Essential considerations towards development of effective nasal antibiotic formulation: features, strategies, and future directions

References

• Emad NA, Ahmed B, Alhalmi A, et al. Recent progress in nanocarriers for direct nose to brain drug delivery. J Drug Deliv Sci Technol. 2021;64:1–11. doi: 10.1016/j.jddst.2021.102642
   Web of Science ®Google Scholar
• Kakad S, Kshirsagar S. Nose to brain delivery of Efavirenz nanosuspension for effective neuro AIDS therapy: in-vitro, in-vivo and pharmacokinetic assessment. Heliyon. 2021;7(11):e08368. doi: 10.1016/j.heliyon.2021.e08368
   PubMed Web of Science ®Google Scholar
• Crowe TP, Hsu WH. Evaluation of recent intranasal drug delivery systems to the central nervous system. Pharmaceutics. 2022;14(3):1–26. doi: 10.3390/pharmaceutics14030629
   Web of Science ®Google Scholar
• Carlton DA, Beahm DD, Chiu AG. Topical antibiotic therapy in chronic rhinosinusitis: an update. Int Forum Allergy Rhinol. 2019;9(S1):S27–S31. doi: 10.1002/alr.22338
   PubMedGoogle Scholar
• Volpe V, Giacomodonato MN, Sordelli DO, et al. Ciprofloxacin loaded o/w microemulsion against Staphylococcus aureus. Analytical and biological studies for topical and intranasal administration. J Drug Deliv Sci Technol. 2020;57:1–9. doi: 10.1016/j.jddst.2020.101705
   Web of Science ®Google Scholar
• Sousa J, Alves G, Oliveira P, et al. Intranasal delivery of ciprofloxacin to rats: A topical approach using a thermoreversible in situ gel. Eur J Pharm Sci. 2017;97:30–37. doi: 10.1016/j.ejps.2016.10.033
   PubMed Web of Science ®Google Scholar
• Gizurarson S. Anatomical and histological factors affecting intranasal drug and vaccine delivery. Curr Drug Deliv. 2012;9(6):566–582. doi: 10.2174/156720112803529828
   PubMed Web of Science ®Google Scholar
• Bourganis V, Kammona O, Alexopoulos A, et al. Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics. Eur J Pharm Biopharm. 2018;128:337–362. doi: 10.1016/j.ejpb.2018.05.009
   PubMed Web of Science ®Google Scholar
• Abouhussein DMN, Khattab A, Bayoumi NA, et al. Brain targeted rivastigmine mucoadhesive thermosensitive in situ gel: Optimization, in vitro evaluation, radiolabeling, in vivo pharmacokinetics and biodistribution. J Drug Deliv Sci Technol. 2018;43:129–140. doi: 10.1016/j.jddst.2017.09.021
   Web of Science ®Google Scholar
• Tan MSA, Parekh HS, Pandey P, et al. Nose-to-brain delivery of antipsychotics using nanotechnology: a review. Expert Opin Drug Deliv. 2020;17(6):839–853. doi: 10.1080/17425247.2020.1762563
   PubMed Web of Science ®Google Scholar
• Thornhill MH, Dayer MJ, Durkin MJ, et al. Risk of adverse reactions to oral antibiotics prescribed by dentists. J Dent Res. 2019;98(10):1081–1087. doi: 10.1177/0022034519863645
   PubMed Web of Science ®Google Scholar
• Liang EH, Chen LH, Macy E. Adverse reactions associated with penicillins, carbapenems, monobactams, and Clindamycin: a retrospective population-based study. J Allergy Clin Immunol Pract. 2020;8(4):1302–1313.e2. doi: 10.1016/j.jaip.2019.11.035
   PubMed Web of Science ®Google Scholar
• Tai J, Lee K, Kim TH. Current perspective on nasal delivery systems for chronic rhinosinusitis. Pharmaceutics. 2021;13(2):1–21. doi: 10.3390/pharmaceutics13020246
   Web of Science ®Google Scholar
• Miyake MM, Bleier BS. Future topical medications in chronic rhinosinusitis. Int Forum Allergy Rhinol. 2019;9(S1):S32–S46. doi: 10.1002/alr.22341
   PubMedGoogle Scholar
• Johnston A, Holt DW. Substandard drugs: a potential crisis for public health. Br J Clin Pharmacol. 2014;78(2):218–243. doi: 10.1111/bcp.12298
   PubMed Web of Science ®Google Scholar
• World Health Organization. Substandard and falsified medical products. Geneva: WHO; 2018 [cited 2022 Dec 17]. Available from: https://www.who.int/news-room/fact-sheets/detail/substandard-and-falsified-medical-products.
   Google Scholar
• World Health Organization. WHO Global surveillance and monitoring system for substandard and falsified medical products. Geneva: WHO. 2017;1–65.
   Google Scholar
• Kelesidis T, Falagas ME. Substandard/Counterfeit antimicrobial drugs. Clin Microbiol Rev. 2015;28(2):443–464. doi: 10.1128/CMR.00072-14
   PubMed Web of Science ®Google Scholar
• Jean-Baptiste T, Carpenter JF, Dahl K, et al. Substandard quality of the antimicrobials sold in the street markets in haiti. Antibiotics. 2020;9(7):407–408. doi: 10.3390/antibiotics9070407
   Google Scholar
• Zabala GA, Bellingham K, Vidhamaly V, et al. Substandard and falsified antibiotics: neglected drivers of antimicrobial resistance? BMJ Glob Heal. 2022;7(8):1–12. doi: 10.1136/bmjgh-2022-008587
   Web of Science ®Google Scholar
• Schäfermann S, Hauk C, Wemakor E, et al. Substandard and falsified antibiotics and medicines against noncommunicable diseases in western Cameroon and northeastern democratic Republic of Congo. Am J Trop Med Hyg. 2020;103(2):894–908. doi: 10.4269/ajtmh.20-0184
   PubMed Web of Science ®Google Scholar
• Khuluza F, Kigera S, Heide L. Low prevalence of substandard and falsified antimalarial and antibiotic medicines in public and faith-based health facilities of Southern Malawi. Am J Trop Med Hyg. 2017;96:1124–1135. doi: 10.4269/ajtmh.16-1008
   PubMed Web of Science ®Google Scholar
• Pan H, Luo H, Chen S, et al. Pharmacopoeial quality of antimicrobial drugs in southern China. Lancet Glob Health. 2016;4(5):e300–e302. doi: 10.1016/S2214-109X(16)00049-8
   PubMed Web of Science ®Google Scholar
• Ke W-R, Yoon Kyung Chang R, Chan H-K. Engineering the right formulation for enhanced drug delivery. Adv Drug Deliv Rev. 2022;191:114561.
   PubMed Web of Science ®Google Scholar
• Friedman ND, Temkin E, Carmeli Y. The negative impact of antibiotic resistance. Clin Microbiol Infect. 2016;22(5):416–422. doi: 10.1016/j.cmi.2015.12.002
   PubMed Web of Science ®Google Scholar
• Kays MB, Smith DW, Wack MF, et al. Levofloxacin treatment failure in a patient with fluoroquinolone-resistant Streptococcus pneumoniae pneumonia. Pharmacotherapy. 2002;22(3):395–399. doi: 10.1592/phco.22.5.395.33185
   PubMed Web of Science ®Google Scholar
• Davidson R, Rodrigo C, Brunton JL, et al. Resistance to Levofloxacin and failure of treatment of pneumococcal pneumonia. N Eng J Med. 2002;346(10):747–750. doi: 10.1056/NEJMoa012122
   PubMed Web of Science ®Google Scholar
• Laffleur F, Bauer B. Progress in nasal drug delivery systems. Int J Pharm. 2021;607:120994. doi: 10.1016/j.ijpharm.2021.120994
   PubMed Web of Science ®Google Scholar
• Izadi E, Afshan G, Patel RP, et al. Levofloxacin: Insights into antibiotic resistance and product quality. Front Pharmacol. 2019;10:1–7. doi: 10.3389/fphar.2019.00881
   PubMed Web of Science ®Google Scholar
• Gnamey J, Gambogou B, Dossou M, et al. Contribution of storage conditions of antibiotics in pharmacies on efficacy loss of Amoxicillin and Tetracycline against strains of Escherichia coli and Staphylococcus aureus in the city of Lome. Am J Physiol Biochem Pharmacol. 2019;9(3):52. doi: 10.5455/ajpbp.20190323032932
   Google Scholar
• Weinstein ZB, Zaman H. Evolution of Rifampin Resistance in Escherichia coli and Mycobacterium smegmatis Due to Substandard Drugs. Antimicrob Agents Chemother. 2019;63(1):e01243–18.
   PubMed Web of Science ®Google Scholar
• Crowe TP, Greenlee MHW, Kanthasamy AG, et al. Mechanism of intranasal drug delivery directly to the brain. Life Sci. 2018;195:44–52. doi: 10.1016/j.lfs.2017.12.025
   PubMed Web of Science ®Google Scholar
• Whyte A, Boeddinghaus R. The maxillary sinus: physiology, development and imaging anatomy. Dentomaxillofac Radiol. 2019;48(8):20190205–20190215. doi: 10.1259/dmfr.20190205
   PubMed Web of Science ®Google Scholar
• Lochhead JJ, Thorne RG. Intranasal delivery of biologics to the central nervous system. Adv Drug Deliv Rev. 2012;64(7):614–628. doi: 10.1016/j.addr.2011.11.002
   PubMed Web of Science ®Google Scholar
• Costa CP, Moreira JN, Sousa Lobo JM, et al. Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: a current overview of in vivo studies. Acta Pharm Sin B. 2021;11(4):925–940. doi: 10.1016/j.apsb.2021.02.012
   PubMed Web of Science ®Google Scholar
• Frieri M, Kumar K, Boutin A. Antibiotic resistance. J Infect Public Health. 2017;10(4):369–378. doi: 10.1016/j.jiph.2016.08.007
   PubMed Web of Science ®Google Scholar
• Kumar A, Schweizer HP. Bacterial resistance to antibiotics: active efflux and reduced uptake. Adv Drug Deliv Rev. 2005;57(10):1486–1513. doi: 10.1016/j.addr.2005.04.004
   PubMed Web of Science ®Google Scholar
• Baddour LM, Dayer MJ, Thornhill MH. Adverse drug reactions due to oral antibiotics prescribed in the community setting–England. Infect Dis (Auckl). 2019;51(11–12):866–869. doi: 10.1080/23744235.2019.1663918
   PubMed Web of Science ®Google Scholar
• Lynch T, Price A. The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. Am Fam Physician. 2007;76(3):391–396.
   PubMed Web of Science ®Google Scholar
• Chhabra R, Gupta R, Gupta LK. Intranasal midazolam versus intravenous/rectal benzodiazepines for acute seizure control in children: A systematic review and meta-analysis. Epilepsy Behav. 2021;125:108390. doi: 10.1016/j.yebeh.2021.108390
   PubMed Web of Science ®Google Scholar
• Manda P, Hargett JK, Vaka SR, et al. Delivery of cefotaxime to the brain via intranasal administration. Drug Dev Ind Pharm. 2011;37(11):1306–1310. doi: 10.3109/03639045.2011.571696
   PubMed Web of Science ®Google Scholar
• Umeda T, Tanaka A, Sakai A, et al. Intranasal rifampicin for Alzheimer’s disease prevention. Alzheimer’s Dement Transl Res Clin Interv. 2018;4(1):304–313. doi: 10.1016/j.trci.2018.06.012
   PubMedGoogle Scholar
• Formica ML, Real DA, Picchio ML, et al. On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles. Appl Mater Today. 2022;29:101631. doi: 10.1016/j.apmt.2022.101631
   Web of Science ®Google Scholar
• Scherließ R. Nasal formulations for drug administration and characterization of nasal preparations in drug delivery. Ther Deliv. 2020;11(3):183–191. doi: 10.4155/tde-2019-0086
   PubMed Web of Science ®Google Scholar
• Fasiolo LT, Manniello MD, Tratta E, et al. Opportunity and challenges of nasal powders: Drug formulation and delivery. Eur J Pharm Sci. 2018;113:2–17. doi: 10.1016/j.ejps.2017.09.027
   PubMed Web of Science ®Google Scholar
• Hasçiçek C, Gönül N, Erk N. Mucoadhesive microspheres containing gentamicin sulfate for nasal administration: preparation and in vitro characterization. Il Farmaco. 2003;58(1):11–16. doi: 10.1016/S0014-827X(02)00004-6
   PubMedGoogle Scholar
• Lim ST, Forbes B, Berry DJ, et al. In vivo evaluation of novel hyaluronan/chitosan microparticulate delivery systems for the nasal delivery of gentamicin in rabbits. Int J Pharm. 2002;231(1):73–82. doi: 10.1016/S0378-5173(01)00873-0
   PubMedGoogle Scholar
• Djupesland PG. Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review. Drug Deliv Transl Res. 2013;3(1):42–62. doi: 10.1007/s13346-012-0108-9
   PubMed Web of Science ®Google Scholar
• World Health Organization. The Top 10 Causes of Death Globally. WHO. 2020 [cited 2022 Dec 17]. Available from: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death.
   Google Scholar
• Ullah H, Ali S. Classification of anti‐bacterial agents and their functions. Antibact Agents (InTech). 2017;1–16. doi: 10.5772/intechopen.68695
   Google Scholar
• Hutchings M, Truman A, Wilkinson B. Antibiotics: past, present and future. Curr Opin Microbiol. 2019;51:72–80. doi: 10.1016/j.mib.2019.10.008
   PubMed Web of Science ®Google Scholar
• Murugaiyan J, Anand Kumar P, Rao GS, et al. Progress in alternative strategies to combat antimicrobial resistance: focus on antibiotics. Antibiotics. 2022;11(2):200–237. doi: 10.3390/antibiotics11020200
   Google Scholar
• Mardikasari SA, Sipos B, Csóka I, et al. Nasal route for antibiotics delivery: Advances, challenges and future opportunities applying the quality by design concepts. J Drug Deliv Sci Technol. 2022;77:1–18. doi: 10.1016/j.jddst.2022.103887
   Web of Science ®Google Scholar
• Lee VS, Pottinger PS, Davis GE. Tolerability and effectiveness of povidone-iodine or mupirocin versus saline sinus irrigations for chronic rhinosinusitis. Am J Otolaryngol - Head Neck Med Surg. 2020;41(5):102604–102608. doi: 10.1016/j.amjoto.2020.102604
   Google Scholar
• Seiberling KA, Aruni W, Kim S, et al. The effect of intraoperative mupirocin irrigation on Staphylococcus aureus within the maxillary sinus. Int Forum Allergy Rhinol. 2013;3(2):94–98. doi: 10.1002/alr.21076
   PubMed Web of Science ®Google Scholar
• Kamijyo A, Matsuzaki Z, Kikushima K, et al. Fosfomycin nebulizer therapy to chronic sinusitis. Auris Nasus Larynx. 2001;28(3):227–232. doi: 10.1016/S0385-8146(01)00049-9
   PubMed Web of Science ®Google Scholar
• Gameiro dos Santos J, Figueirinhas R, Liberal JP, et al. On ciprofloxacin concentration in chronic rhinosinusitis. Acta Otorrinolaringológica Española. 2018;69(1):35–41. doi: 10.1016/j.otorri.2017.06.008
   Google Scholar
• Jahanshahi J, Yazdani J, Hashemian F, et al. The effect of topical vancomycin on the recurrent postoperative sinonasal polyposis: a triple-blinded randomized controlled trial. Egypt J Otolaryngol. 2017;33(1):15–19. doi: 10.4103/1012-5574.199411
   Google Scholar
• Tran DH, Sugamata R, Hirose T, et al. Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with virus internalization process. J Antibiot (Tokyo). 2019;72(10):759–768. doi: 10.1038/s41429-019-0204-x
   PubMed Web of Science ®Google Scholar
• Antunes MB, Feldman MD, Cohen NA, et al. Dose-dependent effects of topical tobramycin in an animal model of pseudomonas sinusitis. Am J Rhinol. 2007;21(4):423–427. doi: 10.2500/ajr.2007.21.3046
   PubMedGoogle Scholar
• Chiu AG, Antunes MB, Palmer JN, et al. Evaluation of the in vivo efficacy of topical tobramycin against pseudomonas sinonasal biofilms. J Antimicrob Chemother. 2007;59(6):1130–1134. doi: 10.1093/jac/dkm087
   PubMed Web of Science ®Google Scholar
• Avincsal MO, Ozbal S, Ikiz AO, et al. Effects of topical intranasal doxycycline treatment in the rat allergic rhinitis model. Clin Exp Otorhinolaryngol. 2014;7(2):106–111. doi: 10.3342/ceo.2014.7.2.106
   PubMed Web of Science ®Google Scholar
• Kumar M, Kakkar V, Mishra AK, et al. Intranasal delivery of streptomycin sulfate (STRS) loaded solid lipid nanoparticles to brain and blood. Int J Pharm. 2014;461(1–2):223–233. doi: 10.1016/j.ijpharm.2013.11.038
   PubMedGoogle Scholar
• Umeda T, Sakai A, Shigemori K, et al. Oligomer-targeting prevention of neurodegenerative dementia by intranasal rifampicin and resveratrol combination – a preclinical study in model mice. Front Neurosci. 2021;15:1–13. doi: 10.3389/fnins.2021.763476
   Web of Science ®Google Scholar
• Umeda T, Uekado R, Shigemori K, et al. Nasal Rifampicin halts the progression of tauopathy by inhibiting tau oligomer propagation in Alzheimer brain extract-injected mice. Biomedicines. 2022;10(2):10. doi: 10.3390/biomedicines10020297
   Web of Science ®Google Scholar
• Wong JP, Yang H, Blasetti KL, et al. Liposome delivery of ciprofloxacin against intracellular Francisella tularensis infection. J Control Release. 2003;92(3):265–273. doi: 10.1016/S0168-3659(03)00358-4
   PubMed Web of Science ®Google Scholar
• Norville IH, Hatch GJ, Bewley KR, et al. Efficacy of liposome-encapsulated ciprofloxacin in a murine model of Q fever. Antimicrob Agents Chemother. 2014;58(9):5510–5518. doi: 10.1128/AAC.03443-14
   PubMed Web of Science ®Google Scholar
• Di Ninno V, Cherwanogrodzky J, Wong JP. Liposome-encapsulated ciprofloxacin is effective in the protection and treatment of BALB/c mice against Francisella tularensis. J Infect Dis. 1993;168(3):793–794.
   PubMed Web of Science ®Google Scholar
• Mardikasari SA, Katona G, Budai-Szűcs M, et al. Quality by design-based optimization of in situ ionic-sensitive gels of amoxicillin-loaded bovine serum albumin nanoparticles for enhanced local nasal delivery. Int J Pharm. 2023;645. doi: 10.1016/j.ijpharm.2023.123435
   PubMedGoogle Scholar
• Mardikasari SA, Budai-Szűcs M, Orosz L, et al. Development of thermoresponsive-gel-matrix-embedded amoxicillin trihydrate-loaded bovine serum albumin nanoparticles for local intranasal therapy. Gels. 2022;8(11):750. doi: 10.3390/gels8110750
   PubMed Web of Science ®Google Scholar
• Vigasova D, Nemergut M, Liskova B, et al. Multi-pathogen infections and Alzheimer’s disease. Microb Cell Fact. 2021;20(1):1–13. doi: 10.1186/s12934-021-01520-7
   PubMed Web of Science ®Google Scholar
• Gao L, Shuai Y, Wen L, et al. Benefit and safety of antibiotics for Alzheimer’s disease: protocol for a systematic review and meta-analysis. Med (United States). 2022;101(47):E31637. doi: 10.1097/MD.0000000000031637
   Google Scholar
• Iqbal UH, Zeng E, Pasinetti GM. The use of antimicrobial and antiviral drugs in alzheimer’s disease. Int J Mol Sci. 2020;21(14):1–19. doi: 10.3390/ijms21144920
   Web of Science ®Google Scholar
• Ashraf GM, Tarasov VV, Makhmutovа A, et al. The possibility of an infectious etiology of Alzheimer disease. Mol Neurobiol. 2019;56:4479–4491. doi: 10.1007/s12035-018-1388-y
   PubMed Web of Science ®Google Scholar
• Itzhaki RF, Lathe R, Balin BJ, et al. Microbes and Alzheimer’s Disease. J Alzheimer’s Dis. 2016;51(4):979–984. doi: 10.3233/JAD-160152
   PubMed Web of Science ®Google Scholar
• Emery DC, Shoemark DK, Batstone TE, et al. 16S rRNA next generation sequencing analysis shows bacteria in Alzheimer’s post-mortem brain. Front Aging Neurosci. 2017;9:1–13. doi: 10.3389/fnagi.2017.00195
   PubMed Web of Science ®Google Scholar
• Hathout RM, Abdelhamid SG, El-Housseiny GS, et al. Hathout, 2020 - Comparing cefotaxime and ceftriaxone in combating meningitis through nose to brain delivery using biochemoinformatics tools.Pdf.
   Google Scholar
• Nair A, Jacob S. A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm. 2016;7(2):27. doi: 10.4103/0976-0105.177703
   PubMedGoogle Scholar
• Ahmed TA, Badr-Eldin SM, Ahmed OAA, et al. Intranasal optimized solid lipid nanoparticles loaded in situ gel for enhancing trans-mucosal delivery of simvastatin. J Drug Deliv Sci Technol. 2018;48:499–508. Available from. doi: 10.1016/j.jddst.2018.10.027
   Web of Science ®Google Scholar
• Yu YS, AboulFotouh K, Xu H, et al. Feasibility of intranasal delivery of thin-film freeze-dried, mucoadhesive vaccine powders. Int J Pharm. 2023;640:122990. doi: 10.1016/j.ijpharm.2023.122990
   PubMedGoogle Scholar
• Hamblin KA, Armstrong SJ, Barnes KB, et al. Liposome encapsulation of ciprofloxacin improves protection against highly virulent francisella tularensis strain schu s4. Antimicrob Agents Chemother. 2014;58(6):3053–3059. doi: 10.1128/AAC.02555-13
   PubMed Web of Science ®Google Scholar
• Thambavita D, Galappatthy P, Mannapperuma U, et al. Biowaiver monograph for immediate-release solid oral dosage forms: amoxicillin trihydrate. J Pharm Sci. 2017;106(10):2930–2945. doi: 10.1016/j.xphs.2017.04.068
   PubMed Web of Science ®Google Scholar
• Singh SS, Thakur TS. New crystalline salt forms of levofloxacin: conformational analysis and attempts towards the crystal structure prediction of the anhydrous form. Cryst Eng Comm. 2014;16(20):4215–4230. doi: 10.1039/c4ce00263f
   Google Scholar
• Hickey MB, Peterson ML, Manas ES, et al. Hydrates and solid-state reactivity: a survey of β-lactam antibiotics. J Pharm Sci. 2007;96(5):1090–1099. doi: 10.1002/jps.20919
   PubMed Web of Science ®Google Scholar
• Pandey M, Rani P, Adhikari L, et al. Preparation and characterization of cyclodextrin complexes of doxycycline hyclate for improved photostability in aqueous solution. J Incl Phenom Macrocyclic Chem. 2022;102(3–4):271–278. doi: 10.1007/s10847-021-01116-z
   Web of Science ®Google Scholar
• Grepioni F, Braga D, Chelazzi L, et al. Improving solubility and storage stability of rifaximin via solid-state solvation with Transcutol®. Cryst Eng Comm. 2019;21(35):5278–5283. doi: 10.1039/C9CE00567F
   Google Scholar
• Turos E, Reddy GSK, Greenhalgh K, et al. Penicillin-bound polyacrylate nanoparticles: restoring the activity of β-lactam antibiotics against MRSA. Bioorg Med Chem Lett. 2007;17(12):3468–3472. doi: 10.1016/j.bmcl.2007.03.077
   PubMed Web of Science ®Google Scholar
• Cyphert EL, Wallat JD, Pokorski JK, et al. Erythromycin modification that improves its acidic stability while optimizing it for local drug delivery. Antibiotics. 2017;6(2):11–15. doi: 10.3390/antibiotics6020011
   Google Scholar
• Vukomanovic M, Gazvoda L, Kurtjak M, et al. Development of a ternary cyclodextrin–arginine–ciprofloxacin antimicrobial complex with enhanced stability. Commun Biol. 2022;5(1):1–13. doi: 10.1038/s42003-022-04197-9
   PubMed Web of Science ®Google Scholar
• Thakur A, Jain S, Pant A, et al. Cyclodextrin derivative enhances the ophthalmic delivery of poorly soluble azithromycin. ACS Omega. 2022;7(27):23050–23060. doi: 10.1021/acsomega.1c07218
   PubMedGoogle Scholar
• Ding Y, Pang Y, Vara Prasad CVNS, et al. Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin. Drug Deliv. 2020;27(1):334–343. doi: 10.1080/10717544.2020.1724210
   PubMed Web of Science ®Google Scholar
• Shetty N, Ahn P, Park H, et al. Improved physical stability and aerosolization of inhalable amorphous ciprofloxacin powder formulations by incorporating synergistic colistin. Mol Pharm. 2018;15(9):4004–4020. doi: 10.1021/acs.molpharmaceut.8b00445
   PubMed Web of Science ®Google Scholar
• Hao X, Li J, Wang C, et al. Profoundly improved photostability of dimetronidazole by cocrystallization. Environ Sci Atmos. 2022;24(35):6165–6171. doi: 10.1039/D2CE00597B
   Google Scholar
• Tran LTC, Gueutin C, Frebourg G, et al. Erythromycin encapsulation in nanoemulsion-based delivery systems for treatment of Helicobacter pylori infection: protection and synergy. Biochem Biophys Res Commun. 2017;493(1):146–151. doi: 10.1016/j.bbrc.2017.09.060
   PubMed Web of Science ®Google Scholar
• Nugrahani I, Sulaiman MR, Eda C, et al. Stability and antibiotic potency improvement of levofloxacin by producing new salts with 2, 6- and 3, 5-dihydroxybenzoic acid and their comprehensive structural study. Pharmaceutics. 2023;15(1):1–23. doi: 10.3390/pharmaceutics15010124
   Web of Science ®Google Scholar
• Lin Y, Yoon Kyung Chang R, Britton WJ, et al. Storage stability of phage-ciprofloxacin combination powders against Pseudomonas aeruginosa respiratory infections. Int J Pharm. 2020;591:119952. doi: 10.1016/j.ijpharm.2020.119952
   PubMedGoogle Scholar
• Ustariz-Peyret C, Coudane J, Vert M, et al. Labile conjugation of a hydrophilic drug to PLA oligomers to modify a drug delivery system: Cephradin in a PLAGA matrix. J Microencapsul. 2000;17(5):615–624. doi: 10.1080/026520400417667
   PubMed Web of Science ®Google Scholar
• Coessens V, Schacht EH, Domurado D. Synthesis and in vitro stability of macromolecular prodrugs of norfloxacin. J Control Release. 1997;47(3):283–291. doi: 10.1016/S0168-3659(97)01655-6
   Web of Science ®Google Scholar
• Dyab AKF, Mohamed MA, Meligi NM, et al. Encapsulation of erythromycin and bacitracin antibiotics into natural sporopollenin microcapsules: antibacterial, cytotoxicity, in vitro and in vivo release studies for enhanced bioavailability. RSC Adv. 2018;8(58):33432–33444. doi: 10.1039/C8RA05499A
   PubMed Web of Science ®Google Scholar
• Kaur A, Kumar R. Enhanced bactericidal efficacy of polymer stabilized silver nanoparticles in conjugation with different classes of antibiotics. RSC Adv. 2019;9(2):1095–1105. doi: 10.1039/C8RA07980C
   PubMed Web of Science ®Google Scholar
• Pereira JM, Mejia-Ariza R, Ilevbare GA, et al. Interplay of degradation, dissolution and stabilization of clarithromycin and its amorphous solid dispersions. Mol Pharm. 2013;10(12):4640–4653. doi: 10.1021/mp400441d
   PubMedGoogle Scholar
• Park JB, Park YJ, Kang CY, et al. Modulation of microenvironmental pH and utilization of alkalizers in crystalline solid dispersion for enhanced solubility and stability of clarithromicin. Arch Pharm Res. 2015;38(5):839–848. doi: 10.1007/s12272-014-0471-9
   PubMed Web of Science ®Google Scholar
• Changsan N, Chan H-K, Separovic F, et al. Physicochemical Characterization and Stability of Rifampicin Liposome dry powder formulations for inhalation. J Pharm Sci. 2009;98(2):628–639. doi: 10.1002/jps.21441
   PubMed Web of Science ®Google Scholar
• Bhattacharya D, Saha B, Mukherjee A, et al. Gold nanoparticles conjugated antibiotics: stability and functional evaluation. Nanosci Nanotechnol. 2012;2(2):14–21. doi: 10.5923/j.nn.20120202.04
   Google Scholar
• Mendes C, Buttchevitz A, Barison A, et al. Investigation of β-cyclodextrin–norfloxacin inclusion complexes. Part 2. Inclusion mode and stability studies. Expert Rev Anti Infect Ther. 2015;13(1):131–140. doi: 10.1586/14787210.2015.982092
   PubMed Web of Science ®Google Scholar
• Popielec A, Agnes M, Yannakopoulou K, et al. Self-assembled cyclodextrin-based nanoparticles for meropenem stabilization. J Drug Deliv Sci Technol. 2018;45:20–27. doi: 10.1016/j.jddst.2018.02.018
   Web of Science ®Google Scholar
• Garnero C, Chattah AK, Aloisio C, et al. Improving the stability and the Pharmaceutical Properties of Norfloxacin Form C Through Binary Complexes with β-cyclodextrin. AAPS Pharm Sci Tech. 2018;19(5):2255–2263. doi: 10.1208/s12249-018-1033-0
   PubMed Web of Science ®Google Scholar
• Shinozaki T, Ono M, Higashi K, et al. A novel drug-drug cocrystal of levofloxacin and Metacetamol: reduced hygroscopicity and improved photostability of levofloxacin. J Pharm Sci. 2019;108(7):2383–2390. doi: 10.1016/j.xphs.2019.02.014
   PubMed Web of Science ®Google Scholar
• Watcharadulyarat N, Rattanatayarom M, Ruangsawasdi N, et al. PEG–PLGA nanoparticles for encapsulating ciprofloxacin. Sci Rep. 2023;13(1):1–11. doi: 10.1038/s41598-023-27500-y
   PubMed Web of Science ®Google Scholar
• Mwila C, Walker RB. Improved stability of rifampicin in the presence of gastric‐resistant isoniazid microspheres in acidic media. Pharmaceutics. 2020;12(3):1–28.
   Web of Science ®Google Scholar
• Potdar SB, Landge VK, Barkade SS, et al. Flavor encapsulation and release studies in food. In:Sonawane SH, Bhanvase BA, Sivakumar M, editors. Encapsulation Act Mol Their Deliv Syst INC. 2020. p. 293–321. doi: 10.1016/B978-0-12-819363-1.00016-8
   Google Scholar
• Ng LH, Ling JKU, Hadinoto K. Formulation strategies to improve the stability and handling of oral solid dosage forms of highly hygroscopic pharmaceuticals and nutraceuticals. Pharmaceutics. 2022;14(10):14. doi: 10.3390/pharmaceutics14102015
   Web of Science ®Google Scholar
• Aguilar-Toala JE, Quintanar-Guerrero D, Liceaga AM, et al. Encapsulation of bioactive peptides: a strategy to improve the stability, protect the nutraceutical bioactivity and support their food applications. RSC Adv. 2022;12(11):6449–6458. doi: 10.1039/D1RA08590E
   PubMed Web of Science ®Google Scholar
• Corsini F, Griffini G. Recent progress in encapsulation strategies to enhance the stability of organometal halide perovskite solar cells. JPhys Energy. 2020;2(3):031002. doi: 10.1088/2515-7655/ab8774
   Google Scholar
• Sonawane SH, Bhanvase BA, Sivakumar M, et al., editors. Current overview of encapsulation. Encapsulation Act Mol Their Deliv Syst INC. 2020. p. 1–8. doi: 10.1016/B978-0-12-819363-1.00001-6
   Google Scholar
• Santos AM, Júnior CCS, Júnior JACN, et al. Antibacterial drugs and cyclodextrin inclusion complexes: a patent review. Expert Opin Drug Deliv. 2023;20(3):349–366. doi: 10.1080/17425247.2023.2175815
   PubMed Web of Science ®Google Scholar
• Boczar D, Michalska K. Cyclodextrin inclusion complexes with antibiotics and antibacterial agents as drug-delivery systems—a pharmaceutical perspective. Pharmaceutics. 2022;14(7):14. doi: 10.3390/pharmaceutics14071389
   Web of Science ®Google Scholar
• Popielec A, Loftsson T. Effects of cyclodextrins on the chemical stability of drugs. Int J Pharm. 2017;531(2):532–542. doi: 10.1016/j.ijpharm.2017.06.009
   PubMedGoogle Scholar
• Zoppi A, Garnero C, Linck YG, et al. Enalapril: β-CD complex: Stability enhancement in solid state. Carbohydr Polym. 2011;86(2):716–721. doi: 10.1016/j.carbpol.2011.05.008
   Web of Science ®Google Scholar
• Guo M, Sun X, Chen J, et al. Pharmaceutical cocrystals: a review of preparations, physicochemical properties and applications. Acta Pharm Sin B. 2021;11(8):2537–2564. doi: 10.1016/j.apsb.2021.03.030
   PubMed Web of Science ®Google Scholar
• Salem A, Khanfar E, Nagy S, et al. Cocrystals of tuberculosis antibiotics: Challenges and missed opportunities. Int J Pharm. 2022;623:121924. doi: 10.1016/j.ijpharm.2022.121924
   PubMedGoogle Scholar
• Bashimam M, El-Zein H. Pharmaceutical cocrystal of antibiotic drugs: A comprehensive review. Heliyon. 2022;8(12):e11872. doi: 10.1016/j.heliyon.2022.e11872
   PubMed Web of Science ®Google Scholar
• Napiórkowska A, Kurek M. Coacervation as a novel method of microencapsulation of essential oils—a review. Molecules. 2022;27(16):5142. doi: 10.3390/molecules27165142
   PubMed Web of Science ®Google Scholar
• Moulik SP, Rakshit AK, Pan A, et al. An overview of coacervates: the special disperse state of amphiphilic and polymeric materials in solution. Colloids and Interfaces. 2022;6(3):45. doi: 10.3390/colloids6030045
   Web of Science ®Google Scholar
• Liu YH, Kuo SC, Yao BY, et al. Colistin nanoparticle assembly by coacervate complexation with polyanionic peptides for treating drug-resistant gram-negative bacteria. Acta Biomater. 2018;82:133–142. doi: 10.1016/j.actbio.2018.10.013
   PubMed Web of Science ®Google Scholar
• Emami F, Vatanara A, Park EJ, et al. Drying technologies for the stability and bioavailability of biopharmaceuticals. Pharmaceutics. 2018;10(3):1–22. doi: 10.3390/pharmaceutics10030131
   Web of Science ®Google Scholar
• Luo WC, O’Reilly Beringhs A, Kim R, et al. Impact of formulation on the quality and stability of freeze-dried nanoparticles. Eur J Pharm Biopharm. 2021;169:256–267. doi: 10.1016/j.ejpb.2021.10.014
   PubMed Web of Science ®Google Scholar
• Duralliu A, Matejtschuk P, Stickings P, et al. The influence of moisture content and temperature on the long-term storage stability of freeze-dried high concentration immunoglobulin G (IgG). Pharmaceutics. 2020;12(4):303–316. doi: 10.3390/pharmaceutics12040303
   PubMed Web of Science ®Google Scholar
• Henriques P, Fortuna A, Doktorovová S. Spray dried powders for nasal delivery: Process and formulation considerations. Eur J Pharm Biopharm. 2022;176:1–20. doi: 10.1016/j.ejpb.2022.05.002
   PubMed Web of Science ®Google Scholar
• Adali MB, Barresi AA, Boccardo G, et al. Spray freeze-drying as a solution to continuous manufacturing of pharmaceutical products in bulk. Processes. 2020;8(6):709–727. doi: 10.3390/pr8060709
   Web of Science ®Google Scholar
• Adeli E. The use of spray freeze drying for dissolution and oral bioavailability improvement of Azithromycin. Powder Technol. 2017;319:323–331. doi: 10.1016/j.powtec.2017.06.043
   Web of Science ®Google Scholar
• Wu ZL, Zhao J, Xu R. Recent advances in oral nano-antibiotics for bacterial infection therapy. Int J Nanomedicine. 2020;15:9587–9610. 10.2147/IJN.S279652. ;():.
   PubMed Web of Science ®Google Scholar
• Shaaban MI, Shaker MA, Mady FM. Imipenem/Cilastatin encapsulated polymeric nanoparticles for destroying carbapenem-resistant bacterial isolates. J Nanobiotechnology. 2017;15(1):1–12. doi: 10.1186/s12951-017-0262-9
   PubMedGoogle Scholar
• Pezron I, Tirucherai GS, Duvvuri S, et al. Prodrug strategies in nasal drug delivery. Expert Opin Ther Pat. 2002;12(3):331–340. doi: 10.1517/13543776.12.3.331
   Web of Science ®Google Scholar
• Krishnamoorthy R, Mitra AK. Prodrugs for nasal drug delivery. Adv Drug Deliv Rev. 1998;29(1–2):135–146. doi: 10.1016/S0169-409X(97)00065-3
   PubMed Web of Science ®Google Scholar
• Pires PC, Fazendeiro AC, Rodrigues M, et al. European Journal of Pharmaceutical Sciences Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a microemulsion - formulation development and in vivo pharmacokinetics. Eur J Pharm Sci. 2021;164:164. doi: 10.1016/j.ejps.2021.105918
   Web of Science ®Google Scholar
• Rautiola D, Maglalang PD, Cheryala N, et al. Special section on drug delivery technologies intranasal coadministration of a diazepam prodrug with a converting enzyme results in rapid absorption of diazepam in rats s. J Pharmacol Exp Ther. 2019;370(3):796–805. doi: 10.1124/jpet.118.255943
   PubMed Web of Science ®Google Scholar
• Markovic M, Ben-Shabat S, Dahan A. Prodrugs for improved drug delivery: lessons learned from recently developed and marketed products. Pharmaceutics. 2020;12(11):12. doi: 10.3390/pharmaceutics12111031
   Web of Science ®Google Scholar
• Jubeh B, Breijyeh Z, Karaman R. Antibacterial Prodrugs to Overcome Bacterial Resistance. Molecules. 2020;25(7):1–16. doi: 10.3390/molecules25071543
   Web of Science ®Google Scholar
• Botti G, Dalpiaz A, Pavan B. Targeting systems to the brain obtained by merging prodrugs, nanoparticles, and nasal administration. Pharmaceutics. 2021 13;13(8):1144. doi: 10.3390/pharmaceutics13081144.
   PubMed Web of Science ®Google Scholar
• Stebbins ND, Ouimet MA, Uhrich KE. Antibiotic-containing polymers for localized, sustained drug delivery. Adv Drug Deliv Rev. 2014;78:77–87. doi: 10.1016/j.addr.2014.04.006
   PubMed Web of Science ®Google Scholar
• Pati R, Sahu R, Panda J, et al. Encapsulation of zinc-rifampicin complex into transferrin-conjugated silver quantum-dots improves its antimycobacterial activity and stability and facilitates drug delivery into macrophages. Sci Rep. 2016;6(1):1–14. doi: 10.1038/srep24184
   PubMedGoogle Scholar
• Cal PMSD, Matos MJ, Bernardes GJL. Trends in therapeutic drug conjugates for bacterial diseases: a patent review. Expert Opin Ther Pat. 2017;27(2):179–189. doi: 10.1080/13543776.2017.1259411
   PubMed Web of Science ®Google Scholar
• Wang S, Gao Y, Jin Q, et al. Emerging antibacterial nanomedicine for enhanced antibiotic therapy. Biomater Sci. 2020;8(24):6825–6839. doi: 10.1039/D0BM00974A
   PubMed Web of Science ®Google Scholar
• Zazo H, Colino CI, Lanao JM. Current applications of nanoparticles in infectious diseases. J Control Release. 2016;224:86–102. doi: 10.1016/j.jconrel.2016.01.008
   PubMed Web of Science ®Google Scholar
• Yeh YC, Huang TH, Yang SC, et al. Nano-based drug delivery or targeting to eradicate bacteria for infection mitigation: a review of recent advances. Front Chem. 2020;8:1–22. doi: 10.3389/fchem.2020.00286
   PubMed Web of Science ®Google Scholar
• Zhang L, Jiang Y, Ding Y, et al. Investigation into the antibacterial behaviour of suspensions of ZnO nanoparticles (ZnO nanofluids). J Nanopart Res. 2007;9(3):479–489. doi: 10.1007/s11051-006-9150-1
   Web of Science ®Google Scholar
• Aruguete DM, Hochella MF. Bacteria-nanoparticle interactions and their environmental implications. Environ Chem. 2010;7(1):3–9. doi: 10.1071/EN09115
   Web of Science ®Google Scholar
• Tang J, Ouyang Q, Li Y, et al. Nanomaterials for delivering antibiotics in the therapy of pneumonia. Int J Mol Sci. 2022;23(24):23. doi: 10.3390/ijms232415738
   Web of Science ®Google Scholar
• Le H, Karakasyan C, Jouenne T, et al. Application of polymeric nanocarriers for enhancing the bioavailability of antibiotics at the target site and overcoming antimicrobial resistance. Appl Sci. 2021;11(22):11. doi: 10.3390/app112210695
   Google Scholar
• Alexander A, Agrawal M, Bhupal Chougule M, et al. Nose-to-brain drug delivery: An alternative approach for effective brain drug targeting. An alternative approach for effective brain drug targeting. In:Shegokar R, editor. Nanopharmaceuticals Vol 1 Expect Realities Multifunct Drug Deliv Syst. Elsevier Inc; 2020. p. 175–200. doi: 10.1016/B978-0-12-817778-5.00009-9
   Google Scholar
• Liu L, Pan M, Li Y, et al. Efficacy of nasal irrigation with hypertonic saline on chronic rhinosinusitis: systematic review and meta-analysis. Braz J Otorhinolaryngol. 2020;86:639–646. Available from. doi: 10.1016/j.bjorl.2020.03.008
   PubMed Web of Science ®Google Scholar
• Rabago D, Pasic T, Zgierska A, et al. The efficacy of hypertonic saline nasal irrigation for chronic sinonasal symptoms. Otolaryngol--Head Neck Surg. 2005;133(1):3–8. doi: 10.1016/j.otohns.2005.03.002
   PubMed Web of Science ®Google Scholar
• Culig J, Leppée M, Vceva A, et al. Efficiency of hypertonic and isotonic seawater solutions in chronic rhinosinusitis. Med Glas (Zenica). 2010;7(2):116–123.
   PubMedGoogle Scholar
• Bastier PL, Lechot A, Bordenave L, et al. Nasal irrigation: from empiricism to evidence-based medicine. A review. Eur Ann Otorhinolaryngol Head Neck Dis. 2015;132(5):281–285. doi: 10.1016/j.anorl.2015.08.001
   PubMed Web of Science ®Google Scholar
• Washington N, Steele RJC, Jackson SJ, et al. Determination of baseline human nasal pH and the effect of intranasally administered buffers. Int J Pharm. 2000;198(2):139–146. doi: 10.1016/S0378-5173(99)00442-1
   PubMedGoogle Scholar
• Kim BG, Kim JH, Kim SW, et al. Nasal pH in patients with chronic rhinosinusitis before and after endoscopic sinus surgery. Am J Otolaryngol - Head Neck Med Surg. 2013;34:505–507.
   Google Scholar
• Gizurarson S. The effect of cilia and the mucociliary clearance on successful drug delivery. Biol Pharm Bull. 2015;38(4):497–506. doi: 10.1248/bpb.b14-00398
   PubMed Web of Science ®Google Scholar
• Jiao J, Zhang L. Influence of intranasal drugs on human nasal mucociliary clearance and ciliary beat frequency. Allergy Asthma Immunol Res. 2019;11(3):306–319. doi: 10.4168/aair.2019.11.3.306
   PubMed Web of Science ®Google Scholar
• Mallants R, Jorissen M, Augustijns P. Beneficial effect of antibiotics on ciliary beat frequency of human nasal epithelial cells exposed to bacterial toxins. J Pharm Pharmacol. 2010;60(4):437–443. doi: 10.1211/jpp.60.4.0005
   Web of Science ®Google Scholar
• Gosepath J, Grebneva N, Mossikhin S, et al. Topical antibiotic, antifungal, and antiseptic solutions decrease ciliary activity in nasal respiratory cells. Am J Rhinol. 2002;16(1):25–31. doi: 10.1177/194589240201600105
   PubMedGoogle Scholar
• Workman AD, Cohen NA. The effect of drugs and other compounds on the ciliary beat frequency of human respiratory epithelium. Am j rhinol allergy. 2014;28(6):454–464. doi: 10.2500/ajra.2014.28.4092
   PubMed Web of Science ®Google Scholar
• Pham QD, Nöjd S, Edman M, et al. Mucoadhesion: mucin-polymer molecular interactions. Int J Pharm. 2021;610:610. doi: 10.1016/j.ijpharm.2021.121245
   Google Scholar
• Zahir-Jouzdani F, Wolf JD, Atyabi F, et al. In situ gelling and mucoadhesive polymers: why do they need each other? Expert Opin Drug Deliv. 2018;15(10):1007–1019. doi: 10.1080/17425247.2018.1517741
   PubMed Web of Science ®Google Scholar
• Nazir F, Tabish TA, Tariq F, et al. Stimuli-sensitive drug delivery systems for site-specific antibiotic release. Drug Discov Today. 2022;27(6):1698–1705. doi: 10.1016/j.drudis.2022.02.014
   PubMed Web of Science ®Google Scholar
• Sousa J, Alves G, Fortuna A, et al. Intranasal delivery of topically-acting levofloxacin to rats: a proof-of-concept pharmacokinetic study. Pharm Res. 2017;34(11):2260–2269. doi: 10.1007/s11095-017-2232-1
   PubMed Web of Science ®Google Scholar
• Agrawal M, Saraf S, Saraf S, et al. Stimuli-responsive In situ gelling system for nose-to-brain drug delivery. J Control Release. 2020;327:235–265. doi: 10.1016/j.jconrel.2020.07.044
   PubMed Web of Science ®Google Scholar
• Karavasili C, Fatouros DG. Smart materials: in situ gel-forming systems for nasal delivery. Drug Discov Today. 2016;21(1):157–166. doi: 10.1016/j.drudis.2015.10.016
   PubMed Web of Science ®Google Scholar
• Piazzini V, Landucci E, D’Ambrosio M, et al. Chitosan coated human serum albumin nanoparticles: a promising strategy for nose-to-brain drug delivery. Int J Biol Macromol. 2019;129:267–280. doi: 10.1016/j.ijbiomac.2019.02.005
   PubMed Web of Science ®Google Scholar
• Ferreira NN, de Oliveira Junior E, Granja S, et al. Nose-to-brain co-delivery of drugs for glioblastoma treatment using nanostructured system. Int J Pharm. 2021;603:1–13. doi: 10.1016/j.ijpharm.2021.120714
   Google Scholar
• Kaur G, Goyal J, Behera PK, et al. Unraveling the role of chitosan for nasal drug delivery systems: a review. Carbohydr Polym Technol Appl. 2023;5:100316. doi: 10.1016/j.carpta.2023.100316
   Google Scholar
• Jelkmann M, Leichner C, Zaichik S, et al. A gellan gum derivative as in-situ gelling cationic polymer for nasal drug delivery. Int J Biol Macromol. 2020;158:1037–1046. doi: 10.1016/j.ijbiomac.2020.04.114
   PubMed Web of Science ®Google Scholar
• Huang G, Xie J, Shuai S, et al. Nose-to-brain delivery of drug nanocrystals by using Ca2+ responsive deacetylated gellan gum based in situ-nanogel. Int J Pharm. 2021;594:120182. doi: 10.1016/j.ijpharm.2020.120182
   PubMed Web of Science ®Google Scholar
• Wang M, Ma X, Zong S, et al. The prescription design and key properties of nasal gel for CNS drug delivery: a review. Eur J Pharm Sci. 2024;192:106623. doi: 10.1016/j.ejps.2023.106623
   PubMed Web of Science ®Google Scholar
• Preston KB, Randolph TW. Stability of lyophilized and spray dried vaccine formulations. Adv Drug Deliv Rev. 2021;171:50–61. doi: 10.1016/j.addr.2021.01.016
   PubMed Web of Science ®Google Scholar