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Surrogate markers

MRS

&
Pages 111-114 | Published online: 10 Jul 2009

References

  • Kalra S, Arnold DL, Cashman NR. Biological markers in the diagnosis and treatment of ALS. J Neurol Sci 1999; 165 (Suppl 1): S27–32.
  • Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience 1991; 45(1): 37–45.
  • Moffett JR, Namboodiri MA, Cangro CB, Neale JH. Immuno- histochemical localization of N-acetylaspartate in rat brain. Neuroreport 1991; 2(3): 131–134.
  • Battistuta J, Bjartmar C, Trapp BD. Post mortem degradation of N-acetyl aspartate and N-acetyl aspartylglutamate: an HPLC analysis of different rat CNS regions. Neurochem Res 2001; 26(6): 695–702.
  • Pioro EP, Antel JP, Cashman NR, Arnold DL. Detection of cortical neuron loss in motor neuron disease by proton magnetic resonance spectroscopic imaging in vivo. Neurology 1994; 44(10): 1933–1938.
  • Jones AP, Gunawardena WJ, Coutinho CM, Gatt JA, Shaw IC, Mitchell JD. Preliminary results of proton magnetic resonance- spectroscopy in motor neuron disease (amytrophic lateral sclerosis). J Neurol Sci 1995; 129 (suppl): 85–89.
  • Giroud M, Walker P, Bernard D et al. Reduced brain N-acetyl-aspartate in frontal lobes suggests neuronal loss in patients with amyotrophic lateral sclerosis. Neurological Research 1996; 18(3): 241–243.
  • Gredal O, Rosenbaum S, Topp S, Karlsborg M, Strange P, Werdelin L. Quantification of brain metabolites in amyotrophic lateral sclerosis by localized proton magnetic resonance spectro- scopy. Neurology 1997; 48(4): 878–881.
  • Rooney WD, Miller RG, Gelinas D, Schuff N, Maudsley AA, Weiner MW. Decreased N-acetylaspartate in motor cortex and corticospinal tract in ALS. Neurology 1998; 50(6): 1800– 1805.
  • Block W, Karitzky J, Traber F et al. Proton magnetic resonance spectroscopy of the primary motor cortex in patients with motor neuron disease: subgroup analysis and follow-up measurements. Arch Neurol 1998; 55(7): 931–936.
  • Strong MJ, Grace GM, Orange JB, Leeper HA, Menon RS, Aere C. A prospective study of cognitive impairment in ALS. Neurology 1999; 53(8): 1665–1670.
  • Chan S, Shungu DC, Douglas-Akinwande A, Lange DJ, Rowland LP. Motor neuron diseases: comparison of single- voxel proton MR spectroscopy of the motor cortex with MR imaging of the brain. Radiology 1999; 212(3): 763– 769.
  • Bowen BC, Pattany PM, Bradley WG et al. MR imaging and localized proton spectroscopy of the precentral gyrus in amyotrophic lateral sclerosis. AJNR Am J Neuroradiol 2000; 21(4): 647–658.
  • Pohl C, Block W, Karitzky J et al. Proton magnetic resonance spectroscopy of the motor cortex in 70 patients with amyo- trophic lateral sclerosis. Arch Neurol 2001; 58(5): 729–735.
  • Vielhaber S, Kaufmann J, Kanowski M et al. Effect of creatine supplementation on metabolite levels in ALS motor cortices. Exp Neurol 2001; 172(2): 377–382.
  • Sarchielli P, Pelliccioli GP, Tarducci R et al. Magnetic resonance imaging and 1H-magnetic resonance spectroscopy in amyotrophic lateral sclerosis. Neuroradiology 2001; 43(3): 189–197.
  • Schuff N, Rooney WD, Miller R et al. Reanalysis of multislice (1)H MRSI in amyotrophic lateral sclerosis. Magn Reson Med 2001; 45(3): 513–516.
  • Abe K, Takanashi M, Watanabe Y et al. Decrease in N- acetylaspartate/creatine –ratio in the motor area and the frontal lobe in amyotrophic lateral sclerosis. Neuroradiology 2001; 43(7): 537–541.
  • Kenn W, Ochs G, Pabst TA, Hahn D. 1H spectroscopy in patients with amyotrophic lateral sclerosis. J Neuroimaging 2001; 11(3): 293–297.
  • Suhy J, Miller RG, Rule R et al. Early detection and longitudinal changes in amyotrophic lateral sclerosis by 1H MRSI. Neurology 2002; 58: 773–779.
  • Hanstock CC, Cwik VA, Martin WR. Reduction in metabolite transverse relation times in amyotrophic lateral sclerosis. J Neurol Sci 2002; 198: 37–41.
  • Kalra S, Genge A, Arnold DL. A prospective, randomized, placebo controlled evaluation of corticoneuronal response to intrathecal BDNF therapy in ALS using magnetic resonance spectroscopy: feasibility and results. ALS and Other Motor Neuron Disorders. (In press.)
  • Kalra S, Cashman NR, Caramanos Z, Genge A, Arnold DL. Magnetic resonance spectroscopic imaging reveals lack of improvement in neuronal integrity with gabapentin therapy. American Journal of Neuroradiology. (In press.)
  • Cwik VA, Hanstock CC, Allen PS, Martin WR. Estimation of brainstem neuronal loss in amyotrophic lateral sclerosis with in vivo proton magnetic resonance spectroscopy. Neurology 1998; 50(1): 72–77.
  • Pioro EP, Majors AW, Mitsumoto H, Nelson DR, Ng TC. 1H-MRS evidence of neurodegeneration and excess glutamate- zglutamine in ALS medulla. Neurology 1999; 53(1): 71–79.
  • Kalra S, Cashman NR, Caramanos Z, Genge A, Arnold DL. Gabapentin therapy for amyotrophic lateral sclerosis: lack of improvement in neuronal integrity shown by MR spectroscopy. AJNR Am J Neuroradiol 2003; 24(3): 476–480.
  • Kalra S, Genge A, Arnold D. A prospective, randomized, placebo controlled evaluation of corticoneuronal response to intrathecal BDNF therapy in ALS using magnetic resonance spectroscopy: feasibility and results. Amyotroph Lateral Scler Other Motor Neuron Disord 2003; 4(1): 22–26.
  • Parent A. Carpenter’s Human Neuroanatomy. 9th ed. Baltimore: Williams and Wilkins, 1996.
  • Martin JE, Swash M. The pathology of motor neuron disease. In: Leigh PN, Swash M, editors. Motor Neuron Disease. Biology and Management. London: Springer-Verlag, 1995: 93–118.
  • Kalra S, Cashman NR, Genge A, Arnold DL. Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy. Neuroreport 1998; 9(8): 1757– 1761.
  • Matthews PM, Cianfaglia L, McLaurin J et al. Demonstration of reversible decreases in N-acetylaspartate (NAA) in a neuronal cell line: NAA decreases as a marker of sublethal neuronal dysfunction. Proceedings of the Society of Magnetic Resonance and the European Society for Magnetic Resonance in Medicine and Biology 1, 147. 1995. (Abstract).
  • Demougeot C, Garnier P, Mossiat C et al. N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury. J Neurochem 2001; 77(2): 408–415.
  • Gasparovic C, Arfai N, Smid N, Feeney DM. Decrease and recovery of N-acetylaspartate/creatine in rat brain remote from focal injury. J Neurotrauma 2001; 18(3): 241–246.
  • Jenkins BG, Klivenyi P, Kustermann E et al. Non-linear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington’s disease mice. J Neurochem 2000; 74(5): 2108–2119.
  • De Stefano N, Matthews PM, Arnold DL. Reversible decreases in N-acetylaspartate after acute brain injury. MRM 1995; 34(5): 721–727.
  • Uno M, Ueda S, Hondo H, Matsumoto K, Harada M. Effectiveness of revascularization surgery evaluated by proton magnetic resonance spectroscopy and single photon emission computed tomography. Neurologia Medico-Chirurgica 1996; 36(8): 560–566.
  • Cendes F, Andermann F, Dubeau F, Matthews PM, Arnold DL. Normalization of neuronal metabolic dysfunction after surgery for temporal lobe epilepsy. Evidence from proton MR spectro- scopic imaging. Neurology 1997; 49(6): 1525–1533.
  • Vion-Dury J, Nicoli F, Salvan AM, Confort-Gouny S, Dhiver C, Cozzone PJ. Reversal of brain metabolic alterations with zidovudine detected by proton localized magnetic resonance spectroscopy. Lancet 1995; 345(8941): 60–61.
  • Andreassen OA, Jenkins BG, Dedeoglu A et al. Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation. J Neurochem 2001; 77(2): 383–390.

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