Treatment of cardiac resynchronization therapy non-responders: current approaches and new frontiers

References

• Brignole M, Auricchio A, Baron-Esquivias G, et al. 2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: the task force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). Eur Heart J. 2013 Aug;34(29):2281–2329.
   PubMed Web of Science ®Google Scholar
• Bradley DJ, Bradley EA, Baughman KL, et al. Cardiac resynchronization and death from progressive heart failure: a meta-analysis of randomized controlled trials. JAMA. 2003 Feb 12;289(6):730–740.
   PubMed Web of Science ®Google Scholar
• Cleland JG, Daubert JC, Erdmann E, et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med. 2005 Apr 14;352(15):1539–1549.
   PubMed Web of Science ®Google Scholar
• Holzmeister J, Leclercq C. Implantable cardioverter defibrillators and cardiac resynchronisation therapy. Lancet. 2011 Aug 20;378(9792):722–730.
   PubMed Web of Science ®Google Scholar
• Vanderheyden M, Mullens W, Delrue L, et al. Myocardial gene expression in heart failure patients treated with cardiac resynchronization therapy responders versus nonresponders. J Am Coll Cardiol. 2008 Jan 15;51(2):129–136.
   PubMed Web of Science ®Google Scholar
• European Heart Rhythm A, European Society of C, Heart Rhythm S. et al. 2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management. Europace. 2012 Sep;14(9):1236–1286.
   PubMed Web of Science ®Google Scholar
• Mullens W, Grimm RA, Verga T, et al. Insights from a cardiac resynchronization optimization clinic as part of a heart failure disease management program. J Am Coll Cardiol. 2009 Mar 3;53(9):765–773.
   PubMed Web of Science ®Google Scholar
• Maass AH, Vernooy K, Cramer MJ, et al. Refining success of cardiac resynchronization therapy using a simple score predicting the amount of reverse ventricular remodelling: results from the MARC study authors reply. Europace. 2018 Feb 1;20(2):393.
   PubMed Web of Science ®Google Scholar
• Woo GW, Petersen-Stejskal S, Johnson JW, et al. Ventricular reverse remodeling and 6-month outcomes in patients receiving cardiac resynchronization therapy: analysis of the MIRACLE study. J Interv Card Electrophysiol. 2005 Mar;12(2):107–113.
   PubMed Web of Science ®Google Scholar
• Barsheshet A, Goldenberg I, Moss AJ, et al. Response to preventive cardiac resynchronization therapy in patients with ischaemic and nonischaemic cardiomyopathy in MADIT-CRT. Eur Heart J. 2011 Jul;32(13):1622–1630.
   PubMed Web of Science ®Google Scholar
• White JA, Yee R, Yuan X, et al. Delayed enhancement magnetic resonance imaging predicts response to cardiac resynchronization therapy in patients with intraventricular dyssynchrony. J Am Coll Cardiol. 2006 Nov 21;48(10):1953–1960.
   PubMed Web of Science ®Google Scholar
• Bleeker GB, Kaandorp TA, Lamb HJ, et al. Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy. Circulation. 2006 Feb 21;113(7):969–976.
   PubMed Web of Science ®Google Scholar
• Grines CL, Bashore TM, Boudoulas H, et al. Functional abnormalities in isolated left bundle branch block the effect of interventricular asynchrony. Circulation. 1989 Apr;79(4):845–853.
   PubMed Web of Science ®Google Scholar
• Singh JP, Gras D. Biventricular pacing: current trends and future strategies. Eur Heart J. 2012 Feb;33(3):305–313.
   PubMed Web of Science ®Google Scholar
• Moss AJ, Hall WJ, Cannom DS, et al. Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med. 2009 Oct 1;361(14):1329–1338.
   PubMed Web of Science ®Google Scholar
• Ponikowski P, Voors AA, Anker SD, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016 Jul 14;37(27):2129–2200.
   PubMed Web of Science ®Google Scholar
• Epstein AE, DiMarco JP, Ellenbogen KA, et al. 2012 ACCF/AHA/HRS focused update incorporated into the ACCF/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2013 Jan 22;61(3):e6–75.
   PubMed Web of Science ®Google Scholar
• Auricchio A, Fantoni C, Regoli F, et al. Characterization of left ventricular activation in patients with heart failure and left bundle-branch block. Circulation. 2004 Mar 9;109(9):1133–1139.
   PubMed Web of Science ®Google Scholar
• Peichl P, Kautzner J, Cihak R, et al. The spectrum of inter- and intraventricular conduction abnormalities in patients eligible for cardiac resynchronization therapy. Pacing Clin Electrophysiol. 2004 Aug;27(8):1105–1112.
   PubMed Web of Science ®Google Scholar
• van Stipdonk AMW, Vanbelle S, Ter Horst IAH, et al. Large variability in clinical judgement and definitions of left bundle branch block to identify candidates for cardiac resynchronisation therapy. Int J Cardiol. 2019 Jul 1;286:61–65.
   PubMed Web of Science ®Google Scholar
• van Stipdonk Amw, Ter Horst I, Kloosterman M, et al. QRS area is a strong determinant of outcome in cardiac resynchronization therapy. Circ Arrhythm Electrophysiol. 2018 Dec;11(12):e006497.
   PubMed Web of Science ®Google Scholar
• Mafi Rad M, Wijntjens GW, Engels EB, et al. Vectorcardiographic QRS area identifies delayed left ventricular lateral wall activation determined by electroanatomic mapping in candidates for cardiac resynchronization therapy. Heart Rhythm. 2016 Jan;13(1):217–225.
   PubMed Web of Science ®Google Scholar
• van Deursen CJ, Vernooy K, Dudink E, et al. Vectorcardiographic QRS area as a novel predictor of response to cardiac resynchronization therapy. J Electrocardiol. 2015 Jan-Feb;48(1):45–52.
   PubMed Web of Science ®Google Scholar
• Ruschitzka F, Abraham WT, Singh JP, et al. Cardiac-resynchronization therapy in heart failure with a narrow QRS complex. N Engl J Med. 2013 Oct 10;369(15):1395–1405.
   PubMed Web of Science ®Google Scholar
• Auricchio A, Abraham WT. Cardiac resynchronization therapy: current state of the art: cost versus benefit. Circulation. 2004 Jan 27;109(3):300–307.
   PubMed Web of Science ®Google Scholar
• Singh JP, Klein HU, Huang DT, et al. Left ventricular lead position and clinical outcome in the multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT) trial. Circulation. 2011 Mar 22;123(11):1159–1166.
   PubMed Web of Science ®Google Scholar
• European Society of C, European Heart Rhythm A, Brignole M. et al. 2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: the task force on cardiac pacing and resynchronization therapy of the European society of cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). Europace. 2013 Aug;15(8):1070–1118.
   Google Scholar
• Roubicek T, Wichterle D, Kucera P, et al. Left ventricular lead electrical delay is a predictor of mortality in patients with cardiac resynchronization therapy. Circ Arrhythm Electrophysiol. 2015 Oct;8(5):1113–1121.
   PubMed Web of Science ®Google Scholar
• Gold MR, Birgersdotter-Green U, Singh JP, et al. The relationship between ventricular electrical delay and left ventricular remodelling with cardiac resynchronization therapy. Eur Heart J. 2011 Oct;32(20):2516–2524.
   PubMed Web of Science ®Google Scholar
• Singh JP, Berger RD, Doshi RN, et al. Targeted left ventricular lead implantation strategy for non-left bundle branch block patients: the ENHANCE CRT Study. JACC Clin Electrophysiol. 2020 Sep;6(9):1171–1181.
   PubMedGoogle Scholar
• Khan FZ, Virdee MS, Palmer CR, et al. Targeted left ventricular lead placement to guide cardiac resynchronization therapy: the TARGET study: a randomized, controlled trial. J Am Coll Cardiol. 2012 Apr 24;59(17):1509–1518.
   PubMed Web of Science ®Google Scholar
• Leyva F, Foley PW, Chalil S, et al. Cardiac resynchronization therapy guided by late gadolinium-enhancement cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2011 Jun 13;13(1):29.
   PubMed Web of Science ®Google Scholar
• Sommer A, Kronborg MB, Norgaard BL, et al. Multimodality imaging-guided left ventricular lead placement in cardiac resynchronization therapy: a randomized controlled trial. Eur J Heart Fail. 2016 Nov;18(11):1365–1374.
   PubMed Web of Science ®Google Scholar
• Saba S, Marek J, Schwartzman D, et al. Echocardiography-guided left ventricular lead placement for cardiac resynchronization therapy: results of the speckle tracking assisted resynchronization therapy for electrode region trial. Circ Heart Fail. 2013 May;6(3):427–434.
   PubMed Web of Science ®Google Scholar
• Hayes DL, Boehmer JP, Day JD, et al. Cardiac resynchronization therapy and the relationship of percent biventricular pacing to symptoms and survival. Heart Rhythm. 2011 Sep;8(9):1469–1475.
   PubMed Web of Science ®Google Scholar
• Lubitz SA, Singh JP. Biventricular pacing: more is better. Eur Heart J. 2015 Feb 14;36(7):407–409.
   PubMed Web of Science ®Google Scholar
• Koplan BA, Kaplan AJ, Weiner S, et al. Heart failure decompensation and all-cause mortality in relation to percent biventricular pacing in patients with heart failure: is a goal of 100% biventricular pacing necessary? J Am Coll Cardiol. 2009 Jan 27;53(4):355–360.
   PubMed Web of Science ®Google Scholar
• Ruwald MH, Mittal S, Ruwald AC, et al. Association between frequency of atrial and ventricular ectopic beats and biventricular pacing percentage and outcomes in patients with cardiac resynchronization therapy. J Am Coll Cardiol. 2014 Sep 9;64(10):971–981.
   PubMed Web of Science ®Google Scholar
• Upadhyay GA, Steinberg JS. Managing atrial fibrillation in the CRT patient: controversy or consensus? Heart Rhythm. 2012 Aug;9(8):S51–9.
   PubMed Web of Science ®Google Scholar
• Rienstra M, Damman K, Mulder BA, et al. Beta-blockers and outcome in heart failure and atrial fibrillation: a meta-analysis. JACC Heart Fail. 2013 Feb;1(1):21–28.
   PubMed Web of Science ®Google Scholar
• Plummer CJ, Frank CM, Bari Z, et al. A novel algorithm increases the delivery of effective cardiac resynchronization therapy during atrial fibrillation: the CRTee randomized crossover trial. Heart Rhythm. 2018 Mar;15(3):369–375.
   PubMed Web of Science ®Google Scholar
• Marrouche NF, Kheirkhahan M, Brachmann J. Catheter ablation for atrial fibrillation with heart failure. N Engl J Med. 2018 Aug 2;379(5):492.
   PubMedGoogle Scholar
• Gasparini M, Leclercq C, Lunati M, et al. Cardiac resynchronization therapy in patients with atrial fibrillation: the CERTIFY study (cardiac resynchronization therapy in atrial fibrillation patients multinational registry). JACC Heart Fail. 2013 Dec;1(6):500–507.
   PubMed Web of Science ®Google Scholar
• Herczku C, Kun C, Edes I, et al. Radiofrequency catheter ablation of premature ventricular complexes improved left ventricular function in a non-responder to cardiac resynchronization therapy. Europace. 2007 May;9(5):285–288.
   PubMed Web of Science ®Google Scholar
• Bulava A, Heinc P, Hutyra M, et al. Case report: symptoms of advanced heart failure–a case for radiofrequency catheter ablation? J Interv Card Electrophysiol. 2006 Aug;16(2):117–122.
   PubMed Web of Science ®Google Scholar
• Lakkireddy D, Di Biase L, Ryschon K, et al. Radiofrequency ablation of premature ventricular ectopy improves the efficacy of cardiac resynchronization therapy in nonresponders. J Am Coll Cardiol. 2012 Oct 16;60(16):1531–1539.
   PubMed Web of Science ®Google Scholar
• Gold MR, Niazi I, Giudici M, et al. A prospective comparison of AV delay programming methods for hemodynamic optimization during cardiac resynchronization therapy. J Cardiovasc Electrophysiol. 2007 May;18(5):490–496.
   PubMed Web of Science ®Google Scholar
• Ellenbogen KA, Gold MR, Meyer TE, et al. Primary results from the SmartDelay determined AV optimization: a comparison to other AV delay methods used in cardiac resynchronization therapy (SMART-AV) trial: a randomized trial comparing empirical, echocardiography-guided, and algorithmic atrioventricular delay programming in cardiac resynchronization therapy. Circulation. 2010 Dec 21;122(25):2660–2668.
   PubMed Web of Science ®Google Scholar
• Brenyo A, Kutyifa V, Moss AJ, et al. Atrioventricular delay programming and the benefit of cardiac resynchronization therapy in MADIT-CRT. Heart Rhythm. 2013 Aug;10(8):1136–1143.
   PubMed Web of Science ®Google Scholar
• Gold MR, Yu Y, Singh JP, et al. The effect of left ventricular electrical delay on AV optimization for cardiac resynchronization therapy. Heart Rhythm. 2013 Jul;10(7):988–993.
   PubMed Web of Science ®Google Scholar
• Fischer A, Hansalia R, Buckley S, et al. Lack of clinical predictors of optimal V-V delay in patients with cardiac resynchronization devices. J Interv Card Electrophysiol. 2009 Aug;25(2):153–158.
   PubMed Web of Science ®Google Scholar
• Boriani G, Biffi M, Muller CP, et al. A prospective randomized evaluation of VV delay optimization in CRT-D recipients: echocardiographic observations from the RHYTHM II ICD study. Pacing Clin Electrophysiol. 2009 Mar;32(1):S120–5.
   PubMedGoogle Scholar
• Boriani G, Muller CP, Seidl KH, et al. Randomized comparison of simultaneous biventricular stimulation versus optimized interventricular delay in cardiac resynchronization therapy the resynchronization for the hemodynamic treatment for heart failure management II implantable cardioverter defibrillator (RHYTHM II ICD) study. Am Heart J. 2006 May;151(5):1050–1058.
   PubMed Web of Science ®Google Scholar
• Singh JP, Cha YM, Lunati M, et al. Real-world behavior of CRT pacing using the AdaptivCRT algorithm on patient outcomes: effect on mortality and atrial fibrillation incidence. J Cardiovasc Electrophysiol. 2020 Apr;31(4):825–833.
   PubMed Web of Science ®Google Scholar
• Gasparini M, Birnie D, Lemke B, et al. Adaptive cardiac resynchronization therapy reduces atrial fibrillation incidence in heart failure patients with prolonged av conduction: the adaptive crt randomized trial. Circ Arrhythm Electrophysiol. 2019 May;12(5):e007260.
   PubMed Web of Science ®Google Scholar
• Brugada J, Delnoy PP, Brachmann J, et al. Contractility sensor-guided optimization of cardiac resynchronization therapy: results from the RESPOND-CRT trial. Eur Heart J. 2017 Mar 7;38(10):730–738.
   PubMed Web of Science ®Google Scholar
• Leclercq C, Burri H, Curnis A, et al. Cardiac resynchronization therapy non-responder to responder conversion rate in the more response to cardiac resynchronization therapy with multipoint pacing (MORE-CRT MPP) study: results from phase I. Eur Heart J. 2019 Sep 14;40(35):2979–2987.
   PubMed Web of Science ®Google Scholar
• Thibault B, Dubuc M, Khairy P, et al. Acute haemodynamic comparison of multisite and biventricular pacing with a quadripolar left ventricular lead. Europace. 2013 Jul;15(7):984–991.
   PubMed Web of Science ®Google Scholar
• Pappone C, Calovic Z, Vicedomini G, et al. Multipoint left ventricular pacing improves acute hemodynamic response assessed with pressure-volume loops in cardiac resynchronization therapy patients. Heart Rhythm. 2014 Mar;11(3):394–401.
   PubMed Web of Science ®Google Scholar
• Rinaldi CA, Kranig W, Leclercq C, et al. Acute effects of multisite left ventricular pacing on mechanical dyssynchrony in patients receiving cardiac resynchronization therapy. J Card Fail. 2013 Nov;19(11):731–738.
   PubMed Web of Science ®Google Scholar
• Clementy N, Bernard-Brunet A, Pierre B, et al. Successful ‘quadrangular’ pacing in a non-responder patient to cardiac resynchronization therapy. Eur Heart J. 2011 Sep;32(17):2215.
   PubMed Web of Science ®Google Scholar
• Providencia R, Rogers D, Papageorgiou N, et al. Long-Term results of triventricular versus biventricular pacing in heart failure: a propensity-matched comparison. JACC Clin Electrophysiol. 2016 Dec;2(7):825–835.
   PubMedGoogle Scholar
• Chapman M, Bates MGD, Behar JM, et al. A novel quadripolar active fixation left-ventricular pacing lead for cardiac resynchronization therapy: initial United Kingdom experience. JACC Clin Electrophysiol. 2019 Sep;5(9):1028–1035.
   PubMedGoogle Scholar
• Auricchio A, Prinzen FW. Enhancing response in the cardiac resynchronization therapy patient: the 3B perspective-bench, bits, and bedside. JACC Clin Electrophysiol. 2017 Nov;3(11):1203–1219.
   PubMedGoogle Scholar
• Teng AE, Lustgarten DL, Vijayaraman P, et al. Usefulness of his bundle pacing to achieve electrical resynchronization in patients with complete left bundle branch block and the relation between native QRS axis, duration, and normalization. Am J Cardiol. 2016 Aug 15;118(4):527–534.
   PubMed Web of Science ®Google Scholar
• Ajijola OA, Upadhyay GA, Macias C, et al. Permanent His-bundle pacing for cardiac resynchronization therapy: initial feasibility study in lieu of left ventricular lead. Heart Rhythm. 2017 Sep;14(9):1353–1361.
   PubMed Web of Science ®Google Scholar
• Rademakers LM, van Hunnik A, Kuiper M, et al. A possible role for pacing the left ventricular septum in cardiac resynchronization therapy. JACC Clin Electrophysiol. 2016 Aug;2(4):413–422.
   PubMedGoogle Scholar
• Huang W, Wu S, Vijayaraman P, et al. Cardiac resynchronization therapy in patients with nonischemic cardiomyopathy using left bundle branch pacing. JACC Clin Electrophysiol. 2020 Jul;6(7):849–858.
   PubMedGoogle Scholar
• Reddy VY, Miller MA, Neuzil P, et al. Cardiac resynchronization therapy with wireless left ventricular endocardial pacing: the SELECT-LV study. J Am Coll Cardiol. 2017 May 2;69(17):2119–2129.
   PubMed Web of Science ®Google Scholar
• Singh JP, Abraham WT, Auricchio A, et al. Design and rationale for the stimulation of the left ventricular endocardium for cardiac resynchronization therapy in non-responders and previously untreatable patients (SOLVE-CRT) trial. Am Heart J. 2019 Nov;217:13–22.
   PubMed Web of Science ®Google Scholar
• Singh JP. Electrical therapy for advanced heart failure: is it time for a multidisciplinary approach or a new subspecialty? Expert Rev Cardiovasc Ther. 2007 Sep;5(5):811–815.
   PubMedGoogle Scholar
• Altman RK, Parks KA, Schlett CL, et al. Multidisciplinary care of patients receiving cardiac resynchronization therapy is associated with improved clinical outcomes. Eur Heart J. 2012 Sep;33(17):2181–2188.
   PubMed Web of Science ®Google Scholar
• Boehmer JP, Hariharan R, Devecchi FG, et al. A multisensor algorithm predicts heart failure events in patients with implanted devices: results from the multiSENSE study. JACC Heart Fail. 2017 Mar;5(3):216–225.
   PubMed Web of Science ®Google Scholar
• Whellan DJ, Ousdigian KT, Al-Khatib SM, et al. Combined heart failure device diagnostics identify patients at higher risk of subsequent heart failure hospitalizations: results from PARTNERS HF (program to access and review trending information and evaluate correlation to symptoms in patients with heart failure) study. J Am Coll Cardiol. 2010 Apr 27;55(17):1803–1810.
   PubMed Web of Science ®Google Scholar
• Cowie MR, Sarkar S, Koehler J, et al. Development and validation of an integrated diagnostic algorithm derived from parameters monitored in implantable devices for identifying patients at risk for heart failure hospitalization in an ambulatory setting. Eur Heart J. 2013 Aug;34(31):2472–2480.
   PubMed Web of Science ®Google Scholar