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Review

Deep brain stimulation and other surgical modalities for the management of essential tremor

, , , , , & show all
Pages 817-833 | Received 06 Mar 2020, Accepted 04 Aug 2020, Published online: 21 Oct 2020

References

  • Louis ED, Ferreira JJ. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord. 2010;25(5):534–541.
  • Elias WJ, Shah BB. Tremor. JAMA. 2014;311(9):948.
  • Bhatia KP, Bain P, Bajaj N, et al. Consensus statement on the classification of tremors. from the task force on tremor of the international parkinson and movement disorder society. Mov Disord. 2017;33(1):75–87.
  • Zesiewicz TA, Elble RJ, Louis ED, et al. Evidence-based guideline update: treatment of essential tremor: report of the Quality Standards Subcommittee Of The American Academy Of Neurology. Neurology. 2011;77(19):1752–1755.
  • Dallapiazza RF, Lee DJ, De Vloo P, et al. Outcomes from stereotactic surgery for essential tremor. J Neurol Neurosurg. 2019;90(4):474–482.•• Excellent review on outcomes from stereotactic surgery for essential tremor.
  • Dallapiazza R, McKisic MS, Shah B, et al. Neuromodulation for movement disorders. Neurosurg Clinics NA. 2014;25(1):47–58.
  • Krack P, Martinez-Fernandez R, Del Álamo M, et al. Current applications and limitations of surgical treatments for movement disorders. Mov Disord. 2017;32(1):36–52.•Excellent review that discusses the current clinical state of the art of functional neurosurgery in the treatment of Parkinson’s disease, tremor, and dystonia.
  • Murata J-I, Kitagawa M, Uesugi H, et al. Electrical stimulation of the posterior subthalamic area for the treatment of intractable proximal tremor. J Neurosurg. 2003;99(4):708–715.
  • Barbe MT, Reker P, Hamacher S, et al. DBS of the PSA and the VIM in essential tremor. Neurology. 2018;91(6):e543–e550. • A comparison study for essential tremor between PSA and VIM.
  • Schlaier J, Anthofer J, Steib K, et al. Deep brain stimulation for essential tremor: targeting the dentato-rubro-thalamic tract? Neuromodulation: Technol Neural Interface. 2014;18(2):105–112.
  • Fiechter M, Nowacki A, Oertel MF, et al. Deep brain stimulation for tremor: is there a common structure? Stereotact Funct Neurosurg. 2017;95(4):243–250.
  • Eisinger RS, Wong J, Almeida L, et al. Ventral intermediate nucleus versus zona incerta region deep brain stimulation in essential tremor. Mov Disord Clin Pract. 2017;5(1):75–82.
  • Holslag JAH, Neef N, Beudel M, et al. Deep brain stimulation for essential tremor: a comparison of targets. World Neurosurg. 2018;110:e580–e584..
  • Goldman MS, Ahlskog JE, Kelly PJ. The symptomatic and functional outcome of stereotactic thalamotomy for medically intractable essential tremor. J Neurosurg. 1992;76(6):924–928.
  • Schuurman PR, Bosch DA, Bossuyt PM, et al. A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor. N Engl J Med. 2000;342(7):461–468.
  • Cooper I. Cryogenic cooling and freezing of the basal ganglia. Confin Neurol. 1962;22:336–340.
  • Brodkey JS, Miyazaki Y, Ervin FR, et al. Reversible heat lesions with radiofrequency current: a method of stereotactic localization. J Neurosurg. 1964;21(1):49–53.
  • Sapareto SA, Dewey WC. Thermal dose determination in cancer therapy. Int J Radiat Oncol Biol Phys. 1984;10(6):787–800.
  • Burchiel KJ. Thalamotomy for movement disorders. Neurosurg Clinics NA. 1995;6(1):55–71.
  • Jourdain VA, Schechtmann G. Health economics and surgical treatment for parkinson’s disease in a world perspective: results from an international survey. Stereotact Funct Neurosurg. 2014;92(2):71–79.
  • Nowinski WL, Liu J, Thirunavuukarasuu A. Quantification and visualization of three-dimensional inconsistency of the ventrointermediate nucleus of the thalamus in the Schaltenbrand-Wahren brain atlas. Acta Neurochir (Wien). 2008;150(7):647–653.
  • Zirh A, Reich SG, Dougherty PM, et al. Stereotactic thalamotomy in the treatment of essential tremor of the upper extremity: reassessment including a blinded measure of outcome. J Neurol Neurosurg. 1999;66(6):772–775.
  • Tomlinson FH, Jack CR, Kelly PJ. Sequential magnetic resonance imaging following stereotactic radiofrequency ventralis lateralis thalamotomy. J Neurosurg. 1991;74(4):579–584.
  • Schreglmann SR, Krauss JK, Chang JW, et al. Functional lesional neurosurgery for tremor: back to the future? J Neurol Neurosurg. 2018;89(7):727–735.
  • Pahwa R, Lyons KE, Wilkinson SB, et al. Comparison of thalamotomy to deep brain stimulation of the thalamus in essential tremor. Mov Disord. 2001;16(1):140–143.
  • Organ LW. Electrophysiologic principles of radiofrequency lesion making. Appl Neurophysiol. 1976;39(2):69–76.
  • Anderson VC, Burchiel KJ, Hart MJ, et al. A randomized comparison of thalamic stimulation and lesion on self-paced finger movement in essential tremor. Neurosci Lett. 2009;462(2):166–170.
  • Sasada S, Agari T, Sasaki T, et al. Efficacy of fiber tractography in the stereotactic surgery of the thalamus for patients with essential tremor. Neurol Med Chi (Tokyo). 2017;57(8):392–401.
  • Kim M, Jung NY, Park CK, et al. Comparative evaluation of magnetic resonance-guided focused ultrasound surgery for essential tremor. Stereotact Funct Neurosurg. 2017;95(4):279–286.
  • Larsson B, Leksell L, Rexed B, et al. The high-energy proton beam as a neurosurgical tool. Nature. 1958;182(4644):1222–1223.
  • DeVita VT Jr, Rosenberg SA. Two hundred years of cancer research. N Engl J Med. 2012;366(23):2207–2214.
  • Leksell L. Cerebral radiosurgery. I. Gammathalanotomy in two cases of intractable pain. Acta Chir Scand. 1968;134(8):585–595.
  • Leksell L. The stereotaxic method and radiosurgery of the brain. Acta Chir Scand. 1951;102(4):316–319.
  • Witjas T, Carron R, Krack P, et al. A prospective single-blind study of gamma knife thalamotomy for tremor. Neurology. 2015;85(18):1562–1568.•Prospective study of gamma knife thalamotomy for tremor.
  • Lim S-Y, Hodaie M, Fallis M, et al. Gamma knife thalamotomy for disabling tremor: a blinded evaluation. Arch Neurol. 2010;67(5):584–588.•Prospective study of gamma knife thalamotomy for tremor.
  • Higuchi Y, Matsuda S, Serizawa T. Gamma knife radiosurgery in movement disorders: indications and limitations. Mov Disord. 2016;32(1):28–35.
  • Niranjan A, Raju SS, Kooshkabadi A, et al. Stereotactic radiosurgery for essential tremor: retrospective analysis of a 19-year experience. Mov Disord. 2017;32(5):769–777.
  • Niranjan A, Raju SS, Monaco EA, et al. Is staged bilateral thalamic radiosurgery an option for otherwise surgically ineligible patients with medically refractory bilateral tremor? J Neurosurg. 2018;128(2):617–626.
  • Kondziolka D, Ong JG, Lee JYK, et al. Gamma knife thalamotomy for essential tremor. J Neurosurg. 2008;108(1):111–117.
  • Duma CM. Movement disorder radiosurgery–planning, physics and complication avoidance. Prog Neurol Surg. 2007;20:249–266.
  • Ohye C, Higuchi Y, Shibazaki T, et al. Gamma knife thalamotomy for parkinson disease and essential tremor: a prospective multicenter study. Neurosurgery. 2011;70(3):526–536.•Prospective study of gamma knife thalamotomy for tremor.
  • Friedman DP, Goldman HW, Flanders AE, et al. Stereotactic radiosurgical pallidotomy and thalamotomy with the gamma knife: MR imaging findings with clinical correlation–preliminary experience. Radiology. 1999;212(1):143–150.
  • Smith WP, Young LA, Phillips MH, et al. Clinical positioning accuracy for multisession stereotactic radiotherapy with the gamma knife perfexion. Technol Cancer Res Treat. 2017;16(6):893–899.
  • Ma L, Pinnaduwage D, McDermott M, et al. Whole-procedural radiological accuracy for delivering multi-session gamma knife radiosurgery with a relocatable frame system. Technol Cancer Res Treat. 2014;13(5):403–408.
  • Kim T, Sheehan J, Schlesinger D. Inter- and intrafractional dose uncertainty in hypofractionated Gamma Knife radiosurgery. J Appl Clin Med Phys. 2016;17(2):487–496.
  • Schlesinger D, Xu Z, Taylor F, et al. Interfraction and intrafraction performance of the gamma knife extend system for patient positioning and immobilization. J Neurosurg. 2012;117(Suppl(Special_Suppl)):217–224.
  • Levivier M, Gevaert T, Negretti L. Gamma knife, cyberknife, tomoTherapy. Curr Opin Neurol. 2011;24(6):616–625.
  • McTyre E, Helis CA, Farris M, et al. Emerging indications for fractionated gamma knife radiosurgery. Neurosurgery. 2017;80(2):210–216.
  • Witjas T, Carron R, Boutin E, et al. Essential tremor: update of therapeutic strategies (medical treatment and gamma knife thalamotomy). Rev Neurol (Paris). 2016;172(8–9):408–415.
  • Young RF, Jacques S, Mark R, et al. Gamma knife thalamotomy for treatment of tremor: long-term results. J Neurosurg. 2000;93(Suppl 3):128–135.
  • Young RF, Li F, Vermeulen S, et al. Gamma knife thalamotomy for treatment of essential tremor: long-term results. J Neurosurg. 2010;112(6):1311–1317.
  • Kooshkabadi A, Lunsford LD, Tonetti D, et al. Gamma knife thalamotomy for tremor in the magnetic resonance imaging era. J Neurosurg. 2013;118(4):713–718.
  • Cho KR, Kim HR, Im YS, et al. Outcome of gamma knife thalamotomy in patients with an intractable tremor. J Korean Neurosurg Soc. 2015;57(3):192–195.
  • Tuleasca C, Witjas T, Najdenovska E, et al. Assessing the clinical outcome of Vim radiosurgery with voxel-based morphometry: visual areas are linked with tremor arrest!, 1–6 (2017).
  • Benabid A-L, Chabardes S, Mitrofanis J, et al. Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson’s disease. Lancet Neurol. 2009;8(1):67–81.••Excellent review on effects of DBS in Parkinson.
  • Kochanski R, Sani S. Awake versus asleep deep brain stimulation surgery: technical considerations and critical review of the literature. Brain Sci. 2018;8(1):17.
  • Roth A, Buttrick SS, Cajigas I, et al. Accuracy of frame-based and frameless systems for deep brain stimulation: A meta-analysis. J Clin Neurosci. 2018;57:1–5.
  • Ho AL, Pendharkar AV, Brewster R, et al. Frameless robot-assisted deep brain stimulation surgery: an initial experience. Operative Neurosurg (Hagerstown). 2019;17(4):424–431.
  • Granziera C, Pollo C, Russmann H, et al. Sub-acute delayed failure of subthalamic DBS in Parkinson’s disease: the role of micro-lesion effect. Parkinsonism Related Disord. 2008;14(2):109–113.
  • Caparros-Lefebvre D, Ruchoux MM, Blond S, et al. Long-term thalamic stimulation in Parkinson’s disease: postmortem anatomoclinical study. Neurology. 1994;44(10):1856–1860.
  • Boockvar JA, Telfeian A, Baltuch GH, et al. Long-term deep brain stimulation in a patient with essential tremor: clinical response and postmortem correlation with stimulator termination sites in ventral thalamus. Case report. J Neurosurg. 2000;93(1):140–144.
  • Picillo M, Lozano AM, Kou N, et al. Programming deep brain stimulation for tremor and dystonia: the toronto western hospital algorithms. Brain Stimul. 2016;9(3):438–452.
  • Haddock A, Mitchell KT, Miller A, et al. Automated deep brain stimulation programming for tremor. IEEE Trans Neural Syst Rehabil Eng. 2018;26(8):1618–1625.
  • Tan H, Debarros J, He S, et al. Decoding voluntary movements and postural tremor based on thalamic LFPs as a basis for closed-loop stimulation for essential tremor. Brain Stimul. 2019;12(4):858–867.
  • Stanslaski S, Afshar P, Cong P, et al. Design and validation of a fully implantable, chronic, closed-loop neuromodulation device with concurrent sensing and stimulation. IEEE Trans Neural Syst Rehabil Eng. 2012;20(4):410–421.
  • Bittar RG, Burn SC, Bain PG, et al. Deep brain stimulation for movement disorders and pain. J Clin Neurosci. 2005;12(4):457–463.
  • Hubble JP, Busenbark KL, Wilkinson S, et al. Deep brain stimulation for essential tremor. Neurology. 1996;46(4):1150–1153.
  • Koller W, Pahwa R, Busenbark K, et al. High-frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor. Ann Neurol. 1997;42(3):292–299.
  • Ondo W, Jankovic J, Schwartz K, et al. Unilateral thalamic deep brain stimulation for refractory essential tremor and Parkinson’s disease tremor. Neurology. 1998;51(4):1063–1069.
  • Kumar K, Kelly M, Toth C. Deep brain stimulation of the ventral intermediate nucleus of the thalamus for control of tremors in Parkinson’s disease and essential tremor. Stereotact Funct Neurosurg. 1999;72(1):47–61.
  • Limousin P, Speelman JD, Gielen F, et al. Multicentre European study of thalamic stimulation in parkinsonian and essential tremor. J Neurol Neurosurg. 1999;66(3):289–296.
  • Ondo W, Almaguer M, Jankovic J, et al. Thalamic deep brain stimulation: comparison between unilateral and bilateral placement. Arch Neurol. 2001;58(2):218–222.
  • Koller WC, Lyons KE, Wilkinson SB, et al. Long‐term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor. Mov Disord. 2001;16(3):464–468.
  • Rehncrona S, Johnels B, Widner H, et al. Long-term efficacy of thalamic deep brain stimulation for tremor: double-blind assessments. Mov Disord. 2003;18(2):163–170.
  • Sydow O, Thobois S, Alesch F, et al. Multicentre European study of thalamic stimulation in essential tremor: a six year follow up. J Neurol Neurosurg. 2003;74(10):1387–1391.
  • Kiss ZHT, Wilkinson M, Krcek J, et al. Is the target for thalamic deep brain stimulation the same as for thalamotomy? Mov Disord. 2003;18(10):1169–1175.
  • Papavassiliou E, Rau G, Heath S, et al. Thalamic deep brain stimulation for essential tremor: relation of lead location to outcome. Neurosurgery. 2004;54(5):1120–1130.
  • Putzke JD, Wharen RE, Obwegeser AA, et al. Thalamic deep brain stimulation for essential tremor: recommendations for long-term outcome analysis. Can J Neurol Sci. 2004;31(3):333–342.
  • Pahwa R, Lyons KE, Wilkinson SB, et al. Long-term evaluation of deep brain stimulation of the thalamus. J Neurosurg. 2006;104(4):506–512.
  • Blomstedt P, Hariz GM, Hariz MI, et al. Thalamic deep brain stimulation in the treatment of essential tremor: a long-term follow-up. Br J Neurosurg. 2009;21(5):504–509.
  • Plaha P, Javed S, Agombar D, et al. Bilateral caudal zona incerta nucleus stimulation for essential tremor: outcome and quality of life. J Neurol Neurosurg. 2011;82(8):899–904.
  • Sandvik U, Koskinen L-O, Lundquist A, et al. Thalamic and subthalamic deep brain stimulation for essential tremor. Neurosurgery. 2011;70(4):840–846.
  • Fytagoridis A, Sandvik U, Åström M, et al. Long term follow-up of deep brain stimulation of the caudal zona incerta for essential tremor. J Neurol Neurosurg. 2012;83(3):258–262.
  • Favilla CG, Ullman D, Wagle Shukla A, et al. Worsening essential tremor following deep brain stimulation: disease progression versus tolerance. Brain. 2012;135(5):1455–1462.
  • Nazzaro JM, Pahwa R, Lyons KE. Erratum: long-term benefits in quality of life after unilateral thalamic deep brain stimulation for essential tremor. J Neurosurg. 2012;117(3):640–641.
  • Peng-Chen Z, Morishita T, Vaillancourt D, et al. Unilateral thalamic deep brain stimulation in essential tremor demonstrates long-term ipsilateral effects. Parkinsonism Related Disord. 2013;19(12):1113–1117.
  • Baizabal-Carvallo JF, Kagnoff MN, Jimenez-Shahed J, et al. The safety and efficacy of thalamic deep brain stimulation in essential tremor: 10 years and beyond. J Neurol Neurosurg. 2014;85(5):567–572.
  • Palareti G, Legnani C, Cosmi B, et al. Comparison between different D-Dimer cutoff values to assess the individual risk of recurrent venous thromboembolism: analysis of results obtained in the DULCIS study. Int Jnl Lab Hem. 2015;38(1):42–49.
  • Huss DS, Dallapiazza RF, Shah BB, et al. Functional assessment and quality of life in essential tremor with bilateral or unilateral DBS and focused ultrasound thalamotomy. Mov Disord. 2015;30(14):1937–1943.
  • Fenoy AJ, Schiess MC. Deep brain stimulation of the dentato-rubro-thalamic tract: outcomes of direct targeting for tremor. Neuromodulation: Technol Neural Interface. 2017;20(5):429–436.
  • Wharen REJ, Okun MS, Guthrie BL, et al. Thalamic DBS with a constant-current device in essential tremor: A controlled clinical trial. Parkinsonism Related Disord. 2017;40:18–26.
  • Cury RG, Fraix V, Castrioto A, et al. Thalamic deep brain stimulation for tremor in Parkinson disease, essential tremor, and dystonia. Neurology. 2017;89(13):1416–1423.
  • De Jesus S, Almeida L, Shahgholi L, et al. Square biphasic pulse deep brain stimulation for essential tremor: the BiP tremor study. Parkinsonism Related Disord. 2018;46:41–46.
  • Moldovan A-S, Hartmann CJ, Trenado C, et al. Less is more - Pulse width dependent therapeutic window in deep brain stimulation for essential tremor. Brain stimulation. 2018;11(5):1132–1139.
  • Paschen S, Forstenpointner J, Becktepe J, et al. Long-term efficacy of deep brain stimulation for essential tremor. Neurology. 2019;92(12):e1378–e1386.
  • Tsuboi T, Jabarkheel Z, Zeilman PR, et al. Longitudinal follow-up with VIM thalamic deep brain stimulation for dystonic or essential tremor. Neurology. 2020;94(10):e1073–e1084.
  • Obwegeser AA, Uitti RJ, Turk MF, et al. Thalamic stimulation for the treatment of midline tremors in essential tremor patients. Neurology. 2000;54(12):2342–2344.
  • Wintermark M, Druzgal J, Huss DS, et al. Imaging findings in MR imaging-guided focused ultrasound treatment for patients with essential tremor. Am J Neuroradiol. 2014;35(5):891–896.
  • Meng Y, Solomon B, Boutet A, et al. Magnetic resonance-guided focused ultrasound thalamotomy for treatment of essential tremor: A 2-year outcome study. Mov Disord. 2018;33(10):1647–1650.
  • Tempany CMC, McDannold NJ, Hynynen K, et al. Focused ultrasound surgery in oncology: overview and principles. Radiology. 2011;259(1):39–56.
  • Lynn JG, Zwemer RL, Chick AJ, et al. A new method for the generation and use of focused ultrasound in experimental biology. J Gen Physiol. 1942;26(2):179–193.
  • Fry WJ, Barnard JW, Fry FJ, et al. Ultrasonically produced localized selective lesions in the central nervous system. Am J Phys Med. 1955;34(3):413–423.
  • Fry WJ, Barnard JW, Fry EJ, et al. Ultrasonic lesions in the mammalian central nervous system. Science. 1955;122(3168):517–518.
  • Elias WJ, Huss D, Voss T, et al. A pilot study of focused ultrasound thalamotomy for essential tremor. N Engl J Med. 2013;369(7):640–648.
  • Quadri SA, Waqas M, Khan I, et al. High-intensity focused ultrasound: past, present, and future in neurosurgery. Neurosurg Focus. 2018;44(2):E16–9.
  • Krishna V, Sammartino F, Rezai A. A review of the current therapies, challenges, and future directions of transcranial focused ultrasound technology. JAMA Neurol. 2018;75(2):246–249.
  • Clarke RL, Haar Ter GR. Temperature rise recorded during lesion formation by high-intensity focused ultrasound. Ultrasound Med Biol. 1997;23(2):299–306.
  • Rohani M, Fasano A. Focused ultrasound for essential tremor: review of the evidence and discussion of current hurdles. Tremor Other Hyperkinet Mov (N Y). 2017;7:462.•Excellent review of focused ultrasound for essential tremor.
  • Gallay MN, Moser D, Rossi F, et al. Incisionless transcranial MR-guided focused ultrasound in essential tremor: cerebellothalamic tractotomy. J Ther Ultrasound. 2016 Feb 13;4:5.
  • Chang WS, Jung HH, Kweon EJ, et al. Unilateral magnetic resonance guided focused ultrasound thalamotomy for essential tremor: practices and clinicoradiological outcomes. J Neurol Neurosurg. 2015;86(3):257–264.
  • Elias WJ, Lipsman N, Ondo WG, et al. A randomized trial of focused ultrasound thalamotomy for essential tremor. N Engl J Med. 2016;375(8):730–739.
  • Schreglmann SR, Bauer R, Hägele-Link S, et al. Unilateral cerebellothalamic tract ablation in essential tremor by MRI-guided focused ultrasound. Neurology. 2017;88(14):1329–1333.
  • Tam F, Huang Y, Schwartz ML, et al. A computerized tablet system for evaluating treatment of essential tremor by magnetic resonance guided focused ultrasound. 1–7 (2017).
  • Zaaroor M, Sinai A, Goldsher D, et al. Magnetic resonance–guided focused ultrasound thalamotomy for tremor: a report of 30 Parkinson’s disease and essential tremor cases. J Neurosurg. 2017;128(1):202–210.
  • Chang JW, Park CK, Lipsman N, et al. A prospective trial of magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: results at the 2-year follow-up. Ann Neurol. 2018;83(1):107–114.•A Prospective study offocused ultrasound thalamotomy for essential tremor with a long-term (2-year) follow-up.
  • Boutet A, Ranjan M, Zhong J, et al. Focused ultrasound thalamotomy location determines clinical benefits in patients with essential tremor. Brain. 2018;141(12):3405–3414.
  • Schuurman PR, Bosch DA, Merkus MP, et al. Long-term follow-up of thalamic stimulation versus thalamotomy for tremor suppression. Mov Disord. 2008;23(8):1146–1153.
  • Shih LC, LaFaver K, Lim C, et al. Loss of benefit in VIM thalamic deep brain stimulation (DBS) for essential tremor (ET): how prevalent is it? Parkinsonism Related Disord. 2013;19(7):676–679.
  • Fasano A, Helmich RC. Tremor habituation to deep brain stimulation: underlying mechanisms and solutions. Mov Disord. 2019;34(12):1761–1773.
  • Kronenbuerger M, Fromm C, Block F, et al. On-demand deep brain stimulation for essential tremor: A report on four cases. Mov Disord. 2005;21(3):401–405.
  • Garcia Ruiz P, Muñiz de Igneson J, Lopez Ferro O, et al. Deep brain stimulation holidays in essential tremor. J Neurol. 2001;248(8):725–726.
  • Speelman JD, Schuurman R, de Bie RMA, et al. Stereotactic neurosurgery for tremor. Mov Disord. 2002;17(Suppl 3):S84–8.
  • Mitchell KT, Larson P, Starr PA, et al. Benefits and risks of unilateral and bilateral ventral intermediate nucleus deep brain stimulation for axial essential tremor symptoms. Parkinsonism Related Disord. 2019;60:126–132.
  • Levi V, Eleopra R, Franzini A, et al. Is deep brain stimulation still an option for tremor recurrence after focused ultrasound thalamotomy? A case report. J Clin Neurosci. 2019;68:344–346.

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