694
Views
1
CrossRef citations to date
0
Altmetric
Original Research

Lenvatinib-induced renal failure: two first-time case reports and review of literature

, , , , , , , , , , & show all
Pages 379-385 | Received 15 Dec 2017, Accepted 03 Apr 2018, Published online: 13 Apr 2018

References

  • Yamamoto Y, Matsui J, Matsushima T, et al. Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage. Vasc Cell. 2014;6:18.
  • Schlumberger M, Tahara M, Wirth LJ, et al. Lenvatinib versus placebo in radioiodine-refractory thyroid cancer. N Engl J Med. 2015 Feb 12;372:621–630.
  • Motzer RJ, Hutson TE, Glen H, et al. Lenvatinib, everolimus, and the combination in patients with metastatic renal cell carcinoma: a randomised, phase 2, open-label, multicentre trial. Lancet Oncol. 2015 Nov;16:1473–1482.
  • Cheng AL, Finn RS, Qin S, et al. Phase III trial of lenvatinib (LEN) vs sorafenib (SOR) in first-line treatment of patients (pts) with unresectable hepatocellular carcinoma (uHCC). J Clin Oncol. 2017;35.
  • Vergote I, Teneriello M, Powell MA, et al. A phase II trial of lenvatinib in patients with advanced or recurrent endometrial cancer: angiopoietin-2 as a predictive marker for clinical outcomes. J Clin Oncol. 2013;31:5520.
  • Makker V, Rasco DW, Ductus CE, et al. A phase Ib/II trial of lenvatinib (LEN) plus pembrolizumab (Pembro) in patients (Pts) with endometrial carcinoma. J Clin Oncol. 2017;35:5598.
  • Tahara M, Kiyota N, Yamazaki T, et al. Lenvatinib for anaplastic thyroid cancer. Front Oncol. 2017;7:25.
  • Lenvatinib in recurrent and/or metastatic adenoid cystic carcinomas of the salivary glands: ACC-LEN14 (ACC-LEN14) - NCT02860936. [cited 2017 Dec 15]. Available from: https://clinicaltrials.gov/ct2/show/NCT02860936
  • Agenzia Italiana del Farmaco. [cited 2017 Dec 13]. Available from: http://www.agenziafarmaco.gov.it/
  • Porta C, Levy A, Hawkins R, et al. Impact of adverse events, treatment modifications, and dose intensity on survival among patients with advanced renal cell carcinoma treated with first-line sunitinib: a medical chart review across ten centers in five European countries. Cancer Med. 2014;3:1517–1526.
  • Brose MS, Worden FP, Newbold KL, et al. Effect of age on the efficacy and safety of lenvatinib in radioiodine-refractory differentiated thyroid cancer in the phase III SELECT trial. J Clin Oncol. 2017 Aug 10;35(23):2692–2699. PubMed PMID: 28613956; eng.
  • Ikeda K, Kudo M, Kawazoe S, et al. Phase 2 study of lenvatinib in patients with advanced hepatocellular carcinoma. J Gastroenterol. 2017;52:512–519.
  • Kiyota N, Schlumberger M, Muro K, et al. Subgroup analysis of Japanese patients in a phase 3 study of lenvatinib in radioiodine-refractory differentiated thyroid cancer. Cancer Sci. 2015;106:1714–1721.
  • Boissier E, Mir O, Hollebecque A, et al. Predictive factors of renal toxicities related to anti-VEGFR multikinase inhibitors in phase 1 trials. Invest New Drugs. 2017;35:79–86.
  • Cosmai L, Gallieni M, Liguigli W, et al. Renal toxicity of anticancer agents targeting vascular endothelial growth factor (VEGF) and its receptors (VEGFRs). J Nephrol. 2017 Apr;30:171–180.
  • Eremina V, Jefferson JA, Kowalewska J, et al. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med. 2008 Mar 13;358:1129–1136.
  • Keizer RJ, Gupta A, Mac Gillavry MR, et al. A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080. J Pharmacokinet Pharmacodyn. 2010;37:347–363.
  • Smith ER, Tan SJ, Holt SG, et al. FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts. Sci Rep. 2017 Jun 13;7:3345.
  • Lameire N. Nephrotoxicity of recent anti-cancer agents. Clin Kidney J. 2014 Feb;7:11–22.
  • Perazella MA, Izzedine H. New drug toxicities in the onco-nephrology world. Kidney Int. 2015 May;87:909–917.
  • Kandula P, Agarwal R. Proteinuria and hypertension with tyrosine kinase inhibitors. Kidney Int. 2011 Dec;80:1271–1277.
  • Zamorano JL, Lancellotti P, Rodriguez Munoz D, et al. 2016 ESC position paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC committee for practice guidelines: the task force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC). Eur Heart J. 2016 Sep 21;37:2768–2801.
  • Porta C, Cosmai L, Gallieni M, et al. Renal effects of targeted anticancer therapies. Nat Reviews Nephrol. 2015;11:354–370.
  • Brandes AA, Bartolotti M, Tosoni A, et al. Practical Management of Bevacizumab-Related Toxicities in Glioblastoma. Oncologist. 2015;20:166–175.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.