Long axial field-of-view PET/CT devices: are we ready for the technological revolution?

References

• Cal-Gonzalez J, Rausch I, Shiyam Sundar LK, et al. Hybrid imaging: instrumentation and data processing. Front Phys. 2018;6:47.
   Web of Science ®Google Scholar
• Filippi L, Biancone L, Petruzziello C, et al. Tc-99m HMPAO-labeled leukocyte scintigraphy with hybrid SPECT/CT detects perianal fistulas in crohn disease. Clin Nucl Med. 2006;31(9):541–542.
   PubMed Web of Science ®Google Scholar
• Ell PJ, Kayani I, Groves AM. 18F-fluorodeoxyglucose PET/CT in cancer imaging. Clin Med. 2006;6(3):240–244.
   PubMed Web of Science ®Google Scholar
• Hammes J, Bischof GN, Drzezga A. Molecular imaging in early diagnosis, differential diagnosis and follow-up of patients with neurodegenerative diseases. Clin Transl Imaging. 2017;5(5):465–471.
   Web of Science ®Google Scholar
• Filippi L, Scopinaro F, Pelle G, et al. Molecular response assessed by 68Ga-DOTANOC and survival after 90Y microsphere therapy in patients with liver metastases from neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2016;43(3):432–440.
   PubMed Web of Science ®Google Scholar
• Surti S. Update on Time-of-Flight PET Imaging. J Nucl Med. 2015;56(1):98–105.
   PubMed Web of Science ®Google Scholar
• Fabbri A, Cencelli VO, Bennati P, et al. Dual isotope imaging with LaBr3: cecrystal and H8500 PSPMT. J Inst. 2013;8. C02022–C02022.
   Web of Science ®Google Scholar
• Gundacker S, Heering A. The silicon photomultiplier: fundamentals and applications of a modern solid-state photon detector. Phys Med Biol. 2020;65(17):17TR01.
   PubMed Web of Science ®Google Scholar
• Filippi L, Schillaci O. Digital PET and detection of recurrent prostate cancer: what have we gained, and what is still missing? Expert Rev Med Devices. 2021;18(11):1107–1110.
   PubMed Web of Science ®Google Scholar
• Alberts I, Prenosil G, Sachpekidis C, et al., Digital versus analogue PET in [68Ga]Ga-PSMA-11 PET/CT for recurrent prostate cancer: a matched-pair comparison. Eur J Nucl Med Mol Imaging. 2020;47(3):614–623.
   PubMed Web of Science ®Google Scholar
• Jakoby BW, Bercier Y, Conti M, et al. Physical and clinical performance of the mCT time-of-flight PET/CT scanner. Phys Med Biol. 2011;56(8):2375–2389.
   PubMed Web of Science ®Google Scholar
• Rausch I, Cal-González J, Dapra D, et al. Performance evaluation of the Biograph mCT Flow PET/CT system according to the NEMA NU2-2012 standard. EJNMMI Phys. 2015;2(1):26.
   PubMedGoogle Scholar
• Carlier T, Ferrer L, Conti M, et al. From a PMT-based to a SiPM-based PET system: a study to define matched acquisition/reconstruction parameters and NEMA performance of the biograph vision 450. EJNMMI Physics. 2020;7(1):55.
   PubMed Web of Science ®Google Scholar
• van Sluis J, de Jong J, Schaar J, et al. Performance characteristics of the digital biograph vision PET/CT system. J Nucl Med. 2019;60(7):1031–1036.
   PubMed Web of Science ®Google Scholar
• Alberts I, Sachpekidis C, Prenosil G, et al. Digital PET/CT allows for shorter acquisition protocols or reduced radiopharmaceutical dose in [18F]-FDG PET/CT. Ann Nucl Med. 2021;35(4):485–492.
   PubMed Web of Science ®Google Scholar
• Siman W, Kappadath SC. Comparison of step-and-shoot and continuous-bed-motion PET modes of acquisition for limited-view organ scans. J Nucl Med Technol. 2017;45(4):290–296.
   PubMed Web of Science ®Google Scholar
• Katal S, Eibschutz LS, Saboury B, et al. Advantages and applications of total-body PET scanning. Diagnostics. 2022;12(2):426.
   Web of Science ®Google Scholar
• Pantel AR, Viswanath V, Daube-Witherspoon ME, et al. PennPET explorer: human imaging on a whole-body imager. J Nucl Med. 2020;61(1):144–151.
   PubMed Web of Science ®Google Scholar
• Prenosil GA, Sari H, Fürstner M, et al. Performance characteristics of the biograph vision quadra PET/CT system with a long axial field of view using the NEMA NU 2-2018 standard. J Nucl Med. 2022;63(3):476–484.
   PubMed Web of Science ®Google Scholar
• Spencer BA, Berg E, Schmall JP, et al. Performance evaluation of the uEXPLORER total-body PET/CT scanner based on NEMA NU 2-2018 with additional tests to characterize PET scanners with a long axial field of view. J Nucl Med. 2021;62(6):861–870.
   PubMed Web of Science ®Google Scholar
• Carvalho KC, Cunha IW, Rocha RM, et al. GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker. Clinics. 2011;66(6):965–972.
   PubMed Web of Science ®Google Scholar
• Hu Y, Liu G, Yu H, et al. Diagnostic performance of total-body 18F-FDG PET/CT with fast 2-min acquisition for liver tumours: comparison with conventional PET/CT. Eur J Nucl Med Mol Imaging. 2022;49(10):3538–3546.
   PubMed Web of Science ®Google Scholar
• Mohammadi N, Akhlaghi P. Evaluation of radiation dose to pediatric models from whole body PET/CT imaging. J Applied Clin Med Phys. 2022;23(4). DOI:10.1002/acm2.13545.
   PubMed Web of Science ®Google Scholar
• Chen W, Liu L, Li Y, et al. Evaluation of pediatric malignancies using total-body PET/CT with half-dose [18F]-FDG. Eur J Nucl Med Mol Imaging. 2022;49(12):4145–4155.
   PubMed Web of Science ®Google Scholar
• Dimitrakopoulou-Strauss A, Pan L, Sachpekidis C. Parametric imaging with dynamic PET for oncological applications: protocols, interpretation, current applications and limitations for clinical use. Semin Nucl Med. 2022;52:312–329.
   Google Scholar
• Dimitrakopoulou-Strauss A, Pan L, Sachpekidis C. Kinetic modeling and parametric imaging with dynamic PET for oncological applications: general considerations, current clinical applications, and future perspectives. Eur J Nucl Med Mol Imaging. 2021;48(1):21–39.
   PubMed Web of Science ®Google Scholar
• Wang D, Zhang X, Liu H, et al., Assessing dynamic metabolic heterogeneity in non-small cell lung cancer patients via ultra-high sensitivity total-body [18F]FDG PET/CT imaging: quantitative analysis of [18F]FDG uptake in primary tumors and metastatic lymph nodes. Eur J Nucl Med Mol Imaging. 2022;49(13): 4692–4704.
   PubMed Web of Science ®Google Scholar
• Yu H, Gu Y, Fan W, et al. Expert consensus on oncological [18F]FDG total-body PET/CT imaging (version 1). Eur Radiol. 2022. DOI:10.1007/s00330-022-08960-8.
   Web of Science ®Google Scholar
• Filippi L, Chiaravalloti A, Schillaci O, et al. The potential of PSMA-targeted alpha therapy in the management of prostate cancer. Expert Rev Anticancer Ther. 2020;20(10):823–829.
   PubMed Web of Science ®Google Scholar
• Fendler WP, Bluemel C, Czernin J, et al. PET imaging in prostate cancer, future trends: PSMA ligands. Clin Transl Imaging. 2016;4(6):467–472.
   Google Scholar
• Alberts I, Sachpekidis C, Gourni E, et al. Dynamic patterns of [68Ga]Ga-PSMA-11 uptake in recurrent prostate cancer lesions. Eur J Nucl Med Mol Imaging. 2020;47(1):160–167.
   PubMed Web of Science ®Google Scholar
• Alberts I, Prenosil G, Mingels C, et al. Feasibility of late acquisition [68Ga]Ga-PSMA-11 PET/CT using a long axial field-of-view PET/CT scanner for the diagnosis of recurrent prostate cancer—first clinical experiences. Eur J Nucl Med Mol Imaging. 2021;48(13):4456–4462.
   PubMed Web of Science ®Google Scholar
• Strauss DS, Sachpekidis C, Kopka K, et al. Pharmacokinetic studies of [68 Ga]Ga-PSMA-11 in patients with biochemical recurrence of prostate cancer: detection, differences in temporal distribution and kinetic modelling by tissue type. Eur J Nucl Med Mol Imaging. 2021;48(13):4472–4482.
   PubMed Web of Science ®Google Scholar
• Wahl RL, Dilsizian V, Palestro CJ. At Last, 18 F-FDG for Inflammation and Infection! J Nucl Med. 2021;62(8):1048–1049.
   PubMed Web of Science ®Google Scholar
• Abdelhafez Y, Raychaudhuri SP, Mazza D, et al. Total-Body 18 F-FDG PET/CT in autoimmune inflammatory arthritis at ultra-low dose: initial observations. J Nucl Med. 2022;63(10):1579–1585.
   PubMed Web of Science ®Google Scholar
• Slart RHJA, Tsoumpas C, Glaudemans AWJM, et al. Long axial field of view PET scanners: a road map to implementation and new possibilities. Eur J Nucl Med Mol Imaging. 2021;48(13):4236–4245.
   PubMed Web of Science ®Google Scholar
• Xiao J, Yu H, Sui X, et al. Can the BMI-based dose regimen be used to reduce injection activity and to obtain a constant image quality in oncological patients by 18F-FDG total-body PET/CT imaging? Eur J Nucl Med Mol Imaging. 2021;49(1):269–278.
   PubMed Web of Science ®Google Scholar