191
Views
0
CrossRef citations to date
0
Altmetric
Original Research

Pharmacokinetic and pharmacodynamic interaction of DWP16001, a sodium-glucose cotransporter-2 inhibitor, with phentermine in healthy subjects

, , , , , & show all
Pages 479-485 | Received 09 May 2023, Accepted 26 Jul 2023, Published online: 25 Aug 2023

References

  • Wright EM, Loo DD, Hirayama BA. Biology of human sodium glucose transporters. Physiol Rev. 2011 Apr;91(2):733–794. doi: 10.1152/physrev.00055.2009
  • Cowie MR, Fisher M. SGLT2 inhibitors: mechanisms of cardiovascular benefit beyond glycaemic control. Nat Rev Cardiol. 2020 Dec;17(12):761–772. doi: 10.1038/s41569-020-0406-8
  • Bailey CJ, Day C, Bellary S. Renal protection with SGLT2 inhibitors: effects in acute and chronic kidney disease. Curr Diab Rep. 2022 Jan;22(1):39–52. doi: 10.1007/s11892-021-01442-z
  • Tsapas A, Karagiannis T, Kakotrichi P, et al. Comparative efficacy of glucose-lowering medications on body weight and blood pressure in patients with type 2 diabetes: a systematic review and network meta-analysis. Diab Obes Metab. 2021 Sep;23(9):2116–2124. doi: 10.1111/dom.14451
  • Zheng H, Liu M, Li S, et al. Sodium-glucose co-transporter-2 inhibitors in non-diabetic adults with overweight or obesity: a systematic review and meta-analysis. Front Endocrinol. 2021;12:706914. doi: 10.3389/fendo.2021.706914
  • American Diabetes Association Professional Practice C. 9. Pharmacologic approaches to glycemic treatment: standards of medical Care in diabetes-2022. Diabetes Care. 2022 Jan 1;45(Suppl 1):S125–S143. doi: 10.2337/dc22-S009
  • Li S, Vandvik PO, Lytvyn L, et al. SGLT-2 inhibitors or GLP-1 receptor agonists for adults with type 2 diabetes: a clinical practice guideline. BMJ. 2021 May 11;373(1091). doi: 10.1136/bmj.n1091
  • Choi MK, Nam SJ, Ji HY, et al. Comparative pharmacokinetics and pharmacodynamics of a novel sodium-glucose cotransporter 2 inhibitor, DWP16001, with dapagliflozin and ipragliflozin. Pharmaceutics. 2020 Mar 15;12(3):268. doi: 10.3390/pharmaceutics12030268
  • Hwang JG, Lee S, Huh W, et al. Dose-dependent glucosuria of DWP16001, a novel selective sodium-glucose cotransporter-2 inhibitor, in healthy subjects. Br J Clin Pharmacol. 2022 Sep;88(9):4100–4110. doi: 10.1111/bcp.15348
  • Kwak SH, Han KA, Kim KS, et al. Efficacy and safety of enavogliflozin, a novel SGLT2 inhibitor, in Korean people with type 2 diabetes: a 24-week, multicentre, randomized, double-blind, placebo-controlled, phase III trial. Diab Obes Metab. 2023 Mar 5;25(7):1865–1873. doi: 10.1111/dom.15046
  • Bray GA, Heisel WE, Afshin A, et al. The science of obesity management: an endocrine society scientific statement. Endocr Rev. 2018 Apr 1;39(2):79–132. doi: 10.1210/er.2017-00253
  • Dong Z, Xu L, Liu H, et al. Comparative efficacy of five long-term weight loss drugs: quantitative information for medication guidelines. Obes Rev. 2017 Dec;18(12):1377–1385. doi: 10.1111/obr.12606
  • Garvey WT, Ryan DH, Look M, et al. Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study. Am J Clin Nutr. 2012 Feb;95(2):297–308. doi: 10.3945/ajcn.111.024927
  • World Health Organization Obesity and overweight. 9 Jun 2021. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight [Accessed 3 Mar 2023].
  • American Diabetes Association Professional Practice C. 8. Obesity and weight management for the prevention and treatment of type 2 diabetes: standards of medical care in diabetes-2022. Diabetes Care. 2022 Jan 1;45(Suppl 1):S113–S124. doi: 10.2337/dc22-S008
  • Simonds SE, Pryor JT, Koegler FH, et al. Determining the effects of combined liraglutide and phentermine on metabolic parameters, blood pressure, and heart rate in lean and obese male mice. Diabetes. 2019 Apr;68(4):683–695. doi: 10.2337/db18-1149
  • Garvey WT, Ryan DH, Bohannon NJ, et al. Weight-loss therapy in type 2 diabetes: effects of phentermine and topiramate extended release. Diabetes Care. 2014 Dec;37(12):3309–3316. doi: 10.2337/dc14-0930
  • Tronieri JS, Wadden TA, Walsh OA, et al. Effects of liraglutide plus phentermine in adults with obesity following 1 year of treatment by liraglutide alone: a randomized placebo-controlled pilot trial. Metabolism. 2019 Jul;96:83–91.
  • Hollander P, Bays HE, Rosenstock J, et al. Coadministration of canagliflozin and phentermine for weight management in overweight and obese Individuals without diabetes: a randomized Clinical trial. Diabetes Care. 2017 May;40(5):632–639. doi: 10.2337/dc16-2427
  • Kim JH, Kim DK, Choi WG, et al. In vitro metabolism of DWP16001, a novel sodium-glucose cotransporter 2 inhibitor, in human and animal hepatocytes. Pharmaceutics. 2020 Sep 11;12(9):865. doi: 10.3390/pharmaceutics12090865
  • Garvey WT. Phentermine and topiramate extended-release: a new treatment for obesity and its role in a complications-centric approach to obesity medical management. Expert Opin Drug Saf. 2013 Sep;12(5):741–756. doi: 10.1517/14740338.2013.806481
  • Johnson DB, Quick J. Topiramate and phentermine. Treasure Island (FL): StatPearls; 2022.
  • Kadokura T, Zhang W, Krauwinkel W, et al. Clinical pharmacokinetics and pharmacodynamics of the novel SGLT2 inhibitor ipragliflozin. Clin Pharmacokinet. 2014 Nov;53(11):975–988. doi: 10.1007/s40262-014-0180-z
  • Kasichayanula S, Liu X, Lacreta F, et al. Clinical pharmacokinetics and pharmacodynamics of dapagliflozin, a selective inhibitor of sodium-glucose co-transporter type 2. Clin Pharmacokinet. 2014 Jan;53(1):17–27. doi: 10.1007/s40262-013-0104-3
  • DeFronzo RA, Hompesch M, Kasichayanula S, et al. Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes. Diabetes Care. 2013 Oct;36(10):3169–3176. doi: 10.2337/dc13-0387
  • Kim KK, Cho HJ, Kang HC, et al. Effects on weight reduction and safety of short-term phentermine administration in Korean obese people. Yonsei Med J. 2006 Oct 31;47(5):614–625. doi: 10.3349/ymj.2006.47.5.614
  • Pereira MJ, Eriksson JW. Emerging role of SGLT-2 inhibitors for the treatment of obesity. Drugs. 2019 Feb;79(3):219–230. doi: 10.1007/s40265-019-1057-0
  • McGill JB, Subramanian S. Safety of sodium-glucose co-transporter 2 inhibitors. Am J Cardiol. 2019 Dec 15;124 Suppl 1:S45–S52. doi: 10.1016/j.amjcard.2019.10.029

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.