
   Web of Science ®Google Scholar
• Ge X, Wei M, He S, et al. Advances of non-ionic surfactant vesicles (niosomes) and their application in drug delivery. Pharmaceutics. 2019 Jan 29;11(2):55–64. doi: 10.3390/pharmaceutics11020055
   PubMed Web of Science ®Google Scholar
• Ansari M, Eslami H. Preparation and study of the inhibitory effect of nano-niosomes containing essential oil from artemisia absinthium on amyloid fibril formation. Studies. 2020;12:21–25. doi: 10.22038/nmj.2020.07.0009
   Google Scholar
• Khallaf RA, Aboud HM, Sayed OM. Surface modified niosomes of olanzapine for brain targeting via nasal route; preparation, optimization, and in vivo evaluation. J Liposome Res. 2020;30(2):163–173. doi: 10.1080/08982104.2019.1610435
   PubMed Web of Science ®Google Scholar
• Al Qtaish N, Gallego I, Paredes AJ, et al. Nanodiamond Integration into Niosomes as an emerging and efficient gene therapy nanoplatform for central nervous system diseases. ACS Appl Mater Interfaces. 2022;14(11):13665–13677. doi: 10.1021/acsami.2c02182
   PubMed Web of Science ®Google Scholar
• Sita VG, Jadhav D, Vavia P. Niosomes for nose-to-brain delivery of bromocriptine: formulation development, efficacy evaluation and toxicity profiling. J Drug Deliv Sci Technol. 2020;58:101791. doi: 10.1016/j.jddst.2020.101791
   Web of Science ®Google Scholar
• Ag Seleci D, Maurer V, Barlas FB, et al. Transferrin-decorated niosomes with integrated InP/ZnS quantum dots and magnetic iron oxide nanoparticles: dual targeting and imaging of glioma. Int J Mol Sci. 2021;22(9):4556. doi: 10.3390/ijms22094556
   PubMed Web of Science ®Google Scholar
• Lee C-S, Lee M, Na K, et al. Stem cell-derived extracellular vesicles for cancer therapy and tissue engineering applications. Mol Pharm. 2023;20(11):5278–5311. doi: 10.1021/acs.molpharmaceut.3c00376
   PubMedGoogle Scholar
• Gangadaran P, Rajendran RL, Kwack MH, et al. Application of cell-derived extracellular vesicles and engineered nanovesicles for hair growth: from mechanisms to therapeutics. Front Cell Dev Biol. 2022;10:963278. doi: 10.3389/fcell.2022.963278
   PubMed Web of Science ®Google Scholar
• Kenari AN, Kastaniegaard K, Greening DW, et al. Exosome-mimetic nanovesicles contain distinct proteome and post-translational modified protein cargo, in comparison to exosomes. Proteomics. 2019;19(8):1800161. doi: 10.1002/pmic.201800161
   Web of Science ®Google Scholar
• Sharma P, Ludwig S, Muller L, et al. Immunoaffinity-based isolation of melanoma cell-derived exosomes from plasma of patients with melanoma. J Extracell Vesicles. 2018;7(1):1435138. doi: 10.1080/20013078.2018.1435138
   PubMed Web of Science ®Google Scholar
• Li W-J, Chen H, Tong M-L, et al. Comparison of the yield and purity of plasma exosomes extracted by ultracentrifugation, precipitation, and membrane-based approaches. Open Chem. 2022;20(1):182–191. doi: 10.1515/chem-2022-0139
   Web of Science ®Google Scholar
• Coughlan C, Bruce KD, Burgy O, et al. Exosome isolation by ultracentrifugation and precipitation and techniques for downstream analyses. Curr Protoc Cell Biol. 2020 Sep;88(1):e110. doi: 10.1002/cpcb.110
   PubMedGoogle Scholar
• Kim HY, Kim TJ, Kang L, et al. Mesenchymal stem cell-derived magnetic extracellular nanovesicles for targeting and treatment of ischemic stroke. Biomaterials. 2020;243:119942. doi: 10.1016/j.biomaterials.2020.119942
   PubMed Web of Science ®Google Scholar
• Wang J, Zhu X, Li C, et al. Efficient exosome extraction through the conjugation of superparamagnetic iron oxide nanoparticles for the targeted delivery in rat brain. Mater Today Chem. 2022;23:100637. doi: 10.1016/j.mtchem.2021.100637
   Web of Science ®Google Scholar
• Jia G, Han Y, An Y, et al. NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo. Biomaterials. 2018 Sep;178:302–316. doi: 10.1016/j.biomaterials.2018.06.029
   PubMed Web of Science ®Google Scholar
• Li B, Chen X, Qiu W, et al. Synchronous disintegration of ferroptosis defense axis via engineered exosome‐conjugated magnetic nanoparticles for glioblastoma therapy. Adv Sci. 2022;9(17):2105451. doi: 10.1002/advs.202105451
   Web of Science ®Google Scholar
• Altanerova U, Babincova M, Babinec P, et al. Human mesenchymal stem cell-derived iron oxide exosomes allow targeted ablation of tumor cells via magnetic hyperthermia. Int J Nanomedicine. 2017;12:7923–7936. doi: 10.2147/IJN.S145096
   PubMed Web of Science ®Google Scholar
• Kutchy NA, Ma R, Liu Y, et al. Extracellular vesicle-mediated delivery of ultrasmall superparamagnetic iron oxide nanoparticles to mice brain [brief research report]. Front Pharmacol. 2022 Apr 07;13:13. doi: 10.1002/jev2.12185
   Web of Science ®Google Scholar
• Kim HY, Kumar H, Jo M-J, et al. Therapeutic efficacy-potentiated and diseased organ-targeting nanovesicles derived from mesenchymal stem cells for spinal cord injury treatment. Nano Lett. 2018;18(8):4965–4975. doi: 10.1021/acs.nanolett.8b01816
   PubMed Web of Science ®Google Scholar
• Vendel E, Rottschäfer V, De Lange CME, et al. A 3D brain unit model to further improve prediction of local drug distribution within the brain. PLoS One. 2020;15(9):e0238397. doi: 10.1371/journal.pone.0238397
   PubMed Web of Science ®Google Scholar
• Meng Q, Meng H, Pan Y, et al. Influence of nanoparticle size on blood–brain barrier penetration and the accumulation of anti-seizure medicines in the brain. J Mater Chem. 2022;10(2):271–281. doi: 10.1039/D1TB02015C
   PubMed Web of Science ®Google Scholar
• Chaulagain B, Gothwal A, Lante Lamptey RN, et al. Experimental models of in vitro blood–brain barrier for CNS drug delivery: an evolutionary perspective. Int J Mol Sci. 2023;24(3):2710. doi: 10.3390/ijms24032710
   PubMed Web of Science ®Google Scholar
• Chien C-Y, Xu L, Pacia CP, et al. Blood–brain barrier opening in a large animal model using closed-loop microbubble cavitation-based feedback control of focused ultrasound sonication. Sci Rep. 2022;12:16147. doi: 10.1038/s41598-022-20568-y
   PubMed Web of Science ®Google Scholar
• Zhang B, Yan W, Zhu Y, et al. Nanomaterials in neural‐stem‐cell‐mediated regenerative medicine: imaging and treatment of neurological diseases. Adv Mater. 2018;30(17):1705694. doi: 10.1002/adma.201705694
   PubMed Web of Science ®Google Scholar
• Gogoi M, Sarma HD, Bahadur D, et al. Biphasic magnetic nanoparticles–nanovesicle hybrids for chemotherapy and self-controlled hyperthermia. Nanomedicine. 2014;9(7):955–970. doi: 10.2217/nnm.13.90
   PubMed Web of Science ®Google Scholar