Effects of continuous and pulsatile flows generated by ventricular assist devices on renal function and pathology

References

• Goldstein DJ, Oz MC, Rose EA. Implantable left ventricular assist devices. N Engl J Med. 1998;339: 1522–1533. Review.
   PubMed Web of Science ®Google Scholar
• Rose EA, Gelijns AC, Moskowitz AJ, et al. Randomized evaluation of mechanical assistance for the treatment of congestive heart failure (REMATCH) study group. Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med. 2001;345:1435–1443.
   PubMed Web of Science ®Google Scholar
• Slaughter MS, Rogers JG, Milano CA, et al. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009;361:2241–2251.
   PubMed Web of Science ®Google Scholar
• Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). [cited 2018 Jan 16] Available from: http://www.uab.edu/medicine/intermacs/
   Google Scholar
• Rogers JG, Pagani FD, Tatooles AJ, et al. Intrapericardial left ventricular assist device for advanced heart failure. N Engl J Med. 2017;376:451–460.
   PubMed Web of Science ®Google Scholar
• Mehra MR, Naka Y, Uriel N, et al. A fully magnetically levitated circulatory pump for advanced heart failure. N Engl J Med. 2017;376:440–450.
   PubMed Web of Science ®Google Scholar
• Orime Y, Shiono M, Nakata K, et al. The role of pulsatility in end-organ microcirculation after cardiogenic shock. Asaio J. 1996;42:M724–M729.
   PubMed Web of Science ®Google Scholar
• Sezai A, Shiono M, Orime Y, et al. Renal circulation and cellular metabolism during left ventricular assisted circulation: comparison study of pulsatile and nonpulsatile assists. Artif Organs. 1997;21:830–835.
   PubMed Web of Science ®Google Scholar
• Nishimura T, Tatsumi E, Takaichi S, et al. Prolonged nonpulsatile left heart bypass with reduced systemic pulse pressure causes morphological changes in the aortic wall. Artif Organs. 1998;22:405–410.
   PubMed Web of Science ®Google Scholar
• Ohnishi H, Itoh T, Nishinaka T, et al. Morphological changes of the arterial systems in the kidney under prolonged continuous flow left heart bypass. Artif Organs. 2002;26:974–979.
   PubMed Web of Science ®Google Scholar
• Saito S, Westaby S, Piggot D, et al. End-organ function during chronic nonpulsatile circulation. Ann Thorac Surg. 2002;74:1080–1085.
   PubMed Web of Science ®Google Scholar
• Kihara S, Litwak KN, Nichols L, et al. Smooth muscle cell hypertrophy of renal cortex arteries with chronic continuous flow left ventricular assist. Ann Thorac Surg. 2003;75:178–183, discussion 183
   PubMed Web of Science ®Google Scholar
• Ootaki C, Yamashita M, Ootaki Y, et al. Reduced pulsatility induces periarteritis in kidney: role of the local renin-angiotensin system. J Thorac Cardiovasc Surg. 2008;136:150–158.
   PubMed Web of Science ®Google Scholar
• Thyberg J, Hedin U, Sjölund M, et al. Regulation of differentiated properties and proliferation of arterial smooth muscle cells. Arteriosclerosis. 1990;10:966–990.
   PubMedGoogle Scholar
• Butler J, Geisberg C, Howser R, et al. Relationship between renal function and left ventricular assist device use. Ann Thorac Surg. 2006;81:1745–1751.
   PubMed Web of Science ®Google Scholar
• Iwashima Y, Yanase M, Horio T, et al. Serial changes in renal function as a prognostic indicator in advanced heart failure patients with left ventricular assist system. Ann Thorac Surg. 2012;93:816–823.
   PubMed Web of Science ®Google Scholar
• Frazier OH, Rose EA, Oz MC, et al. Multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system in patients awaiting heart transplantation. J Thorac Cardiovasc Surg. 2001;122:1186–1195.
   PubMed Web of Science ®Google Scholar
• Radovancevic B, Vrtovec B, de Kort E, et al. End-organ function in patients on long-term circulatory support with continuous- or pulsatile-flow assist devices. J Heart Lung Transplant. 2007;26:815–818.
   PubMed Web of Science ®Google Scholar
• Letsou GV, Myers TJ, Gregoric ID, et al. Continuous axial-flow left ventricular assist device (Jarvik 2000) maintains kidney and liver perfusion for up to 6 months. Ann Thorac Surg. 2003;76:1167–1170.
   PubMed Web of Science ®Google Scholar
• Russell SD, Rogers JG, Milano CA, et al. Renal and hepatic function improve in advanced heart failure patients during continuous-flow support with the HeartMate II left ventricular assist device. Circulation. 2009;120:2352–2357.
   PubMed Web of Science ®Google Scholar
• Sandner SE, Zimpfer D, Zrunek P, et al. Renal function and outcome after continuous flow left ventricular assist device implantation. Ann Thorac Surg. 2009;87:1072–1078.
   PubMed Web of Science ®Google Scholar
• Westaby S, Banning A, Neil D, et al. Optimism derived from 7.5 years of continuous-flow circulatory support. J Thorac Cardiovasc Surg. 2010;139:e45–e47.
   PubMed Web of Science ®Google Scholar
• Demirozu ZT, Etheridge WB, Radovancevic R, et al. Results of HeartMate II left ventricular assist device implantation on renal function in patients requiring post-implant renal replacement therapy. J Heart Lung Transplant. 2011;30:182–187.
   PubMed Web of Science ®Google Scholar
• Singh M, Shullo M, Kormos RL, et al. Impact of renal function before mechanical circulatory support on posttransplant renal outcomes. Ann Thorac Surg. 2011;91:1348–1354.
   PubMed Web of Science ®Google Scholar
• Hasin T, Topilsky Y, Schirger JA, et al. Changes in renal function after implantation of continuous-flow left ventricular assist devices. J Am Coll Cardiol. 2012;59:26–36.
   PubMed Web of Science ®Google Scholar
• Kirklin JK, Naftel DC, Kormos RL, et al. Quantifying the effect of cardiorenal syndrome on mortality after left ventricular assist device implant. J Heart Lung Transplant. 2013;32:1205–1213.
   PubMed Web of Science ®Google Scholar
• Brisco MA, Kimmel SE, Coca SG, et al. Prevalence and prognostic importance of changes in renal function after mechanical circulatory support. Circ Heart Fail. 2014;7:68–75.
   PubMed Web of Science ®Google Scholar
• Raichlin E, Baibhav B, Lowes BD, et al. Outcomes in patients with severe preexisting renal dysfunction after continuous-flow left ventricular assist device implantation. Asaio J. 2016;62:261–267.
   PubMed Web of Science ®Google Scholar
• Yoshioka D, Takayama H, Colombo PC, et al. Changes in end-organ function in patients with prolonged continuous-flow left ventricular assist device support. Ann Thorac Surg. 2017;103:717–724.
   PubMed Web of Science ®Google Scholar
• Westaby S, Bertoni GB, Clelland C, et al. Circulatory support with attenuated pulse pressure alters human aortic wall morphology. J Thorac Cardiovasc Surg. 2007;133:575–576.
   PubMed Web of Science ®Google Scholar
• Segura AM, Gregoric I, Radovancevic R, et al. Morphologic changes in the aortic wall media after support with a continuous-flow left ventricular assist device. J Heart Lung Transplant. 2013;32:1096–1100.
   PubMedGoogle Scholar
• Ambardekar AV, Hunter KS, Babu AN, et al. Changes in aortic wall structure, composition, and stiffness with continuous-flow left ventricular assist devices: a pilot study. Circ Heart Fail. 2015;8:944–952.
   PubMed Web of Science ®Google Scholar
• Sandner SE, Zimpfer D, Zrunek P, et al. Renal function after implantation of continuous versus pulsatile flow left ventricular assist devices. J Heart Lung Transplant. 2008;27:469–473.
   PubMed Web of Science ®Google Scholar
• Kamdar F, Boyle A, Liao K, et al. Effects of centrifugal, axial, and pulsatile left ventricular assist device support on end-organ function in heart failure patients. J Heart Lung Transplant. 2009;28:352–359.
   PubMed Web of Science ®Google Scholar
• Nadziakiewicz P, Szygula-Jurkiewicz B, Niklewski T, et al. Effects of left ventricular assist device support on end-organ function in patients with heart failure: comparison of pulsatile- and continuous-flow support in a single-center experience. Transplant Proc. 2016;48:1775–1780.
   PubMed Web of Science ®Google Scholar
• Potapov EV, Dranishnikov N, Morawietz L, et al. Arterial wall histology in chronic pulsatile-flow and continuous-flow device circulatory support. J Heart Lung Transplant. 2012;31:1171–1176.
   PubMed Web of Science ®Google Scholar
• Khot UN, Mishra M, Yamani MH, et al. Severe renal dysfunction complicating cardiogenic shock is not a contraindication to mechanical support as a bridge to cardiac transplantation. J Am Coll Cardiol. 2003;41:381–385.
   PubMed Web of Science ®Google Scholar
• Cowger J, Sundareswaran K, Rogers JG, et al. Predicting survival in patients receiving continuous flow left ventricular assist devices: the HeartMate II risk score. J Am Coll Cardiol. 2013;61:313–321.
   PubMed Web of Science ®Google Scholar
• Borgi J, Tsiouris A, Hodari A, et al. Significance of postoperative acute renal failure after continuous-flow left ventricular assist device implantation. Ann Thorac Surg. 2013;95:163–169.
   PubMed Web of Science ®Google Scholar
• Palomba H, de Castro I, Neto AL, et al. Acute kidney injury prediction following elective cardiac surgery: AKICS score. Kidney Int. 2007;72:624–631.
   PubMed Web of Science ®Google Scholar
• Gambardella I, Gaudino M, Ronco C, et al. Congestive kidney failure in cardiac surgery: the relationship between central venous pressure and acute kidney injury. Interact Cardiovasc Thorac Surg. 2016;23:800–805.
   PubMed Web of Science ®Google Scholar
• Topkara VK, Dang NC, Barili F, et al. Predictors and outcomes of continuous veno-venous hemodialysis use after implantation of a left ventricular assist device. J Heart Lung Transplant. 2006;25:404–408.
   PubMed Web of Science ®Google Scholar
• Alba AC, Rao V, Ivanov J, et al. Predictors of acute renal dysfunction after ventricular assist device placement. J Card Fail. 2009;15:874–881.
   PubMedGoogle Scholar
• Imamura T, Kinugawa K, Shiga T, et al. Preoperative levels of bilirubin or creatinine adjusted by age can predict their reversibility after implantation of left ventricular assist device. Circ J. 2013;77:96–104.
   PubMed Web of Science ®Google Scholar
• Topkara VK, Coromilas EJ, Garan AR, et al. Preoperative proteinuria and reduced glomerular filtration rate predicts renal replacement therapy in patients supported with continuous-flow left ventricular assist devices. Circ Heart Fail. 2016;9:pii: e002897.
   Web of Science ®Google Scholar
• Hasin T, Grupper A, Dillon JJ, et al. Early gains in renal function following implantation of HeartMate II left ventricular assist devices may not persist to one year. Asaio J. 2017;63:401–407.
   PubMed Web of Science ®Google Scholar
• Damman K, Testani JM. The kidney in heart failure: an update. Eur Heart J. 2015;36: 1437–1444. Review.
   PubMed Web of Science ®Google Scholar
• Mullens W, Abrahams Z, Francis GS, et al. Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J Am Coll Cardiol. 2009;53:589–596.
   PubMed Web of Science ®Google Scholar
• Takeda K, Takayama H, Colombo PC, et al. Incidence and clinical significance of late right heart failure during continuous-flow left ventricular assist device support. J Heart Lung Transplant. 2015;34:1024–1032.
   PubMed Web of Science ®Google Scholar
• Rother RP, Bell L, Hillmen P, et al. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA. 2005;293:1653–1662, Review
   PubMed Web of Science ®Google Scholar
• John R, Panch S, Hrabe J, et al. Activation of endothelial and coagulation systems in left ventricular assist device recipients. Ann Thorac Surg. 2009;88:1171–1179.
   PubMed Web of Science ®Google Scholar
• Nascimbene A, Hernandez R, George JK, et al. Association between cell-derived microparticles and adverse events in patients with nonpulsatile left ventricular assist devices. J Heart Lung Transplant. 2014;33:470–477.
   PubMed Web of Science ®Google Scholar
• Ahmad T, Wang T, O’Brien EC, et al. Effects of left ventricular assist device support on biomarkers of cardiovascular stress, fibrosis, fluid homeostasis, inflammation, and renal injury. JACC Heart Fail. 2015;3:30–39.
   PubMed Web of Science ®Google Scholar
• Sivalingam Z, Larsen SB, Grove EL, et al. Neutrophil gelatinase-associated lipocalin as a risk marker in cardiovascular disease. Clin Chem Lab Med. 2017;56:5–18.
   PubMed Web of Science ®Google Scholar
• Lou X, Templeton DL, John R, et al. Effects of continuous flow left ventricular assist device support on microvascular endothelial function. J Cardiovasc Transl Res. 2012;5:345–350.
   PubMed Web of Science ®Google Scholar
• Hasin T, Matsuzawa Y, Guddeti RR, et al. Attenuation in peripheral endothelial function after continuous flow left ventricular assist device therapy is associated with cardiovascular adverse events. Circ J. 2015;79:770–777.
   PubMed Web of Science ®Google Scholar
• Sansone R, Stanske B, Keymel S, et al. Macrovascular and microvascular function after implantation of left ventricular assist devices in end-stage heart failure: role of microparticles. J Heart Lung Transplant. 2015;34:921–932.
   PubMed Web of Science ®Google Scholar
• Witman MA, Garten RS, Gifford JR, et al. Further peripheral vascular dysfunction in heart failure patients with a continuous-flow left ventricular assist device: the role of pulsatility. JACC Heart Fail. 2015;3:703–711.
   PubMed Web of Science ®Google Scholar
• Rautureau Y, Paradis P, Schiffrin EL. Cross-talk between aldosterone and angiotensin signaling in vascular smooth muscle cells. Steroids. 2011;76:834–839.
   PubMed Web of Science ®Google Scholar
• Kurtz A. Control of renin synthesis and secretion. Am J Hypertens. 2012;25: 839–847. Review.
   PubMed Web of Science ®Google Scholar
• Many M, Giron F, Birtwell WC, et al. Effects of depulsation of renal blood flow upon renal function and renin secretion. Surgery. 1969;66:242–249.
   PubMed Web of Science ®Google Scholar
• Taylor KM, Bain WH, Russell M, et al. Peripheral vascular resistance and angiotensin II levels during pulsatile and non-pulsatile cardiopulmonary bypass. Thorax. 1979;34:594–598.
   PubMed Web of Science ®Google Scholar
• Fukae K, Tominaga R, Tokunaga S, et al. The effects of pulsatile and nonpulsatile systemic perfusion on renal sympathetic nerve activity in anesthetized dogs. J Thorac Cardiovasc Surg. 1996;111:478–484.
   PubMed Web of Science ®Google Scholar
• Welp H, Rukosujew A, Tjan TD, et al. Effect of pulsatile and non-pulsatile left ventricular assist devices on the renin-angiotensin system in patients with end-stage heart failure. Thorac Cardiovasc Surg. 2010;58(Suppl 2):S185–S188.
   PubMedGoogle Scholar
• Montezano AC, Nguyen Dinh Cat A, Rios FJ, et al. Angiotensin II and vascular injury. Curr Hypertens Rep. 2014;16:431.
   PubMed Web of Science ®Google Scholar
• Lan TH, Huang XQ, Tan HM. Vascular fibrosis in atherosclerosis. Cardiovasc Pathol. 2013;22:401–407.
   PubMed Web of Science ®Google Scholar
• Cheng A, Williamitis CA, Slaughter MS. Comparison of continuous-flow and pulsatile-flow left ventricular assist devices: is there an advantage to pulsatility? Ann Cardiothorac Surg. 2014;3:573–581.
   PubMedGoogle Scholar
• Slaughter MS. Long-term continuous flow left ventricular assist device support and end-organ function: prospects for destination therapy. J Card Surg. 2010;25: 490–494. Review.
   PubMed Web of Science ®Google Scholar
• Karimov JH, Moazami N, Kobayashi M, et al. First report of 90-day support of 2 calves with a continuous-flow total artificial heart. J Thorac Cardiovasc Surg. 2015;150:687-693.e1.
   Web of Science ®Google Scholar